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Inicio Cirugía Española Diferencias bioquímicas entre los quistes de mama benignos tipo II únicos y as...
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Vol. 71. Núm. 1.
Páginas 24-27 (enero 2002)
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Vol. 71. Núm. 1.
Páginas 24-27 (enero 2002)
Acceso a texto completo
Diferencias bioquímicas entre los quistes de mama benignos tipo II únicos y asociados a tipo I
Biochemical differences between single benign type II breast cysts and those associated with type II breast cysts
Visitas
9546
A. Ruibal*,**,1, M.J. Núñez***, F. Martínez Arribas***, F. Rabadan***, J. Schneider**,***, A. Tejerina**,***
* Laboratorio de Biología Tumoral FJD. Departamento de Medicina Nuclear. Fundación Jiménez Díaz
** Fundación Tejerina
*** Centro de Patología de la Mama. Madrid
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Estadísticas
Resumen
Introducción

Los quistes mamarios tipo II se caracterizan por presentar en el líquido altas concentraciones de Na+, albúmina, pH y cloruros (Cl-) y parecen corresponder al estadio más avanzado de la enfermedad macroquística. En el presente estudio hemos querido analizar la posible influencia de la coexistencia de quistes tipo I, reflejo de la actividad de la enfermedad, sobre las características bioquímicas de los quistes tipo II

Pacientes y métodos

El grupo estudio incluyó 124 líquidos de quistes tipo II (Na+/K+ > 1,5), de los cuales 72 fueron únicos y 52 asociados a quistes tipo I. En ellos determinamos las concentraciones de Na+, K+, Cl-, glucosa, albúmina, pH y volumen

Resultados

Los quistes tipo II únicos presentaron mayores valores de pH (p = 0,0306) e índice Na+K+ (p = 0,0205), así como menores de K+ (p = 0,0313) y volumen (p = 0,0014). No se constataron diferencias entre ambos grupos en las mujeres en fase folicular, pero sí en las de fase luteínica y menopáusicas. Cuando el dintel clasificador de los quistes fue establecido en una relación Na+/K+ > 3, observamos que los quistes tipo II únicos presentaban valores mayores de pH y menor volumen

Conclusiones

Los resultados anteriores indican que los quistes tipo II únicos presentan unas características bioquímicas distintas de cuando se asocian con quistes tipo I, de tal modo que en esta situación adquieren ciertas propiedades de estos últimos, locual puede ser el exponente de una fase más activa de la enfermedad

Palabras clave:
Líquido de quiste
Quistes mamarios benignos
Tipo II
Introduction

Type II breast cysts are characterized by high concentrations in their fluids of Na+, albumin and chlorides and high pH. These cysts seem to reflect the most advanced stage of macrocystic disease. The aim of the present study was to analyze the possible influence of the coexistence of type I cysts, which reflect the most active stage of the disease, on the biochemical characteristics of type II breast cysts

Patients and methods

We analyzed the fluid of 124 type II breast cysts (Na+/K+ > 1.5) of which 72 were single and 52 were associated with type I cysts. Concentrations of Na+, K+, chloride, glucose and albumin in the fluids, as well as volume and pH values, were determined

Results

In single type II cysts, pH values (p = 0.0306) and Na+/K+ index (p = 0.0205) were higher while K+ levels (p = 0.0313) and volume (p = 0.0014) were lower. No differences were found between subgroups of cysts in women at the follicular phase but differences were found in women at the luteal phase and in postmenopausal women. When the cut-off point for classifying cysts was established at a Na+/K+ index of > 3, single type I cysts showed higher pH values and lower volume

Conclusions

The results of this study suggest that single type II breast cysts present several biochemical features that differ from those associated with type I cysts. When type I and II cysts coexist, type II cysts acquire several features of type I cysts, possibly reflecting the most active phase of the disease

Key words:
Cyst fluids
Benign breast cysts
Type II
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