array:23 [ "pii" => "S0025775300712711" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71271-1" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71271" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:286-91" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2982 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2863 "PDF" => 113 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712723" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71272-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71272" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:292-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3695 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3539 "PDF" => 150 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales breves</span>" "titulo" => "Análisis clínico de la tromboembolia pulmonar no sospechada en el servicio de urgencias" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "292" "paginaFinal" => "293" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical analysis of the unsuspected pulmonary embolism in the emergency department" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Pere Tudela, Antonia Segura, Juan Valencia, Anna Carreres" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Pere" "apellidos" => "Tudela" ] 1 => array:2 [ "nombre" => "Antonia" "apellidos" => "Segura" ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Valencia" ] 3 => array:2 [ "nombre" => "Anna" "apellidos" => "Carreres" ] ] ] 1 => array:2 [ "autoresLista" => "Ester Davant, Manuel Monreal" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Ester" "apellidos" => "Davant" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Monreal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712723?idApp=UINPBA00004N" "url" => "/00257753/0000011400000008/v1_201307291447/S0025775300712723/v1_201307291447/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S002577530071270X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71270-X" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71270" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:281-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2007 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1852 "PDF" => 149 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Monitorización de la enfermedad mínima residual mediante detección conjunta de los reordenamientos <span class="elsevierStyleItalic">PML/RARα</span> y <span class="elsevierStyleItalic">RARα/PML</span> en la leucemia promielocítica aguda" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "285" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Monitoring of minimal residual disease by combined detection of PML/RARα and RARα/PML rearrangements in acute promyelocytic leukemia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pascual Bolufer,, Eva Barragán, Miguel Ángel Sanz, Guillermo Martín, Enrique Lerma, Esperanza Afán de Ribera" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Pascual" "apellidos" => "Bolufer," ] 1 => array:2 [ "nombre" => "Eva" "apellidos" => "Barragán" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Sanz" ] 3 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Martín" ] 4 => array:2 [ "nombre" => "Enrique" "apellidos" => "Lerma" ] 5 => array:2 [ "nombre" => "Esperanza" "apellidos" => "Afán de Ribera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530071270X?idApp=UINPBA00004N" "url" => "/00257753/0000011400000008/v1_201307291447/S002577530071270X/v1_201307291447/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Estimación de la prevalencia de infección por VIH-1 en la embarazada y efectividad de la zidovudina administrada durante la gestación en la prevención de la transmisión vertical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "286" "paginaFinal" => "291" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Tomás Ramos Amador, Jesús Ruiz Contreras, Rafael Bastero, Carmen Barrio, Pilar Moreno, Rafael Delgado, Eloy Muñoz, Jesús Jiménez" "autores" => array:8 [ 0 => array:3 [ "nombre" => "José Tomás" "apellidos" => "Ramos Amador" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Jesús Ruiz" "apellidos" => "Contreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 2 => array:3 [ "nombre" => "Rafael" "apellidos" => "Bastero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 3 => array:3 [ "nombre" => "Carmen" "apellidos" => "Barrio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 4 => array:3 [ "nombre" => "Pilar" "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 5 => array:3 [ "nombre" => "Rafael" "apellidos" => "Delgado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 6 => array:3 [ "nombre" => "Eloy" "apellidos" => "Muñoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] ] 7 => array:3 [ "nombre" => "Jesús" "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Inmunodeficiencias, Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Servicio de Neonatología. Departamento de Pediatría, Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "Servicio de Microbiología, Madrid" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] 3 => array:3 [ "entidad" => "Departamento de Obstetricia y Ginecología. Hospital 12 de Octubre. Madrid" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. J.T. Ramos Amador. Unidad de Inmunodeficiencias. Hospital 12 de Octubre. Carretera de Andalucía, km 5,4. 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Estimate of the HIV-1 prevalence in pregnant women and effectiveness of zidovudine administered during pregnancy in reducing perinatal transmission" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1998-01-07" "fechaAceptado" => "1999-09-02" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221299" "palabras" => array:3 [ 0 => "VIH-1" 1 => "Zidovudina" 2 => "Transmisión vertical" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">: A pesar de la eficacia probada de la zidovudina (ZDV) administrada a la embarazada enla disminución de la transmisión vertical del VIH-1, existen importantes dudas sobre la efectividad yel cumplimiento en la práctica clínica. Los objetivos han sido determinar la efectividad de la ZDV duranteel embarazo a las mujeres con infección por VIH en la reducción de la transmisión vertical (TV)y analizar la tendencia en el tiempo de la prevalencia de infección y de los casos identificados precozmente.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">: Se han seleccionado los pares de madres/hijos seguidos prospectivamente desdeel nacimiento, en el período comprendido entre el 1 de enero de 1987 y el 30 de octubre de 1997.Se ha considerado infectado al niño con anticuerpos positivos a partir de los 18 meses, o al menos 2determinaciones mediante reacción en cadena de la polimerasa (PCR) positivas en los primeros 3 mesesde vida.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">: Se han identificado 229 madres y 248 niños. Se administró ZDV a 34 madres en el embarazocon una media (DE) de 4,7 (3,1) meses. El valor medio de CD4 fue de 465 (261) células ×10<span class="elsevierStyleSup">6</span>/l. Las únicas variables asociadas con un mayor riesgo de transmisión fueron el tiempo de roturade bolsa (mediana en transmisoras 6 h, mediana en no transmisoras 1,04 h; p = 0,023) y el tratamientocon ZDV. De las madres tratadas durante el embarazo sólo un niño resultó infectado (TV2,9%), frente a 37 niños en las no tratadas (TV 17,5%) (p = 0,029; odds ratio [OR]: 0,14; intervalode confianza [IC] del 95%: 0,07-0,92). La prevalencia estimada de infección por VIH-1 en mujeresgestantes en nuestra área se sitúa en torno al 0,39% (IC del 95%: 0,34-0,45). En los primeros 5años del período de estudio, 14 niños (9,7%) fueron identificados como seropositivos después del períodoneonatal, en comparación a sólo 3 a partir de 1992 (p = 0,034).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">: En este estudio, la prevalencia estimada de infección por VIH-1 en mujeres embarazadases elevada. El tratamiento con ZDV durante el embarazo se asocia a una disminución en la transmisiónvertical del VIH-1. Es posible que la disponibilidad de esta medida haya contribuido a la mayoridentificación de las embarazadas seropositivas observada en el tiempo.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">: Despite the proven efficacy of zidovudine (ZDV) for reducing perinatal transmission ofHIV-1, questions remain about its implementation and effectiveness in routine practice. The aimsof this study were to assess the impact of ZDV administered during pregnancy in preventing perinatalHIV-1 transmission, and to determine the proportion of early identification of maternal HIV-1 infectionover time.</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">: We prospectively followed from birth a cohort of children born between1/1/1987 and 31/10/1997 to HIV-1-infected mothers. Infant infection status was assessed by followupbeyond 18 months or HIV-PCR up to 3 months of age.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">: 229 mothers and 248 infants were identified in the cohort. ZDV was administered duringpregnancy as monotherapy to 34 mothers for a mean of 4,7 (3,1) months prior to delivery. There wereno differences in baseline characteristics between the treated and untreated groups. Mean (SD) CD4cell count was 465 (261) cells × 10<span class="elsevierStyleSup">6</span>/l. Factors associated with transmission were a more prolongedtime of rupture of obstetric membranes (median 6 vs 1,04 hours; p = 0,023) and ZDV treatment.Among the ZDV-treated mothers only one child was infected (2,9%), whereas 37 children born to 212untreated women became infected. (OR: 0,14; 95% CI: 0,07-0,92). The estimated prevalence ofHIV-1 in pregnant women in our area is about 0,39% (95% CI: 0,34-0,45). From 1987 to 1991,9,7% of infected women were nor identified at the perinatal period, as compared to 2,5% in the last5 years of the study period (p = 0,034).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">: In this study, the estimated prevalence of HIV-1 infection is high. ZDV during pregnancyis significantly associated with a decrease in perinatal transmission in our setting. The awareness ofan effective treatment might have contributed to the increased identification of HIV-infected mothersprior to delivery observed over time in our cohort of children born to HIV-infected mothers.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." 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Estimación de la prevalencia de infección por VIH-1 en la embarazada y efectividad de la zidovudina administrada durante la gestación en la prevención de la transmisión vertical
Estimate of the HIV-1 prevalence in pregnant women and effectiveness of zidovudine administered during pregnancy in reducing perinatal transmission