Radioquimioterapia en el tratamiento del carcinoma localmente avanzado o recurrente de vulva

Díez, J.; Moreno, J.; Urquijo, E.; Rementería, A.; Luján, S.; Rodríguez-Escudero, F.; Casquero, F.

doi:10.1016/S0210-573X(02)77171-2

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Resumen

Se trata a 3 pacientes con carcinomas localmenteavanzados de vulva, y otras seis con carcinoma recurrente vulvar o inguinal mediante radioquimioterapia. Como agentes quimioterápicos se utilizan mitomicina C y 5-fluorouracilo. El tratamiento radioterápico alcanzó, por lo menos, 60 Gy. Todas las pacientes con carcinoma avanzado obtuvieron una respuesta clínica completa, y en el momento de la última revisión estaban vivas y sin evidencia de enfermedad. De las pacientes con recidiva, dos (33,3%)consiguieron una respuesta completa, dos (33,3%)una respuesta parcial (que posibilitó la cirugía de rescate), y dos (33,3%) no obtuvieron respuesta. De estegrupo, el 66,6% estaban vivas y sin enfermedad. Laradioquimioterapia es un excelente método de tratamiento del carcinoma vulvar localmente avanzadoque evita cirugías mutilantes, y también es efectivoen el tratamiento de la recidiva tumoral.

Summary

We treated 3 patients with locally advanced vulvar carcinoma and 6 more with vulvar or inguinal recurrences with chemoradiation. Mitomycin C and 5 Fluorourocil were used for chemotherapy, and radiotherapy achieved 60Gy or more. All the patients with advanced carcinoma made a complete clinical recovery, and were still alive and disease free at the last follow-up. Of the patients with recurrent disease, 2 (33.3%) made a complete clinical recovery, 2 (33.3%) made a partial recovery and underwent salvage surgery, and 2 (33.3%) did not improve. Of this group 66.6% were alive and disease free. Chemoradiation is an excellent method of treatment for locally advanced vulvar carcinoma, avoiding radical surgery. It is also effective in the management of tumour recurrence.

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