Información del artículo
Un control riguroso de la glucemia, principalmente en los pacientes con diabetes tipo 1, requeriría la regeneración funcional del páncreas dañado. Los estudios clínicos recientes sobre implante de islotes pancreáticos procedentes de donantes en pacientes diabéticos han alimentado las expectativas de un tratamiento generalizado basado en esta metodología; no obstante, existe una gran desproporción entre los posibles donantes y el número de pacientes con diabetes que podrían recibir este tratamiento. Esta falta de órganos y tejidos que podría permitir una terapia celular, no sólo para la diabetes sino para otras enfermedades que requieren igualmente un recambio celular, ha relanzado recientemente la investigación sobre las posibilidades terapéuticas de las denominadas células madre pluripotenciales. La presente revisión incluye algunos resultados previos de nuestro laboratorio sobre la obtención de células productoras de insulina a partir de células madre embrionarias de ratón y su utilización en ratones diabéticos.
Palabras clave:
Células madre
Terapia celular
Diabetes
Trasplante de islotes
Insulina
Optimal control of blood glucose, mainly in patients with type 1 diabetes, would require functional regeneration of the damaged pancreas. Recent clinical trials of islet transplantation in diabetic patients have increased expectations for a generalized treatment based on this methodological approach. Nevertheless, the demand for pancreases outweighs their availability. This scarcity of organs and tissues for cellular therapy, not only for type 1 diabetic patients but also for the treatment of other diseases in which cellular replacement is also required, has recently increased research into the therapeutic possibilities of pluripotent stem cells. The present review includes previous results from our laboratory on the harvesting of insulin-producing cells from mouse embryonic stem cells and their utilization in diabetic mice.
Key words:
Stem cells
Cellular therapy
Diabetes
Islet transplantation
Insulin
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