Información del artículo
Desde los primeros años de la utilización de la terapia antirretroviral de gran actividad (TARGA) rápidamente se observaron dos hechos: su gran efectividad y la importancia de un correcto cumplimiento para conseguir los objetivos terapéuticos. Los regímenes terapéuticos han cambiado recientemente, las pautas complejas con una elevada carga de comprimidos, dosificación de tres veces al día y restricciones alimentarias ha dado paso a tratamientos más sencillos
Los principales avances han sido: nuevas formulaciones y nuevos fármacos que permiten la dosificación de una vez al día, la utilización de ritonavir para potenciar la biodisponibilidad de los inhibidores de proteasa y la coformulación de principios activos en una sola cápsula. En la presente revisión se analizan los factores facilitadores y las barreras para una adhesión óptima y el impacto de las intervenciones en el régimen terapéutico. La adherencia es un problema multidimensional complejo; la simplificación del tratamiento constituye un aspecto importante; sin embargo, debe acompañarse de otras estrategias enfocadas al paciente y al equipo asistencial para lograr el objetivo de una terapia antirretroviral efectiva prolongada en todos los pacientes
Palabras clave:
Tratamiento antirretroviral
VIH
Adherencia
Cumplimiento
Intervenciones
Within the first few years after the introduction of highly active antiretroviral therapy two facts became evident: the treatment was highly effective and proper compliance was essential to achieve the therapeutic objectives. Recently, the regimens containing these drugs have changed. Complex dosing with a large number of tablets taken three times daily together with dietary restrictions has given way to simpler treatments. The main advances include new formulations and new drugs that allow once-daily dosing, the use of ritonavir to enhance the bioavailability of the protease inhibitors and the coformulation of active ingredients in a single capsule. This review analyzes the impact of these interventions on the therapeutic regimen and it discusses the factors that facilitate and those that hinder optimal adherence to highly active antiviral treatment
Adherence is a complex, multidimensional problem. Simplification of the treatment is an important aspect, but it should be accompanied by other strategies focussed on the patient and the medical team in order to achieve effective long-term antiretroviral therapy in all patients
Key words:
Antiretroviral treatment
HIV
Adherence
Compliance
Interventions
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Bibliografía
[1.]
D.L. Sackett, J.C. Snow.
The magnitude of compliance and noncompliance.
Compliance with therapeutic regimens, pp. 11-27
[2.]
D.L. Paterson, S. Swindells, J. Mohr, M. Brester, R.N. Michelle, E.N. Vergis.
Adherence to Protease Inhibitor therapy and outcomes in patients with HIV infection.
Ann Intern Med, 133 (2000), pp. 21-30
[3.]
S. Low-Beer, B. Yip, M.V. O’Shaughnessy, R.S. Hogg, J.S. Montaner.
Adherence to triple therapy and viral load response.
J Acquir Immune Defic Syndr, 23 (2000), pp. 360-361
[4.]
Bennett D, Zaidi I, Heneine W. Prevalence of mutations associated with antiretroviral drug resistance among recently diagnosed persons with HIV, 1998-2000. Program and abstracts of the 9th Conference on Retroviruses and Opportunistic Infections; February 24-28, 2002; Seattle, Washington. Abstract 372.
[5.]
Grant RM, Kahn JO, Warmerdam M. Transmission and transmissibility of drug resistant HIV-1. Acute infection: Resistance, fitness, and transmission. Program and abstracts of the 9th Conference on Retroviruses and Opportunistic Infections; February 24-28, 2002; Seattle, Washington. Abstract 368.
[6.]
J.S. Montaner, P. Reiss, D. Cooper, S. Vella, M. Harris, B. Convay.
A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: The INCAS Trial. Italy, The Netherlands, Canada and Australia Study.
JAMA, 279 (1998), pp. 930-937
[7.]
D. Kaufmann, G. Pantaleo, P. Sudre, A. Telenti.
CD4-cell count in HIV-1 infected individuals remaining viraemic with highly active antirretroviral therapy (HAART).
Lancet, 351 (1998), pp. 723-724
[8.]
G. Fatkenheur, A. Theisen, J. Rockstroh, T. Grabow, C. Wicke, K. Becker.
Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients.
AIDS, 11 (1997), pp. F113-F116
[9.]
S. Mannheimer, G. Friedland, J. Matts, C. Child, M. Chesney.
The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials.
Clin Infect Dis, 34 (2002), pp. 1115-1121
[10.]
P. Nieuwkerk, E. Gisolf, M. Sprangers, S. Danner.
Adherence over 48 weeks in an antiretroviral clinical trial: Variable within patients, affected by toxicities and independently predictive of virological response.
Antivir Ther, 6 (2001), pp. 97-103
[11.]
M.V. Le, G. Chene, M.P. Carrieri, A. Alioum, F. Brun-Vezinet, L. Piroth.
Predictors of virological rebound in HIV-1-infected patients initiating a protease inhibitor-containing regimen.
AIDS, 16 (2002), pp. 21-29
[12.]
H. Knobel, A. Guelar, A. Carmona, M. Espona, A. González, J.L. López-Colomes.
Virologic outcome and predictors of virological failure on highly active antiretroviral therapy containing protease inhibitors in a cohort of HIV-infected patients.
AIDS Patient Care STDS, 15 (2001), pp. 193-199
[13.]
G. Lucas, R. Chaisson, R. Moore.
Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions.
Ann Intern Med, 131 (1999), pp. 897-904
[14.]
D.R. Bangsberg, S. Perry, E.D. Charlebois, R.A. Clark, M. Roberston, A.R. Zolopa.
Non-adherence to highly active antiretroviral therapy predicts progression to AIDS.
AIDS, 15 (2001), pp. 1181-1183
[15.]
Knobel H, Carmona A, Guelar A, González A, Hernecki J, Díez A. Adherence in patients treated with HAART: Influence in hospital admissions. En: 13th International AIDS Conference. Durban, Sudáfrica. 2000 (abstract MoPeD2556).
[16.]
P. García de Olalla, H. Knobel, A. Carmona, A. Guelar, J.L. López-Colomes, J.A. Cayla.
Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients.
J Acquir Immune Defic Syndr, 30 (2002), pp. 105-110
[17.]
R.S. Hogg, K. Heath, D. Bangsberg, B. Yip, N. Press, M.V. O’Shaughnessy.
Intermittent use of triple-combination therapy is predictive of mortality atbaseline and after 1 year of follow-up.
AIDS, 16 (2002), pp. 1051-1058
[18.]
W.M. Valenti.
HIV management: New technologies improve outcome and contain costs.
AIDS Read, 12 (2002), pp. 64-66
[19.]
A. Ammassari, M.P. Trota, R. Murri, F. Castelli, P. Narciso, P. Noto.
Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature.
J Acquir Immune Defic Syndr, 31 (2002), pp. S123-S127
[20.]
J.H. Samet, H. Libman, K.A. Steger, R.K. Dhawan, J. Chen, A.H. Shevitz.
Compliance with zidovudine therapy in patients infected with HIV: A cross sectional study in a municipal hospital clinic.
Am J Med, 92 (1992), pp. 495-502
[21.]
J.A. Bartlett.
Addresing the challenges of adherence.
J Acquir Immune Defic Syndr, 29 (2002), pp. 2-10
[22.]
B.J. Turner.
Adherence to antiretroviral therapy by Human Immunodeficiency Virus-infected patients.
Clin Infec Dis, 33 (2001), pp. 865-872
[23.]
L.J. Eldred, A.W. Wu, R.E. Chaisson, R.D. Moore.
Adherence to antiretroviral and Pneumocystis prophilaxis in HIV disease.
J Acquir Immune Defic Syndr, 18 (1998), pp. 117-125
[24.]
D.R. Bangsberg, F.M. Hecht, E.D. Charlebois, A.R. Zolopa, M. Holodniy, L. Sheiner.
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.
AIDS, 14 (2000), pp. 357-366
[25.]
M.A. Chesney, J.R. Ickoviks, D.B. Chambers, A.L. Gifford, J. Neidig, B. Zwickl.
Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments.
AIDS care, 12 (2000), pp. 255-266
[26.]
V. Gordillo, J. Del Amo, V. Soriano, J. González-Lahoz.
Sociodemographic and psychological variables influencing adherence to antiretroviral therapy.
AIDS, 13 (1999), pp. 1763-1769
[27.]
A. Tuldrá, C. Fumaz, M. Ferrer, R. Bayes, A. Arno, M. Balague.
Prospective randomized two-arm controlled study to determine the efficacy of a specific intervention to improve long-term adherence to highly active antiretroviral therapy.
J Acquir Immune Defic Syndr, 25 (2000), pp. 221-228
[28.]
S. Metha, R.D. Moore, N.H.M. Graham.
Potential factors affecting adherence with HIV therapy.
AIDS, 11 (1997), pp. 1665-1670
[29.]
V. Stone, J. Hogan, P. Schuman, A.M. Rompalo, A.A. Howard, C. Korkontzelou.
Antiretroviral regimen complexity, self-reported adherence, and HIV patients understanding their regimens: Survey of women in the HER study.
J Acquir Immune Defic Syndr, 28 (2001), pp. 124-131
[30.]
M. Chesney.
Factors affecting adherence to antiretroviral therapy.
Clin Infect Dis, 30 (2000), pp. 171-176
[31.]
J. Gallant, D. Block.
Adherence to antiretroviral regimens in HIV-infected patients: Results of a survey among physicians and patients.
J Int Asc Phys AIDS Care, 4 (1998), pp. 32-35
[32.]
A.J. Claxton, J. Cramer, C. Pierce.
A systematic review of the associations between dose regimens and medication compliance.
Clin Ther, 23 (2001), pp. 1296-1310
[33.]
J.A. Bartlett, R. Demasi, J. Quin, C. Moxham, F. Rousseau.
Overview of the effectiveness of triple combination therapy in antiretroviral naive HIV-1 infected adults.
AIDS, 15 (2001), pp. 1369-1377
[34.]
A. Ammassari, R. Murri, P. Pezotti, M.P. Trotta, L. Ravasio, P. De Longis.
Self-reported symptoms and medication side effects influence adherenceto highly active antiretroviral therapy in persons with HIV infection.
J Acquir Immune Defic Syndr, 28 (2001), pp. 445-449
[35.]
S. Durán, M. Saves, B. Spire, V. Cailleton, A. Sobel, P. Carrieri.
Failure to maintain long-term adherence to highly active antiretroviral therapy: The role of lipodystrophy.
AIDS, 15 (2001), pp. 2441-2444
[36.]
A.L. Gifford, J.E. Bormann, M.J. Shively, B.C. Wright, D.D. Richman, S.A. Bozzette.
Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens.
J Acquir Immune Defic Syndr, 23 (2000), pp. 386-395
[37.]
H. Knobel.
¿Cómo y porqué debe monitorizarse la adherencia al tratamiento antirretroviral en la actualidad?.
Enferm Infecc Microbiol Clin, 20 (2002), pp. 481-483
[38.]
D.L. Paterson, B. Potoski, B. Capitano.
Measurement of adherence to antiretroviral medications.
J Acquir Immune Defic Syndr, 31 (2002), pp. 103-106
[39.]
H. Knobel, C. Codina, J.M. Miro, A. Carmona, B. García, A. Antela.
Recomendaciones de GESIDA/SEFH/PNS para mejorar la adherencia del tratamiento antirretroviral.
Enferm Infecc Microbiol Clin, 18 (2000), pp. 27-39
[40.]
R. Rubio, J. Berenguer, J.M. Miró, A. Antela, J.A. Iribarren, J. González.
Recomendaciones de GESIDA/Plan Nacional sobre el SIDA respecto al tratamiento antirretroviral en pacientes adultos infectados por el virus de la inmunodeficiencia humana en el año 2002.
Enferm Infecc Microbiol Clin, 20 (2002), pp. 244-303
[41.]
M. Dybul, A.S. Fauci, J.G. Bartlett, J.E. Kaplan, A.K. Pau.
Panel on Clinical Practices for Treatment of HIV. Guidelines for Using Antiretroviral Agents among HIV-Infected Adults and Adolescents.
Ann Intern Med, 137 (2002), pp. 381-433
[42.]
T. Morgenstern, D. Grimes, R. Grimes.
Assessment of readiness to initiate antiretroviral therapy.
HIV Clin Trials, 3 (2002), pp. 168-172
[43.]
R.M. Grimes, L. Lal, S.T. Lewis.
Frequency of medical history items, drug interactions, and lifestyle characteristics that may interfere with antiretroviral medications.
HIV Clin Trials, 3 (2002), pp. 161-167
[44.]
G.H. Friedland, L.A. Andrews.
Adherence to antiretroviral therapy.
AIDS Reviews, 3 (2001), pp. 111-120
[45.]
A.I. Mushlin, F.A. Appel.
Diagnosing potential noncompliance. Physicians’ ability in a behavioral dimension of medical care.
Arch Intern Med, 137 (1977), pp. 318-321
[47.]
S. Staszewski, P. Keiser, J. Montaner, F. Raffi, J. Gathe, V. Brotas.
Abacavir-Lamivudine-Zidovudine vs Indinavir-Lamivudine-Zidovudine in antirretroviral-naïve HIV-infected adults. A randomized equivalence trial.
JAMA, 285 (2001), pp. 1155-1163
[48.]
Jordan J, Cahn P, Vibhagool A. Predictors of adherence and efficacy in HIV-1 infected patients treated with abacavir plus Combivir or indinavir plus combivir. Final 48-week data from CNA3014. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, USA. 2002 (abstract 543).
[49.]
Jordan J, Cahn P, Vibhagool A. Patient satisfaction with treatment is associated with adherence and treatment continuation: Results from 3014 study. 42nd ICAAC. San Diego, Ca, USA. 2002 (abstract: O-1101).
[50.]
R.M. Gulick, H.J. Ribaudo, C.M. Shikuma, S. Lustgarten, W.A. Meyer, K. Klingman, et al.
ACTG 5095: A comparative study of 3 protease inhibitor-sparing antiretroviral regimens for the initial treatment of HIV infection. Abstracts of the 2nd IAS Conference on HIV Pathogenesis and Treatment. Paris, France, 13-16 July 2003.
Antiviral Therapy, 8 (2003), pp. 194
[51.]
D. Podzamczer, E. Ferrer, E. Consiglio, J.M. Gatell, P. Pérez, J.L. Pérez.
A randomized clinical trial comparing nelfinavir or nevirapine associated to zidovudine/lamivudine in HIV-infected naive patients (the Combine Study).
Antivir Ther, 7 (2002), pp. 81-90
[52.]
S. Staszewski, J. Morales-Ramírez, K.T. Tashima, A. Rachlis, D. Skiest, J. Stanford.
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults: Study 006 Team.
N Engl J Med, 341 (1999), pp. 1865-1873
[53.]
E. Ribera, K. Aguirrebengoa, C. Miralles, A. Antela, A. Ribero, J.R. Arribas.
Simplificación del tratamiento antirretroviral.
Enferm Infecc Microbiol Clin, 20 (2002), pp. 48-57
[54.]
E. Martínez, I. Conget, L. Lozano, R. Casamitjana, J.M. Gatell.
Reversion of metabolic abnormalities after switching from HIV-1 protease inhibitors to nevirapine.
AIDS, 13 (1999), pp. 805-810
[55.]
J.P. Dieleman, I.C. Gyssens, M.J.C.M. Sturkenboom, H.G.M. Niesters, M.E. Van der Ende.
Substituting nevirapine for protease inhibitors because of intolerance.
AIDS, 13 (1999), pp. 1423-1424
[56.]
P. Barreiro, V. Soriano, F. Blanco, C. Casimiro, J.J. De la Cruz, J. González-Lahoz.
Risks and benefits of replacing protease inhibitors by nevirapine in HIV-infected subjects under long-term successful triple combination therapy.
AIDS, 14 (2000), pp. 807-812
[57.]
F. Raffi, B. Bonnet, V. Ferré, J.L. Esnault, P. Perre, V. Reliquet.
Substitution of a nonnucleoside reverse transcriptase inhibitor for a protease inhibitor in the treatment of patients with undetectable plasma human immunodeficiency virus type 1 RNA.
Clin Infect Dis, 31 (2000), pp. 1274-1278
[58.]
L. Ruiz, E. Negredo, P. Domingo, R. Paredes, E. Francia, M. Balagué.
Antiretroviral treatment simplification with nevirapine in protease inhibitor-experienced patients with HIV-associated lipodystrophy: 1-year prospective follow-up of a multicenter, randomized, controlled study.
J Acquir Immune Defic Syndr, 27 (2001), pp. 229-236
[59.]
E. Negredo, L. Cruz, R. Paredes, L. Ruiz, C.R. Fumaz, A. Bonjoch.
Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression.
Clin Infect Dis, 34 (2002), pp. 504-510
[60.]
E. Martínez, M.A. García-Viejo, J.L. Blanco, L. Bianchi, E. Buira, I. Conget.
Impact of switching from human immunodeficiency virus type 1 protease inhibitors to efavirenz in successfully treated adults with lipodystrophy.
Clin Infect Dis, 31 (2000), pp. 1266-1273
[61.]
D. Rey, M.P. Schmitt, M. Partisani, G. Hess-Kempf, V. Krantz, E. De Mautort.
Efavirenz as a substitute for protease inhibitors in HIV-1-infected patients with undetectable plasma viral load on HAART: A median follow-up of 64 weeks.
J Acquir Immune Defic Syndr, 27 (2001), pp. 459-462
[62.]
H. Knechten, K.H. Stürner, C. Höhn, p. Braun.
Switch to efavirenz in a protease inhibitor-containing regimen.
HIV Clinical Trials, 2 (2001), pp. 200-204
[63.]
B. Hirschel, M. Flepp, H.C. Bucher, C. Zellweger, A. Telenti, T. Wagels.
Switching from protease inhibitors to efavirenz: Differences in efficacy and tolerance among risk groups: A case-control study from the Swiss HIV Cohort.
AIDS, 16 (2002), pp. 381-385
[64.]
N. Clumeck, F. Goebel, W. Rozembaum, J. Gerstoft, S. Staszewski, J. Montaner.
Simplification with abacavir-based triple nucleoside therapy versus continued protease inhibitor-based highly active antiretroviral therapy in HIV-1-infected patients with undetectable plasma HIV-1 RNA.
AIDS, 15 (2001), pp. 1517-1526
[65.]
M. Opravil, B. Hirschel, A. Lazzarin, H. Furrer, J.P. Chave, S. Yerly.
A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection.
J Infect Dis, 185 (2002), pp. 1251-1260
[66.]
B. Masquelier, D. Neau, G. Chêne, J. Larbere, V. Birac, J.M. Ragnaud.
Mechanism of virologic failure after substitution of a protease inhibitor by nevirapine in patients with suppressed plasma HIV-1 RNA.
J AIDS, 28 (2001), pp. 309-312
[67.]
J.P. Dieleman, M.C.J.M. Sturkenboom, F.W. Wit, M. Jambroes, J.W. Mulder, J.H. Ten Veen.
Low risk of treatment failure after substitution of nevirapine for protease inhibitors among human immunodeficiency virus-infected patients with virus suppression.
J Infect Dis, 185 (2002), pp. 1261-1268
[68.]
Martínez E, Podzamczer D, Ribera E, Domingo P, Knobel H, Dalmau,D, et al. Switching Protease Inhibitors to Nevirapine (NEV), Efavirenz (EFA) or Abacavir (ABA): A Randomized, Multicenter, Open-Label, Simplification Trial. 9th CROI. Seattle, Feb 24-28 2002. Abstract: LB17.
[69.]
C. Katlama, S. Fenske, B. Gazzard, A. Lazzarin, N. Clumeck, J. Mallolas.
TRIZAL study: Switching from successful HAART to Trizivir (abacavir-lamivudine-zidovudine combination tablet): 48 weeks efficacy, safety and adherence results.
HIV Med, 4 (2003), pp. 79-86
[70.]
Becker S, Rachlis A, Gill J. Successful substitution of protease inhibitors with efavirenz (EFV) in patients with undetectable viral loads. A prospective, randomized, multicenter, open-label study (DMP 049). En: Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections; February 4-8, 2001; Chicago. Abstract 20.
[71.]
Knobel H, Guelar A, Vallecillo G, Carmona A, Saballs P, González A, et al. Simplified antiretroviral therapy with zidovudine, lamivudine and abacavir as salvage therapy for heavily non-adherents patients. XIV International AIDS Conference; July 7-12, 2002. Abstract [WePeB5829].
[72.]
B.A. Boyle.
Efficacy and safety of once-daily antiretroviral therapy.
AIDS Read, 12 (2002), pp. 90-96
[73.]
K.A. Rosenbach, R. Allison, J. Nadler.
Daily dosing of Highly Active Antiretroviral Therapy.
Clin Infect Dis, 34 (2002), pp. 686-692
[74.]
Luber AD. The push for once-daily HAART: A call for caution. Medscape HIV/AIDS ejournal 2002;8(3).
[75.]
S. Staszewski, A. Haberl, A. Carlebach, C. Rottmann, V. Miller, p. Gute.
A simple, once-daily dosing regimen for treating HIV-1 infection in intravenous drug users.
HIV Medicine, 1 (2000), pp. 162-163
[76.]
J.M. Molina, F. Ferchal, C. Rancinan, F. Raffi, W. Rozenbaum, D. Sereni.
Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients.
J Infect Dis, 82 (2000), pp. 599-602
[77.]
F. Maggiolo, M. Migliorino, R. Maserati, A. Pan, M. Rizzi, G. Provettoni.
Virological and immunological responses to a once-a-day antiretroviral regimen with didanosine, lamivudine and efavirenz.
Antivir Ther, 6 (2001), pp. 249-253
[78.]
R. Landman, R. Schiemann, S. Thiam, M. Vray, A. Canestri, S. Mboup.
Once-a-day highly active antiretroviral therapy in treatment-naive HIV-1-infected adults in Senegal.
AIDS, 17 (2003), pp. 1017-1022
[79.]
Maggiolo F, Arici C, Gregis GL. A controlled, randomized, prospective study on a Once-a-day therapy for Hiv infection. 42nd ICAAC. San Diego, Ca, USA 2002 (abstract: H-163).
[80.]
Staszewski S, Gallant J, Pozniak AL, Suleiman JMAH, DeJesús E, Lu B, et al. Efficacy and safety of tenofovir disoproxil fumarate (TDF) versus stavudine (d4T) when used in combination with lamivudine (3TC) and efavirenz (EFV) in HIV-1 infected patients naive to antiretroviral therapy (ART): 96-week interim results. In: 10th Conference on Retroviruses and Opportunistic Infections, Boston, Feb 10-14, 2003; abstract 564b.
[81.]
Raffi F, Saag M, Cahn P, Wolff M, Pearce D, Molina JM, et al. Randomized, double-blind, mulcenter comparison of emtricitabine QD to stavudine BID in treatment-naïve HIV-infected patients. En: 2nd IAS Conference on HIV Pathogenesis and Treatment, Paris, France, 13-16 July 2003 (abstract 38) Antiviral Therapy 2003;(Supl 1):193.
[82.]
P. Barreiro, V. Soriano, E. Casas, J. González-Lahoz.
Different degree of immune recovery in HIV-infected patients receiving antiretroviral regimens containing protease inhibitors or non-nucleosides.
AIDS, 16 (2002), pp. 245-259
[83.]
D. Kempf, K. Marsh, G. Kumar, A.D. Rodrigues, J.F. Denissen, E. McDonald.
Pharmacokinetic enhancement of inhibitors of the HIV protease by coadministration with ritonavir.
Antimicrob Agents Chemother, 41 (1997), pp. 654-660
[84.]
J. Mallolas, J.L. Blanco, M. Sarasa, V. Giner, E. Martínez, M.A. García-Viejo.
Dose-finding study of once-daily indinavir/ritonavir plus zidovudine and lamivudina in HIV-infected patients.
J Acquir Immune Defic Syndr, 25 (2000), pp. 229-235
[85.]
L. Mole, D. Schmidgall, M. Holodniy.
A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection.
J Acquir Immune Defic Syndr, 27 (2001), pp. 260-265
[86.]
P.G. Cardiello, R.P. Van Heeswijk, E.A. Hassink, P. Srasuebkul, A. Mahanontharit, T.M. Samor.
Simplifying protease inhibitor therapy with once-daily dosing of saquinavir soft-gelatin capsules/ritonavir (1600/100 mg): HIVNAT 001.3 Study.
J Acquir Immune Defic Syndr, 29 (2002), pp. 464-470
[87.]
Montaner JSG, Saag MS, Barylski C. FOCUS study: Saquinavir QD versus efavirenz QD regimen 48 week analysis in HIV infected patients. Program and abstracts of the 42th ICAAC; September 27-30, 2002; San Diego, California. Abstract H-167.
[88.]
Wood R, Trepo C, Livrozet J. Amprenavir 600 mg/ritonavir 100 mg BID or amprenavir 1.200 mg/ritonavir 200 mg QD given in combination with abacavir and lamivudine maintains efficacy in ART-naive HIV-1 infected adults over 12 weeks. 8th Conference on Retroviruses and Opportunistic Infections. Chicago, EUA. 2001 (abstract 332).
[89.]
Bertz R, Foit C, Ye X. Pharmacokinetics of once-daily vs twiice-daily Kaletra in HIV + subjects. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, EUA. 2002 (abstract 126).
[90.]
Piliero P, Cahn P, Pantaleo GL. Atazanavir: A once-daily protease inhibitor with a superior lipid profile. Results of a clinical trial at week 48. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, EUA. 2002 (abstract 706).
[91.]
Squires K, Thiry A, Giordano M. Atazanavir (ATV) qd and efavirenz (EFV) qd with fixed-dose ZDV + 3TC: Comparison of antiviral efficacy and safety through wk 24 (AI424-034). 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, abstract H-1076, 2002.
[92.]
Moyle G. The APPT-1 study: Assessing patients’ preferred treatments. 6th International Congress on Drug Therapy in HIV Infection. 17-22 Novemberc 2002. Glasgow, UK. Abstract P-99.
[93.]
Glaxo Smith Kline letter (July 2003). Early Virologic Non-Response in Patients with HIV Infection Treated With Lamivudine, Abacavir and Tenofovir.
[94.]
J. Urquhard.
Ascertaining how much compliance is enough with outpatient antibiotic regimens.
Postgrad Med J, 68 (1992), pp. S49-S59
[95.]
G. Levy.
A pharmacokinetic perspective on medication noncompliance.
Clin Pharmacol Ther, 54 (1993), pp. 242-244
[96.]
Stone VE. Enhancing adherence to antiretrovirals: Strategies and regimens. Medscape HIV/AIDS ejournal 2002;8(4).
[97.]
J.R. Ickovics, C.S. Meade.
Adherence to antiretroviral therapy among patients with HIV: A critical link between behavioral and biomedical sciences.
J Acquir Immune Defic Syndr, 31 (2002), pp. 98-102
[98.]
J.A. Mitty, V.E. Stone, M. Sands, G. Macalino, T. Flanigan.
Directly observed therapy for the treatment of people with human immunodeficiency virus infection: A work in progress.
Clin Infect Dis, 34 (2002), pp. 984-990
[99.]
L.R. Kirkland, M.A. Fischl, K.T. Tashima, D. Paar, T. Gensler, N.M. Graham.
Response to lamivudine-zidovudine plus abacavir twice daily in antiretroviral-naive, incarcerated patients with HIV infection taking directly observed treatment.
Clin Infect Dis, 34 (2002), pp. 511-518
[100.]
M.S. Stenzel, M. McKenzie, J.A. Mitty, T. Flanagan.
Enhancing adherence to HAART: Modified directly observed therapy.
AIDS Reader, 11 (2001), pp. 317-328
[101.]
S. Clarke, E. Keenan, M. Ryan, M. Barry, F. Mulcahy.
Directly observed antiretroviral therapy for injection drug users with HIV infection.
AIDS Read, 12 (2002), pp. 305-316
[102.]
J.A. Mitty, G. Macalino, L. Taylor, J.I. Harwell, T.p. Flanigan.
Directly observed therapy (DOT) for individuals with HIV: Successes and challenges.
Med Gen Med, 5 (2003), pp. 30
[103.]
Conway B, Prusad J, Reynolds R. Nevirapine (NVP) and protease inhibitor (PI)-based regimens in a directly observed therapy (DOT) program for intravenous drug users (IDUs). Program and abstracts of the 9th Conference on Retroviruses and Opportunistic Infections; February 24-28, 2002; Seattle, Washington. Abstract 545.
[104.]
H. Knobel, A. Carmona, J.L. López, J.L. Gimeno, P. Saballs, A. González.
Adherencia al tratamiento antirretroviral de gran actividad: impacto de una intervención de asesoramiento individualizado.
Enferm Infecc Microbiol Clin, 17 (1999), pp. 78-81
[105.]
A. Tuldrá, A.W. Wu.
Interventions to improve adherence to antiretroviral therapy.
J Acquir Immune Defic Syndr, 31 (2002), pp. 154-157
[106.]
Haynes RB, McDonald H, Garg AX, Montague p.Interventions for helping patients to follow prescriptions for medications (Cochrane Review). En: The Cochrane Library, Issue 3, 2003. Oxford: Update Software.
[107.]
A.M. Peterson, L. Takiya, R. Finley.
Meta-Analysis of Trials of Interventions to Improve Medication Adherence.
Am J Health-Syst Pharm, 60 (2003), pp. 657-665
[108.]
B.p. Sabundayo.
Report on adherence from the XIV International Conference in Barcelona.
The Hopkins HIV Report, 14 (2002),
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