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Necesidad de la creación de un registro global desde los servicios de urgencias" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "347" "paginaFinal" => "349" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Epelde, Miquel Santaló, Guillermo Vázquez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Epelde" ] 1 => array:2 [ "nombre" => "Miquel" "apellidos" => "Santaló" ] 2 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Vázquez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775303739438?idApp=UINPBA00004N" "url" => "/00257753/0000012100000009/v1_201307291557/S0025775303739438/v1_201307291557/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Hiperhomocisteinemia durante el embarazo como factor de riesgo de preeclampsia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "350" "paginaFinal" => "355" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E.v.a. López-Quesada, E.v.a. Also-Rayo, M. Antonia Vilaseca" "autores" => array:3 [ 0 => array:3 [ "nombre" => "E.v.a." "apellidos" => "López-Quesada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "E.v.a." "apellidos" => "Also-Rayo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 2 => array:4 [ "nombre" => "M." "apellidos" => "Antonia Vilaseca" "email" => array:1 [ 0 => "vilaseca@hsjdbcn.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Ginecología y Obstetricia. Hospital Universitari San Joan de Déu. Esplugues de Llobregat. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Departamento de Genética. Universitat de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "Servicio de Bioquímica. Laboratorio de Metabolopatías. Hospital Universitari Sant Joan de Déu. Esplugues de Llobregat. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. M.A. Vilaseca Servicio de Bioquímica. Hospital San Joan de Déu. Passeig Sant Joan de Déu, 2. 08950 Esplugues de Llobregat. Barcelona. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hyperhomocysteinemia during pregnancy as a risk factor of preeclampsia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-05-08" "fechaAceptado" => "2003-05-28" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222029" "palabras" => array:4 [ 0 => "Hiperhomocisteinemia" 1 => "Preeclampsia" 2 => "Gestación" 3 => "Folato" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta una revision sobre el papel que la hiperhomocisteinemia tieneen el desarrollo de preeclampsia, aportando nuestra experiencia endiferentes aspectos bioquimicos y geneticos relacionados con el tema.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las concentraciones de homocisteina plasmatica total (Hct) observadasen gestantes son inferiores a las de mujeres fertiles no gestantes:2.o trimestre (mediana, 5,3 μÊmol/l; rango, 3,1-10 μÊmol/l); 3.er trimestre(mediana, 6,3 μÊmol/l; rango, 3,2-13,0 μÊmol/l). Definimos hiperhomocisteinemia(Hct > P95) durante el embarazo toda concentracion > 7,7 μÊmol/l (2.o trimestre) y > 10,5 μÊmol/l (3.er trimestre).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Encontramos asociacion entre hiperhomocisteinemia y preeclampsia: laHct es significativamente superior en el grupo de preeclampsias que enlos controles; odds ratio (OR) para preeclampsia en hiperhomocisteinemicas= 7,7 (intervalo de confianza [IC] 95%, 1,7-34,8). Las preeclampsiasmuestran tambien un aumento generalizado del resto de losaminoacidos. La correlacion negativa observada en gestantes controlesentre homocisteina y folato no se observa en las preeclampticas.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No hemos encontrado asociacion entre las concentraciones de homocisteinaen las preeclampticas y la intolerancia a la glucosa.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La velocimetria Doppler de arterias uterinas en el 2.o trimestre es unmetodo que puede ser util para identificar a gestantes con riesgo depreeclampsia. La adicion de la determinacion de Hct no mejora significativamentesu predictibilidad.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los polimorfismos en los genes implicados en el metabolismo de lahomocisteina estudiados no pueden ser considerados como determinantesde la hiperhomocisteinemia observada en las gestantes conpreeclampsia.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A revision about the role of hyperhomocysteinemia in the developmentof preeclampsia is presented, which summarises our experiencein different biochemical and genetic points in relation to this possibleassociation.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Plasma total homocysteine concentrations (tHcy) during pregnancywere significantly lower than those of non-pregnant women: 2nd trimester(median, 5.3 ìmol/l; range, 3.1-10.0 μmol/l); 3rd trimester(median, 6.3 μmol/l; range, 3.2-13.0 ìmol/l). Hyperhomocysteinemia(tHcy > P95) was established as values higher than 7.7 ìmol/l in the2nd trimester, and as values higher than 10.5 ìmol/l in the 3rd trimesterof pregnancy.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We found an association between hyperhomocysteinemia and preeclampsia:tHcy values were significantly higher in the preeclampticgroup than in uncomplicated pregnancies; the OR for preeclampsia inhyperhomocysteinemic patients was 7.7 (CI 95%, 1.7-34.8). The otheramino acid concentrations were also higher in preeclamptic women.The negative correlation observed between homocysteine andfolate in the control group, was not present in preeclamptic women.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:72 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Hiperhomocisteinemia durante el embarazo como factor de riesgo de preeclampsia
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E.v.a. López-Quesadaa, E.v.a. Also-Rayob, M. Antonia Vilasecac,
Autor para correspondencia
vilaseca@hsjdbcn.org
Correspondencia: Dra. M.A. Vilaseca Servicio de Bioquímica. Hospital San Joan de Déu. Passeig Sant Joan de Déu, 2. 08950 Esplugues de Llobregat. Barcelona. España.
Correspondencia: Dra. M.A. Vilaseca Servicio de Bioquímica. Hospital San Joan de Déu. Passeig Sant Joan de Déu, 2. 08950 Esplugues de Llobregat. Barcelona. España.
a Servicio de Ginecología y Obstetricia. Hospital Universitari San Joan de Déu. Esplugues de Llobregat. Barcelona
b Departamento de Genética. Universitat de Barcelona
c Servicio de Bioquímica. Laboratorio de Metabolopatías. Hospital Universitari Sant Joan de Déu. Esplugues de Llobregat. Barcelona. España