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Vol. 50. Núm. 7.
Páginas 261-265 (julio 2003)
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Vol. 50. Núm. 7.
Páginas 261-265 (julio 2003)
Acceso a texto completo
TSH recombinante y determinación de tiroglobulina en el seguimiento del carcinoma diferenciado de tiroides
Recombinant tsh and thyroglobulin determination in the follow-up of differentiated thyroid carcinoma
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6767
E. Navarro
Autor para correspondencia
elena.navarro.sspa@junatadeandalucia.es

Correspondencia: Dra. E. Navarro. Servicio de Endocrinología. Hospitales Universitarios Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
Servicio de Endocrinología. Centro de Diagnóstico. Hospitales Universitarios Virgen del Rocío. Sevilla. España
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Los pacientes diagnosticados y tratados de carcinoma diferenciado de tiroides requieren de monitorización periódica, durante toda su vida, con el fin de detectar posibles recidivas. En el seguimiento de estos pacientes desempeñan un papel principal la determinación de tiroglobulina y los rastreos periódicos con 131I, realizados en situación de hipotiroidismo. La introducción de TSH recombinante (TSHr) ofrece una alternativa a esta situación de hipotiroidismo. Varios estudios recientes han demostrado que la sensibilidad de las exploraciones realizadas con TSHr son equivalentes a las de hipotiroidismo, y que la determinación de tiroglobulina tras TSHr es más sensible que la tiroglobulina en el eutiroidismo para detectar una enfermedad residual o una recidiva. Por ello, se plantea que puede utilizarse la determinación de tiroglobulina tras TSHr como test único en el seguimiento de los pacientes con carcinoma diferenciado de bajo riesgo.

Patients diagnosed and treated for a differentiated thyroid carcinoma require long-life period follow up to detect potential recurrences. In the follow-up of these patients, thyroglobulin measurement and whole body scan with radioiodine under hypothyroidism play an essential role. The recent introduction of recombinant TSH is an alternative to avoid hypothyroidism. Several papers have recently reported that explorations under TSH are equivalent to those performed under hypothyroidism and Tg measurement after rTSH is more sensitive than its measurement while the patient is euthiroid to detect residual disease or recurrence. So, the proposal is to use Tg after rTSH as the single test for the follow-up of patients with low risk differentiated thyroid carcinoma.

Key words:
Differentiated thyroid carcinoma
Thyroglobulin
Recombinant TSH
Follow-up
Palabras clave:
Carcinoma diferenciado de tiroides
Tiroglobulina
TSH recombinante
Seguimiento
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Bibliografía
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Copyright © 2003. Sociedad Española de Endocrinología y Nutrición
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