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array:23 [ "pii" => "S0025775301717721" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71772-1" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71772" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:206-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1802 "formatos" => array:3 [ "EPUB" => 4 "HTML" => 1427 "PDF" => 371 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717733" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71773-3" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71773" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:209-13" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1390 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1204 "PDF" => 179 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis poblacional de la necesidad de cambios y tasas de continuidad de los diferentes fármacos antihipertensivos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "209" "paginaFinal" => "213" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A population-based study of need for changes and continuing rates of antihypertensive drugs" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Francisco Javier Sierra Alonso, Carlos Lagarejos Tricas, Francisco Cirujano Pita, Natalia Villalba Guijorro, M.<span class="elsevierStyleSup">a</span> Jesús Muñoz Sanz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Javier Sierra Alonso" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Lagarejos Tricas" ] 2 => array:2 [ "nombre" => "Francisco" "apellidos" => "Cirujano Pita" ] 3 => array:2 [ "nombre" => "Natalia" "apellidos" => "Villalba Guijorro" ] 4 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Jesús Muñoz Sanz" ] ] ] 1 => array:2 [ "autoresLista" => "Francisco Rodríguez Salvanés" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Rodríguez Salvanés" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717733?idApp=UINPBA00004N" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717733/v1_201307291450/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S002577530171771X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71771-X" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71771" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:201-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2142 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1903 "PDF" => 234 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Características clínicas y prevalencia de los estados de hipercoagulabilidad en pacientes con enfermedad tromboembólica venosa" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "205" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical manifestations and prevalence of hypercoagulable states in patients with venous thromboembolic disease" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Andrés Briones, Dolores Nauffal, Miguel Ángel Martínez, Rosario Menéndez, Miguel Perpiñá" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Andrés" "apellidos" => "Briones" ] 1 => array:2 [ "nombre" => "Dolores" "apellidos" => "Nauffal" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Martínez" ] 3 => array:2 [ "nombre" => "Rosario" "apellidos" => "Menéndez" ] 4 => array:2 [ "nombre" => "Miguel" "apellidos" => "Perpiñá" ] ] ] 1 => array:2 [ "autoresLista" => "Piedad Villa" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Piedad" "apellidos" => "Villa" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530171771X?idApp=UINPBA00004N" "url" => "/00257753/0000011600000006/v1_201307291450/S002577530171771X/v1_201307291450/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Influencia de la menopausia en la concentración plasmática de homocisteína" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "206" "paginaFinal" => "208" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Consuelo Fernández-Miranda, María de la Calle, José Manuel Bris, Mercedes Muelas, Pilar Gómez, Pilar Díaz-Rubio" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Consuelo" "apellidos" => "Fernández-Miranda" "email" => array:1 [ 0 => "cfmiranda@inicia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "María" "apellidos" => "de la Calle" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "José" "apellidos" => "Manuel Bris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Mercedes" "apellidos" => "Muelas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Pilar" "apellidos" => "Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Pilar" "apellidos" => "Díaz-Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna. Unidad de Lípidos. Hospital Universitario 12 de Octubre. Madrid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Ginecología. Unidad de Menopausia. Hospital Universitario 12 de Octubre. Madrid." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Bioquímica. Hospital Universitario 12 de Octubre. Madrid." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. C. Fernández-Miranda. Servicio de Medicina Interna. Hospital Universitario 12 de Octubre. Ctra. de Andalucía, km 5,400. 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Influence of menopausal status in homocysteine plasma levels" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-10-16" "fechaAceptado" => "2001-01-09" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221346" "palabras" => array:4 [ 0 => "Homocisteína" 1 => "Posmenopausia" 2 => "Ácido fólico" 3 => "Colesterol" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec221347" "palabras" => array:4 [ 0 => "Homocysteine" 1 => "Postmenopausal status" 2 => "Folic acid" 3 => "Cholesterol" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La elevación de las concentraciones de homocisteína plasmática en las mujeres posmenopáusicas se ha descrito en algunos estudios, aunque en otros no se ha objetivado. Creemos de interés conocer si en las mujeres españolas se encuentran aumentados los valores de homocisteína tras la menopausia.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En 100 mujeres posmenopáusicas (edad media [DE] 56 [6] años) se determinaron las concentraciones de homocisteína, creatinina, ácido fólico, vitamina B12 y lipoproteínas. Los controles fueron 50 mujeres con menstruaciones periódicas (edad: 29 [6] años), 50 varones con edad similar a las mujeres posmenopáusicas y 50 varones con edad similar a las premenopáusicas. Todos los sujetos del estudio se encontraban sanos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las concentraciones de homocisteína fueron más elevadas en las mujeres posmenopáusicas que en las premenopáusicas (8,6 [2,1]; intervalo de confianza [IC] del 95%, 8,2-9,1, frente a 7,7 [1,6]; IC del 95%, 7,2-8,1<span class="elsevierStyleHsp" style=""></span>μmol/l; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05), sin que fueran diferentes en los dos grupos de varones. Se objetivó hiperhomocisteinemia en 9 mujeres posmenopáusicas y en ninguna premenopáusica (el 9 frente al 0%; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,03). Los valores de colesterol unido a las lipoproteínas de baja densidad fueron superiores (155 [32]; IC del 95%, 148-161, frente a 111 [32]; IC del 95%, 101-120<span class="elsevierStyleHsp" style=""></span>mg/dl; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05), y los de colesterol unido a las lipoproteínas de alta densidad inferiores (54 [12]; IC del 95%, 52-57, frente a 64 [18]; IC del 95%, 59-69<span class="elsevierStyleHsp" style=""></span>mg/dl; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05) en las mujeres posmenopáusicas que en las premenopáusicas. Las concentraciones de homocisteína en las posmenopáusicas estaban asociadas negativamente a las de ácido fólico y positivamente a las de creatinina, sin existir asociación con la edad, concentración de vitamina B12 y lipoproteínas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La concentración de homocisteína aumenta en las mujeres posmenopáusicas. Esto puede contribuir, junto con la existencia de hipercolesterolemia, a aumentar su riesgo cardiovascular.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Some studies have found that postmenopausal women have increased plasma homocysteine levels while others do not. The aim of this study was to know if homocysteine levels are increased in Spanish postmenopausal women.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 100 postmenopausal women (age: mean [SD] 56 [6] years) homocysteine,creatinine, folic acid, vitamin B12 and lipoproteins were determined. Controls were 50 premenopausal women (age: 29 [6] years), 50 men with similar age to postmenopausal women, and 50 men with similar age to premenopausal women. All the subjects of the study were healthy.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Homocysteine concentrations were higher in postmenopausal compared with premenopausal women (8.6 [2.1]; 95% confidence interval [CI], 8.2-9.1 vs 7.7 [1.6]; 95% CI, 7.2-8.1 μmol/l; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05), but were not different between both men groups. Hyperhomocysteinemia was found in 9 postmenopausal but in any premenopausal women (9% vs 0%; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.03).Low density lipoprotein cholesterol values were higher (155 [32]; 95% CI, 148-161 vs 111[32]; 95% CI, 101-120<span class="elsevierStyleHsp" style=""></span>mg/dl; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05), and high density lipoprotein cholesterol lower (54[12]; 95% CI, 52-57 vs 64 [18]; 95% CI, 59-69<span class="elsevierStyleHsp" style=""></span>mg/dl; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) in postmenopausal than premenopausal women. In postmenopausal women homocysteine levels were negatively associated with folic acid and positively associated with creatinine levels, but there was not association with age, vitamin B12 serum levels and lipoproteins.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In postmenopausal women increased homocysteine concentrations, together with hypercholesterolemia, could contribute to the raise of their cardiovascular risk.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dyslipoproteinemia in women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.T. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Endocrinol Metab Clin North Am" "fecha" => "1990" "volumen" => "19" "paginaInicial" => "381" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2192879" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine as a risk factor for vascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.M. Graham" 1 => "L.E. Daly" 2 => "H.M. Refsum" 3 => "K. Robinson" 4 => "L.E. Brattström" 5 => "P.M. Ueland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1997" "volumen" => "277" "paginaInicial" => "1775" "paginaFinal" => "1781" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9178790" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concentraciones plasmáticas de homocisteína en pacientes con infarto cerebral isquémico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Vila" 1 => "R. Deulofeu" 2 => "A. Chamorro" 3 => "C. Piera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1998" "volumen" => "110" "paginaInicial" => "605" "paginaFinal" => "608" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and ischemic heart disease. Results of a prospective study with implications regarding prevention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.J. Wald" 1 => "H.C. Watt" 2 => "M.R. Law" 3 => "D.G. Weir" 4 => "J. McPartlin" 5 => "J.M. Scott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1998" "volumen" => "158" "paginaInicial" => "862" "paginaFinal" => "867" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9570171" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La hiperhomocisteinemia es frecuente en pacientes con enfermedad coronaria. Estudio de 202 enfermos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Fernández-Miranda" 1 => "J.L. Aranda" 2 => "P. Gómez González" 3 => "P. Díaz-Rubio" 4 => "J. Estenoz" 5 => "A. Gómez de la Cámara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1999" "volumen" => "113" "paginaInicial" => "407" "paginaFinal" => "410" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Mansoor" 1 => "C. Bergmark" 2 => "A. Svardal" 3 => "P.E. Lonning" 4 => "P.M. Ueland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arterioscler Thromb Vasc Biol" "fecha" => "1995" "volumen" => "15" "paginaInicial" => "232" "paginaFinal" => "240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7749831" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine levels and mortality in patients with coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "O. Nygard" 1 => "J.E. Nordrehaug" 2 => "H. Refsum" 3 => "P.M. Ueland" 4 => "M. Farstad" 5 => "S.E. Vollset" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199707243370403" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "337" "paginaInicial" => "230" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9227928" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonfasting plasma total homocysteine level and mortality in middle-aged and elderly men and women in Jerusalem" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Kark" 1 => "J. Selhub" 2 => "B. Adler" 3 => "J. Gofin" 4 => "J.H. Abramson" 5 => "G. Friedman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1999" "volumen" => "131" "paginaInicial" => "321" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10475884" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Folic acid responsive postmenopausal homocysteinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.E. Brattstrom" 1 => "B.L. Hultberg" 2 => "J.E. Hardebo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "1985" "volumen" => "34" "paginaInicial" => "1073" "paginaFinal" => "1077" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3932819" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine and menopausal status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.G.A.J. Wouters" 1 => "M.Th.E.C. Moorrees" 2 => "M.J. Van Der Mooren" 3 => "H.J. Blom" 4 => "G.H.J. Boers" 5 => "L.A. Schellekens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Invest" "fecha" => "1995" "volumen" => "25" "paginaInicial" => "801" "paginaFinal" => "805" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8582443" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased plasma homocysteine after menopause" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.E. Hak" 1 => "K.H. Polderman" 2 => "I.C. Westendorp" 3 => "C. Jakobs" 4 => "A. Hofman" 5 => "J.C.M Witteman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2000" "volumen" => "149" "paginaInicial" => "163" "paginaFinal" => "168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10704628" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status. European COMAC Group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Verhoef" 1 => "R. Meleady" 2 => "L.E. Daly" 3 => "I.M. Graham" 4 => "K. Robinson" 5 => "G.H. Boers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/euhj.1999.1522" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "1999" "volumen" => "20" "paginaInicial" => "1234" "paginaFinal" => "1244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10454975" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Andersson" 1 => "L. Brattström" 2 => "B. Israelsson" 3 => "A. Isaksson" 4 => "A. Hamfelt" 5 => "B. Hultberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Invest" "fecha" => "1992" "volumen" => "22" "paginaInicial" => "79" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1572391" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disordered methionine/ homocysteine metabolism in premature vascular disease. Its ocurrence, cofactor therapy, and enzymology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.P. Dudman" 1 => "D.E. Wilcken" 2 => "J. Wang" 3 => "J.F. Lynch" 4 => "D. Macey" 5 => "P. Lundberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arterioscler Thromb" "fecha" => "1993" "volumen" => "13" "paginaInicial" => "1253" "paginaFinal" => "1260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8364009" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine: an emerging age-related cardiovascular risk factor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Moustapha" 1 => "K. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Geriatrics" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "49" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10605435" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Brattström" 1 => "A. Lindgren" 2 => "B. Israelsson" 3 => "A. Andersson" 4 => "B. Hultberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Intern Med" "fecha" => "1994" "volumen" => "236" "paginaInicial" => "633" "paginaFinal" => "641" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7989898" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid, fully automated measurement of plasma homocysteine with the Abbott IMx analyser" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.T. Shipchandler" 1 => "E.E. Moore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1995" "volumen" => "41" "paginaInicial" => "991" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7600701" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of reduced glomerular filtration rate on plasma total homocysteine concentration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Arnadottir" 1 => "B. Hultberg" 2 => "P. Nilsson-Ehle" 3 => "H. Thysell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/00365519609088586" "Revista" => array:6 [ "tituloSerie" => "Scand J Clin Lab Invest" "fecha" => "1996" "volumen" => "56" "paginaInicial" => "41" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8850171" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Hordaland Homocysteine Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Nygard" 1 => "S.E. Vollset" 2 => "H. Refsum" 3 => "I. Stensvold" 4 => "A. Tverdal" 5 => "J.E. Nordrehaug" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1995" "volumen" => "274" "paginaInicial" => "1526" "paginaFinal" => "1533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7474221" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Nygard" 1 => "H. Refsum" 2 => "P.M. Ueland" 3 => "S.E. Volset" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "1998" "volumen" => "67" "paginaInicial" => "263" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9459374" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum total homocysteine concentrations in the Third National Health and Nutrition Examinations Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Selhub" 1 => "P.F. Jacques" 2 => "I.H. Rosenberg" 3 => "G. Rogers" 4 => "B.A. Bowman" 5 => "E.W. Gunter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1999" "volumen" => "131" "paginaInicial" => "331" "paginaFinal" => "339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10475885" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.J. Blom" 1 => "G.H. Boers" 2 => "J.P. Van den Elzen" 3 => "J.J. Van Roessel" 4 => "J.M. Trijbels" 5 => "A. Tangerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Invest" "fecha" => "1988" "volumen" => "18" "paginaInicial" => "633" "paginaFinal" => "638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3147189" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J. Van der Mooren" 1 => "M.G.A.J. Wouters" 2 => "H.J. Blom" 3 => "L.A. Schellekens" 4 => "T.K.A.B. Eskes" 5 => "R. Rolland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Invest" "fecha" => "1994" "volumen" => "24" "paginaInicial" => "733" "paginaFinal" => "736" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7890010" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of secuential three- monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Van der Mooren" 1 => "P.N.M. Demacker" 2 => "H.J. Blom" 3 => "Y.B. Rijke" 4 => "R. Rolland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Fertil Steril" "fecha" => "1997" "volumen" => "67" "paginaInicial" => "67" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8986686" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled study of the effects of 17 beta-estradiol-dydrogesterone on plasma homocysteine in postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Mijatovic" 1 => "P. Kenemans" 2 => "C. Jakobs" 3 => "W.M. Van Baal" 4 => "E.R. Peters-Muller" 5 => "M.J. Van der Mooren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Obstet Gynecol" "fecha" => "1998" "volumen" => "91" "paginaInicial" => "432" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9491873" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of estrogen replacement therapy on total plasma homocysteine in healthy postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.B. Berger" 1 => "R.R. Herrmann" 2 => "D.A. Dumesic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4065/75.1.18" "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "2000" "volumen" => "75" "paginaInicial" => "18" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10630752" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of folic acid fortification on plasma folate and total homocysteine concentrations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.F. Jacques" 1 => "J. Selhub" 2 => "A.G. Bostom" 3 => "P.W.F Wilson" 4 => "I.H. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199905133401901" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "1449" "paginaFinal" => "1454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10320382" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1998" "volumen" => "316" "paginaInicial" => "894" "paginaFinal" => "898" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and vascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.J. Hankey" 1 => "J.W. Eikelboom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(98)11058-9" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "354" "paginaInicial" => "407" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10437885" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homocysteine and risk of cardiovascular disease among postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.M. Ridker" 1 => "J.E. Manson" 2 => "J.E. Buring" 3 => "J. Shih" 4 => "M. Matias" 5 => "C.H. Hennekens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1999" "volumen" => "281" "paginaInicial" => "1817" "paginaFinal" => "1821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10340369" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717721/v1_201307291450/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011600000006/v1_201307291450/S0025775301717721/v1_201307291450/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717721?idApp=UINPBA00004N" ]
