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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2011;29 Supl 3:20-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 15809 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 13227 "PDF" => 2571 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Amebas intestinales no patógenas: una visión clinicoanalítica" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "20" "paginaFinal" => "28" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Non-pathogenic intestinal amoebae: a clinical-analytical overview" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bárbara Gomila Sard, Rafael Toledo Navarro, J. Guillermo Esteban Sanchis" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Bárbara Gomila" "apellidos" => "Sard" ] 1 => array:2 [ "nombre" => "Rafael Toledo" "apellidos" => "Navarro" ] 2 => array:2 [ "nombre" => "J. Guillermo" "apellidos" => "Esteban Sanchis" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X11700234?idApp=UINPBA00004N" "url" => "/0213005X/00000029000000S3/v1_201305090313/S0213005X11700234/v1_201305090313/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0213005X11700210" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(11)70021-0" "estado" => "S300" "fechaPublicacion" => "2011-03-01" "aid" => "70021" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2011;29 Supl 3:8-13" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1895 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1520 "PDF" => 366 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis de resultados del Programa de Control de Calidad Externo SEIMC de carga viral del VIH-1 y del VHC. Año 2009" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "8" "paginaFinal" => "13" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Analysis of the results of the HIV-1 and HCV viral load of the SEIMC External Quality Control Program. Year 2009" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nieves Orta Mira, María del Remedio Guna Serrano, José-Carlos Latorre Martínez, María Rosario Ovies, Marta Poveda, Enrique Ruiz de Gopegui, José L. Pérez, Concepción Gimeno Cardona" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Nieves" "apellidos" => "Orta Mira" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "del Remedio Guna Serrano" ] 2 => array:2 [ "nombre" => "José-Carlos Latorre" "apellidos" => "Martínez" ] 3 => array:2 [ "nombre" => "María Rosario" "apellidos" => "Ovies" ] 4 => array:2 [ "nombre" => "Marta" "apellidos" => "Poveda" ] 5 => array:2 [ "nombre" => "Enrique Ruiz" "apellidos" => "de Gopegui" ] 6 => array:2 [ "nombre" => "José L." "apellidos" => "Pérez" ] 7 => array:2 [ "nombre" => "Concepción Gimeno" "apellidos" => "Cardona" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X11700210?idApp=UINPBA00004N" "url" => "/0213005X/00000029000000S3/v1_201305090313/S0213005X11700210/v1_201305090313/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Infección oculta por el virus de la hepatitis C" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "14" "paginaFinal" => "19" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Vicente Carreño García, Javier Bartolomé Nebreda, Inmaculada Castillo Aguilar, Juan Antonio Quiroga Estévez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Vicente" "apellidos" => "Carreño García" "email" => array:1 [ 0 => "fehvhpa@fehv.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Javier Bartolomé" "apellidos" => "Nebreda" ] 2 => array:2 [ "nombre" => "Inmaculada Castillo" "apellidos" => "Aguilar" ] 3 => array:2 [ "nombre" => "Juan Antonio" "apellidos" => "Quiroga Estévez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Fundación para el Estudio de las Hepatitis Virales, Madrid, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Occult hepatitis C virus infection" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec138716" "palabras" => array:4 [ 0 => "Infección oculta" 1 => "ARN-VHC" 2 => "Anti-core VHC" 3 => "CMSP" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec138715" "palabras" => array:4 [ 0 => "Occult infection" 1 => "HCV-RNA" 2 => "Anti-core HCV" 3 => "PBMC" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La infección oculta por el virus de la hepatitis C (VHC) se caracteriza por la detección del ARN-VHC en hígado en ausencia de anti-VHC y de ARN-VHC en suero determinados mediante técnicas convencionales. El desarrollo de un nuevo EIA para la detección de anticuerpos frente a un epítopo conservado de la proteína core del VHC junto con la determinación del ARN-VHC en células mononucleares de sangre periférica y en suero tras concentrar las partículas virales mediante ultracentrifugación, permite diagnosticar a más del 90% de los pacientes con infección oculta por VHC sin necesidad de realizar una biopsia hepática. El daño histológico causado por la infección oculta por VHC comprende desde cambios mínimos hasta cirrosis y carcinoma hepatocelular, aunque en general es una enfermedad más benigna que la hepatitis crónica C clásica. Se ha detectado una prevalencia significativa de infección oculta por VHC en grupos de riesgo como pacientes en hemodiálisis y familiares de pacientes diagnosticados de hepatitis C oculta. Además, esta infección oculta puede darse en sujetos sin evidencias clínicas ni bioquímicas de enfermedad hepática.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Occult hepatitis C virus (HCV) infection is characterized by the detection of HCV-RNA in liver in the absence of anti-HCV and serum HCV-RNA determined by conventional techniques. The development of a new enzyme immunoassay for the detection of antibodies against a conserved epitope in the HCV core protein, together with the detection of HCV-RNA in peripheral blood mononuclear cells and in serum after concentrating the viral particles by ultracentrifugation, allow diagnosis of more than 90% of patients with occult HCV without the need to perform a liver biopsy. Histological damage in occult HCV infection ranges from minimal changes to liver cirrhosis and hepatocellular carcinoma, although in general this disease is less severe than classical chronic hepatitis C. A significant prevalence of occult HCV infection has been identified in risk groups such as hemodialysis patients and the family members of patients with occult hepatitis C. This occult HCV infection can also be found in subjects without clinical or biochemical evidence of liver disease.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Replication of hepatitis C virus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Bartenschlager" 1 => "V. 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Infección oculta por el virus de la hepatitis C
Occult hepatitis C virus infection
Vicente Carreño García
, Javier Bartolomé Nebreda, Inmaculada Castillo Aguilar, Juan Antonio Quiroga Estévez
Autor para correspondencia
Fundación para el Estudio de las Hepatitis Virales, Madrid, España
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Infección oculta por el virus de la hepatitis C
Vicente Carreño García, Javier Bartolomé Nebreda, Inmaculada Castillo Aguilar, Juan Antonio Quiroga Estévez
10.1016/S0213-005X(11)70022-2Enferm Infecc Microbiol Clin. 2011;29 Supl 3:14-9