Información del artículo
La diabetes mellitus es una de las enfermedades con mayor impacto sociosanitario, no sólo por su alta prevalencia, sino también por sus complicaciones crónicas y su elevada tasa de mortalidad. La forma más exacta de estimar la prevalencia de DM es la práctica de un test de tolerancia oral a la glucosa. En España, la prevalencia de DM se estima en un 6,2% para grupos de edad 30-65 años, y en un 10% para 30-89 años. La proporción de DM conocida frente a la ignorada oscila entre 1/3 y 2/3 del total. Los factores de riesgo de DM más importantes son la edad, la obesidad y la historia familiar de DM. La incidencia de DM2 se estima en 8/1.000 habitantes año. La prevalencia de las distintas complicaciones crónicas varía en función del tipo de DM, tiempo de evolución y grado de control metabólico, estimándose globalmente en la siguiente: neuropatía 25%, retinopatía 32% y nefropatía 23%. La DM es una de las principales causas de mortalidad en España, ocupando el tercer lugar en mujeres y el séptimo en varones.
Palabras clave:
Diabetes
Diabetes mellitus tipo 2
Incidencia
Prevalencia
Mortalidad
España
Diabetes mellitus is one of the most important diseases, not only because its high prevalence but also by its chronical complications and its high mortality. The most exact method to investigate diabetes prevalence is the population based study by the oral glucose tolerance test. In Spain, the prevalence in the 30-65 year-old population is 6.5% and 10.3% in the 30-89 year-old population. The prevalence rates of known diabetes and unknown diabetes are 1/3 to 2/3. The DM2 incidence in Spain is 8/1,000 persons-year. The prevalence of the chronic complications of DM varies according to type of diabetes, evolution of the disease and degree of metabolic control: neuropathy 25%, retinopathy 32% and nephropathy 23%. Diabetes is one of the most important causes of mortality in Spain, being the 3rd in woman and the 7th in men.
Key words:
Diabetes
Type 2 diabetes mellitus
Incidence
Prevalence
Mortality
Spain
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Bibliografía
[1.]
Diabetes care and Research in Europe.
The Saint Vincent Declaration.
Diabet Med, 7 (1990), pp. 360
[2.]
Alberti KGMM.
Problems related to definitions and epidemiology of type 2 (non-insulin-dependent) diabetes mellitus: studies throughout the world.
Diabetología, 36 (1993), pp. 978-984
[3.]
L. Jovanovic, B. Gondos.
Type 2 diabetes: the epidemic of the new millenium.
Ann Clin Lab Sci, 29 (1999), pp. 33-42
[4.]
A.Y.W. Chan, C.S. Ho, C.S. Cockram, R. Swaminathan.
Handling of blood specimens for glucose analysis.
J Clin Chem Clin Biochem, 28 (1990), pp. 185-186
[5.]
Associació Catalana de Ciències de Laboratori Clínic, Consell Assessor sobre la Diabetes a Catalunya.
Recomanacions sobre la mesura de la concentració de glucosa en el plasma.
1999 Fecha de acceso: abril de, (2000),
[6.]
A.B.M. Swai, D.G. McLarty, H.M. Kitange, P.M. Kilima, G. Masuki, B.I. Mtinangi, et al.
Study in Tanzania of impaired glucose tolerance Methodological myth?.
Diabetes, 40 (1991), pp. 516-520
[7.]
R. Corcoy, J. Ordóñez, C. Castell, G. Tarin, R. Treserras.
Prueba oral de tolerancia a la glucosa y medida de la concentración de glucosa: ¿se realizan correctamente?.
Quim Clin, 13 (1994), pp. 68-72
[8.]
K.G.M.M. Alberti, P.Z. Zimmet.
Definition, diagnosis and classification of diabetes mellitus and its complications. Provisional Report of a WHO consultation.
Diabet Med, 15 (1998), pp. 539-553
[9.]
K.L. Ramaiya, A.B.M. Swai, D.G. McLarty, R.S. Bhopal, K.G.M.M. Alberti.
Prevalence of diabetes and cardiovascular disease risk factors in Hindu Indian subcommunities in Tanzania.
BMJ, 303 (1991), pp. 271-276
[10.]
R. Klein, B.E.K. Klein, K.L.P. Linton, S.E. Moss.
Microalbuminuria in a population-based study of diabetes.
Arch Intern Med, 152 (1992), pp. 153-158
[11.]
R. Trevisan, M. Vedovato, A. Tiengo.
The epidemiology of diabetes mellitus.
Neprol Dial Transplant, (1998), pp. 2-5
[12.]
P.Z. Zimmet, D.J. McCarty, M.P. De Courten.
The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome.
J Diabetes Complications, 11 (1997), pp. 60-68
[13.]
P.H. Bennet, C. Bogardus, J. Tuomilehto, P. Zimmet.
Epidemiology and natural history of type 2 diabetes: non-obese and obese.
International textbook of diabetes mellitus, pp. 147-156
[14.]
R.D. Lindeman, L.J. Romero, R. Hundley, A.S. Allen, H.C. Liang, R.N. Baumgartner, et al.
Prevalences of type 2 diabetes, the insulin resistance syndrome, and coronary heart disease in an elderly, biethnic population.
Diabetes Care, 21 (1998), pp. 959-966
[15.]
A. Ramachandran, C. Snelatha, E. Latha, M. Manoharan, V. Vigía.
Impacts of urbanisation on the lifestyle and on the prevalence of diabetes in native Asian Indian population.
Diabetes Res Clin Pract, 44 (1999), pp. 207-213
[16.]
K.M. West, J.M. Kalbfleisch.
Glucose tolerance, nutrition and diabetes in Uruguay, Venezuela, Malaya and East Pakistan.
Diabetes, 19 (1966), pp. 656-663
[17.]
M.J. Tormo, C. Navarro, M.D. Chirlaque, D. Pérez.
Factores de riesgo cardiovascular en la región de Murcia, España.
Rev Esp Salud Pública, 71 (1997), pp. 515-529
[18.]
C. Castell, R. Treserras, J. Serra, A. Goday, G. Lloveras, L.l. Salleras.
Prevalence of diabetes in Catalonia (Spain): an oral glucose tolerance test-based population study.
Diabetes Res Clin Pract, 43 (1999), pp. 33-40
[19.]
J. Bayo, C. Sola, F. García, P.M. Latorre, J.A. Vázquez.
Prevalencia de la diabetes mellitus no dependiente de la insulina en Lejona (Vizcaya).
Med Clin (Barc), 101 (1993), pp. 609-612
[20.]
R.J. Jarrett, H. Keen, J.H. Fuller, M. McCartney.
Worsening to diabetes in men with impaired glucose tolerance (borderline diabetes).
Diabetología, 16 (1979), pp. 25-30
[21.]
L.O. Ohlson, B. Larsson, H. Eriksson.
Diabetes mellitus in Swedish middle-aged men. The study of men born 1913 and 1923.
Diabetología, 30 (1987), pp. 386-393
[22.]
K.F. Eriksson, F. Lindgärde.
Impaired glucose tolerance in a middle-aged male urban population: a new approach for identifying high-risk cases.
Diabetología, 33 (1990), pp. 526-531
[23.]
M.P. Garancini, G. Calori, G.l. Ruototo.
Prevalence of NIDDM and impaired glucose tolerance in Italy: an OGTT-based population study.
Diabetologia, 38 (1995), pp. 306-313
[24.]
J. Bayo, P.M. Latorre, F. García, J.A. Vázquez.
Factores de riesgo asociados a la prevalencia de diabetes mellitus no insulinodependiente en Lejona (Vizcaya).
Med Clin (Barc), 107 (1996), pp. 572-577
[25.]
J.A. Vázquez, S. Gaztambide, E. Soto-Pedre.
Estudio prospectivo a 10 años sobre la incidencia y factores de riesgo de diabetes mellitus tipo 2.
Med Clin (Barc), 115 (2000), pp. 534-539
[26.]
R.J. Jarrett, P. McCartney, H. Keen.
The Bedford Survey: ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risks indices for coronary heart disease in borderline diabetics.
Diabetología, 22 (1982), pp. 79-84
[27.]
W.J. De Grauw, E.H. Van den Lisdonk, H.J. Van den Hoogen, C. Van Weel.
Cardiovascular morbidity and mortality in type 2 diabetic patients: a 22-year historical cohort study in Dutch general practice.
Diabetic Med, 12 (1995), pp. 117-122
[28.]
E.M. Damsgaard, A. Froland, C.E. Mogensen.
Over-mortality as related to age and gender in patients with established non-insulin-dependent diabetes mellitus.
J Diab Comp, 11 (1997), pp. 77-82
[29.]
K.F. Eriksson, F. Lindgärde.
No excess 12-year mortality in men with impaired glucose tolerance who participated in the Malmö Preventive Trial with diet and exercise.
Diabetología, 41 (1998), pp. 1010-1016
[30.]
G. Bruno, F. Merletti, P. Boffetta, P. Cavallo-Perin, G. Bargero, G. Gallone, et al.
Impact of glycaemic control, hypertension and insulin treatment on general and cause-specific mortality: an Italian population-based cohort of type II (non-insulin-dependent) diabetes mellitus.
Diabetología, 42 (1999), pp. 297-301
[31.]
S. Vilbergsson, G. Sigurdsson, H. Sigvaldason, A.B. Hreidarsson, N. Sigfusson.
Prevalence and incidence of NIDDM in Iceland: evidence for stable incidence among males and females 1967- 1991 – The Reykjavik Study.
Diabetic Med, 14 (1997), pp. 491-498
[32.]
D.K. Anderson, K. Svardsudd, G. Tibblin.
Prevalence and incidence of diabetes in a Swedish community 1972-1987.
Diabetic Med, 8 (1991), pp. 428-434
[33.]
A. Reunanen.
Prevalence and incidence of type 2 in Finland.
Acta Endocrinol, 262 (1984), pp. 31-35
[34.]
I. Njolstad, E. Arnesen, P.G. Lund-Larsen.
Sex differences in risk factors for clinical diabetes mellitus in a general population: a 12-year follow-up of the Finnmark Study.
Am J Epidemiol, 147 (1998), pp. 49-58
[35.]
H. Keen, R.J. Jarrett, P. McCartney.
The ten-year follow-up of the Bedford Survey (1962-1972): glucose tolerance and diabetes.
Diabetología, 22 (1982), pp. 73-78
[36.]
R.J. Heine, G. Nijpels, J.M. Mooy.
New data on the rate of progression of impaired glucose tolerance to NIDDM and predicting factors.
DiabeticMed, 13 (1996), pp. 12-14
[37.]
K.M. Alberti.
Impaired glucose tolerance: what are the clinical implications?.
Diabetes Res Clin Pract, 40 (1998), pp. 3-8
[38.]
J.H. Warram, R.J. Sigal, B.C. Martin, A.S. Krolewski, J.S. Soeldner.
Natural history of impaired glucose tolerance: follow-up at Joslin Clinic.
Diabetic Med, 13 (1996), pp. 40-45
[39.]
S.L. Edelstein, W.C. Knowler, R.P. Bain, R. Andres, E.L. Barrett-Connor, G.K. Dowse, et al.
Predictors of progression from impaired glucose tolerance to NIDDM. An analysis of six prospective studies.
Diabetes, 46 (1997), pp. 701-710
[40.]
S.M. Haffner, H. Miettinen, M.P. Stern.
Are risk factors for conversion to NIDDM similar in high and low risk populations?.
Diabetología, 40 (1997), pp. 62-66
[41.]
M.A. Charles, A. Fontbonne, N. Thibult, J.M. Warnet, G.E. Rosselin, E. Eschwege.
Risk factors for NIDDM in white population-Paris Prospective Study.
Diabetes, 40 (1991), pp. 796-799
[42.]
B.C. Martin, J.H. Warram, A.S. Krolewski, R.N. Bergman, J.S. Soeldner, C.R. Kahn.
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.
Lancet, 342 (1992), pp. 925-929
[43.]
National Diabetes Data Group.
Diabetes in America.
[44.]
WHO Study Group.
Diabetes mellitus: technical report series n.° 727.
[45.]
I.J. Perry, S.G. Wannamethee, M.K. Walker, A.G. Thompson, P.H. Whincup, A.G. Shaper.
Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men.
BMJ, 310 (1995), pp. 560-564
[46.]
V.J. Carey, E.E. Walters, G.A. Colditz, C.G. Solomon, W.C. Willett, B.A. Rosner, et al.
Body fat distribution and risk of noninsulin-dependent diabetes mellitus in women. The Nurse’s Health Study.
Am J Epidemiol, 145 (1997), pp. 614-619
[47.]
J. Franch, J.C. Álvarez, F. Álvarez, F. Diego, R. Hernández, A. Cueto.
Epidemiología de la diabetes mellitus en la provincia de León.
Med Clin (Barc), 98 (1992), pp. 609-612
[48.]
P.L. De Pablos Velasco, F.J. Martínez Martín, F. Rodríguez-Pérez, B.J. Anía, A. Losada, P. Betancor.
Prevalence and determinants o diabetes mellitus and glucose intolerance in Canarian Caucasian population – Comparison of the ADA and the 1985 WHO criteria. The Guia Study.
Diabetic Med, 18 (2001), pp. 235-241
[49.]
J.M. Hernández, B. Costa.
y el Grupo para el Estudio de la Diabetes (ABS de Falset). Diagnóstico de salud de la población diabética en la comarca del Priorat (Tarragona).
Aten Primaria, 8 (1991), pp. 668-674
[50.]
B. Tamayo-Marco, E. Faure-Nogueras, M.J. Roche-Asensio, E. Rubio-Calvo, E. Sánchez-Oriz.
Salvador-Oliván JA. Prevalence of diabetes and impaired glucose tolerance in Aragón, Spain.
Diabetes Care, 20 (1997), pp. 534-536
[51.]
J. Espinàs, R.M. Salla, M. BellvehíM, E. Reig, T. Iruela, E. Muñoz, et al.
Reevaluación del programa de diabetes mellitus tipo II Propuesta de indicadores de calidad.
Aten Primaria, 1 (1993), pp. 123-126
[52.]
L.L. Vila, E. Subirats, T. Vila, N. Margalef, M. Cardona, R. Vallescar.
Prevalencia de diabetes en La Cerdanya (comarca del Pirineo Oriental).
Endocrinología, 41 (1994), pp. 305-309
[53.]
T. Mur, J. Franch, J. MoratóJ, A. Llobera, Vilarrubias, C. Ros.
Nefropatía y microalbuminuria en la diabetes tipo II.
Aten Primaria, 16 (1995), pp. 516-524
[54.]
B. Zorrilla, J.L. Cantero.
Martínez M y Red de Médicos Centinelas de la Comunidad de Madrid. Estudio de la diabetes mellitus no insulinodependiente en atención primaria en la Comunidad de Madrid a través de la red de médicos centinelas.
Aten Primaria, 20 (1997), pp. 543-548
[55.]
J.M. Baena, M. Oller, R. Martín, M. Nicolau, A. Altés, C. Iglesias.
Impacto de los nuevos criterios diagnósticos propuestos por la Asociación Americana de Diabetes (ADA-97) sobre la prevalencia diagnóstica de diabetes mellitus tipo 2.
Aten Primaria, 24 (1999), pp. 97-100
[56.]
M.C. Serna, M. Madrid, I. Cruz, E. Gasco, M. Ribelles, L.l. Serra.
Estimación de la prevalencia de diabetes mellitus en seis comarcas de la provincia de Lleida.
Endocrinología, 46 (1999), pp. 83-86
[57.]
Botas P, Delgado E, Castaño G, díaz de greñu C, prieto J, Díaz-Cadórniga FJ. prevalencia de diabetes mellitus e intolerancia a la glucosa en población entre 30 y 75 años en Asturias. Revista Clínica Española [en prensa]
[58.]
I. Libman, S.A. Arslanian.
Type II diabetes mellitus: no longer just adults.
Pediatr Ann, 28 (1999), pp. 589-593
[59.]
A. Fagot-Campagna, N.R. Burrows, D.F. Williamson.
The public health epidemiology of type 2 diabetes in children and adolescents: a case study of American Indian adolescents in the Southwestern United States.
Clin Chim Acta, 286 (1999), pp. 81-95
[60.]
O. Pinhas-Hamiel, D. Standiford, D. Hamiel, L.M. Dolan, R. Cohen, P.S. Zeitier.
The type 2 family: a setting for development and treatment of adolescent type 2 diabetes mellitus.
Arch Pediatr Adolesc Med, 153 (1999), pp. 1063-1067
[61.]
J. MoratóJ, J. Franch, R. Carrillo, M. Vía, A. Herrera, L.l. Valerio.
Cronología de las complicaciones en la diabetes del adulto. El estudio Raval Sud.
An Med Intern, 12 (1995), pp. 431-437
[62.]
D. Figuerola, A. Recasens, C. Castell.
Lloveras G y Grupo Catalán de Estudio de la Diabetes (GCED). La asistencia al diabético en Cataluña. Estudio en una muestra de población.
Med Clin (Barc), 99 (1992), pp. 90-95
[63.]
T.M. Davis, I.M. Stratton, C.J. Fox, R.R. Holman, R.C. Turner.
(UKPDS 22). Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM.
Diabetes Care, 20 (1997), pp. 1435-1441
[64.]
J.T. Shaw, D.M. Purdie, H.A. Neil, J.C. Levy, R.C. Turner.
The relative risks of hyperglycaemia, obesity and dyslipidaemia in the relatives of patients with type 2 diabetes mellitus.
Diabetología, 42 (1999), pp. 24-27
[65.]
A. Costa, M. Ríos, R. Casamitjana, R. Gomis, I. Conget.
High prevalence of abnormal glucose tolerance and metabolic disturbances in first degree relatives of NIDDM patients. A study in Catalonia, a Mediterranean community.
Diabetes Res Clin Pract, 41 (1998), pp. 191-196
[66.]
S.M. Haffner.
Epidemiology of type 2 diabetes: risk factors.
Diabetes Care, 21 (1998), pp. 3-6
[67.]
G. Hosey, S. Gordon, A. Levine.
Type 2 diabetes in people of color.
Nurse Pract Forum, 9 (1998), pp. 108-114
[68.]
J.S. Carter, J.A. Pugh, A. Monterrosa.
Non-insulin-dependent diabetes mellitus in minorities in the United States.
Ann Intern Med, 125 (1996), pp. 221-232
[69.]
F. Kelestimur, M. Cetin, H. Pasaoglu, B. Coksevim, F. Cetinkaya, K. Unluhizarci, et al.
The prevalence and identification of risk factors for type 2 diabetes mellitus and impaired glucose tolerance in Kayseri, central Anatolia, Turkey.
Acta Diabetol, 36 (1999), pp. 85-91
[70.]
M. Abu Sayeed, L. Ali, M.Z. Hussain, M.A. Rumi, A. Banu, A.K. Azad Khan.
Effect of socioeconomic risk factors on the difference in prevalence of diabetes between rural and urban populations in Bangladesh.
Diabetes Care, 20 (1997), pp. 551-555
[71.]
B.A. Ramlo-Halsted, S.V. Edelman.
The natural history of type 2 diabetes. Implications for clinical practice.
Prim Care, 26 (1999), pp. 771-789
[72.]
G. Nijpels.
Determinants for the progression from impaired glucose tolerance to non-insulin-dependent diabetes mellitus.
Eur J Clin Invest, 28 (1998), pp. 8-13
[73.]
P. Chou, C.L. Li, G.S. Wu, S.T. Tsai.
Progression to type 2 diabetes among high-risk groups in Kin-Chen, Kinmen. Exploring the natural history of type 2 diabetes.
Diabetes Care, 21 (1998), pp. 1183-1187
[74.]
ADA (American Diabetes Association).
Report of the expert committee on the diagnosis and classification of diabetes mellitus.
Diabetes Care, 20 (1997), pp. 1183-1197
[75.]
Y. Sakurai, K. Teruya, N. Shimada, T. Umeda, H. Tanaka, T. Muto, et al.
Association between duration of obesity and risk on non-insulin-dependent diabetes mellitus. The Sitetsu Study.
Am J Epidemiol, 149 (1999), pp. 256-260
[76.]
S.G. Wannamethee, A.G. Shaper.
Weight change and duration of overweight and obesity in the incidence of type 2 diabetes.
Diabetes Care, 22 (1999), pp. 1266-1270
[78.]
E.J. Feskens, R.M. Van Dam.
Dietary fat and the etiology of type 2 diabetes: an epidemiological perspective.
Nutr Metab Cardiovasc Dis, 9 (1999), pp. 87-95
[79.]
J. Salmeron, J.E. Manson, M.J. Stamfer, G.A. Colditz, A.L. Wing, W.C. Willet.
Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women.
JAMA, 277 (1997), pp. 472-477
[80.]
J.S. Hannah, B.V. Howard.
Dietary fats, insulin resistance, and diabetes.
J Cardiovasc Risk, 1 (1994), pp. 31-37
[81.]
K.a. Meyer, L.H. Kushi, D.R. Jacobs Jr, J. Slavin, T.A. Sellers, A.R. Folsom.
Carbohydrates, dietary fiber, and incident type 2 diabetes in older women.
Am J Clin Nutr, 71 (2000), pp. 921-930
[82.]
W.H. Kao, A.R. Folsom, F.J. Nieto, J.P. Mo, R.L. Watson, F.L. Brancati.
Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study.
Arch Intern Med, 159 (1999), pp. 2151-2159
[83.]
D.E. Williams, N.J. Wareham, B.D. Cox, C.D. Byrne, C.N. Hales, N.E. Day.
Frequent salad vegetable consumption is associated with a reduction in the risk of diabetes mellitus.
J Clin Epidemiol, 52 (1999), pp. 329-335
[84.]
K. Tsumura, T. Hayashi, C. Suematsu, G. Eno, S. Fujii, K. Okada.
Daily alcohol consumption and the risk of type 2 diabetes in Japanese men: the Osaka Health Survey.
Diabetes Care, 22 (1999), pp. 1432-1437
[85.]
E.B. Rimm, J. Chan, M.J. Stampfer, G.A. Colditz, W.C. Willett.
Prospective study of cigarette smoking, alcohol use and the risk of diabetes in men.
BMJ, 310 (1995), pp. 555-559
[86.]
J.T. Salonen, K. Nyyssonen, T.P. Tuomainen, P.H. Maenpaa, H. Korpela, G.A. Kaplan, et al.
Increased risk of non-insulin-dependent diabetes at low plasma vitamin E concentrations: a four year follow up study in men.
BMJ, 311 (1995), pp. 1124-1127
[87.]
K. Okada, T. Hayashi, K. Tsumura, C. Suematsu, G. Endo, S. Fujii.
Leisure-time physical activity at weekends and the risk of type 2 diabetes mellitus in Japanese men: the Osaka Health Survey.
Diabet Med, 17 (2000), pp. 53-58
[88.]
A.R. Folsom, L.H. Kushi, C.P. Hong.
Physical activity and incident diabetes mellitus in postmenopausal women.
Am J Public Health, 90 (2000), pp. 134-138
[89.]
Y. Takemura, S. Kikuchi, Y. Inaba, H. Yasuda, K. Nakagawa.
The protective effect of good physical fitness when young on the risk of impaired glucose tolerance when old.
Prev Med, 28 (1999), pp. 14-19
[90.]
D.E. Kelley, B.H. Goodpaster.
Effects of physical activity on insulin action and glucose tolerance in obesity.
Med Sci Sports Exerc, 31 (1999), pp. 619-623
[91.]
M. Wei, L.W. Gibbons, T.L. Mitchell, J.B. Kampert, C.D. Lee, S.N. Blair.
The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men.
Ann Intern Med, 130 (1999), pp. 89-96
[92.]
H. Wallberg-Henriksson, J. Rincón, J.R. Zierath.
Exercise in the management of non-insulin-dependent diabetes mellitus.
Sports Med, 25 (1998), pp. 25-35
[93.]
K.L. Ramaiya, A.B.M. Swai, K.G.M.M. Alberti, D. McLarty.
Life style changes decrease rates of glucose intolerance and cardiovascular risk factors: a six year intervention study in a high risk Hindu Indian subcommunity.
Diabetología, 35 (1992), pp. A60
[94.]
S. Uchimoto, K. Tsumura, T. Hayashi, C. Suematsu, G. Endo, S. Fujii, et al.
Impact of cigarette smoking on the incidence of type 2 diabetes mellitus in middle-aged Japanese men: the Osaka Health Survey.
Diabet Med, 16 (1999), pp. 951-955
[95.]
Y. Morikawa, H. Nakgama, M. Ishizaki, M. Tabata, M. Nishijo, K. Miura, et al.
Ten-year follow-up study on the relation between the development of non-insulin-dependent diabetes mellitus and occupation.
Am J Ind Med, 31 (1997), pp. 80-84
[96.]
N. Kawakami, S. Araki, N. Takatsuka, H. Shimizu, H. Ishibashi.
Overtime, psychosocial working conditions, and occurrence of non-insulin-dependent diabetes mellitus in Japanese men.
J Epidemiol Community Health, 53 (1999), pp. 359-363
[97.]
N. Kawakami, N. Takatsuka, H. Shimizu, H. Ishibashi.
Depressive symptoms and occurrence of type 2 diabetes among Japanese men.
Diabetes Care, 22 (1999), pp. 1071-1076
[98.]
E.T. Skarfors, K.I. Selinus, H.O. Lithell.
Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala.
BMJ, 303 (1991), pp. 755-760
[99.]
D.I. Phillips.
Birth weight and the future development of diabetes. A review of the evidence.
Diabetes Care, 21 (1998), pp. 150-155
[100.]
C.N. Hales, D.J.P. Barker, P.M.S. Clark, L.J. Cox, C. Fall, C. Osmond, et al.
Fetal and infant growth and impaired glucose tolerance at age 64.
BMJ, 303 (1991), pp. 1019-1022
[101.]
L.E. Minchoff, J.A. Grandin, X. Syndrome.
Recognition and management of this metabolic disorder in primary care.
Nurse Pract, 21 (1996), pp. 74-75
[102.]
W.S. Cutfield, P. Wilton, H. Bennmarker, K. Albertsson-Wikland, P. Chatelain, M.B. Ranke, et al.
Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment.
Lancet, 355 (2000), pp. 610-613
[103.]
R.E. Ratner.
Type 2 diabetes mellitus: the grand overview.
Diabet Med, 15 (1998), pp. 4-7
[104.]
P.A. Dyson, M.S. Hammersley, R.J. Morris, R.R. Holman, R.C. Turner.
The Fasting Hyperglycaemia Study: II. Randomized controlled trial of reinforced healthy-living advice in subjects with increased but not diabetic fasting plasma glucose.
Metabolism, 46 (1997), pp. 50-55
[105.]
J.L. Chiasson, R. Gomis, M. Hanefeld, R.G. JoséR, A. Karasik, M. Laakso.
The STOP-NIDDM: an international study on the efficacy of an alpha-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Study to Prevent Non-Insulin-Dependent Diabetes Mellitus.
Diabetes Care, 21 (1998), pp. 1720-1725
[106.]
J. Toumilehto, J. Lindstrom, J.G. Eriksson, T.T. Valle, H. Hamalainen, P. Ilanne-Parikka, et al.
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
N Engl J Med, 344 (2001), pp. 1343-1350
[107.]
C. La Vecchia, E. Negri, S. Franceschi, B. D’Avanzo, P. Boyle.
A case-control study of diabetes mellitus and cancer risk.
Br J Cancer, 70 (1994), pp. 950-953
[108.]
E.E. Calle, T.K. Murphy, C. Rodríguez, M.J. Thun, C.W. Heath Jr..
Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults.
Cancer Causes Control, 9 (1998), pp. 403-410
[109.]
F.B. Hu, J.E. Manson, S. Liu, D. Hunter, G.A. Colditz, K.B. Michels, et al.
Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women.
J Natl Cancer Inst, 91 (1999), pp. 542-547
[110.]
T. Cundy, G. Gamble, K. Towed, P.G. Henley, P. MacPherson, A.B. Roberts.
Perinatal mortality in type 2 diabetes mellitus.
Diabet Med, 17 (2000), pp. 33-39
[111.]
A.L. Calle Pascual, J.R. Calle Hernández.
Factores de riesgo cardiovascular y tratamiento con insulina en pacientes diabéticos tipo II en quienes ha fracasado el tratamiento con hipoglucemiantes orales.
Med Clin (Barc), 101 (1993), pp. 165-167
[112.]
T. Mur, J. Franch, J. MoratóJ, A. Mena, M. Vilarrubias, A. Llobera.
Macroangiopatía en la diabetes tipo II El estudio Raval Sud.
Aten Primaria, 16 (1995), pp. 67-72
[113.]
J. Fernández de Mendiola, A. Iza, I. Lasa, F. Ibáñez, J.R. Aguirrezabala, M. Aizpuru, et al.
Evaluación de la población diabética tipo II atendida en un equipo de atención primaria.
Aten Primaria, 17 (1996), pp. 432-438
[114.]
I. Goicolea, A. Mancha, B. Pérez, G. Villar, E. Ugarte, J.A. Vázquez.
Prevalencia de complicaciones crónicas de la diabetes en un área sanitaria de Vizcaya.
Endocrinología, 43 (1996), pp. 337-341
[115.]
N. Lara, J. Franch, J. MoratóJ, A. Egido, J. Puig, J. Castillejo.
La dislipemia en la diabetes tipo II ¿Un factor de riesgo para la macroangiopatía?.
Aten Primaria, 18 (1996), pp. 17-24
[116.]
F. Zancada, P. Mena, J.E. Campillo, R. Hernández, M.T. Pérez-Aloe.
Factores de riesgo vascular en la diabetes mellitus no insulinodependiente. Correlación entre albuminuria y hemoglobina glicada.
An Med Intern, 16 (1999), pp. 181-185
[117.]
N.R. Robles, M.C. Cid, F. Roncero, J.L. Pizarro, E. Sánchez-Casado, M. Pérez-Miranda.
Incidencia de nefropatía diabética en la provincia de Badajoz durante el período 1990-1994.
An Med Intern, 13 (1996), pp. 572-575
[118.]
J.M. González-Clemente.
Diabetes mellitus no dependiente de insulina: asistencia en un área de Barcelona.
Med Clin (Barc), 108 (1997), pp. 91-97
[119.]
M. BundóM, J. AubàJ, R. Vallés, O. Torner, A.M. Pérez, J. Massons.
Arteriopatía en la diabetes mellitus tipo 2.
Aten Primaria, 22 (1998), pp. 5-10
[120.]
J. Cabezas-Cerrato.
The prevalence of clinical diabetic polyneuropathy in Spain: a study in primary care and hospital clinic groups.
Diabetología, 41 (1998), pp. 1263-1269
[121.]
J. Fernández Vigo, A. Macarro, J.F. Sabugal, J. Chacón.
Diabetes Ocular (I): retinopatía diabética.
Diabetología, 8 (1994), pp. 89-106
[122.]
J. Fernández-Vigo, A. Macarro, J.F. Perianez, J. Chacón.
Diabetes ocular (II): neuro-oftalmopatía. Catarata. Glaucoma. Otras manifestaciones.
Diabetología, 9 (1994), pp. 5-17
[123.]
J.C. Javitt, L.P. Aiello.
Cost-effectiveness of detecting and treaning diabetic retinopathy.
Ann Intern Med, 124 (1996), pp. 164-169
[124.]
F. Rius, A. Sanmartí.
Nefropatía diabética: epidemiología, fisiopatología y tratamiento.
Educación Diabetológica Profesional, 4 (1994), pp. 6-18
[125.]
P.L. De Pablos, F.J. Martínez Martín, M.P. Martínez, J.A. Aguilar.
Prevalence of nephropathy in a canarian population of non insulin-dependent diabetics. Relationship with obesity, blood pressure, lipid profile and metabolic control.
Diabetes et Metabolism, 24 (1998), pp. 337-343
[126.]
E. Esmatjes, C. Castell, T. González, R. Tresserras, G. Lloveras.
The Catalan Nephropathy Study Group. Epidemiology of renal involvement in Type II diabetics (NIDDM) in Catalonia.
Diabetes research and clinical practice, 32 (1996), pp. 157-163
[127.]
E. Esmatjes, I. Goicolea, L. Cacho, P.L. De Pablos, R. Rodríguez, M.J. Roche, et al.
Nefropatía en la diabetes mellitus tipo II: Prevalencia en España.
Diabetología, 13 (1997), pp. 29-35
[128.]
E. Esmatjes, J. Vidal.
Patología cardíaca de origen extracardíaco. Repercusiones cardíacas de la diabetes mellitus.
Rev Esp Cardiol, 51 (1998), pp. 661-670
[129.]
Y. Groeneveld, H. Petri, J. Hermans, M.P. Springer.
Relationship between blood glucose level and mortality in type 2 diabetes mellitus: a systematic review.
Diabet Med, 16 (1999), pp. 2-13
[130.]
K.T. Chen, C.J. Chen, M.M. Fuh, K.M. Narayan.
Causes of death and associated factors among patients with non-insulin-dependent diabetes mellitus in Taipei, Taiwan.
Diabetes Res Clin Pract, 43 (1999), pp. 101-109
[131.]
S.D. Kanters, J.D. Banga, R.P. Stolk, A. Algra.
Incidence and determinants of mortality and cardiovascular events in diabetes mellitus: a meta-analysis.
Vasc Med, 4 (1999), pp. 67-75
[133.]
A. Goday, M. Serano Ríos.
Epidemiología de la diabetes mellitus en España. Revisión crítica y nuevas perspectivas.
Med Clin (Barc), 102 (1994), pp. 306-315
[134.]
D. Orozco, V. Gil, J.A. PicóJ, J. Tobías, F. Quirce, J. Merino.
Mortalidad por diabetes mellitus en España: análisis comparativo entre las provincias españolas en el período 1981-1986.
Aten Primaria, 15 (1995), pp. 349-356
[135.]
M. Wei, S.P. Gaskill, S.M. Haffner, M.P. Stern.
Effects of diabetes and level of glicemia on all-cause and cardiovascuar mortality. The San Antonio Heart Study.
Diabetes Care, 21 (1998), pp. 1167-1172
[136.]
C.M. Forsblom, T. Sane, P.H. Groop, K.J. Totterman, M. Kallio, C. Saloranta, et al.
Risk factors for mortality in type II (non-insuln-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4.
Diabetología, 41 (1998), pp. 1253-1262
[137.]
R. De Marco, F. Locatelli, G. Zoppini, G. Verlato, E. Bonora, M. Muggeo.
Cause-specific mortality in type 2 diabetes.
The Verona Diabetes Study. Diabetes Care, 22 (1999), pp. 756-761
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