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Inicio Enfermedades Infecciosas y Microbiología Clínica Update on bacterial pathogens: virulence and resistance
Información de la revista
Vol. 26. Núm. S3.
Páginas 3-21 (abril 2008)
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Vol. 26. Núm. S3.
Páginas 3-21 (abril 2008)
Monographic: “update on infectious diseases”
Acceso a texto completo
Update on bacterial pathogens: virulence and resistance
Actualización en patógenos bacterianos: virulencia y resistencia
Visitas
1563
Emilia Cercenadoa,
Autor para correspondencia
ecercenado@terra.es

Correspondence: Dr. E. Cercenado. Servicio de Microbiología. Hospital General Universitario Gregorio Marañón. Dr. Esquerdo, 46. 28007 Madrid. Spain. Telf.: 91-5868459. Fax: 91-5044906.
, Javier Garaub, Benito Almirantec, José Ramón Azanzad, Rafael Cantóne, Ramón Cisternaf, José María Eirosg, Carmen Fariñash, Jesús Fortúni, Francisco Gudiolj, José Mensak, Jerónimo Pachónl, Álvaro Pascualm, José Luis Pérezn, Alejandro Rodríguezo, Miguel Sánchezp, Jordi Vilaq
a Servicio de Microbiología. Hospital General Universitario Gregorio Marañón. Madrid. Spain
b Servicio de Enfermedades Infecciosas. Hospital Mutua de Terrassa. Barcelona. Spain
c Servicio de Enfermedades Infecciosas. Hospitall Vall d’Hebron. Barcelona. Spain
d Servicio de Farmacología Clínica. Hospital de Pamplona. Spain
e Servicio de Microbiología. Hospital Ramón y Cajal. Madrid. Spain
f Servicio de Microbiología. Hospital de Basurto. Bilbao. Spain
g Servicio de Microbiología. Hospital Clínico Universitario. Valladolid. Spain
h Servicio de Enfermedades Infecciosas. Hospital Marqués de Valdecilla. Santander. Spain
i Servicio de Enfermedades Infecciosas. Hospital Ramón y Cajal. Madrid. Spain
j Servicio de Enfermedades Infecciosas. Hospital de Bellvitge. Barcelona. Spain
k Servicio de Medicina Interna. Hospital Clínic. Barcelona. Spain
l Servicio de Enfermedades Infecciosas. Hospital Virgen del Rocío. Sevilla. Spain
m Servicio de Microbiología. Hospital Virgen Macarena. Sevilla. Spain
n Servicio de Microbiología. Hospital Son Dureta. Palma de Mallorca. Spain
o Servicio de Medicina Intensiva. Hospital Joan XXIII. Tarragona. Spain
p Servicio de Medicina Intensiva. Hospital Príncipe de Asturias. Alcalá de Henares. Madrid. Spain
q Servicio de Microbiología. Hospital Clínic. Barcelona. Spain
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The present article is an update of the literature on bacterial pathogens. Recognizing the interest and scientific and public health importance of infections produced by bacterial pathogens with new virulence mechanisms and/or new mechanisms of resistance to antimicrobial agents, a multidisciplinary group of Spanish physicians and microbiologists organized a joint session and revised the most important papers produced in the field during 2006. Each article was analyzed and discussed by one of the members of the panel. This paper focus on a variety of diseases that pose major clinical and public health challenges today; and include infections produced by community-acquired methicillin-resistant Staphylococcus aureus and S. aureus small colony variants, infections produced by multiply resistant coagulase-negative staphylococci, pneumococcal infections, human listeriosis, meningococcal disease, Haemophilus influenzae, pertussis, Escherichia coli, ESBL-producing organisms, and infections due to non-fermenters. After a review of the state of the art, papers selected in this field are discussed.

Key words:
Bacterial infections
Resistance to antimicrobials
Community-acquired-MRSA
S. aureus small colony variants
Resistance to linezolid
Pneumococcal vaccines
Listeria monocytogenes
Neisseria meningitides
Haemophilus influenzae
Bordetella pertussis
Escherichia coli
Klebsiella pneumoniae
ESBL producers
Pseudomonas aeruginosa
Acinetobacter baumannii

El presente artículo recoge una actualización bibliográfica de patógenos bacterianos. Dado el interés científico y la importancia que tienen para la salud pública las infecciones producidas por patógenos bacterianos con nuevos mecanismos de virulencia y/o nuevos mecanismos de resistencia a los antimicrobianos, un grupo multidisciplinario de microbiólogos y clínicos españoles, con experiencia en enfermedades infecciosas, organizó una reunión en la que se revisaron los artículos más importantes en este campo, publicados en 2006.

El contenido de cada uno de los artículos seleccionados fue expuesto y discutido por uno de los miembros del grupo. Este artículo revisa algunas de las enfermedades infecciosas bacterianas que suponen hoy en día algunos de los principales retos para la salud pública e incluye las infecciones producidas por Staphylococcus aureus resistente a meticilina de adquisición comunitaria, las producidas por variantes de colonia pequeña de S. aureus, las relacionadas con estafilococos coagulasa negativa multirresistentes, la infección neumocócica, la listeriosis humana, la infección meningocócica, la tos ferina, las infecciones por Haemophilus influenzae, la diseminación de las bacterias productoras de BLEE, y las infecciones por bacilos gramnegativos no fermentadores. Tras la revisión de la situación actual, se discuten y comentan diferentes artículos relacionados con estos aspectos.

Palabras clave:
Infecciones bacterianas
Resistencia a antibióticos
SARM de adquisición comunitaria
Variantes de colonia pequeña de Staphylococcus aureus
Resistencia a linezolid
Vacunas neumocócicas
Listeria monocytogenes
Neisseria meningitides
Haemophilus influenzae
Bordetella pertussis
Escherichia coli
Klebsiella pneumoniae
Productores de BLEE
Pseudomonas aeruginosa
Acinetobacter baumannii
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References
[1.]
D. Armstrong, H. Neu, L.R. Peterson, A. Tomasz.
The prospects of treatment failure in the chemotherapy of infectious diseases in the 1990s.
Microb Drug Resist, 1 (1995), pp. 1-4
[2.]
D.M. Livermore.
Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?.
Clin Infect Dis, 34 (2002), pp. 634-640
[3.]
C. Urban, S. Segal-Maurer, J.J. Rahal.
Considerations in control and treatment of nosocomial infections due to multidrug-resistant Acinetobacter baumannii.
Clin Infect Dis, 36 (2003), pp. 1268-1274
[4.]
F. Vandenesch, T. Naimi, M. Enright, et al.
Community-acquired methicillin-resistant Staphylcoccus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.
Emerg Infect Dis, 9 (2003), pp. 978-984
[5.]
C. Drosten, S. Günther, W. Preiser, et al.
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
New Engl J Med, 348 (2003), pp. 1967-1976
[6.]
R.C. Moellering Jr.
The growing menace of community-acquired methicilllinresistant Staphylococcus aureus.
Ann Intern Med, 144 (2006), pp. 368-370
[7.]
J. Rodríguez-Baño, D.L. Paterson.
A change in the epidemiology of infectious due to extended-spectrum-beta-lactamase-producing organisms.
Clin Infect Dis, 42 (2006), pp. 935-937
[8.]
G.J. Moran, A. Krishnadasan, R.J. Gorwitz, G.E. Fosheim, L.K. McDougal, R.B. Carey, For the EMERGEncy ID Net Study Group, et al.
Methicillin-resistant S. aureus infections among patients in the emergency department.
N Eng J Med, 355 (2006), pp. 666-674
[9.]
G.W. Coombs, G.R. Nimmo, J.M. Bell, F. Huygens, F.G. O’Brien, M.J. Malkowski, The Australian Group for Antimicrobial Resistance, et al.
Genetic diversity among community methicilllin-resistant Staphylococcus aureus strains causing outpatient infections in Australia.
J Clin Microbiol, 42 (2004), pp. 4735-4743
[10.]
O. Denis, A. Deplano, H. De Beenhouvwer, M. Hallin, G. Huysmans, M.G. Garrino, et al.
Polyclonal emergence and importantion of community-acquired methicillin-resistant Staphylococcus aureus strains harbouring Panton- Valentine leucocidin genes in Belgium.
J Antimicrob Chemother, 56 (2005), pp. 1103-1106
[11.]
A. Broseta, F. Chaves, P. Rojo, J.R. Otero.
Emergencia de un clon de Staphylococcus aureus resistente a la meticilina de origen comunitario en la población pediátrica del sur de Madrid.
Enferm Infecc Microbiol Clin, 24 (2006), pp. 31-35
[12.]
F.C. Tenover, L.K. McDougal, R.V. Goering, G. Killgore, S.J. Projan, J.B. Patel, et al.
Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.
J Clin Microbiol, 44 (2006), pp. 108-118
[13.]
F. Vandenesch, T. Naimi, M.C. Enright, G. Lina, G.R. Nimmo, H. Heffernan, et al.
Community-acquired methicilllin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.
Emerg Infect Dis, 9 (2003), pp. 978-984
[14.]
T.S. Naimi, K.H. LeDell, K. Como-Sabetti, S.M. Borchardt, D.J. Boxrud, J. Etienne, et al.
Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection.
JAMA, 290 (2003), pp. 2976-2984
[15.]
H.F. Chambers.
The changing epidemiology of Staphylococcus aureus?.
Emerg Infect Dis, 7 (2001), pp. 178-182
[16.]
S.E. Crawford, S. Boyle-Vavra, R.S. Daum.
Community-associated methicilllin-resistant Staphylococcus aureus.
Emerging Infections 7,
[17.]
M.J. Rybak, K.L. LaPlante.
Community-associated methicillin-resistant Staphylococcus aureus: a review.
Pharmacotherapy, 25 (2005), pp. 74-85
[18.]
S. Banthia, V.G. Meka, S. Pillai, K. Wener, R. Freedman, S. Pandya, et al.
A fatal case of necrotizing pneumonia caused by community-associated methicillin- resistant Staphylococcus aureus.
Infect Dis Clin Prac, 13 (2005), pp. 132-138
[19.]
L.G. Miller, F. Perdreau-Remington, G. Rieg, S. Mehdi, J. Perlroth, A.S. Bayer, et al.
Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles.
N Engl J Med, 352 (2005), pp. 1445-1453
[20.]
P.V. Adem, C.P. Montgomery, A.N. Husain, T.K. Koogler, V. Arangelovich, M. Humilier, et al.
Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children.
N Engl J Med, 353 (2005), pp. 1245-1251
[21.]
S.L. Kaplan, K.G. Hulten, B.E. Gonzalez, W.A. Hammerman, L. Lamberth, J. Versalovic, et al.
Three-year surveillance of community-acquired Staphylococcus aureus infections in children.
Clin Infect Dis, 40 (2005), pp. 1785-1791
[22.]
B.E. Gonzalez, K.G. Hulten, M.K. Dishop, L.B. Lamberth, W.A. Hammerman, E.O. Mason Jr, et al.
Pulmonary manifestations in children with invasive community- acquired Staphylococcus aureus infection.
Clin Infect Dis, 41 (2005), pp. 583-590
[23.]
S. Salmenlinna, O. Lyytikäinen, J. Vuopio-Varkila.
Community- acquired methicillin-resistant Staphylococcus aureus, Finland.
Emerg Infect Dis, 8 (2002), pp. 602-607
[24.]
T. Yamaguchi, Y. Yokata, J. Terajima, et al.
Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district of Japan.
J Infect Dis, 185 (2002), pp. 1151-1516
[25.]
F.C. Tenover.
Community-associated methicilllin-resistant Staphylococcus aureus: it's not just in communities anymore.
Clin Microbiol Newslett, 28 (2006), pp. 33-36
[26.]
E.A. Eady, J.H. Cove.
Staphylococcal resistance revisited: community-acquired methicilllin-resistant Staphylococcus aureus –an emerging problem for the management of skin and soft tissue infections.
Curr Opin Infect Dis, 16 (2003), pp. 103-124
[27.]
O. Cuevas, E. Cercenado, E. Bouza, C. Castellares, P. Trincado, R. Cabrera, The Spanish Group for the Study of Staphylococcus, et al.
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Spain: a multicentre prevalence study (2002).
Clin Microbiol Infect, 13 (2007), pp. 250-256
[28.]
Y. Gillet, B. Issartel, P. Vanhems, J.C. Fournet, G. Lina, M. Bes, et al.
Association between Staphylococcus aureus strains carrying the gene for Panton-Valentine leukocidin and highly lethal necrotising pneumoniae in young immunocompetent patients.
[29.]
A.M. Mishaan, E.O. Mason Jr., G. Martinez-Aguilar, W. Hammerman, J.J. Propst, J.R. Lupski, et al.
Emergence of a predominant clone of community-acquired Staphylococcus aureus among children in Houston, Texas.
Pediatr Infect Dis J, 24 (2005), pp. 201-206
[30.]
J.M. Boyce, N.L. Havill, B. Maria.
Frequency and possible infection control implications of gastrointestinal colonization with methicillin-resistant Staphylococcus aureus.
J Clin Microbiol, 43 (2005), pp. 5992-5995
[31.]
E. van Duijkeren, M.J. Wolfhagen, M.E. Heck, W.J. Wannet.
Transmission of a Panton-Valentine leucocidin-positive, methicillin-resistant Staphylococcus aureus strain between humans and a dog.
J Clin Microbiol, 43 (2005), pp. 6209-6211
[32.]
Centers for Disease Control and Prevention. Reduced susceptibility of Staphylococcus aureus to vancomycin-Japan,1996. Morb Mortal Wkly Rep. 1997; 46:624-6.
[33.]
Centers for Disease Control and Prevention. Staphylococcus aureus with reduced susceptibility to vancomycin-United States,1997. Morb Mortal Wkly Rep. 1997; 46:765-6.
[34.]
F.C. Tenover, L.C. MacDonald.
Vancomycin-resistant staphylococci and enterococci: epidemiology and control.
Curr Opin Infect Dis, 18 (2005), pp. 300-305
[35.]
M.R. Moore, F. Perdreau-Remington, H.F. Chambers.
Vancomycin treatment failure associated with heterogeneous vancomycin-intermediate Staphylococcus aureus in a patient with endocarditis and in the rabbit model of endocarditis.
Antimicrob Agents Chemother, 47 (2003), pp. 1262-1266
[36.]
K. Sieradzki, A. Tomasz.
Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic seris of clinical isolates of Staphylococcus aureus.
J Bacteriol, 185 (2003), pp. 7103-7110
[37.]
S. Boyle-Vavra, M. Challapalli, R.S. Daum.
Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.
Antimicrob Agents Chemother, 47 (2003), pp. 2036-2039
[38.]
G. Sakoulas, G.M. Eliopoulos, V.G. Fowler Jr, R.C. Moellering Jr, R.P. Novick, N. Lucindo, et al.
Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function.
Antimicrob Agents Chemother, 49 (2005), pp. 2687-2692
[39.]
J. Ariza, M. Pujol, J. Cabo, C. Peña, N. Fernández, J. Liñares, et al.
Vancomycin in surgical infections due to methicillin-resistant Staphylococcus aureus with heterogeneous resistance to vancomycin.
Lancet, 353 (1999), pp. 1587-1588
[40.]
R.A. Proctor, D.M. Bates, P.J. McNamara.
Electron transport-deficient Staphylococcus aureus small-colony variants as emerging pathogens.
Emerging Infections 5,
[41.]
R.A. Proctor, J.M. Balwit, O. Vesga.
Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections.
Infect Agents Dis, 3 (1994), pp. 302-312
[42.]
R.A. Proctor, G. Peters.
Small colony variants in staphylococcal infections: diagnostic and therapeutic implications.
Clin Infect Dis, 27 (1998), pp. 419-423
[43.]
C. von Eiff, C. Heilmann, G. Peters.
Staphylococcus epidermidis: why is it so successful?.
Clin Microbiol Infect, 4 (1998), pp. 207-300
[44.]
R.M. Donlan, J.W. Costerton.
Biofilms: survival mechanisms of clinically relevant microorganisms.
Clin Microbiol Rev, 15 (2002), pp. 167-193
[45.]
H.L. Wood, S.R. Holden, R. Bayston.
Susceptibility of Staphylococcus epidermidis biofilm in CSF shunts to bacteriophage attack.
Eur J Pediatr Surg, 11 (2001), pp. S56-S57
[46.]
B.A. Potoski, J. Adams, L. Clarke, K. Shutt, P.K. Linden, C. Baxter, et al.
Epidemiological profile of linezolid-resistant coagulase-negative staphylococci.
Clin Infect Dis, 43 (2006), pp. 165-171
[47.]
D.E. Low.
Changing trends in antimicrobial-resistant pneumococci: it's not all bad news.
Clin Infect Dis, 41 (2005), pp. S228-233
[48.]
M.H. Kyaw, R. Lynfield, W. Schaffner, A.S. Craig, J. Hadler, A. Reingold, et al.
for Active Bacterial Core Surveillance of the Emerging Infections Program Network.
N Engl J Med, 354 (2006), pp. 1455-1463
[49.]
E. Calbo, A. Díaz, E. Cañadell, J. Fábrega, S. Uriz, M. Xercavins, et al.
for the Spanish Pneumococcal Infection Study Network.
Clin Microbiol Infect, 12 (2006), pp. 867-872
[50.]
D. van de Beek, J. de Gans, L. Spanjaard, M. Weisfelt, J.B. Reitsma, M. Vermeulen.
Clinical features and prognostic factors in adults with bacterial meningitis.
N Engl J Med, 351 (2004), pp. 1849-1859
[51.]
D.M. Vu, D. Kelly, P.T. Heath, N.D. McCarthy, et al.
Effectiveness analysis may underestimate protection of infants after group C meningococcal immunization.
J Infect Dis, 194 (2006), pp. 231-237
[52.]
M.D. Snape, D.F. Kelly, P. Salt, S. Green, et al.
Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization.
Clin Infect Dis, 43 (2006), pp. 1387-1394
[53.]
D.L. Jack, J. Cole, S.G. Naylor, et al.
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease.
Clin Infect Dis, 43 (2006), pp. 1426-1433
[54.]
M. Cerquetti, et al.
Genetic diversity of invasive strains of Haemophilus influenzae type b before and after introduction of the conjugate vaccine in Italy.
Clin Infect Dis, 43 (2006), pp. 317-319
[55.]
C.S. Berenson, et al.
Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease.
J Infect Dis, 194 (2006), pp. 1375-1384
[56.]
T.F. Murphy, et al.
Haemophilus haemolyticus: a human respiratory tract comensal to be distinguished from Haemophilus influenzae.
J Infect Dis, 195 (2007), pp. 81-89
[57.]
Ward, et al.
Bordetella pertussis infections in vaccinated and unvaccinated adolescents and adults, as assesed in a national prospective randomized acellular pertussis vaccine trial (APERT).
Clin Infect Dis, 43 (2006), pp. 151-157
[58.]
J. García-Martínez, et al.
Bordetella pertussis detection by real-time PCR, immunofluorescence and culture: prospective evaluation and molecular epidemiology.
Enferm Infecc Microbiol Clin, 8 (2006), pp. 500-504
[59.]
Lautenbach, et al.
Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: Results from a large hospital-based surveillance study.
J Infect Dis, 194 (2006), pp. 79-85
[60.]
Johnson, et al.
Similarity between human and chicken Escherichia coli isolates in relation to ciprofloxacin resistance status.
J Infect Dis, 194 (2006), pp. 71-78
[61.]
J. Rodríguez-Baño, M.D. Navarro, L. Romero, et al.
Bacteremia due to extended- spectrum B-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge.
Clin Infect Dis, 43 (2006), pp. 1407-1414
[62.]
O. Zimhony, I. Chmelnitsky, R. Bardenstein, et al.
Endocarditis caused by extended- spectrum beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility.
Antimicrob Agents Chemother, 50 (2005), pp. 3179-3182
[63.]
R.J. Mesa, V. Blanc, A.R. Blanch, et al.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage).
J Antimicrob Chemother, 58 (2006), pp. 211-215
[64.]
S. Vourli, H. Tsorlini, H. Katsifa, M. Polemis, L.S. Tzouvelekis, A. Kontodimou, et al.
Emergence of Proteus mirabilis carrying the bla metallo-beta-lactamase gene.
Clin Microbiol Infect, 12 (2006), pp. 691-694
[65.]
Aboufaycal H, Sader HS, Rolston K, Deshpande LM, Toleman M, Bodey G, et al. blaVIM-2 and blaVIM-7 carbapenemase-producing Pseudomonas aeruginosa detected in a tertiary care medical center in the United States: report from the MYSTIC program. J Clin Microbiol. 2006. [Epub ahead of print].
[66.]
M.E. Falagas, P.K. Koletsi, P. Kopterides, A. Michalopoulos.
Risks factors for isolation of strains susceptible only to polymyxin among patients with Pseudomonas aeruginosa bacteremia.
Antimicrob Agents Chemother, 50 (2006), pp. 2541-2543
[67.]
P.E. Fournier, H. Richet.
The epidemiology and control of Acinetobacter baumannii in health care facilities.
Clin Infect Dis, 42 (2006), pp. 692-702
[68.]
W.S. Leung, C.M. Chu, K.Y. Tsang, F.H. Lo, K.F. Lo, P.L. Ho.
Fulminant community-acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome.
Chest, 129 (2006), pp. 102-109
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