metricas
covid
Buscar en
Clínica e Investigación en Ginecología y Obstetricia
Toda la web
Inicio Clínica e Investigación en Ginecología y Obstetricia Radioquimioterapia en el tratamiento del carcinoma localmente avanzado o recurre...
Información de la revista
Vol. 29. Núm. 5.
Páginas 158-161 (enero 2002)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 29. Núm. 5.
Páginas 158-161 (enero 2002)
Acceso a texto completo
Radioquimioterapia en el tratamiento del carcinoma localmente avanzado o recurrente de vulva
Visitas
6677
J. Díeza, J. Morenoa, E. Urquijoa, A. Rementeríaa, S. Lujána, F. Rodríguez-Escuderoa, F. Casquero1
1 Servicio de Oncología Radioterápica. Hospital de Cruces. Bilbao. España.
a Servicio de Oncología Ginecológica. Departamento de Obstetricia y Ginecología.
Este artículo ha recibido
Información del artículo
Resumen

Se trata a 3 pacientes con carcinomas localmenteavanzados de vulva, y otras seis con carcinoma recurrente vulvar o inguinal mediante radioquimioterapia. Como agentes quimioterápicos se utilizan mitomicina C y 5-fluorouracilo. El tratamiento radioterápico alcanzó, por lo menos, 60 Gy. Todas las pacientes con carcinoma avanzado obtuvieron una respuesta clínica completa, y en el momento de la última revisión estaban vivas y sin evidencia de enfermedad. De las pacientes con recidiva, dos (33,3%)consiguieron una respuesta completa, dos (33,3%)una respuesta parcial (que posibilitó la cirugía de rescate), y dos (33,3%) no obtuvieron respuesta. De estegrupo, el 66,6% estaban vivas y sin enfermedad. Laradioquimioterapia es un excelente método de tratamiento del carcinoma vulvar localmente avanzadoque evita cirugías mutilantes, y también es efectivoen el tratamiento de la recidiva tumoral.

Summary

We treated 3 patients with locally advanced vulvar carcinoma and 6 more with vulvar or inguinal recurrences with chemoradiation. Mitomycin C and 5 Fluorourocil were used for chemotherapy, and radiotherapy achieved 60Gy or more. All the patients with advanced carcinoma made a complete clinical recovery, and were still alive and disease free at the last follow-up. Of the patients with recurrent disease, 2 (33.3%) made a complete clinical recovery, 2 (33.3%) made a partial recovery and underwent salvage surgery, and 2 (33.3%) did not improve. Of this group 66.6% were alive and disease free. Chemoradiation is an excellent method of treatment for locally advanced vulvar carcinoma, avoiding radical surgery. It is also effective in the management of tumour recurrence.

El Texto completo está disponible en PDF
Bibliografía
[1.]
H. Kurgan, C.L. Trimble, K.V. Shah.
Human papilloma virus and the pathogenesis of vulvar carcinoma.
Curr Opin Obstet Gynecol, 4 (1992), pp. 582-585
[2.]
A. Akl, M. Akl, G. Boike, J. Hebert, J. Graham.
Preliminary results of chemoradiation as a primary treatment for vulvar carcinoma.
Int J Radiation Oncology Biol Phys, 48 (2000), pp. 415-420
[3.]
P.J. DiSaia, W.T. Creasman, W.M. Rich.
An alternate approach to early cancer of the vulva.
Am J Obstet Gynecol, 133 (1979), pp. 825-832
[4.]
S.C. Han, D.H. Kim, S.A. Higgins, M.L. Carcangiu, B.M. Kacinski.
Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva.
Int J Radiation Oncology Biol Phys, 47 (2000), pp. 1235-1244
[5.]
D. Cavanagh, J.H. Shephard.
The place of pelvic exenteration in the primary management of advanced carcinoma of the vulva.
Gynecol Oncol, 13 (1982), pp. 318-322
[6.]
B. Miller, M. Morris, C. Levenback, T. Burke, D. Gerhenson.
Pelvic exenteration for primary or recurrent vulvar cancer.
Gynecol Oncol, 58 (1995), pp. 202-205
[7.]
N.D. Nigro, G. Seydel, B. Considine, V.K. Vaitkevicius, L. Leich-man, J.J. Kinzie.
Combined preoperative radiation and che-moterapy for squamous cell carcinoma of anal cancer.
Cancer, 51 (1983), pp. 1826-1829
[8.]
M.J. O’Connell, J.A. Martenson, H.S. Wieand, J.E. Krook, J.S. Mac-donald, D.G. Haller, et al.
Improving adjuvant therapy for rectal cancer by combining protacted infusion fluorouracil with radiation therapy after curative surgery.
N Engl J Med, 331 (1994), pp. 502-507
[9.]
L.L. Hughes, T.A. Rich, L. Delclos, J.A. Ajani, R.G. Martin.
Radiotherapy for anal cancer. Experience from 1979-1987.
Int J Radiat Oncol Biol Phys, 17 (1989), pp. 1153-1160
[10.]
T.A. Rich, J.A. Ajan, W.H. Morrison, D. Ota, B. Levin.
Chemoradiation therapy for anal cancer: Radiation plus continuous infusion of 5-fluorouracil with or without cisplatin.
Radiother Oncol, 27 (1993), pp. 209-215
[11.]
W. Levin, G. Goldberg, M. Altaras, B. Bloch, M.G. Shelton.
The use of concomitant chemotherapy and radiotherapy prior to surgery in advanced stage carcinoma of the vulva.
Gynecol Oncol, 25 (1986), pp. 20-25
[12.]
P.J. Eifel, M. Morris, T.W. Burke, C.H. Levenback, D.M. Gershenson.
Prolonged continuous infusion cisplatin and 5 fluorou-racil with radiation for locally advanced carcinoma of the vulva.
Gynecol Oncol, 59 (1995), pp. 51-56
[13.]
S.A. Wahlen, J.D. Slater, R.J. Wagner, W.A. Wang, E.D. Keeney, J.M. Hocko, et al.
Concurrent radiation therapy and chemotherapy in the treatment of primary squamous cell carcinoma of the vulva.
Cancer, 75 (1995), pp. 2289-2294
[14.]
G. Lupi, F. Raspagliesi, R. Zucali, R. Fontanelli, D. Paladini, R. Kenda, et al.
Combined preoperative chemoradiotherapy followed by radical surgery in locally advanced vulvar carcinoma. A pilot study.
[15.]
F. Landoni, A. Maneo, G. Zanetta, A. Colombo, S. Nava, F. Placa, et al.
Concurrent preoperative chemotherapy with 5 Fluorouracil and Mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma.
Gynecol Oncol, 61 (1996), pp. 321-327
[16.]
M.J. Cunningham, R.P. Goyer, S.J. Gibbons, D.C. Kredentser, J.H. Malfetano, H. Keys.
Primary radiation, Cisplatin, and 5 Fluorouracil for advanced squamous carcinoma of the vulva.
Gynecol Oncol, 66 (1997), pp. 258-261
[17.]
D.H. Moore, G.M. Thomas, G.S. Montana, A. Saxer, D.G. Gallup, G. Olt.
Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group.
Int J Radiation Oncology Biol Phys, 42 (1998), pp. 79-85
Copyright © 2002. Elsevier España, S.L.. Todos los derechos reservados
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos