Información del artículo
Durante estos últimos años hemos asistido a un incremento significativo de la resistencia de los microorganismos grampositivos, con un impacto epidemiológico y clínico importante en la práctica diaria. Mientras que en los hospitales españoles la prevalencia de Staphylococcus aureus resistente a la meticilina (SARM) se mantiene en unos valores elevados (alrededor del 25%), en la comunidad están emergiendo nuevas cepas de SARM en pacientes sin factores de riesgo, a menudo productoras de toxinas como la leucocidina de Panton- Valentine. Por otra parte, los estafilococos coagulasanegativos (ECN) están implicados en una gran variedad de infecciones hospitalarias y su resistencia a los antimicrobianos es globalmente superior (p. ej., > 60% a la meticilina) y de más rápida adquisición, en general, que la de S. aureus. Destaca un tercer grupo de microorganismos, Enterococcus sp., por el incremento significativo de la resistencia a ampicilina en E. faecium (el 75% en 2006), y por la emergencia de resistencia a la vancomicina, principalmente en E. faecium (el 3,9% en 2006). Los estudios revisados en este artículo muestran los cambios epidemiológicos experimentados recientemente y la emergencia y diseminación de cepas multirresistentes. Esta diseminación se está produciendo dentro de los hospitales, entre hospitales y centros sociosanitarios, dentro la propia comunidad, e incluso entre países y continentes. Por otra parte, la existencia de un reservorio nosocomial de genes de resistencia, en algunos casos potencialmente transmisibles mediante transferencia horizontal, puede contribuir a agravar el problema de la resistencia y a restringir las opciones terapéuticas.
Palabras clave:
Staphylococcus aureus
Estafilococo coagulasa-negativo
Enterococo resistente a vancomicina
Epidemiología
Resistencia
In the last few years, there has been a significant increase in resistance among Gram-positive microorganisms, with a marked epidemiological and clinical impact in daily clinical practice. While the prevalence of methicillinresistant Staphylococcus aureus (MRSA) in Spanish hospitals remains high (approximately 25%), in the community new MRSA strains are emerging in patients without risk factors, often producing toxins such as Panton-Valentine leucocidin. In addition, coagulasenegative staphylococci (CNS) are involved in a wide variety of hospital infections and their resistance to antimicrobial agents is higher (e.g. > 60% to methicillin) and more rapidly acquired, in general, than that of S. aureus. The third group of microorganisms, Enterococcus sp. are notable for the significant increase in ampicillin resistance in E. faecium (75% in 2006), and for the emergence of vancomycin resistance, mainly in E. faecium (3.9% in 2006). The studies reviewed in the present article show the recent epidemiological changes that have taken place and the emergence and dissemination of multiresistant strains. This dissemination is being produced within hospitals, among hospitals and nursing homes, within the community, and even among countries and continents. Moreover, the existence of a nosocomial reservoir of resistance genes, in some cases potentially transmissible through horizontal transfer, could contribute to exacerbating the problem of resistance and to restricting therapeutic options.
Key words:
Staphylococcus aureus
Coagulase-negative staphylococci
Vancomycin-resistant Enterococcus
Epidemiology
Resistance
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Bibliografía
[1.]
M.P. Jevons.
Celbenin-resistant Staphylococci.
BMJ, (1961), pp. 124-125
[2.]
H. Grundmann, M. Aires-de-Sousa, J. Boyce, E. Tiemersma.
Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat.
Lancet, 368 (2006), pp. 874-885
[3.]
E.P. Trallero, J.G. Arenzana, A.A. Castaneda, L.P. Grisolia.
Unusual multiresistant Staphylococcus aureus in a newborn nursery.
Am J Dis Child, 135 (1981), pp. 689-692
[4.]
F. Parras, M. Rodriguez, E. Bouza, P. Muñoz, E. Cercenado, C. Guerrero, et al.
Epidemic outbreak of methicillin-resistant Staphylococcus aureus in a general hospital. Preliminary report.
Enferm Infecc Microbiol Clin, 9 (1991), pp. 200-207
[5.]
A. Trilla, F. Marco, A. Moreno, A. Prat, E. Soriano, M.T. Jimenez de Anta.
Clinical epidemiology of an outbreak of nosocomial infection caused by Staphylococcus aureus resistant to methicillin and aminoglycosides: efficacy of control measures. Comité de Control de Infecciones.
Med Clin (Barc), 100 (1993), pp. 205-209
[6.]
K. Hiramatsu, H. Hanaki, T. Ino, K. Yabuta, T. Oguri, F.C. Tenover.
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.
J Antimicrob Chemother, 40 (1997), pp. 135-136
[7.]
Vancomycin-resistant Staphylococcus aureus: New York, 2004. MMWR Morb Mortal Wkly Rep. 2004;53:322-3.
[8.]
Staphylococcus aureus resistant to vancomycin: United States, 2002. MMWR Morb Mortal Wkly Rep. 2002;51:565-7.
[9.]
Y. Katayama, T. Ito, K. Hiramatsu.
A new class of genetic element, Staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus.
Antimicrob Agents Chemother, 44 (2000), pp. 1549-1555
[10.]
M. Kuroda, T. Ohta, I. Uchiyama, T. Baba, H. Yuzawa, I. Kobayashi, et al.
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Lancet, 357 (2001), pp. 1225-1240
[11.]
T. Ito, K. Okuma, X.X. Ma, H. Yuzawa, K. Hiramatsu.
Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC.
Drug Resist Updat, 6 (2003), pp. 41-52
[12.]
R. Leclercq.
Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications.
Clin Infect Dis, 34 (2002), pp. 482-492
[13.]
Y. Katayama, T. Ito, K. Hiramatsu.
Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, lowlevel methicillin-resistant Staphylococcus haemolyticus.
Antimicrob Agents Chemother, 45 (2001), pp. 1955-1963
[14.]
T. Ito, K. Okuma, X.X. Ma, H. Yuzawa, K. Hiramatsu.
Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC.
Drug Resist Updat, 6 (2003), pp. 41-52
[15.]
T. Ito, Y. Katayama, K. Asada, N. Mori, K. Tsutsumimoto, C. Tiensasitorn, et al.
Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother, 45 (2001), pp. 1323-1336
[16.]
T. Ito, X.X. Ma, F. Takeuchi, K. Okuma, H. Yuzawa, K. Hiramatsu.
Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.
Antimicrob Agents Chemother, 48 (2004), pp. 2637-2651
[17.]
R.S. Daum, T. Ito, K. Hiramatsu, F. Hussain, K. Mongkolrattanothai, M. Jamklang, et al.
A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds.
J Infect Dis, 186 (2002), pp. 1344-1347
[18.]
K. Hiramatsu, L. Cui, M. Kuroda, T. Ito.
The emergence and evolution of methicillin-resistant Staphylococcus aureus.
Trends Microbiol, 9 (2001), pp. 486-493
[19.]
D.C. Oliveira, A. Tomasz, H. de Lencastre.
The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements.
Microb Drug Resist, 7 (2001), pp. 349-361
[20.]
S.W. Wu, H. de Lencastre, A. Tomasz.
Recruitment of the mecA gene homologue of Staphylococcus sciuri into a tesistance determinant and expression of the resistant phenotype in Staphylococcus aureus.
J Bacteriol, 183 (2001), pp. 2417-2424
[21.]
C.L. Wielders, M.R. Vriens, S. Brisse, L.A. Graaf-Miltenburg, A. Troelstra, A. Fleer, et al.
In-vivo transfer of mecA DNA to Staphylococcus aureus.
Lancet, 357 (2001), pp. 1674-1675
[22.]
H. Wisplinghoff, A.E. Rosato, M.C. Enright, M. Noto, W. Craig, G.L. Archer.
Related clones containing SCCmec type iv predominate among clinically significant Staphylococcus epidermidis isolates.
Antimicrob Agents Chemother, 47 (2003), pp. 3574-3579
[23.]
H. Wisplinghoff, T. Bischoff, S.M. Tallent, H. Seifert, R.P. Wenzel, M.B. Edmond.
Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.
Clin Infect Dis, 39 (2004), pp. 309-317
[24.]
National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32:470-85.
[25.]
O. Cuevas, E. Cercenado, A. Vindel, J. Guinea, M. Sánchez-Conde, M. Sánchez-Somolinos, et al.
Evolution of the antimicrobial resistance of Staphylococcus spp. in Spain: five nationwide prevalence studies, 1986 to 2002.
Antimicrob Agents Chemother, 48 (2004), pp. 4240-4245
[26.]
M. Pujol, C. Pena, R. Pallarés, J. Ayats, J. Ariza, F. Gudiol.
Risk factors for nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus.
Eur J Clin Microbiol Infect Dis, 13 (1994), pp. 96-102
[27.]
F. Chaves, J. García-Martínez, S. de Miguel, F. Sanz, J.R. Otero.
Epidemiology and clonality of methicillin-resistant and methicillin-susceptible Staphylococcus aureus causing bacteremia in a tertiary-care hospital in Spain.
Infect Control Hosp Epidemiol, 26 (2005), pp. 150-156
[28.]
E. García-Vázquez, J. Gómez, R. Banos, M. Canteras, J. Ruiz, V. Banos, et al.
A comparative study of patients with methicillin susceptible versus methicillin resistant Staphylococcus aureus bacteremia: epidemiology and prognostic factors.
Med Clin (Barc), 128 (2007), pp. 681-686
[29.]
R.L. Thompson, I. Cabezudo, R.P. Wenzel.
Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus.
Ann Intern Med, 97 (1982), pp. 309-317
[30.]
E.J. Benner, F.H. Kayser.
Growing clinical significance of methcillin-resistant Staphylococcus aureus.
Lancet, 2 (1968), pp. 741-744
[31.]
P.M. Rountree, M.A. Beard.
Hospital strains of Staphylococcus aureus, with particular reference to methicillin-resistant strains.
Med J Aust, 2 (1968), pp. 1163-1168
[32.]
O. Jessen, K. Rosendal, P. Bulow, V. Faber, K.R. Eriksen.
Changing staphylococci and staphylococcal infections. A ten-year study of bacteria and cases of bacteremia.
N Engl J Med, 281 (1969), pp. 627-635
[33.]
M.T. Parker, J.H. Hewitt.
Methicillin resistance in Staphylococcus aureus.
Lancet, 1 (1970), pp. 800-804
[34.]
A. Tomasz.
Accelerated evolution: emergence of multidrug resistant grampositive bacterial pathogens in the 1990's.
Neth J Med, 52 (1998), pp. 219-227
[35.]
F.D. Lowy.
Antimicrobial resistance: the example of Staphylococcus aureus.
J Clin Invest, 111 (2003), pp. 1265-1273
[36.]
M.A. Dominguez, H. de Lencastre, J. Linares, A. Tomasz.
Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital.
J Clin Microbiol, 32 (1994), pp. 2081-2087
[37.]
P. Aparicio, J. Richardson, S. Martin, A. Vindel, R.R. Marples, B.D. Cookson.
An epidemic methicillin-resistant strain of Staphylococcus aureus in Spain.
Epidemiol Infect, 108 (1992), pp. 287-298
[38.]
A. Vindel, P. Trincado, E. Gómez, R. Cabrera, T. Boquete, C. Sola, et al.
Prevalence and evolution of methicillin-resistant Staphylococcus aureus in Spanish hospitals between 1996 and 2002.
J Clin Microbiol, 44 (2006), pp. 266-270
[39.]
E. Perez-Roth, F. Lorenzo-Diaz, N. Batista, A. Moreno, S. Mendez-Alvarez.
Tracking methicillin-resistant Staphylococcus aureus clones during a 5-year period (1998 to 2002) in a Spanish hospital.
J Clin Microbiol, 42 (2004), pp. 4649-4656
[40.]
I. Montesinos, T. Delgado, D. Riverol, E. Salido, M.A. Miguel, A. Jimenez, et al.
Changes in the epidemiology of meticillin-resistant Staphylococcus aureus associated with the emergence of EMRSA-16 at a university hospital.
J Hosp Infect, 64 (2006), pp. 257-263
[41.]
E. Alcoceba, A. Mena, P.M. Cruz, G. Ruiz, E. Padilla, J. Gil, et al.
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Majorcan hospitals: high prevalence of the epidemic clone EMRSA-15.
Clin Microbiol Infect, 13 (2007), pp. 599-605
[42.]
L.E. Nicolle, L.J. Strausbaugh, R.A. Garibaldi.
Infections and antibiotic resistance in nursing homes.
Clin Microbiol Rev, 9 (1996), pp. 1-17
[43.]
C. Suetens, L. Niclaes, B. Jans, J. Verhaegen, A. Schuermans, J. van Eldere, et al.
Determinants of methicillin-resistant Staphylococcus aureus carriage in nursing homes.
Age Ageing, 36 (2007), pp. 327-330
[44.]
H. Von Baum, C. Schmidt, D. Svoboda, O. Bock-Hensley, C. Wendt.
Risk factors for methicillin-resistant Staphylococcus aureus carriage in residents of German nursing homes.
Infect Control Hosp Epidemiol, 23 (2002), pp. 511-515
[45.]
K. Crossley.
Long-term care facilities as sources of antibiotic-resistant nosocomial pathogens.
Curr Opin Infect Dis, 14 (2001), pp. 455-459
[46.]
R.D. O’Toole, W.L. Drew, B.J. Dahlgren, H.N. Beaty.
An outbreak of methicillinresistant Staphylococcus aureus infection. Observations in hospital and nursing home.
JAMA, 213 (1970), pp. 257-263
[47.]
R.A. Cox, P.E. Bowie.
Methicillin-resistant Staphylococcus aureus colonization in nursing home residents: a prevalence study in Northamptonshire.
J Hosp Infect, 43 (1999), pp. 115-122
[48.]
L.D. Saravolatz, N. Markowitz, L. Arking, D. Pohlod, E. Fisher.
Methicillinresistant Staphylococcus aureus. Epidemiologic observations during a community-acquired outbreak.
Ann Intern Med, 96 (1982), pp. 11-16
[49.]
E.E. Udo, J.W. Pearman, W.B. Grubb.
Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia.
J Hosp Infect, 25 (1993), pp. 97-108
[50.]
Center for Disease Control and Prevention. Four pedriatic deaths from community acquired MRSA-Minnesota and North Dakota,1997-1999. MMWR Morb Mortal Wkly Rep. 1999;48:707-10.
[51.]
G. Lina, Y. Piemont, F. Godail-Gamot, M. Bes, M.O. Peter, V. Gauduchon, et al.
Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia.
Clin Infect Dis, 29 (1999), pp. 1128-1132
[52.]
T.S. Naimi, K.H. LeDell, D.J. Boxrud, A.V. Groom, C.D. Steward, S.K. Johnson, et al.
Epidemiology and clonality of community-acquired methicillin-resistant Staphylococcus aureus in Minnesota, 1996-1998.
Clin Infect Dis, 33 (2001), pp. 990-996
[53.]
Center for Disease Control and Prevention. Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections—Los Angeles County, California, 2002-2003. MMWR Morb Mortal Wkly Rep. 2003;52:88.
[54.]
S.C. Buckingham, L.K. McDougal, L.D. Cathey, K. Comeaux, A.S. Craig, S.K. Fridkin, et al.
Emergence of community-associated methicillin-resistant Staphylococcus aureus at a Memphis, Tennessee Children's Hospital.
Pediatr Infect Dis J, 23 (2004), pp. 619-624
[55.]
S.L. Kaplan, K.G. Hulten, B.E. Gonzalez, W.A. Hammerman, L. Lamberth, J. Versalovic, et al.
Three-year surveillance of community-acquired Staphylococcus aureus infections in children.
Clin Infect Dis, 40 (2005), pp. 1785-1791
[56.]
G. Regev-Yochay, E. Rubinstein, A. Barzilai, Y. Carmeli, J. Kuint, J. Etienne, et al.
Methicillin-resistant Staphylococcus aureus in neonatal intensive care unit.
Emerg Infect Dis, 11 (2005), pp. 453-456
[57.]
A. Broseta, F. Chaves, P. Rojo, J.R. Otero.
Emergence of a single clone of community-associated methicillin-resistant Staphylococcus aureus in southern Madrid children.
Enferm Infecc Microbiol Clin, 24 (2006), pp. 31-35
[58.]
T.S. Naimi, K.H. LeDell, K. Como-Sabetti, S.M. Borchardt, D.J. Boxrud, J. Etienne, et al.
Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection.
JAMA, 290 (2003), pp. 2976-2984
[59.]
K. Okuma, K. Iwakawa, J.D. Turnidge, W.B. Grubb, J.M. Bell, F.G. O’Brien, et al.
Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community.
J Clin Microbiol, 40 (2002), pp. 4289-4294
[60.]
X.X. Ma, T. Ito, C. Tiensasitorn, M. Jamklang, P. Chongtrakool, S. Boyle-Vavra, et al.
Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains.
Antimicrob Agents Chemother, 46 (2002), pp. 1147-1152
[61.]
F. Vandenesch, T. Naimi, M.C. Enright, G. Lina, G.R. Nimmo, H. Heffernan, et al.
Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.
Emerg Infect Dis, 9 (2003), pp. 978-984
[62.]
J. Etienne.
Panton-Valentine leukocidin: a marker of severity for Staphylococcus aureus infection?.
Clin Infect Dis, 41 (2005), pp. 591-593
[63.]
Y. Gillet, B. Issartel, P. Vanhems, J.C. Fournet, G. Lina, M. Bes, et al.
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.
Lancet, 359 (2002), pp. 753-759
[64.]
M. Labandeira-Rey, F. Couzon, S. Boisset, E.L. Brown, M. Bes, Y. Benito, et al.
Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia.
Science, 315 (2007), pp. 1130-1133
[65.]
J.M. Voyich, M. Otto, B. Mathema, K.R. Braughton, A.R. Whitney, D. Welty, et al.
Is Panton-Valentine leukocidin the major virulence determinant in community- associated methicillin-resistant Staphylococcus aureus disease?.
J Infect Dis, 194 (2006), pp. 1761-1770
[66.]
O. Dumitrescu, S. Boisset, C. Badiou, M. Bes, Y. Benito, M.E. Reverdy, et al.
Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
Antimicrob Agents Chemother, 51 (2007), pp. 1515-1519
[67.]
H.A. Carleton, B.A. Diep, E.D. Charlebois, G.F. Sensabaugh, F. Perdreau-Remington.
Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA.
J Infect Dis, 190 (2004), pp. 1730-1738
[68.]
C.D. Salgado, B.M. Farr, D.P. Calfee.
Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors.
Clin Infect Dis, 36 (2003), pp. 131-139
[69.]
R.H. Deurenberg, C. Vink, S. Kalenic, A.W. Friedrich, C.A. Bruggeman, E.E. Stobberingh.
The molecular evolution of methicillin-resistant Staphylococcus aureus.
Clin Microbiol Infect, 13 (2007), pp. 222-235
[70.]
S. Deresinski.
Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey.
Clin Infect Dis, 40 (2005), pp. 562-573
[71.]
D.A. Robinson, M.C. Enright.
Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother, 47 (2003), pp. 3926-3934
[72.]
M.F. Kluytmans-Vandenbergh, J.A. Kluytmans.
Community-acquired methicillin-resistant Staphylococcus aureus: current perspectives.
Clin Microbiol Infect, 12 (2006), pp. 9-15
[73.]
R. Sa-Leao, I.S. Sanches, I. Couto, C.R. Alves, H. De Lencastre.
Low prevalence of methicillin-resistant strains among Staphylococcus aureus colonizing young and healthy members of the community in Portugal.
Microb Drug Resist, 7 (2001), pp. 237-245
[74.]
S.K. Fridkin, J.C. Hageman, M. Morrison, L.T. Sanza, K. Como-Sabetti, J.A. Jernigan, et al.
Methicillin-resistant Staphylococcus aureus disease in three communities.
N Engl J Med, 352 (2005), pp. 1436-1444
[75.]
H.C. Baggett, T.W. Hennessy, K. Rudolph, D. Bruden, A. Reasonover, A. Parkinson, et al.
Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska.
J Infect Dis, 189 (2004), pp. 1565-1573
[76.]
S.V. Kazakova, J.C. Hageman, M. Matava, A. Srinivasan, L. Phelan, B. Garfinkel, et al.
A clone of methicillin-resistant Staphylococcus aureus among professional football players.
N Engl J Med, 352 (2005), pp. 468-475
[77.]
C.E. Zinderman, B. Conner, M.A. Malakooti, J.E. LaMar, A. Armstrong, B.K. Bohnker.
Community-acquired methicillin-resistant Staphylococcus aureus among military recruits.
Emerg Infect Dis, 10 (2004), pp. 941-944
[78.]
S. Bratu, A. Eramo, R. Kopec, E. Coughlin, M. Ghitan, R. Yost, et al.
Community- associated methicillin-resistant Staphylococcus aureus in hospital nursery and maternity units.
Emerg Infect Dis, 11 (2005), pp. 808-813
[79.]
U. Seybold, E.V. Kourbatova, J.G. Johnson, S.J. Halvosa, Y.F. Wang, M.D. King, et al.
Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections.
Clin Infect Dis, 42 (2006), pp. 647-656
[80.]
E.V. Kourbatova, J.S. Halvosa, M.D. King, S.M. Ray, N. White, H.M. Blumberg.
Emergence of community-associated methicillin-resistant Staphylococcus aureus USA 300 clone as a cause of health care-associated infections among patients with prosthetic joint infections.
Am J Infect Control, 33 (2005), pp. 385-391
[81.]
A. Tristan, M. Bes, H. Meugnier, G. Lina, B. Bozdogan, P. Courvalin, et al.
Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006.
Emerg Infect Dis, 13 (2007), pp. 594-600
[82.]
W.E. Kloos, T.L. Bannerman.
Update on clinical significance of coagulase-negative staphylococci.
Clin Microbiol Rev, 7 (1994), pp. 117-140
[83.]
C. Von Eiff, G. Peters, C. Heilmann.
Pathogenesis of infections due to coagulase-negative staphylococci.
Lancet Infect Dis, 2 (2002), pp. 677-685
[84.]
T.L. Bannerman.
Staphylococcus, Micrococcus, and other catalase-positive cocci that grow aerobically.
Manual of clinical microbiology, 8th ed., pp. 384-404
[85.]
M.E. Rupp, G.L. Archer.
Coagulase-negative staphylococci: pathogens associated with medical progress.
Clin Infect Dis, 19 (1994), pp. 231-243
[86.]
J.A. Karlowsky, M.E. Jones, D.C. Draghi, C. Thornsberry, D.F. Sahm, G.A. Volturo.
Prevalence and antimicrobial susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States in 2002.
Ann Clin Microbiol Antimicrob, 3 (2004), pp. 7
[87.]
L.E. Weisman.
Coagulase-negative staphylococcal disease: emerging therapies for the neonatal and pediatric patient.
Curr Opin Infect Dis, 17 (2004), pp. 237-241
[88.]
M.P. Venkatesh, F. Placencia, L.E. Weisman.
Coagulase-negative staphylococcal infections in the neonate and child: an update.
Semin Pediatr Infect Dis, 17 (2006), pp. 120-127
[89.]
M. Miragaia, I. Couto, S.F. Pereira, K.G. Kristinsson, H. Westh, J.O. Jarlov, et al.
Molecular characterization of methicillin-resistant Staphylococcus epidermidis clones: evidence of geographic dissemination.
J Clin Microbiol, 40 (2002), pp. 430-438
[90.]
M. Widerstrom, T. Monsen, C. Karlsson, J. Wistrom.
Molecular epidemiology of meticillin-resistant coagulase-negative staphylococci in a Swedish county hospital: evidence of intra- and interhospital clonal spread.
J Hosp Infect, 64 (2006), pp. 177-183
[91.]
T.G. Krediet, E.M. Mascini, E. van Rooij, J. Vlooswijk, A. Paauw, L.J. Gerards, et al.
Molecular epidemiology of coagulase-negative staphylococci causing sepsis in a neonatal intensive care unit over an 11-year period.
J Clin Microbiol, 42 (2004), pp. 992-995
[92.]
W.C. Van der Zwet, Y.J. Debets-Ossenkopp, E. Reinders, M. Kapi, P.H. Savelkoul, R.M. van Elburg, et al.
Nosocomial spread of a Staphylococcus capitis strain with heteroresistance to vancomycin in a neonatal intensive care unit.
J Clin Microbiol, 40 (2002), pp. 2520-2525
[93.]
T.L. Ross, E.P. Fuss, S.M. Harrington, M. Cai, T.M. Perl, W.G. Merz.
Methicillinresistant Staphylococcus caprae in a neonatal intensive care unit.
J Clin Microbiol, 43 (2005), pp. 363-367
[94.]
F. Chaves, M. García-Álvarez, F. Sanz, C. Alba, J.R. Otero.
Nosocomial spread of a Staphylococcus hominis subsp. novobiosepticus strain causing sepsis in a neonatal intensive care unit.
J Clin Microbiol, 43 (2005), pp. 4877-4879
[95.]
D.J. Diekema, M.A. Pfaller, F.J. Schmitz, J. Smayevsky, J. Bell, R.N. Jones, et al.
Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999.
Clin Infect Dis, 32 (2001), pp. S114-S132
[96.]
B.E. Murray.
Vancomycin-resistant enterococcal infections.
N Engl J Med, 342 (2000), pp. 710-721
[97.]
F. Biavasco, C. Vignaroli, P.E. Varaldo.
Glycopeptide resistance in coagulase-negative staphylococci.
Eur J Clin Microbiol Infect Dis, 19 (2000), pp. 403-417
[98.]
E. Cercenado, M.E. Garcia-Leoni, M.D. Diaz, C. Sanchez-Carrillo, P. Catalan, J.C. de Quiros, et al.
Emergence of teicoplanin-resistant coagulase-negative staphylococci.
J Clin Microbiol, 34 (1996), pp. 1765-1768
[99.]
R. Reynolds, N. Potz, M. Colman, A. Williams, D. Livermore, A. MacGowan.
Antimicrobial susceptibility of the pathogens of bacteraemia in the UK and Ireland 2001-2002: the BSAC Bacteraemia Resistance Surveillance Programme.
J Antimicrob Chemother, 53 (2004), pp. 1018-1032
[100.]
J.E. Ross, T.R. Anderegg, H.S. Sader, T.R. Fritsche, R.N. Jones.
Trends in linezolid susceptibility patterns in 2002: report from the worldwide Zyvox Annual Appraisal of Potency and Spectrum Program.
Diagn Microbiol Infect Dis, 52 (2005), pp. 53-58
[101.]
B.A. Potoski, J. Adams, L. Clarke, K. Shutt, P.K. Linden, C. Baxter, et al.
Epidemiological profile of linezolid-resistant coagulase-negative staphylococci.
Clin Infect Dis, 43 (2006), pp. 165-171
[102.]
L. Martins Teixeira, R.R. Facklam.
Enterococcus.
Manual of clinical microbiology, 8th ed., pp. 422-433
[103.]
Y. Cetinkaya, P. Falk, C.G. Mayhall.
Vancomycin-resistant enterococci.
Clin Microbiol Rev, 13 (2000), pp. 686-707
[104.]
D.B. Clevel.
Movable genetic elements and antibiotic resistance in enterococci.
Eur J Clin Microbiol Infect Dis, 9 (1990), pp. 90-102
[105.]
B.E. Murray.
Beta-lactamase-producing enterococci.
Antimicrob Agents Chemother, 36 (1992), pp. 2355-2359
[106.]
R. Fontana, G. Bertolini, G. Amalfitano, P. Canepari.
Characterization of penicillin-resistant Streptococcus faecium mutants.
FEMS Microbiol Lett, 25 (1984), pp. 21-25
[107.]
J. Oteo, O. Cuevas, C. Navarro, B. Aracil, J. Campos.
Trends in antimicrobial resistance in 3469 enterococci isolated from blood (EARSS experience 2001- 06, Spain): increasing ampicillin resistance in Enterococcus faecium.
J Antimicrob Chemother, 59 (2007), pp. 1044-1045
[108.]
A.H. Uttley, C.H. Collins, J. Naidoo, R.C. George.
Vancomycin-resistant enterococci.
Lancet, 1 (1988), pp. 57-58
[109.]
R. Leclercq, E. Derlot, J. Duval, P. Courvalin.
Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium.
N Engl J Med, 319 (1988), pp. 157-161
[110.]
A.H. Kaplan, P.H. Gilligan, R.R. Facklam.
Recovery of resistant enterococci during vancomycin prophylaxis.
J Clin Microbiol, 26 (1988), pp. 1216-1218
[111.]
F. Depardieu, M.G. Bonora, P.E. Reynolds, P. Courvalin.
The vanG glycopeptide resistance operon from Enterococcus faecalis revisited.
Mol Microbiol, 50 (2003), pp. 931-948
[112.]
T.P. Stinear, D.C. Olden, P.D. Johnson, J.K. Davies, M.L. Grayson.
Enterococcal vanB resistance locus in anaerobic bacteria in human faeces.
Lancet, 357 (2001), pp. 855-856
[113.]
S.A. Ballard, K.K. Pertile, M. Lim, P.D. Johnson, M.L. Grayson.
Molecular characterization of vanB elements in naturally occurring gut anaerobes.
Antimicrob Agents Chemother, 49 (2005), pp. 1688-1694
[114.]
M.C. Domingo, A. Huletsky, A. Bernal, R. Giroux, D.K. Boudreau, F.J. Picard, et al.
Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.
J Antimicrob Chemother, 55 (2005), pp. 466-474
[115.]
L. Guardabassi, H. Christensen, H. Hasman, A. Dalsgaard.
Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.
Antimicrob Agents Chemother, 48 (2004), pp. 4915-4918
[116.]
F.C. Tenover, L.C. McDonald.
Vancomycin-resistant staphylococci and enterococci: epidemiology and control.
Curr Opin Infect Dis, 18 (2005), pp. 300-305
[117.]
D.K. Warren, A. Nitin, C. Hill, V.J. Fraser, M.H. Kollef.
Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit.
Infect Control Hosp Epidemiol, 25 (2004), pp. 99-104
[118.]
L.M. Deshpande, T.R. Fritsche, G.J. Moet, D.J. Biedenbach, R.N. Jones.
Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program.
Diagn Microbiol Infect Dis, 58 (2007), pp. 163-170
[119.]
H.L. Leavis, M.J. Bonten, R.J. Willems.
Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance.
Curr Opin Microbiol, 9 (2006), pp. 454-460
[120.]
National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32:470-85.
[121.]
D.J. Biedenbach, G.J. Moet, R.N. Jones.
Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program (1997-2002).
Diagn Microbiol Infect Dis, 50 (2004), pp. 59-69
[122.]
R.J. Willems, J. Top, M. van Santen, D.A. Robinson, T.M. Coque, F. Baquero, et al.
Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex.
Emerg Infect Dis, 11 (2005), pp. 821-828
[123.]
T.M. Coque, R.J. Willems, J. Fortun, J. Top, S. Diz, E. Loza, et al.
Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?.
Antimicrob Agents Chemother, 49 (2005), pp. 2693-2700
[124.]
S.R. Nallapareddy, H. Wenxiang, G.M. Weinstock, B.E. Murray.
Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island.
J Bacteriol, 187 (2005), pp. 5709-5718
[125.]
P. Ruiz-Garbajosa, M.J. Bonten, D.A. Robinson, J. Top, S.R. Nallapareddy, C. Torres, et al.
Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination.
J Clin Microbiol, 44 (2006), pp. 2220-2228
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