covid
Buscar en
Endocrinología y Nutrición
Toda la web
Inicio Endocrinología y Nutrición TSH recombinante y determinación de tiroglobulina en el seguimiento del carcino...
Información de la revista
Vol. 50. Núm. 7.
Páginas 261-265 (julio 2003)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 50. Núm. 7.
Páginas 261-265 (julio 2003)
Acceso a texto completo
TSH recombinante y determinación de tiroglobulina en el seguimiento del carcinoma diferenciado de tiroides
Recombinant tsh and thyroglobulin determination in the follow-up of differentiated thyroid carcinoma
Visitas
6820
E. Navarro
Autor para correspondencia
elena.navarro.sspa@junatadeandalucia.es

Correspondencia: Dra. E. Navarro. Servicio de Endocrinología. Hospitales Universitarios Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
Servicio de Endocrinología. Centro de Diagnóstico. Hospitales Universitarios Virgen del Rocío. Sevilla. España
Este artículo ha recibido
Información del artículo

Los pacientes diagnosticados y tratados de carcinoma diferenciado de tiroides requieren de monitorización periódica, durante toda su vida, con el fin de detectar posibles recidivas. En el seguimiento de estos pacientes desempeñan un papel principal la determinación de tiroglobulina y los rastreos periódicos con 131I, realizados en situación de hipotiroidismo. La introducción de TSH recombinante (TSHr) ofrece una alternativa a esta situación de hipotiroidismo. Varios estudios recientes han demostrado que la sensibilidad de las exploraciones realizadas con TSHr son equivalentes a las de hipotiroidismo, y que la determinación de tiroglobulina tras TSHr es más sensible que la tiroglobulina en el eutiroidismo para detectar una enfermedad residual o una recidiva. Por ello, se plantea que puede utilizarse la determinación de tiroglobulina tras TSHr como test único en el seguimiento de los pacientes con carcinoma diferenciado de bajo riesgo.

Patients diagnosed and treated for a differentiated thyroid carcinoma require long-life period follow up to detect potential recurrences. In the follow-up of these patients, thyroglobulin measurement and whole body scan with radioiodine under hypothyroidism play an essential role. The recent introduction of recombinant TSH is an alternative to avoid hypothyroidism. Several papers have recently reported that explorations under TSH are equivalent to those performed under hypothyroidism and Tg measurement after rTSH is more sensitive than its measurement while the patient is euthiroid to detect residual disease or recurrence. So, the proposal is to use Tg after rTSH as the single test for the follow-up of patients with low risk differentiated thyroid carcinoma.

Key words:
Differentiated thyroid carcinoma
Thyroglobulin
Recombinant TSH
Follow-up
Palabras clave:
Carcinoma diferenciado de tiroides
Tiroglobulina
TSH recombinante
Seguimiento
El Texto completo está disponible en PDF
Bibliografía
[1.]
S.L. Parker, T. Tong, S. Bolden, P.A. Wingo.
Cancer statistics.
Cancer J Clin, 47 (1997), pp. 5-11
[2.]
S.A. Hundhal, I.D. Fleming, A.M. Fremgen, H.R. Menk.
A national cancer data base report on 53.856 cases of thyroid carcinoma treated in US 1985-1995.
Cancer, 83 (1998), pp. 2638-2648
[3.]
M. Tubiana, M. Schumberger, P. Rougier, A. Laplanche, E. Benhamou, P. Gardet, et al.
Long term results and prognosis factors in patients with differentiated thyroid carcinoma.
Cancer, 55 (1985), pp. 795-799
[4.]
E.L. Mazzaferri, S.M. Jhiang.
Long term impact of initial surgical and medical therapy on papillary and follicular cancer.
Am J Med, 97 (1994), pp. 418-428
[5.]
M. Schumberger.
Papillary and follicular thyroid carcinomas.
N Engl J Med, 338 (1998), pp. 297-306
[6.]
M. Schlumberger, F. Pacini.
Thyroid tumors.
pp. 167-180
[7.]
H. Maxon.
Detection of residual and recurrent thyroid cancer by radionuclide imaging.
Thyroid, 9 (1999), pp. 443-446
[8.]
M. Schlumberger, E. Baudin.
Serum thyroglobulin determination in the follow-up of patients with differentiated thyroid carcinoma.
Eur J Endocrinol, 138 (1998), pp. 249-252
[9.]
C.A. Meier, L.E. Braveman, S.A. Ebner, I. Veronikis, G.H. Daniels, D.S. Ross, et al.
Diagnostic use of recombinant human thyrotropin in patients with thyroid carcinoma (phase I/II study).
J Clin Endocrinol Metab, 78 (1994), pp. 188-196
[10.]
P.W. Ladenson, L.E. Braverman, E.L. Mazzaferri, F. Brucker-Davis, D. Cooper, J. Garber, et al.
Comparison of administration of recombinant human thyrotropin with withdrawal of thyroid hormone for radioactive iodine scanning in patients with thyroid carcinoma.
N Engl J Med, 337 (1997), pp. 888-896
[11.]
B.R. Haugen, F. Pacini, C. Reiners, M. Schlumberger, P.W. Ladenson, S. Sherman, et al.
A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remant or cancer.
J Clin Endocrinol Metab, 84 (1999), pp. 3877-3885
[12.]
J.M. Durski, R.J. Weigel.
McDougall. Recombinant human thyrotropin (rTSH) in the management of differentiated thyroid cancer.
Nucl Med Commun, 21 (2000), pp. 521-528
[13.]
G. Mariani, M. Ferdeghini, C. Augeri, G. Villa, G. Taddei, G. Scopinaro, et al.
Clinical experience with recombinant human thyrotropin in the management of patients with differentiated thyroid cancer.
Cancer Bioth Radiophar, 15 (2000), pp. 211-217
[14.]
R.J. Robbins, M. Tuttle, R. Sharaf, S. Larson, H. Robbins, R. Ghossein, et al.
Preparation by recombinant human thyrotropin or thyroid hormone withdrawal are comparable for the detection of residual differentiated thyroid carcinoma.
J Clin Endocrinol Metab, 86 (2001), pp. 619-624
[15.]
A.F. Cailleux, E. Baudin, J.P. Travagli, M. Ricard, M. Schlumberger.
Is diagnostic iodide 131 scanning useful after total thyroid ablation for differentiated thyroid cancer?.
J Clin Endocrinol Metab, 85 (2000), pp. 175-178
[16.]
F. Pacini, R. Capezzone, C. Elisei, C. Cecarrelli, D. Taddei, A. Pinchera.
Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment.
J Clin Endocrinol Metab, 87 (2002), pp. 1499-1501
[17.]
F. Pacini, E. Molinaro, F. Lippi, M.G. Castagna, L. Agate, C. Ceccarelli, et al.
Prediction of disease status by recombinant hu-man TSH-stimulated serum Tg in the postsurgical follow-up of differentiated thyroid carcinoma.
J Clin Endocrinol Metab, 86 (2001), pp. 56876-56890
[18.]
L. Wartofsky.
and the rTSH stimulated thyroglobulin study group. Management of low risk well differentieted thyroid cancer based only on thyroglobulin measurement after recombinat human thyrotropin.
Thyroid, 12 (2002), pp. 583-590
[19.]
E. Mazzaferri, R. Kloos.
Is diagnostic iodine 131 scaning with recombinat human TSH useful in the follow-up of differentiated thyroid cancer after thyroid ablation?.
J Clin Endocrinol Metab, 87 (2002), pp. 1490-1498
[20.]
R. Robbins, J.T. Chon, M. Fleisher, S. Larson, R.M. Tuttle.
Is the serum thyroglobulin response to recombinant human thyrotropin sufficient by itself to monitor for residual thyroid carcinoma?.
J Clin Endocrinol Metab, 87 (2002), pp. 3242-3247
[21.]
P.W. Ladenson, M. Ewertz, R. Dickey.
Practical application of recombinant thyrotropin testing in clinical practice.
Endocrine Prac, 7 (2001), pp. 195-199
[22.]
L. Wartofsky.
Using baseline and recombinant human TSH stimulated Tg measurements to manage thyroid cancer without diagnostic 131 I scaning.
J Clin Endocrinol Metab, 87 (2002), pp. 1486-1489
Copyright © 2003. Sociedad Española de Endocrinología y Nutrición
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos