Estadísticas

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      "titulo" => "Aspergilosis invasiva en pacientes infectados por el virus de la inmunodeficiencia humana diagnosticados por necropsia: aportación de 4 casos y revisión de la bibliografía"
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          "titulo" => "Invasive aspergillosis in patients with human immunodeficiency virus infection diagnosed by necropsy: the contribution of 4 cases and review of the literature"
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      "titulo" => "Epidemiología de la fiebre Q en la zona norte de Huelva"
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          "titulo" => "The epidemiology of Q fever in the northern area of Huelva, Spain"
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    "titulo" => "Utilidad de la reacción en cadena de la polimerasa (PCR) en el diagnóstico de la meningitis meningocócica"
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        "titulo" => "The usefulness of polymerase chain reaction (PCR) in the diagnosis of meningococcal meningitis"
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        "resumen" => "<span class="elsevierStyleBold">Fundamento&#58;</span> El prop&#243;sito de este estudio es conocer la utilidad diagn&#243;stica de la reacci&#243;n en cadena de la polimerasa &#40;PCR&#41; en la meningitis meningoc&#243;cica&#44; as&#237; como su rentabilidad respecto a los m&#233;todos tradicionalmente usados para el diagn&#243;stico de dicha enfermedad&#46; <br/> <span class="elsevierStyleBold">M&#233;todos&#58;</span> Se estudiaron 115 l&#237;quidos cefalorraqu&#237;deos procedentes de otros tantos pacientes con sospecha de meningitis&#46; Cuarenta y siete l&#237;quidos cefalorraqu&#237;deos proced&#237;an de pacientes con criterios cl&#237;nicos de enfermedad meningoc&#243;cica&#44; 28 de pacientes con meningitis bacteriana de etiolog&#237;a no meningoc&#243;cica&#44; 10 de pacientes con meningitis linfocitaria y 30 de pacientes en los que no se confirm&#243; la existencia de meningitis&#46; Las muestras se procesaron por procedimientos est&#225;ndar para cultivo y por PCR siguiendo una metodolog&#237;a basada en la descrita por Newcombe et al para muestras de plasma&#46; <br/> <span class="elsevierStyleBold">Resultados&#58;</span> De 39 pacientes con sospecha cl&#237;nica de meningitis meningoc&#243;cica o meningitis m&#225;s sepsis&#44; el diagn&#243;stico se confirm&#243; microbiol&#243;gicamente en 35 casos&#59; de ellos&#44; 22 tuvieron cultivo y PCR positivos&#44; tres fueron positivos por microscopia y PCR&#44; y un caso fue positivo s&#243;lo por microscopia&#46; En 9 casos&#44; la confirmaci&#243;n de la meningitis se hizo &#250;nicamente por PCR&#46; Con la utilizaci&#243;n de esta t&#233;cnica&#44; el n&#250;mero de diagn&#243;sticos confirmados microbiol&#243;gicamente se incrementa en un 23&#37; con respecto a los realizados por microscopia y cultivo&#46; <br/>La sensibilidad&#44; especificidad&#44; valor predictivo positivo y valor predictivo negativo del ensayo realizado fueron 87&#44;1&#44; 98&#44;7&#44; 97&#44;1 y 94&#44;1&#44; respectivamente&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#58;</span> Los resultados obtenidos indican que la PCR puede ser empleada rutinariamente para el diagn&#243;stico de laboratorio de la meningitis meningoc&#243;cica como complemento de las t&#233;cnicas de cultivo y microscopia utilizadas habitualmente"
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        "resumen" => "<span class="elsevierStyleBold">Background&#58;</span> The aim of this work was to evaluate the applicability of polymerase chain reaction &#40;PCR&#41; in the microbiological diagnostic of meningococcal meningitis as compared with the conventional methods &#40;Gram stain and culture&#41;&#46; <br/> <span class="elsevierStyleBold">Methods&#58;</span> One hundred and fifteen cerebrosp&#236;nalis fluid samples from 115 patients with suspicious symptoms of meningitis were studied&#46; 47 of them belonged to patients suspicious for meningococcal disease&#59; 28 to patients with bacterial meningitis of other infectious etiologies&#59; 10 to patients with meningitis showing lymphocytic pleocytosis and 30 to patients with an unconfirmed meningitis&#46; The cerebrosp&#236;nalis fluid samples were procesed for culture by standar procedures and by PCR according to the method described by Newcombe et al for peripheral blood samples <br/> <span class="elsevierStyleBold">Results&#58;</span> Thirty five out of 39 patients suspicious of meningococcal meningitis were microbiologically confirmed&#44; being 22 culture and PCR positive&#44; 3 microscopically and PCR positive&#44; 1 only microscopically positive&#44; and 9 positive only by PCR&#46; By using PCR methodology&#44; the number of confirmed diagnostics of meningococcal meningitis increased in a 23&#37; as compared to those obtained by microscopic observation and culture&#46; Sensitivity&#44; specificity&#44; predictive positive value and predictive negative value were 87&#46;1&#44; 98&#46;7&#44; 97&#46;1 and 94&#46;1 respectively for the PCR method&#46; <br/> <span class="elsevierStyleBold">Conclusions&#58;</span> Our results indicate that PCR can be used on routine basis as a complementary technique to the standar laboratory procedures for diagnosis of meningococcal meningitis&#46;"
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