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Inicio Cirugía Española (English Edition) Intramuscular myxoma in psoas muscle and in thigh
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Vol. 101. Núm. 8.
Páginas 577-579 (agosto 2023)
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Vol. 101. Núm. 8.
Páginas 577-579 (agosto 2023)
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Intramuscular myxoma in psoas muscle and in thigh
Mixoma intramuscular en psoas y en muslo
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Rodrigo Kaibel Val
Autor para correspondencia
rodrigokaibelval@gmail.com

Corresponding author.
, Jaime Vázquez Echarri, Ignacio Kaibel Axpe
Clínica médico-quirúrgica ROKAVA, Madrid, Spain
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Intramuscular myxomas are benign tumors with a frequency of 1–1.3 cases per 1 000 000, 70% of which appear in women between the ages of 40 and 70 years. They present as slow-growing painless soft masses, predominantly located in the lower limbs. Since the differential diagnosis is established with malignant soft-tissue neoplasms, the definitive diagnosis is obtained after surgical biopsy. Treatment is surgical. Histologically, intramuscular myxomas are hypocellular and hypovascular, with abundant myxoid content and no mitosis, atypia, or necrosis. They do not become malignant or metastasize. Local recurrence is low.

We present the cases of 2 patients with intramuscular myxoma.

Case 1

The patient is a 60-year-old woman with a mass in the right quadriceps. MRI of the right thigh showed a 2 × 1.7 × 2.1 cm lesion with smooth contours in the vastus lateralis of the right quadriceps, with a homogeneous signal on the non-contrast sequence, similar to the musculature on T1 sequences; post-contrast enhancement was heterogeneous and moderate-intense (Fig. 1).

Fig. 1.

MRI of thighs: (A) intensity similar to the musculature in T1 sequences, without fat suppression; (B and C) high intensity in PD sequences with fat suppression showing cranial and caudal halo; (D) peripheral heterogenous moderate-intense enhancement with hypointense nodular central area and no enhancement in T1 post-contrast.

(0.34MB).

We decided to remove the mass surgically, opening of the fascia lata and the vastus lateralis, followed by en bloc excision of the intramuscular lesion together with the surrounding muscle.

The pathology study showed hypocellular mesenchymal proliferation without atypia, mitosis, or necrosis in an edematous myxoid matrix dissecting the adjacent muscle tissue and in contact with the resection margin. Positivity for smooth muscle actin and desmin was weak, and S100 and p53 expression was negative, which was compatible with an intramuscular myxoma measuring 3.2 × 2.1 × 1.8 cm with margin involvement.

Fourteen months later, the patient has not presented local recurrence.

Case 2

The patient is an asymptomatic 64-year-old man in whom abdominal ultrasound revealed a large, homogeneous, hypoechoic soft tissue lesion adjacent to the right psoas. MRI demonstrated a right retroperitoneal mass measuring 8.3 × 5.5 × 4.2 cm in the psoas in contact with the inferior vena cava and the L2–L5 vertebrae, which was markedly hyperintense on T2, well defined, showing no diffusion restriction, with little post-contrast uptake, slow and progressive, suggesting a myxoid predominance (Fig. 2).

Fig. 2.

Pelvic MRI: (A–C) hyperintense lesion in T2 without fat suppression, well delimited and interior septa; (D and E) T1 sequences with fat suppression and contrast, limited enhancement, slow but progressive; (F) no restriction of diffusion.

(0.71MB).

Laparotomy was performed with the Cattle maneuver and opening of the psoas, followed by simple dissection of the mass, which was adhered to the vertebral bodies without invading them.

The pathology study confirmed hypocellular mesenchymal proliferation, with abundant myxoid stroma, focally invading the peripheral muscle tissue, without atypia, mitosis or tumor necrosis, negative for smooth muscle actin, desmin and S100, compatible with an 11 × 6 × 4 cm intramuscular myxoma with margin involvement.

Follow-up MRI studies 6 and 12 months later showed no local recurrence.

Intramuscular myxomas are painless, solitary, benign soft tissue mesenchymal tumors measuring 2–15 cm,1 that are asymptomatic unless neighboring structures are compressed.2 They are slow-growing and found most frequently in the thighs and buttocks; while they can also appear in the rib cage, abdominal wall or oral cavity,3,4 the psoas is rare.

Multiple lesions may occur as part of Mazabraud or McCune-Albright syndromes.1,5 They are frequently associated with trisomies of chromosomes 8 and 7, like other neoplasms, or somatic mutations of the Arg201 codon of the GNAS1 gene on chromosome 20q13.6

Diagnosis requires imaging tests to delimit the lesion and assess its relationship with adjacent structures, and histological confirmation to differentiate it from sarcomas. Ultrasound shows a well-defined, homogeneous and hypoechoic lesion, and CT shows well-defined, homogeneous and hypointense lesions, with no post-contrast enhancement. MRI is the gold standard, showing well-defined lesions with a capsule, sometimes with intralesional cysts or surrounded by a fatty ring. They usually present homogeneous hypointensity on T1 sequences, with marked hyperintensity on T2 relative to the surrounding tissue, and heterogeneous variable enhancement on images with contrast that can show different patterns,4,7,8 as in our cases.

While they appear well defined macroscopically, histologically they are hypocellular, hypovascular tumors with abundant mucinous stroma devoid of collagen, with no mitosis, atypia or necrosis; also, although they present focal areas of hypercellularity and hypervascularity, their benign behavior does not change.8,9 Microscopically, they usually invade and/or atrophy the surrounding muscle tissue.7,9 Immunohistochemistry usually shows positivity for vimentin and negativity for S-100, desmin, smooth muscle actin and α-1 antitrypsin.2,9

The differential diagnosis is mainly established with other myxoid tumors, both benign and malignant.6,9 Tru-Cut core needle biopsy is recommended for pathology and immunohistochemical studies to differentiate them from sarcomas.9,10

Treatment is surgical resection. In a series of 55 myxomas, no local recurrence was observed after 19 years of follow-up; extended or simple resection has been performed despite margin involvement, and simple resection was recommended due to its lower morbidity.1,10 Local recurrence is around 3%–8%, with higher risk in the first 2 years.1,9 Myomas never metastasize. Recurrence has not been observed in any of our patients.

Funding

This article has received no specific funding from public, commercial or non-profit organisms.

Conflicts of interest

None to declare.

References
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Intramuscular myxoma. A review and follow up study of 34 cases.
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S. Sukpanichyingyong, S. Matsumoto, K. Ae, T. Tanizawa, K. Hayakawa, Y. Funauchi, et al.
Surgical treatment of intramuscular myxoma.
Indian J Orthop, 55 (2021), pp. 892-897

Please cite this article as: Kaibel Val R, Vázquez Echarri J, Kaibel Axpe I. Mixoma intramuscular en psoas y en muslo. Cir Esp. 2023. https://doi.org/10.1016/j.ciresp.2023.02.013

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