Información del artículo
Abstract
Liver transplantation has been remarkably effective in the treatment in patients with endstage liver disease. However, disparity between solid-organ supply and increased demand is the greatest limitation, resulting in longer waiting times and increase in mortality of transplant recipients. This situation creates the need to seek alternatives to orthotopic liver transplantation. Hepatocyte transplantation or liver cell transplantation has been proposed as the best method to support patients.
The procedure consists of transplanting individual cells to a recipient organ in sufficient quantity to survive and restore the function. The capacity of hepatic regeneration is the biological basis of hepatocyte transplantation. This therapeutic option is an experimental procedure in some patients with inborn errors of metabolism, fulminant hepatic failure and acute and chronic liver failure, as a bridge to orthotopic liver transplantation.
In the Hospital La Fe of Valencia, we performed the first hepatocyte trasplantation in Spain creating a new research work on transplant program.
Keywords:
Liver transplantation
Hepatocyte transplantation
Hepatocyte
Inborn errors of liver metabolism
Liver failure
Resumen
El trasplante hepático es el único tratamiento efectivo existente para las enfermedades hepáticas en fase terminal. La desproporción entre la demanda y la oferta de órganos constituye su principal limitación y plantea la necesidad de buscar alternativas al trasplante hepático.
El trasplante celular hepático o trasplante de hepatocitos humanos constituye, en el momento actual, la mejor opción terapéutica sustitutiva. Consiste en trasplantar hepatocitos humanos totalmente diferenciados a un órgano receptor, en cantidad suficiente para que éstos sobrevivan y restauren la función hepática normal, basándose en la capacidad de regeneración hepática. Este tratamiento está en fase clinicoexperimental, y se ha realizado en pacientes con errores congénitos del metabolismo, fallo hepático fulminante y fallo hepático agudo o crónico como puente al trasplante convencional.
En el Hospital La Fe de Valencia hemos puesto en marcha y llevado a cabo el primer trasplante celular hepático en España, por tanto, esto abre una nueva línea de trabajo dentro del Programa de Trasplante Hepático.
Palabras clave:
Trasplante hepático
Trasplante celular hepático
Hepatocitos
Errores congénitos del metabolismo
Fallo hepático
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