Results. LPS administration induced a decrease in PC synthesis as well as changes in prostanoid production. We observed an increment in polymorphonuclear cell infiltration, as indicated by the MPO activity, and increased lipid peroxidation, according to the MDA concentration. Both SS and PTXF totally or partially reversed these effects.
Conclusions.. Our results show that PTXF and SS counteract some of the physiopathologic mechanisms involved in acute gastric mucosa lesions secondary to sepsis and, thus, may prove beneficial in the treatment of these lesions