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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
Open Access
Reactivation autoimmune hepatitis report of two cases
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256
CJ Toranzo González, M Castillo Barradas, A Torres Castro
Specialty Hospital. Centro Médico La raza. Instituto mexicano del seguro social (IMSS). Mexico
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Vol. 27. Núm S3

Abstracts from XVII Mexican Congress of Hepatology

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Introduction and Objectives

To present two clinical cases of patients with autoimmune hepatitis (AIH). After infection by SARS-COV2, presented reactivation of the disease.

Materials and methods

42-year-old female with a history of celiac disease, choledocholithiasis, Arterial hypertension and CACU. Autoimmune hepatitis since 2012 treated with Prednisone, ursodeoxycolic acid and mycophenolic Ac. In March 2022, she presented infection by SARS COV-2 and relapse of AIH due to elevated transaminases; remission was reinduced with prednisone, showing biochemical improvement

48-year-old male history of psoriasis diagnosed with AIH in 2018 under treatment with Prednisone and Azathioprine. In February 2022, he presented a serious infection by SARS-Cov 2, restarting the remission reinduction scheme with prednisone and Azathioprine.

Discussion

In the bibliography consulted, there are no reports about the reactivation of the disease after infection by SARS-CoV-2, although there is a case report for autoimmune hepatitis and an autoimmune hepatitis overlap syndrome/primary biliary cholangitis triggered by COVID-19.

Conclusions

The spectrum of affectations after the pandemic by SARSCOV-2 is still wide, so we consider it important to expose these cases where the history of the infection in the face of an exacerbation by SARSCOV-2; in our experience, remission was reinduced with prednisone and azathioprine of according to international schemes, with good response from patients. We consider it important to report these cases since there is an association between AIH and viral infections such as Epsteinbar, so there may be a clear association between Sarc-cov2 infection and relapse.

Funding

The resources used in this study were from the hospital without any additional financing

Declaration of interest

The authors declare no potential conflicts of interest.

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Table 1. Biochemical characteristics of the two patients

Patient 1
Date  AST  ALT  IgG  Alkaline phosphatase  BT  platelets 
04.11.21  26  48  2765  101  0.5  233 
10.03.22  756  1204  4276  183  4.6  200 
24.03.22  281  800  4544  174  2.7  35 
Patient 2
25.11.21  102  130  2292  1.1  85 
28.03.22  638  731  3577  138  10.1  94 

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