Asociación entre consumo de antiinflamatorios no esteroideos e insuficiencia cardíaca congestiva

Fundamento y objetivo: Estimar la asociación entre el consumo previo de antiinflamatorios no esteroideos (AINE) y el ingreso hospitalario debido a insuficiencia cardíaca congestiva (ICC), y evaluar el efecto de los inhibidores selectivos de la ciclooxigenasa 2 (COX-2) en esta descompensación. Pacientes y método: Estudio de casos y controles: 982 casos de ICC y 788 controles con antecedentes de ICC, que ingresaron en 10 hospitales de Madrid. Resultados: El uso de AINE (distintos de aspirina a dosis bajas) se asoció con un aumento del riesgo de ingreso hospitalario por ICC (odds ratio [OR] bruta = 1,59; intervalo de confianza [IC] del 95%, 1,20-2,09; OR ajustada = 1,40; IC del 95%, 1,03-1,90). Conclusiones: En individuos susceptibles, el consumo de AINE supone un aumento del riesgo de ingreso por ICC.

Background and objective: Our purpose was to estimate the association between the intake of non-steriodal anti-inflammatory drugs (NSAIDs) and hospitalization due to heart failure (HF) and to assess the effect of selective COX-2 inhibitors. Patients and method: This was a case-control study, including 982 patients with HF, and 788 controls, with a history of HF who were hospitalized in 10 hospitals of the community of Madrid. Results: The use of NSAIDs (other than aspirine at low doses) was associated with an increase in the risk of hospitalization due to HF (OR crude = 1.59; 95% interval confidence, 1.20-2.09; OR adjusted, 1.40; 95% interval confidence, 1.03-1.90). Conclusions: Intake of NSAIDs is associated with an increased risk of hospitalization due to HF, in susceptible patients.