The patient is a 78-year-old woman with a history of bilateral breast cancer treated 30 years before (quadrantectomy and bilateral axillary lymphadenectomy with subsequent chemoradiotherapy). She presented with an ulcerative plaque measuring 25cm in diameter, with scarring and exudative areas in the right mammary region that had extended progressively over the last 3 years, suggestive of breast cancer recurrence or radiation-induced squamous-cell carcinoma (Fig. 1). The skin biopsy revealed a basal cell carcinoma. After ruling out surgical treatment due to her age and comorbidity, the patient was treated with Hedgehog pathway inhibitors. After initially administration of itraconazole, with no improvement, treatment with vismodegib was started, resulting in complete response one year after treatment.
Please cite this article as: López Rojo I, Rivas Fidalgo S, Gómez Valdazo A, Díaz Miguel M. Lesión extensa de pared torácica en una paciente con antecedentes de carcinoma de mama. Cir Esp. 2019;97:346.
