metricas
covid
Buscar en
Cirugía Española
Toda la web
Inicio Cirugía Española Diferencias bioquímicas entre los quistes de mama benignos tipo II únicos y as...
Información de la revista
Vol. 71. Núm. 1.
Páginas 24-27 (enero 2002)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 71. Núm. 1.
Páginas 24-27 (enero 2002)
Acceso a texto completo
Diferencias bioquímicas entre los quistes de mama benignos tipo II únicos y asociados a tipo I
Biochemical differences between single benign type II breast cysts and those associated with type II breast cysts
Visitas
9523
A. Ruibal*,**,1, M.J. Núñez***, F. Martínez Arribas***, F. Rabadan***, J. Schneider**,***, A. Tejerina**,***
* Laboratorio de Biología Tumoral FJD. Departamento de Medicina Nuclear. Fundación Jiménez Díaz
** Fundación Tejerina
*** Centro de Patología de la Mama. Madrid
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen
Introducción

Los quistes mamarios tipo II se caracterizan por presentar en el líquido altas concentraciones de Na+, albúmina, pH y cloruros (Cl-) y parecen corresponder al estadio más avanzado de la enfermedad macroquística. En el presente estudio hemos querido analizar la posible influencia de la coexistencia de quistes tipo I, reflejo de la actividad de la enfermedad, sobre las características bioquímicas de los quistes tipo II

Pacientes y métodos

El grupo estudio incluyó 124 líquidos de quistes tipo II (Na+/K+ > 1,5), de los cuales 72 fueron únicos y 52 asociados a quistes tipo I. En ellos determinamos las concentraciones de Na+, K+, Cl-, glucosa, albúmina, pH y volumen

Resultados

Los quistes tipo II únicos presentaron mayores valores de pH (p = 0,0306) e índice Na+K+ (p = 0,0205), así como menores de K+ (p = 0,0313) y volumen (p = 0,0014). No se constataron diferencias entre ambos grupos en las mujeres en fase folicular, pero sí en las de fase luteínica y menopáusicas. Cuando el dintel clasificador de los quistes fue establecido en una relación Na+/K+ > 3, observamos que los quistes tipo II únicos presentaban valores mayores de pH y menor volumen

Conclusiones

Los resultados anteriores indican que los quistes tipo II únicos presentan unas características bioquímicas distintas de cuando se asocian con quistes tipo I, de tal modo que en esta situación adquieren ciertas propiedades de estos últimos, locual puede ser el exponente de una fase más activa de la enfermedad

Palabras clave:
Líquido de quiste
Quistes mamarios benignos
Tipo II
Introduction

Type II breast cysts are characterized by high concentrations in their fluids of Na+, albumin and chlorides and high pH. These cysts seem to reflect the most advanced stage of macrocystic disease. The aim of the present study was to analyze the possible influence of the coexistence of type I cysts, which reflect the most active stage of the disease, on the biochemical characteristics of type II breast cysts

Patients and methods

We analyzed the fluid of 124 type II breast cysts (Na+/K+ > 1.5) of which 72 were single and 52 were associated with type I cysts. Concentrations of Na+, K+, chloride, glucose and albumin in the fluids, as well as volume and pH values, were determined

Results

In single type II cysts, pH values (p = 0.0306) and Na+/K+ index (p = 0.0205) were higher while K+ levels (p = 0.0313) and volume (p = 0.0014) were lower. No differences were found between subgroups of cysts in women at the follicular phase but differences were found in women at the luteal phase and in postmenopausal women. When the cut-off point for classifying cysts was established at a Na+/K+ index of > 3, single type I cysts showed higher pH values and lower volume

Conclusions

The results of this study suggest that single type II breast cysts present several biochemical features that differ from those associated with type I cysts. When type I and II cysts coexist, type II cysts acquire several features of type I cysts, possibly reflecting the most active phase of the disease

Key words:
Cyst fluids
Benign breast cysts
Type II
El Texto completo está disponible en PDF
Bibliografía
[1.]
C.D. Haagensen, C. Bodian, D.E. Haagensen.
WB Saunders, (1981),
[2.]
M. Malatesta, F. Mannello, M. Sebastiani, A. Cardinali, F. Marcheggiani, F. Reno, et al.
Ultrastructural characterization and biochemical profile of human groos cystic breast disease.
Breast Cancer Res Treat, 48 (1998), pp. 211-219
[3.]
S. Ciatto, A. Biggieri, M. Rosselli del Turco, D. Bartoli, A. Iossa.
Rik of breast cancer subsequent to proven gross cystic disease.
Eur J Cancer, 26 (1990), pp. 555-557
[4.]
B. Budai, I. Szamel, Z. Sulyok, M. Nemeth, M. Bak, J. Kralovanszky, et al.
Influence of hormonal status of patients with cystic disease on the composition of cyst fluid and breast cancer risk.
Anticancer Res, 20 (2000), pp. 3879-3886
[5.]
A. Purohit, B. Budai, D.Y. Wang, E.L. Willemsen, A. De Winkel, D. Parish, et al.
Modulation of oestrone sulphate formation and hydrolysis in breast cancer cells by breast cyst fluid from British and Hungarian women.
Br J Cancer, 82 (2000), pp. 492-496
[6.]
W.R. Miller, J.M. Dixon, W.N. Scott, A.P.M. Forrest.
Classification of human breast cysts according to electrolyte and androgen conjugate composition.
Clin Oncol, 9 (1983), pp. 227-232
[7.]
F. Vizoso, A. Fueyo, M.T. Allende, J. Fernández, M. García Moran, A. Ruibal.
Evaluation of human breast cyst according to their biochemical and hormonal composition and cytological examination.
Eur J Surg Oncol, 16 (1990), pp. 209-214
[8.]
F. Vizoso Piñeiro.
Fisiopatología de la enfermedad quística de la mama.
Cir Esp, 57 (1995), pp. 360-369
[9.]
M.K. Shwartz, H. Fleisher, C. Breed.
Enzyme composition of human breast cyst fluid.
Clin Chem, 22 (1976), pp. 1213-1214
[10.]
L.C. Lai, W. Chilchik, N.A. Shaikh, M.J. Reed, V.H.T. James.
Relationship between epidermal growth factor and dehydroepiandrosterone and its sulphate in breast cyst fluid.
Eur J Cancer, 60 (1989), pp. 320-323
[11.]
A. Ruibal, M.I. Nuñez, J. Schneider, M.C. Del Río, F. Rabadan, A. Tejerina.
Transforming growth factor beta 2 (TGFb2) and dehydroepiandrosterone sulphate levels in breast macrocysts fluids. Different behaviour according to the type of cyst.
Int J Biol Markers, 13 (1998), pp. 173-175
[12.]
F. Vizoso, M.T. Allende, J. Fernández, B. Suárez, M.C. Roiz.
Ruibal A: Total lactate dehydrogenase and tumor necrosis factor alpha levels in cyst fluid of women with gross cystic breast disease.
Int J Biol Markers, 7 (1992), pp. 123-125
[13.]
L. Dogliotti, F. Orlandi, M. Torta, G. Buzzi, C. Naldoni, A. Mazzotti, et al.
Cations and dehydroepiandrosterone –sulphate in cyst fluid of pre and menopausal patients with gross cystic disease of the breast. Evidence for the existence of subpopulations.
Eur J Cancer Clin Oncol, 22 (1986), pp. 1301-1307
[14.]
G. Secreto, C. Recchione, G. Fariselli, E. Grignolio, S. Di Pietro.
Circulating levels and breast cyst fluid concentrations of human chorionic gonadotrophin, progesterone and testosterone in women with gross cystic breast disease.
Tumori, 70 (1984), pp. 523-527
[15.]
D.L. Page, W.D. Dupont.
Are breast cysts a premalignant markers?.
Eur J Cancer Clin Oncol, 22 (1986), pp. 635-636
[16.]
J.M. Dixon, W.R. Miller, W.N. Scott.
The morphological basis of human breast cyst populations.
Br J Surg, 79 (1983), pp. 604-606
[17.]
F. Vizoso, M.T. Allende, J.L. García Muñiz, A. Alexandre, A. Fueyo, A. Ruibal.
Serum prolactin levels in women with gross cystic disease.
Int J Biol Markers, 7 (1992), pp. 226-229
[18.]
B. Budai, I. Szamel, Z. Sulyok, M. Nemet, M. Bak, S. Otto, et al.
Characteristics of cystic breast disease with special regard to breast cancer development.
Anticancer Res, 21 (2001), pp. 749-752
[19.]
H.L. Bradlow, C.N. Breed, J.S. Nisselbaum, M. Fleischer, M.K. Schwartz.
pH as a marker of breast cyst fluid biochemical type.
Eur J Surg Oncol, 10 (1984), pp. 721-724
Copyright © 2002. Asociación Española de Cirujanos
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos