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array:22 [ "pii" => "S0025775300712164" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71216-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71216" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:121-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2328 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 2154 "PDF" => 169 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712176" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71217-6" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71217" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:128-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1577 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1478 "PDF" => 94 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Trasplante de células progenitoras hematopoyéticas como tratamiento de rescate en pacientes con linfomas no hodgkinianos agresivos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "131" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hematopoietic stem cell transplantation as salvage treatment in patients with aggresive non-Hodgkin's lymphoma" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Reyes Arranz, César Sanz-Rodríguez, Francisco J. Pajuelo, Carmen Martínez Chamorro, José M<span class="elsevierStyleSup">a</span> Fernández Rañada." "autores" => array:5 [ 0 => array:2 [ "nombre" => "Reyes" "apellidos" => "Arranz" ] 1 => array:2 [ "nombre" => "César" "apellidos" => "Sanz-Rodríguez" ] 2 => array:2 [ "nombre" => "Francisco J." "apellidos" => "Pajuelo" ] 3 => array:2 [ "nombre" => "Carmen" "apellidos" => "Martínez Chamorro" ] 4 => array:2 [ "nombre" => "José M<span class="elsevierStyleSup">a</span>" "apellidos" => "Fernández Rañada." ] ] ] 1 => array:2 [ "autoresLista" => "Agustín Acevedo, Guillermo Pérez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Agustín" "apellidos" => "Acevedo" ] 1 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Pérez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712176?idApp=UINPBA00004N" "url" => "/00257753/0000011400000004/v1_201307291355/S0025775300712176/v1_201307291355/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Utilidad de la prueba de ejercicio cardiopulmonar en pacientes con miopatía mitocondrial" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "127" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J. Fernández, T. Montemayor, J. Castillo" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Montemayor" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Castillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología. Hospital Virgen del Rocío. Sevilla." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Neumología. Hospital Costa del Sol. Ctra. Nacional 340, km. 187. 29600 Marbella. Málaga." ] ] ] 1 => array:3 [ "autoresLista" => "J. Bautista, R. Márquez, L. Jiménezb, J. Arenas, Y. Campos" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Bautista" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Márquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Jiménezb" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Arenas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 4 => array:3 [ "nombre" => "Y." "apellidos" => "Campos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neurología Hospital Virgen del Rocío. Sevilla." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Departamento de Bioquímica.Hospital Virgen del Rocío. Sevilla" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Unidad de Investigación Neuromuscular. Facultad de Medicina. Universidad Complutense de Madrid</span>" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of cardiopulmonary exercise test in patients with mitochondrial myopathies" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-08" "fechaAceptado" => "1999-09-11" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Miopatías mitocondriales" "identificador" => "xpalclavsec220511" "palabras" => array:3 [ 0 => "Prueba de esfuerzo" 1 => "Umbral láctico" 2 => "Miopatías metabólicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las pruebas de ejercicio cardiopulmonar han sido utilizadas en el diagnóstico delas miopatías metabólicas. Se desconoce si existe un patrón de respuesta anormal en las miopatíasmitocondriales con afectación leve y la utilidad de esta técnica en el diagnóstico de sospechainicial.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo en 26 pacientes con miopatías mitocondriales (MM)(15 varones y 11 mujeres) y un grupo control de 14 voluntarios sanos (9 varones y 5 mujeres)de características antropométricas similares. Realizamos pruebas de función respiratoria yprueba de ejercicio en tapiz rodante con determinaciones venosas seriadas de lactato, piruvato,cuerpos cetónicos, ácidos grasos libres y creatincinasa.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con miopatías mitocondriales presentaban limitación al ejercicio,con valores menores de potencia máxima (MM = 143 [47] vatios, C = 187 [40] vatios,p = 0,006), consumo de oxígeno máximo (MM = 27 [8] ml/kg/min, C = 40 [7] ml/kg/min, p =0,001) y pulso de oxígeno (MM = 11 [3] ml/latido, C = 14 [3] ml/latido, p = 0,006). La frecuenciacardíaca en relación con el consumo de oxígeno fue mayor y el umbral anaerobio fuemás precoz en el grupo MM (MM = 48% [14], C = 62% [12], p = 0,01). Los pacientes conpredominio de lípidos en la biopsia muscular (n = 15) presentaban un consumo de oxígeno máximomás bajo. Las curvas de cuerpos cetónicos, ácidos grasos libres y creatincinasa fueron similaresen ambos grupos. La prueba de esfuerzo fue anormal en 17 de 26 pacientes. La sensibilidadde la prueba para el consumo de oxígeno máximo fue de 0,65.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La mayoría de los pacientes con miopatía mitocondrial leve presentan una pruebade ejercicio cardiopulmonar anormal, siendo por tanto una prueba útil en el estudio inicial dedetección de estos pacientes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Exercise tests has been used in the diagnosis of metabolic myopathies. If there isan anormal response pattern in mild mitochondrial myopathy (MM) and her role in the initialsuspect diagnostic is unknown.</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Prospective study of 26 patients with mitochondrial myopathy (15 men,11 women) and a control group of 14 sedentary volunteers (9 men, 5 woman) with similar antropometriccharacteristics. We have maked pulmonary function tests and treadmill exercisewith serial venous sampling of blood lactate, piruvate, ketone bodies, free fatty acids and creatinkinase.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patients with MM showed exercise limitation with lower maximal power (MM = 143[47] vatts, C = 187 [40] vatts, p = 0.006), maximal oxygen uptake (MM = 27 [8] ml/min/kg, C= 40 [7] ml/min/kg, p = 0.001) and maximal oxygen pulse (MM = 11 [3] ml/beat, C = 14 [3]ml/beat, p = 0.006). For the same oxygen uptake the heart rate was higher and the anaerobicthreshold was earlier in MM patients (MM = 48% [14], C = 62% [12], p = 0.01). We found aconsiderable slower maximal oxygen uptake in patients with lipid increase in muscle biopsy (n= 15). Acetoacetate curves, ß-hydroxybutirate, free fatty acids and creatinkinase were similar inboth groups. The exercise test was pathologic in 17/26 of the patients. The sensitivity of theexercise test for maximal oxygen uptake was 0.65.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The cardiopulmonary exercise test is a uselful test in the suspect initial diagnostic ofpatients with mild mitochondrial myopathy because the majority of patients show a pathologic test.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitochondrial encephalomyopathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.L. Peterson" 1 => "M.E. Martens" 2 => "C.P. 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