Influencia del depósito de grasa abdominal en la respuesta terapéutica a atorvastatina en mujeres con hipercolesterolemia familiar heterocigota

Civera, M.; Real, J.T.; Chaves, F.J.; Catalá, M.; García-García, A.B.; Ascaso, J.F.; Armengod, M.E.; Carmena, R.

doi:10.1016/S0214-9168(03)78902-5

Información del artículo

Resumen

Bibliografía

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Estadísticas

Objetivo

Analizar la influencia de parámetros antropométricos (tipo y grado de obesidad) sobre el fenotipo lipoproteico y la respuesta terapéutica a atorvastatina en mujeres con

Métodos

Estudio de intervención no controlado con 20 mg de atorvastatina al día (dosis nocturna) en 34 mujeres con hipercolesterolemia familiar heterocigota seleccionadas de forma aleatoria.

Resultados

El depósito de grasa abdominal influye de forma estadísticamente significativa en los valores de presión arterial y concentraciones plasmáticas basales y postratamiento de los triglicéridos. Existe una interacción negativa entre el depósito de grasa abdominal y la respuesta terapéutica de cLDL, siendo menores los descensos en mujeres con mayor depósito de grasa abdominal. El índice de masa corporal y la edad no influyen en los valores basales de lípidos y apo B ni en la respuesta terapéutica a atorvastatina.

Conclusión

El depósito de grasa abdominal en mujeres con hipercolesterolemia familiar y su corrección en los casos en que esté aumentado debe realizarse para mejorar su perfil lipídico basal y evitar la interacción negativa con atorvastatina.

Palabras clave:

Hipercolesterolemia familiar heterocigota

Respuesta al tratamiento con atorvastatina

Índice cintura-cadera

Depósito de grasa abdominal

Objective

To analyse the influence of anthropometric parameters on lipid and apo B plasma values in fasting situation and after 20 mg/d of atorvastatin in females with heterozygous familial hypercolesterolemia (FH).

Design

Uncontrolled intervention study with 20 mg/d of atrovastatin in 34 females with FH randomly selected.

Results

Abdominal fat deposits influence blood pressure and fasting TG plasma levels pre and post treatment. We have found a significant, negative interaction between abdominal fat deposits and response to 20 mg/d of atorvastatin on cLDL plasma values. Females with higher abdominal fat deposits have lower decreases of cLDL after treatment. No interaction was found between treatment and BMI or age on pre or post treatment lipid and apo B plasma values.

Conclusion

Abdominal fat deposits should be corrected in females with FH in order to control lipid profile and to ovoid negative interaction with atorvastatin.

Key words:

Familial hypercholesterolemia

Treatment response to atorvastatin

Waist to hip ratio

Abdominal fat deposits

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Este trabajo ha sido financiado parcialmente con la beca Parke-Davis 2000 de la Sociedad Española de Arteriosclerosis y Proyecto FIS 99/0008 y 01/0056-02.

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