Estadísticas

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      "titulo" => "Prevalencia de la infección por el virus de la inmunodeficiencia humana en drogodependientes atendidos desde 1991 a 1996 en un centro de desintoxicación de Castilla y León"
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          "titulo" => "The prevalence of infection by the human immunodeficiency virus in drug addicts attended in a detoxication center in Castilla and León (Spain) from 1991 to 1996"
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      "titulo" => "Seroprevalencia frente a Parvovirus B19 en donantes de sangre"
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          "titulo" => "Seroprevalence versus Parvovirus B19 in blood donors"
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    "titulo" => "Citomegalovirus: estudio comparativo de técnicas de diagnóstico"
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        "resumen" => "<span class="elsevierStyleBold">Fundamento&#58;</span> Realizar un estudio comparativo de una serie de t&#233;cnicas de diagn&#243;stico de la infecci&#243;n activa por citomegalovirus &#40;CMV&#41; en sangre &#40;aislamiento de CMV por shell vial&#44; detecci&#243;n de IgG e IgM espec&#237;ficas anti-CMV&#44; antigenemia &#173;detecci&#243;n de ant&#237;geno pp65 mediante tinci&#243;n con peroxidasa&#173; y dos variantes de reacci&#243;n en cadena de la polimerasa &#91;PCR&#93; cualitativa &#173;PCR convencional o en un solo paso y nested PCR&#173; para la detecci&#243;n de DNA viral&#41;&#46; <br/>M&#233;todos&#58; Se ha llevado a cabo el seguimiento de un grupo de 50 enfermos&#44; sometidos a trasplante renal&#44; en los primeros 6 meses postrasplante&#46; Todos ellos excepto seis eran seropositivos con anterioridad al trasplante&#44; y &#250;nicamente uno de los pacientes seronegativos tuvo un donante igualmente seronegativo&#46; <br/>Resultados&#58; En total se han analizado 750 muestras de sangre&#44; de las cuales 8 fueron positivas por shell vial&#44; 91 por detecci&#243;n de IgM espec&#237;fica&#44; 115 por antigenemia&#44; 225 por PCR convencional y 440 por nested PCR&#46; &#218;nicamente en 4 pacientes &#40;uno de ellos el receptor seronegativo con donante seronegativo&#41; no se detect&#243; ninguna muestra positiva a lo largo del seguimiento mediante ninguna de las t&#233;cnicas empleadas&#46; <br/>Conclusiones&#58; La antigenemia ha constituido el m&#233;todo m&#225;s r&#225;pido&#44; barato y sencillo&#44; presentando la ventaja de ofrecer resultados cuantitativos que pemiten establecer una relaci&#243;n con la aparici&#243;n de infecciones sintom&#225;ticas&#46; La PCR cualitativa en las dos variantes empleadas ha sido la t&#233;cnica m&#225;s sensible y precoz&#44; pero a su vez la de mayor dificultad t&#233;cnica&#44; la m&#225;s cara y con la desventaja de que su gran sensibilidad limita su utilidad cl&#237;nica&#46;"
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        "resumen" => "<span class="elsevierStyleBold">Background&#58;</span> The aim of this study was to undertake a comparative study of a series of diagnostic techniques of active infection by cytomegalovirus &#40;CMV&#41; in blood &#40;isolation of CMV by shell vial&#44; detection of specific anti-CMV IgG and IgM&#44; antigenemia &#173;detection of pp65 antigen by staining with peroxidase&#173; and two variants of qualitative polymerase chain reaction &#91;PCR&#93; &#173;conventional PCR or in one step and nested PCR&#173; for detection of viral DNA&#41;&#46; <br/>Methods&#58; Fifty kidney transplant patients were followed for the first 6 post transplant months&#46; All except 6 were seropositive for CMV prior to transplantation and only one seronegative patient had a seronegative donor&#46; <br/>Results&#58; A total of 750 blood samples were analyzed&#44; 8 of which were positive by shell vial&#44; 91 by specific IgM detection&#44; 115 by antigenemia&#44; 225 for conventional PCR and 440 for nested PCR&#46; No positive sample was detected throughout follow up by any of the techniques used in only 4 patients &#40;one being the seronegative receptor with a seronegative donor&#41;&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#58; Antigenemia was found to be the fastest&#44; cheapest and simplest method of diagnosing CMV&#44; presenting the advantage of providing quantitative results which allow the establishment of a relationship with the appearance of symptomatic infections&#46; With the two variants used qualitative PCR was observed to be the earliest and most sensitive technique&#44; while being the most difficult and the most expensive&#44; with the disadvantage that its great sensitivity limits its clinical usefulness"
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