Performance and agreement between classification criteria and rheumatologist's diagnosis of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain

array:24 ["pii" => "S0121812317300488" "issn" => "01218123" "doi" => "10.1016/j.rcreu.2017.02.009" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "131" "copyright" => "Asociación Colombiana de Reumatología" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2017;24:153-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 770 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 585 "PDF" => 179 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S2444440517300572" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2017.09.004" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "131" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2017;24:153-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 373 "formatos" => array:3 [ "EPUB" => 32 "HTML" => 269 "PDF" => 72 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original Investigation" "titulo" => "Performance and agreement between classification criteria and rheumatologist's diagnosis of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "153" "paginaFinal" => "158" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Acuerdo entre los criterios más utilizados para la clasificación de las espondiloartritis (SpA) y el diagnóstico clínico hecho por un reumatólogo experto en un grupo de pacientes jóvenes con dolor lumbar coránico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "John Londoño, Marlon Porras, Ana María Santos, Paola Peña, Enrique Calvo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "John" "apellidos" => "Londoño" ] 1 => array:2 [ "nombre" => "Marlon" "apellidos" => "Porras" ] 2 => array:2 [ "nombre" => "Ana María" "apellidos" => "Santos" ] 3 => array:2 [ "nombre" => "Paola" "apellidos" => "Peña" ] 4 => array:2 [ "nombre" => "Enrique" "apellidos" => "Calvo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0121812317300488" "doi" => "10.1016/j.rcreu.2017.02.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300488?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300572?idApp=UINPBA00004N" "url" => "/24444405/0000002400000003/v1_201712210816/S2444440517300572/v1_201712210816/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0121812317300725" "issn" => "01218123" "doi" => "10.1016/j.rcreu.2017.05.007" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "138" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2017;24:159-63" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4327 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 4009 "PDF" => 311 ] ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "Investigación original" "titulo" => "Efectos del belimumab en pacientes colombianos con lupus eritematoso sistémico, un estudio prospectivo observacional" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "159" "paginaFinal" => "163" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effects of belimumab in Colombian patients with systemic lupus erythematosus; a prospective observational study" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alex Echeverri, Iván Posso-Osorio, Christian Figueroa, Juan-Pablo Suso, Andrés Hormaza, Fabio Bonilla-Abadía, Andrés Agualimpia, Carlos A. Cañas, Gabriel J. Tobón" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Alex" "apellidos" => "Echeverri" ] 1 => array:2 [ "nombre" => "Iván" "apellidos" => "Posso-Osorio" ] 2 => array:2 [ "nombre" => "Christian" "apellidos" => "Figueroa" ] 3 => array:2 [ "nombre" => "Juan-Pablo" "apellidos" => "Suso" ] 4 => array:2 [ "nombre" => "Andrés" "apellidos" => "Hormaza" ] 5 => array:2 [ "nombre" => "Fabio" "apellidos" => "Bonilla-Abadía" ] 6 => array:2 [ "nombre" => "Andrés" "apellidos" => "Agualimpia" ] 7 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Cañas" ] 8 => array:2 [ "nombre" => "Gabriel J." "apellidos" => "Tobón" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444440517300596" "doi" => "10.1016/j.rcreue.2017.09.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300596?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300725?idApp=UINPBA00004N" "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300725/v2_201709141206/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0121812317300312" "issn" => "01218123" "doi" => "10.1016/j.rcreu.2017.02.006" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "121" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2017;24:145-52" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4161 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 3524 "PDF" => 628 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Investigación original" "titulo" => "Esclerodermia localizada juvenil: ¿es una enfermedad benigna?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "145" "paginaFinal" => "152" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Juvenile localized scleroderma: is it a benign disease?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 746 "Ancho" => 995 "Tamanyo" => 121917 ] ] "descripcion" => array:1 [ "es" => "Cambios crónicos de la esclerodermia caracterizados por zonas de hiperpigmentación, hipopigmentación y esclerosis cutánea." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Christine Arango, Clara Malagón, María del Pilar Gómez, Catalina Mosquera, Ricardo Yépez, Tatiana González, Camilo Vargas" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Christine" "apellidos" => "Arango" ] 1 => array:2 [ "nombre" => "Clara" "apellidos" => "Malagón" ] 2 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Gómez" ] 3 => array:2 [ "nombre" => "Catalina" "apellidos" => "Mosquera" ] 4 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Yépez" ] 5 => array:2 [ "nombre" => "Tatiana" "apellidos" => "González" ] 6 => array:2 [ "nombre" => "Camilo" "apellidos" => "Vargas" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444440517300511" "doi" => "10.1016/j.rcreue.2017.08.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300511?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300312?idApp=UINPBA00004N" "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300312/v2_201709141206/es/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original Investigation" "titulo" => "Performance and agreement between classification criteria and rheumatologist's diagnosis of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "153" "paginaFinal" => "158" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "John Londoño, Marlon Porras, Ana María Santos, Paola Peña, Enrique Calvo" "autores" => array:5 [ 0 => array:4 [ "nombre" => "John" "apellidos" => "Londoño" "email" => array:1 [ 0 => "john.londono@unisabana.edu.co" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Marlon" "apellidos" => "Porras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Ana María" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Paola" "apellidos" => "Peña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Enrique" "apellidos" => "Calvo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Reumatología e Inmunología, Facultad de Medicina – Universidad de La Sabana, Campus del Puente del Común, Chía, Cundinamarca, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Militar Central – Universidad Militar Nueva Granada, Bogotá, D.C., Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Radiología, Universidad Nacional de Colombia, Bogotá, D.C., Colombia" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Acuerdo entre los criterios más utilizados para la clasificación de las espondiloartritis (SpA) y el diagnóstico clínico hecho por un reumatólogo experto en un grupo de pacientes jóvenes con dolor lumbar coránico" ] ] "textoCompleto" => "IntroductionSpondyloarthritis (SpA) are a group of chronic inflammatory disorders that share clinical, radiological, HLA-B27 association, positive family history and pathophysiological characteristics. SpA affect approximately 1.5% of the general population. Predominantly, SpA begins in individuals younger than 45 years and clinically compromises the axial spine, peripheral joints, tendons and ligament insertions (entheses), having also extra-musculoskeletal manifestations in the skin, mucosa, gut and the eyes, producing impairment of functional capacity.<a class="elsevierStyleCrossRef" href="#bib0185">1</a> The incidence of SpA in the general population is related to the prevalence of HLA-B27. This explains why SpA is most commonly diagnosed in Anglo-Saxon populations where the prevalence of HLA-B27 could reach up to 14%.<a class="elsevierStyleCrossRef" href="#bib0190">2</a>One of the clinical manifestations present in all stages of the disease, is inflammatory back pain (IBP).<a class="elsevierStyleCrossRef" href="#bib0195">3</a> In clinical practice is difficult to differentiate between the mechanical or inflammatory origin of pain. Traditionally clinical and epidemiological studies have used classification criteria to identify the two groups of patients. The frequency of inflammatory back pain has been estimated at 5% of all patients with chronic low back pain (CLBP).<a class="elsevierStyleCrossRef" href="#bib0200">4</a> At the same time, the CLBP is the most common cause of disability in men between 15 and 45 years of age and it is important to differentiate between the sources of pain given the prognostic and therapeutic implications.<a class="elsevierStyleCrossRef" href="#bib0205">5</a>In the last 30 years, several classification criteria for SpA have attempted to include the early stages as well as the undifferentiated forms of the disease (uSpA).<a class="elsevierStyleCrossRefs" href="#bib0210">6–10</a> According to the European Spondyloarthropathy Study Group (ESSG) criteria, SpA has been traditionally classified as follows: ankylosing spondylitis (AS), reactive arthritis (ReA), undifferentiated spondyloarthritis (uSpA), psoriatic arthritis (PsA), and arthritis associated with inflammatory bowel disease (IBD).<a class="elsevierStyleCrossRef" href="#bib0215">7</a>The Assessment of Spondyloarthritis International Society (ASAS) proposes a new classification criteria that includes two sets; axial and peripheral according to the prevalence of symptoms. The new ASAS criteria include the use of MRI of the sacroiliac joints and HLA-B27 as a fundamental part of the diagnosis.<a class="elsevierStyleCrossRefs" href="#bib0220">8,10</a>There is no gold standard for the diagnosis of SpA because of the heterogeneity of the musculoskeletal symptoms.<a class="elsevierStyleCrossRef" href="#bib0245">11</a> Sometimes epidemiological classification criteria are used as a tool in the diagnosis of these diseases with acceptable clinical performance.<a class="elsevierStyleCrossRef" href="#bib0250">12</a> However, the results may vary depending on the prevalence of the disease. In the Latin American countries uSpA corresponds to the most common form of presentation, with predominance of a mixture of axial and peripheral symptoms, low frequency of HLA-B27 and with less radiological (joint) damage of the axial skeleton.<a class="elsevierStyleCrossRefs" href="#bib0255">13–15</a> Other HLA molecules have been implicated as responsible for this variation in clinical presentation. In routine clinical practice, the diagnostic decision depends exclusively on the experience of the rheumatologist who assesses the patient.<a class="elsevierStyleCrossRef" href="#bib0270">16</a>The objective of this study is to establish an agreement between the most widely used classification criteria and a rheumatologist's diagnosis in a group of Colombian patients.Materials and methodsParticipants and clinical assessment of patientsA total of 133 patients, >18 years, with past or current history of CLBP (≥3 months) occurring before age 45 years, who attended consecutively over a period of six months at outpatient clinic of CLBP were included in the study. These patients were referred by other medical specialties: general practitioner, family medicine, internal medicine, orthopedics, rehabilitation medicine and neurosurgery. All patients underwent in the same diagnostic algorithm that included the use of a structured questionnaire completed by the rheumatologist from the available data at the time of visit with socio-demographic information; history related to pain: date of the onset, trigger, morning stiffness, insidious onset, improved with the exercise, worsening with rest, awakening at night because of pain, good response to no steroidal anti-inflammatory drugs, degree of disability by pain, cervical and thoracic spine compromise, button pain; history of arthritis, enthesitis, dactilitys; personal and family history related to the SpA: infections, uveitis, psoriasis or inflammatory bowel disease. All patients were applied specific instruments related to functional status and activity of the SpA: BASFI,<a class="elsevierStyleCrossRef" href="#bib0275">17</a> BASDAI,<a class="elsevierStyleCrossRef" href="#bib0365">18</a> visual analog scale (VAS) of pain and disease activity. For the physical examination ASAS recommendations were followed and included: occiput to wall distance, thoracic expansibility, Shober test, painful enthesis account by Mander's Index and tender and swollen joints account on a total of 44. HLA typing, PCR and VSG.<a class="elsevierStyleCrossRef" href="#bib0370">19</a>ImagingAll patients underwent MRI of sacroiliac joints using contrast agents and fat suppression techniques (projections in T1, T2 and STIR), radiographs of the pelvis. All images were evaluated by a radiologist with experience in SpA who remained blinded to the clinical information of the patients. Sacroiliitis by images was defined by New York and ASAS criteria for X-ray and MRI respectively. Pre-radiographic sacroiliitis in cases of normal pelvic X-ray with sacroiliitis evidence by MRI.<a class="elsevierStyleCrossRef" href="#bib0290">20</a>Diagnosis and classification of patientsFinally, an expert rheumatologist in the field of SpA evaluated independently the clinical and laboratory findings of the patients and divided the patients into the two groups: SpA and none SPA. No SpA patients were diagnosed with different pathologies: osteoarthritis, postural syndrome, rheumatoid arthritis and fibromyalgia SpA. Using the expert opinion as gold standard for diagnosis of SpA, the operation (sensitivity and specificity) of the EGSS and ASAS criteria were established. In addition, the degree of agreement between the ESSG and the ASAS classification criteria with clinical diagnosis, was calculated using the kappa index.StatisticsData analysis was performed using Stata 10.0. Measures of central tendency and dispersion for the continuous variables were used for data presentation. Frequency and percentage values were used for the categorical variables. The Student's t-test and the Kruskal–Wallis test were used to compare the continuous variables. For the nominal variables, the chi-squared test was used, and Fisher's exact test was used if necessary. In this study, p<0.05 was considered statistically significant, and 95% confidence intervals (CIs) were calculated.Ethics approvalThe study followed the norms established by the Helsinki Declaration, The Guidelines for Good Clinical Practice, and the Resolution 8430 (1993) of the Colombian Ministry for Social Protection. Moreover, was reviewed and approved by the Ethics Committees of the University of La Sabana and the Central Military Hospital. Each patient signed an informed consent form, and confidentiality was strictly maintained.ResultsA total of 133 patients were included, 81 patients with SpA and 52 none SpA. Of SpA patients, 33 (40.7%) had AS, 32 (39.5%) uSpA and 16 (19.8%) ReA. 55 (67.9%) were males, with a ratio male/female of 2:1. The more frequent clinical manifestations were IBP, and enthesopathy. In none SpA patients, 24 had postural syndrome, 14 fibromyalgia, 12 osteoarthritis and two rheumatoid arthritis.There was no significant difference between the two groups of patients in age at the onset of symptoms, disease duration, age at the time of evaluation and indices of function and activity of disease. HLA-B27 was present in 42% of the patients with SpA (57.6% in AS, 18.8% in uSpA and 56.3% in ReA) and only in 3.8% of the patients with other diseases (p<0.001). In terms of clinical characteristics, there were significant differences in all variables. Arthritis and uveitis were more common in SpA patients and were associated with HLA-B27 allele. Blood markers of inflammation were more elevated in patients with SpA than in controls (p=0.005). IBP, enthesopathy, blood and radiological evidence of sacroiliitis, were the variables with more significance in SpA (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>X-ray and MRI resultsIn the patients with SpA, the pelvic X-ray showed evidence of sacroiliitis in 44%, compared with 43% with MRI. Sacroiliitis in the X-ray was strongly correlated with SpA 44.4% vs 15.4% (p=0.001) and was present in 33 (100%) of the patients with AS, 2 patients with uSpA (6.25%) and 1 patient with ReA (6.25%) and 8 (15.4%) non-SpA patients. The MRI was positive in (35/81) 43.2% of the SpA patients and (6/52) 11.5% of non-SpA patients (p=0.000). MRI provided evidence of pre-radiographic sacroiliitis in 10 of the 30 patients with uSpA (33.3%) and 5 of the 15 patients with ReA (33.3%). Furthermore, the MRI showed pre-radiographic sacroiliitis in 6 patients in the control group, of whom only 1 patient had similar radiographical findings (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).Performance of the ESSG and ASAS classification criteriaWhen we analyzed the performance of the ESSG criteria in this population, we found that 95% of the SpA patients met the criteria. None of the non-SpA patients met the criteria. The results also showed that 96.3% of the SpA patients and 19.2% of the non-SpA patients met the new ASAS criteria. ASAS criteria have 96% of sensibility and 80% of specificity, and ESSG criteria 95% and 100%, respectively.When we analyzed the agreement of the classification criteria with the diagnosis established by the rheumatologist, we found a Cohen's kappa index of 0.938 for the ESSG criteria (95% CI: 0.877–0.998) and 0.790 for the ASAS criteria (95% CI: 0.682–0.898) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>DiscussionThe population described here is a sample of patients who suffer from different forms of SpA. All of the patients were recruited during outpatient consultations at the Rheumatology Department of one national referral hospitals for highly complex diseases. These patients were referred to the Department after having been evaluated by other medical specialties (Orthopedics, Rehabilitation Medicine, Neurosurgery, Ophthalmology and Internal Medicine), when SpA was established as a possible diagnosis due to the presence of chronic low back pain.As described in other populations, the predominant symptoms among the SpA patients were lower back pain, arthritis and enthesopathy. Other symptoms such as dactylitis and uveitis were observed in the same proportions reported in previous studies.<a class="elsevierStyleCrossRefs" href="#bib0225">9,21</a> In the non-SpA patients, the most common symptoms were chronic lower back pain and gluteal pain. The time of disease progression was lower in our group of patients than that reported by Feldtkeller in 2003 (6.5±8.3 years vs. 8.8±7.6 years, respectively).<a class="elsevierStyleCrossRef" href="#bib0300">22</a>HLA-B27 was present in a smaller proportion of our patients (42%) compared with other populations. Although this lower prevalence seems to be the trend in current publications, the lower prevalence may reflect the racial composition of our population and the relatively high number of patients with undifferentiated and reactive forms of the disease.<a class="elsevierStyleCrossRef" href="#bib0295">21</a> In this study, 28 patients fulfilled the new ASAS criteria with axial involvement: 24 patients met the radiological requirement and 15 patients met the requirement contingent on a positive HLA-B27 test (11 patients met both requirements; thus, 4 patients were only positive for HLA-B27, and 13 patients only had images showing sacroiliitis). This difference is an important detail because it appears that imaging offered better results for patient classification than HLA-B27 characterization, with a better performance of plain radiography for sacroiliitis diagnosis than MRI in our study. However, in this group of patients, HLA-B27 positivity was strongly associated with the clinical markers traditionally considered to be associated with more severe forms of the disease (AS, uveitis and arthritis).As reported by Weber, non-SpA patients may have positive results in the MRI of the sacroiliac joints and spine. Healthy controls can have isolated foci of hyperintensity on STIR (bone pseudo-edema) with a frequency close to 27%.<a class="elsevierStyleCrossRefs" href="#bib0305">23,24</a> The other hand, arthrosis is common condition in patients over 40 years old. It can cause unilateral or bilateral, symmetrical or asymmetrical sacroiliac joint inflammation.<a class="elsevierStyleCrossRef" href="#bib0315">25</a> This conditions could explain why several of our patients in whom SpA was ruled out had positive MRI results (n=6) and justifies the increase in the number of false positives that resulted from using this set of criteria. When the sacroiliac joint MRI results were combined with the ESSG criteria, 1 additional patient met the requirements for SpA. These data may justify reconsidering the use of this diagnostic method in patients with a diagnosis of uSpA because the other clinical and laboratory criteria can provide the necessary diagnostic information. This uncommon pre-radiographic sacroiliitis suggests a better prognosis in our population, with less likelihood of progression to AS, which is the more severe form of SpA. However, this progression must be examined using a different study design in larger patient populations.Nevertheless, after reviewing the most recent literature on this regard Banegas Illescas and collaborators conclude that the ASAS criteria have limitations concerning the diagnostic and prognostic utility of MRI in these patients. Firstly, in absence of bone edema or osteitis the MRI-identified structural lesions are not diagnostic of sacroilitis. This exclusion is contradictory due to the fact that the other radiological marker of sacroiliitis is based on structural changes seen on the simple X-ray according to New York new modified criteria despite the great inter-observer variability.<a class="elsevierStyleCrossRefs" href="#bib0320">26–28</a> Several trials have shown that MRI is not only capable of finding structural lesions before they can be seen on the X-ray without active inflammatory lesions,<a class="elsevierStyleCrossRefs" href="#bib0310">24,29</a> but it is also capable of increasing its diagnostic sensibility from 67% to 81%, when erosions are analyzed besides bone edema without changes in specificity (88%).<a class="elsevierStyleCrossRef" href="#bib0310">24</a>Considering these observations, the agreement between the classification criteria and the clinical diagnosis was good in this group of patients and also highlighted a better interpretation of the ESSG criteria.The results obtained in this study should be analyzed with the understanding that there is a higher proportion of reactive and undifferentiated forms of SpA in Latin American patients than in Anglo-Saxon populations. In our populations, peripheral manifestations are predominant compared with axial involvement, and the prevalence of HLA-B27 is low as a result of miscegenation.The patients who were evaluated and participated in this study were referred to the SpA clinic after an outpatient consultation at the Department of Rheumatology of one tertiary care hospital that are the national referral center for a population of over half a million people. This referral creates a filter so that the patients included in this study represented the most severe forms of the disease. This meant that only patients with more complex were evaluated by the rheumatologist, causing a selection bias. For this reason, the number of patients with SpA is significantly higher than the other diseases. However, in the context of the objective of the present study, the sample size, allowed the agreement between the clinical diagnosis in real life of outpatient care of patients and the classification criteria for SpA used most frequently. This explains why the performance of the classification criteria is greater than previously reported in open community.<a class="elsevierStyleCrossRefs" href="#bib0340">30–32</a> Therefore, it is necessary to study in Latin-American countries which really is the performance ESSG and ASAS criteria, where the percentage of patients with HLA-B27 positive and axial compromise is smaller compared with Anglo-Saxon populations.<a class="elsevierStyleCrossRefs" href="#bib0355">33,34</a>In conclusion, the ESSG and ASAS classification criteria and the clinical diagnosis made by expert rheumatologists were well correlated in the Colombian population. However, in the present study, the ESSG criteria showed a higher degree of agreement with clinical diagnosis, which should be analyzed in other Latin American populations.Ethical disclosuresProtection of human and animal subjectsThe authors declare that no experiments were performed on humans or animals for this study.Confidentiality of dataThe authors declare that they have followed the protocols of their work center on the publication of patient data.Right to privacy and informed consentThe authors declare that no patient data appear in this article.FinancialSupported by the University of La Sabana. No financial support or benefits from commercial sources.Conflict of interestNot any additional conflict of interest exist with regard to this work." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres901014" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec882081" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres901013" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec882080" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Participants and clinical assessment of patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Imaging" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Diagnosis and classification of patients" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistics" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Ethics approval" ] ] ] 6 => array:3 [ "identificador" => "sec0040" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0045" "titulo" => "X-ray and MRI results" ] 1 => array:2 [ "identificador" => "sec0050" "titulo" => "Performance of the ESSG and ASAS classification criteria" ] ] ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0060" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0065" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0070" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0075" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0080" "titulo" => "Financial" ] 10 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflict of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-04-03" "fechaAceptado" => "2017-02-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec882081" "palabras" => array:4 [ 0 => "Spondyloarthritis" 1 => "Classification criteria" 2 => "ESSG" 3 => "ASAS" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec882080" "palabras" => array:4 [ 0 => "Espondiloartritis" 1 => "Criterios de clasificación" 2 => "ESSG" 3 => "ASAS" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectiveTo evaluate the performance of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain. MethodsWe assessed the ASAS and the European Spondyloarthropathy Study Group (ESSG) classification criteria in a group of 133 patients who attended consecutively over a period of six months at outpatient clinic of low back pain. All the patients were evaluated with the same protocol. The patients were divided into two groups according to the diagnosis. The diagnosis was compared with the diagnosis made by a expert rheumatologist blinded to patient information. Results81 patients with SpA and 52 with other diagnoses were included. There were no differences in age and age of onset of symptoms between the two groups. The SpA group included 55 males and more common clinical findings were: enthesitis, arthritis, sacroiliitis, HLA-B27-positive, previous infection, and dactylitis. The sensitivity and specificity of criteria were: ASAS criteria 96% of sensibility and 80% of specificity, and ESSG criteria 95% and 100% respectively.The agreement between the classification criteria and the diagnosis established by the rheumatologist showed a Cohen's kappa index of 0.938 for ESSG criteria (95% CI: 0.877–0.998) and 0.790 for the ASAS criteria (95% CI: 0.682–0.898). ConclusionIn a Colombian group of SpA patients, the new ASAS classification criteria have a good concordance with clinical diagnosis but are not superior to the ESSG criteria." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "ObjetivoEvaluar el acuerdo entre los criterios de clasificación para SpA y el diagnóstico de un experto reumatólogo en un grupo de pacientes con dolor lumbar. MétodosSe evaluó el comportamiento de los criterios de ASAS y del ESSG en 133 pacientes que acudieron de forma consecutiva durante seis meses a la clínica ambulatoria de dolor lumbar. Todos los pacientes se evaluaron con el mismo protocolo. Los pacientes fueron divididos en dos grupos de acuerdo con el diagnóstico. Posteriormente se estableció del acuerdo diagnóstico con el de un experto reumatólogo ciego a la información previa de los pacientes. Resultados81 pacientes con SpA y 52 con otros diagnósticos fueron incluidos. No hubo diferencias en la edad y la edad de aparición de los síntomas. El grupo SpA incluyó a 55 varones y los hallazgos más comunes fueron: entesitis, artritis, sacroileítis, infección previa, HLA-B27, y dactilitis. La sensibilidad y especificidad de los criterios fueron: ASAS 96% de sensibilidad y 80% de especificidad, y ESSG 95% y 100% respectivamente.El acuerdo entre los criterios de clasificación y el diagnóstico del reumatólogo mostró un índice kappa de 0,938 con criterios ESSG (IC del 95%: 0,877–0,998) y 0,790 para los criterios ASAS (IC del 95%: 0,682–0,898). ConclusiónEn un grupo de pacientes colombianos SpA, los nuevos criterios de clasificación ASAS tienen una buena concordancia con el diagnóstico clínico, pero no son superiores a los criterios ESSG." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">All patients (n=133) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA (n=81) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non SpA (n=52) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age in years, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">33.7 (10.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">33.6 (11.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">33.9 (8.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age in years at the onset of symptoms, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27.6 (8.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">26.6 (7.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">29.2 (8.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.070 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Males \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24.6 (6.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Females \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31.1 (8.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disease duration (y), mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.8 (7.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.5±8.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.7±4.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Male gender, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">66.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">67.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">65.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HLA-B27, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Family history of SpA, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ESR, mm/h (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.9 (11.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15.5 (12.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.5 (9.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C-reactive protein, g/dl, mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.2±3.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.8±3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.4±1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.023 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#tblfn0010">**</a>BASDAI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.5±2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.1±2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.6±1.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#tblfn0015">***</a>BASFI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.0±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.6±2.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.1±2.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General patient<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>VAS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.1±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.4±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.8±2.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.110 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General physician<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>VAS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.8±2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.1±2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.8±0.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sacroiliitis evidenced by radiography (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">44 (33.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">36 (44.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (15.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Active inflammation in sacroiliac joints (MRI)% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 (21.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27 (33.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sacroiliitis by X-ray or MRI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">63 (47.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">51 (63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 (23.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1513534.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "VAS=Visual Analog Scale." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "**" "nota" => "Bath Ankylosing Spondylitis Disease Activity Index." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "***" "nota" => "Bath Ankylosing Spondylitis Functional Index; MRI: Magnetic Resonance Image, ESR: Erythrocyte sedimentation rate" ] ] ] "descripcion" => array:1 [ "en" => "Clinical characteristics of the evaluated patients." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ASAS \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Others \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ESSG \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Others \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Does not meet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Does not meet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Meets \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Meets \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1513533.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Agreement between the classification criteria and the clinical diagnoses." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib0185" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ankylosing spondylitis: introductory comments on its diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Khan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2002" "volumen" => "61" "numero" => "Suppl 3" "paginaInicial" => "iii3" "paginaFinal" => "iii7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12381505" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0190" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ankylosing spondylitis: an overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Sieper" 1 => "J. Braun" 2 => "M. Rudwaleit" 3 => "A. Boonen" 4 => "A. Zink" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2002" "volumen" => "61" "numero" => "Suppl 3" "paginaInicial" => "iii8" "paginaFinal" => "iii18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12381506" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0195" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical history as a screening test for ankylosing spondylitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Calin" 1 => "J. Porta" 2 => "J.F. Fries" 3 => "D.J. Schurman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1977" "volumen" => "237" "paginaInicial" => "2613" "paginaFinal" => "2614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/140252" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0200" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How to diagnose axial spondyloarthritis early" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Rudwaleit" 1 => "D. van der Heijde" 2 => "M.A. Khan" 3 => "J. Braun" 4 => "J. Sieper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2003.011247" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2004" "volumen" => "63" "paginaInicial" => "535" "paginaFinal" => "543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15082484" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0205" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of disabilities and associated health conditions among adults--United States, 1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "CDC" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "MMWR Morb Mortal Wkly Rep" "fecha" => "2001" "volumen" => "50" "paginaInicial" => "120" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11393491" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0210" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Criteria of the classification of spondylarthropathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Amor" 1 => "M. Dougados" 2 => "M. Mijiyawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Rhum Mal Osteoartic" "fecha" => "1990" "volumen" => "57" "paginaInicial" => "85" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2181618" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0215" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Dougados" 1 => "S. van der Linden" 2 => "R. Juhlin" 3 => "B. Huitfeldt" 4 => "B. Amor" 5 => "A. Calin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1991" "volumen" => "34" "paginaInicial" => "1218" "paginaFinal" => "1227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1930310" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0220" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rudwaleit" 1 => "R. Landewe" 2 => "D. van der Heijde" 3 => "J. Listing" 4 => "J. Brandt" 5 => "J. Braun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2009.108217" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "770" "paginaFinal" => "776" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19297345" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0225" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rudwaleit" 1 => "D. van der Heijde" 2 => "R. Landewe" 3 => "J. Listing" 4 => "N. Akkoc" 5 => "J. Brandt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2009.108233" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "777" "paginaFinal" => "783" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19297344" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0230" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rudwaleit" 1 => "D. van der Heijde" 2 => "R. Landewe" 3 => "N. Akkoc" 4 => "J. Brandt" 5 => "C.T. Chou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2010.133645" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2011" "volumen" => "70" "paginaInicial" => "25" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21109520" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0245" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thoughts concerning the early diagnosis of ankylosing spondylitis and related diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Khan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2002" "volumen" => "20" "numero" => "Suppl 28" "paginaInicial" => "S6" "paginaFinal" => "S10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12463439" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0250" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of cases of inflammatory rheumatic disorders: performance of a telephone questionnaire designed for use by patient interviewers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Guillemin" 1 => "A. Saraux" 2 => "P. Fardellone" 3 => "P. Guggenbuhl" 4 => "J.M. Behier" 5 => "J. Coste" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2003" "volumen" => "62" "paginaInicial" => "957" "paginaFinal" => "963" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12972474" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0255" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ankylosing spondylitis in the Mexican mestizo: patterns of disease according to age at onset" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Burgos-Vargas" 1 => "A. Naranjo" 2 => "J. Castillo" 3 => "G. Katona" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1989" "volumen" => "16" "paginaInicial" => "186" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2787404" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0260" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Caracterización de las espondiloartropatías y determinación de factores de mal pronóstico en una población de pacientes colombianos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Londono" 1 => "L. González" 2 => "A. Ramírez" 3 => "P. Santos" 4 => "L. Ávila" 5 => "A. Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Colomb Reumatol" "fecha" => "2005" "volumen" => "12" "paginaInicial" => "195" "paginaFinal" => "207" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0265" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary ankylosing spondylitis: patterns of disease in a Brazilian population of 147 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.D. Sampaio-Barros" 1 => "M.B. Bertolo" 2 => "M.H. Kraemer" 3 => "J.F. Neto" 4 => "A.M. Samara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2001" "volumen" => "28" "paginaInicial" => "560" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296959" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0270" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and classification in spondyloarthritis: identifying a chameleon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. van Tubergen" 1 => "U. Weber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrrheum.2012.33" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Rheumatol" "fecha" => "2012" "volumen" => "8" "paginaInicial" => "253" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22450552" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0275" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Calin" 1 => "S. Garrett" 2 => "H. Whitelock" 3 => "L.G. Kennedy" 4 => "J. O’Hea" 5 => "P. Mallorie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1994" "volumen" => "21" "paginaInicial" => "2281" "paginaFinal" => "2285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7699629" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0365" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Garrett" 1 => "T. Jenkinson" 2 => "L.G. Kennedy" 3 => "H. Whitelock" 4 => "P. Gaisford" 5 => "A. Calin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1994" "volumen" => "21" "paginaInicial" => "2286" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7699630" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0370" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.R.M. Sieper" 1 => "X. Baraliakos" 2 => "J. Brandt" 3 => "J. Braun" 4 => "R. Burgos-Vargas" 5 => "M. Dougados" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.104018" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "ii1" "paginaFinal" => "ii44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19433414" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0290" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rudwaleit" 1 => "A.G. Jurik" 2 => "K.G. Hermann" 3 => "R. Landewe" 4 => "D. van der Heijde" 5 => "X. Baraliakos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2009.110767" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "1520" "paginaFinal" => "1527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454404" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0295" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rudwaleit" 1 => "D. van der Heijde" 2 => "R. Landewe" 3 => "N. Akkoc" 4 => "J. Brandt" 5 => "C.T. Chou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2010" "volumen" => "24" "paginaInicial" => "24" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0300" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Feldtkeller" 1 => "M.A. Khan" 2 => "D. van der Heijde" 3 => "S. van der Linden" 4 => "J. Braun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-002-0237-4" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "61" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12634937" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0305" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "U. Weber" 1 => "R.G. Lambert" 2 => "S.J. Pedersen" 3 => "J. Hodler" 4 => "M. Ostergaard" 5 => "W.P. Maksymowych" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res" "fecha" => "2010" "volumen" => "62" "paginaInicial" => "1763" "paginaFinal" => "1771" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0310" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnostic utility of magnetic resonance imaging in spondylarthritis: an international multicenter evaluation of one hundred eighty-seven subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "U. Weber" 1 => "R.G. Lambert" 2 => "M. Ostergaard" 3 => "J. Hodler" 4 => "S.J. Pedersen" 5 => "W.P. Maksymowych" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.27571" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2010" "volumen" => "62" "paginaInicial" => "3048" "paginaFinal" => "3058" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20496416" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028213034250" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0315" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sacroiliac joints: osteoarthritis or arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.I. Garcia Diez" 1 => "X. Tomas Batlle" 2 => "J. Pomes Tallo" 3 => "M.D. Amo Conill" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.reuma.2008.12.008" "Revista" => array:6 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2009" "volumen" => "5" "paginaInicial" => "40" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794641" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0320" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New ASAS criteria for the diagnosis of spondyloarthritis: diagnosing sacroiliitis by magnetic resonance imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.E. Banegas Illescas" 1 => "C. Lopez Menendez" 2 => "M.L. Rozas Rodriguez" 3 => "R.M. Fernandez Quintero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rx.2013.05.004" "Revista" => array:6 [ "tituloSerie" => "Radiologia" "fecha" => "2014" "volumen" => "56" "paginaInicial" => "7" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24119715" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0325" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. van der Linden" 1 => "H.A. Valkenburg" 2 => "A. Cats" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1984" "volumen" => "27" "paginaInicial" => "361" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6231933" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0375" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variacion entre dos observadores en la evaluacion radiografica de las articulaciones sacroiliacas: I Estudio en poblaciones con riesgo y sin riesgo de sacroiliitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Sanabria" 1 => "J. Orozco" 2 => "L. Gomez" 3 => "R. Burgos-Vargas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Rev Mex Reumatol" "fecha" => "1994" "volumen" => "9" "paginaInicial" => "6" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0380" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? A cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "U. Weber" 1 => "S.J. Pedersen" 2 => "M. Ostergaard" 3 => "K. Rufibach" 4 => "R.G. Lambert" 5 => "W.P. Maksymowych" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar3854" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2012" "volumen" => "14" "paginaInicial" => "R124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22626458" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0340" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performances of the Assessment of SpondyloArthritis International Society axial spondyloarthritis criteria for diagnostic and classification purposes in patients visiting a rheumatologist because of chronic back pain: results from a multicenter, cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Molto" 1 => "S. Paternotte" 2 => "D. Comet" 3 => "E. Thibout" 4 => "M. Rudwaleit" 5 => "P. Claudepierre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res" "fecha" => "2013" "volumen" => "65" "paginaInicial" => "1472" "paginaFinal" => "1481" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0345" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Molto" 1 => "S. Paternotte" 2 => "D. van der Heijde" 3 => "P. Claudepierre" 4 => "M. Rudwaleit" 5 => "M. Dougados" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2013-204262" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2015" "volumen" => "74" "paginaInicial" => "746" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24389295" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0350" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance of different criteria sets for inflammatory back pain in patients with axial spondyloarthritis with and without radiographic sacroiliitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Solmaz" 1 => "S. Akar" 2 => "O. Soysal" 3 => "Y. Akkoc" 4 => "G. Can" 5 => "V. Gerdan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-014-2622-2" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2014" "volumen" => "33" "paginaInicial" => "1475" "paginaFinal" => "1479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24770795" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0355" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance of the Assessment of Spondyloarthritis International Society criteria for the classification of spondyloarthritis in early spondyloarthritis clinics participating in the ESPERANZA programme" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Tomero" 1 => "J. Mulero" 2 => "E. de Miguel" 3 => "C. Fernandez-Espartero" 4 => "M. Gobbo" 5 => "M.A. Descalzo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatology (Oxford, England)" "fecha" => "2014" "volumen" => "53" "paginaInicial" => "353" "paginaFinal" => "360" "itemHostRev" => array:3 [ "pii" => "S1462388911001669" "estado" => "S300" "issn" => "14623889" ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0360" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ankylosing Spondylitis Related Diseases in the Mexican Mestizo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Burgos-Vargas" 1 => "J. Granados-Arriola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Spine" "fecha" => "1990" "volumen" => "4" "paginaInicial" => "665" "paginaFinal" => "678" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300488/v2_201709141206/en/main.assets" "Apartado" => array:4 [ "identificador" => "45322" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Investigaciones originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/01218123/0000002400000003/v2_201709141206/S0121812317300488/v2_201709141206/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300488?idApp=UINPBA00004N"]

Estadísticas

Original Investigation

Acuerdo entre los criterios más utilizados para la clasificación de las espondiloartritis (SpA) y el diagnóstico clínico hecho por un reumatólogo experto en un grupo de pacientes jóvenes con dolor lumbar coránico

John Londoñoa,b,

Autor para correspondencia

john.londono@unisabana.edu.co

Corresponding author.

, Marlon Porrasa, Ana María Santosa, Paola Peñab, Enrique Calvoc

a Departamento de Reumatología e Inmunología, Facultad de Medicina – Universidad de La Sabana, Campus del Puente del Común, Chía, Cundinamarca, Colombia

b Servicio de Reumatología, Hospital Militar Central – Universidad Militar Nueva Granada, Bogotá, D.C., Colombia

c Departamento de Radiología, Universidad Nacional de Colombia, Bogotá, D.C., Colombia

Leído

2826

Veces
se ha leído el artículo

703

Total PDF

2123

Total HTML

Compartir estadísticas

 array:24 [
  "pii" => "S0121812317300488"
  "issn" => "01218123"
  "doi" => "10.1016/j.rcreu.2017.02.009"
  "estado" => "S300"
  "fechaPublicacion" => "2017-07-01"
  "aid" => "131"
  "copyright" => "Asociaci&#243;n Colombiana de Reumatolog&#237;a"
  "copyrightAnyo" => "2017"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Colomb Reumatol. 2017;24:153-8"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 770
    "formatos" => array:3 [
      "EPUB" => 6
      "HTML" => 585
      "PDF" => 179
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S2444440517300572"
      "issn" => "24444405"
      "doi" => "10.1016/j.rcreue.2017.09.004"
      "estado" => "S300"
      "fechaPublicacion" => "2017-07-01"
      "aid" => "131"
      "copyright" => "Asociaci&#243;n Colombiana de Reumatolog&#237;a"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Colomb Reumatol. 2017;24:153-8"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 373
        "formatos" => array:3 [
          "EPUB" => 32
          "HTML" => 269
          "PDF" => 72
        ]
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Investigation</span>"
        "titulo" => "Performance and agreement between classification criteria and rheumatologist&#39;s diagnosis of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "153"
            "paginaFinal" => "158"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Acuerdo entre los criterios m&#225;s utilizados para la clasificaci&#243;n de las espondiloartritis &#40;SpA&#41; y el diagn&#243;stico cl&#237;nico hecho por un reumat&#243;logo experto en un grupo de pacientes j&#243;venes con dolor lumbar cor&#225;nico"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "John Londo&#241;o, Marlon Porras, Ana Mar&#237;a Santos, Paola Pe&#241;a, Enrique Calvo"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "John"
                "apellidos" => "Londo&#241;o"
              ]
              1 => array:2 [
                "nombre" => "Marlon"
                "apellidos" => "Porras"
              ]
              2 => array:2 [
                "nombre" => "Ana Mar&#237;a"
                "apellidos" => "Santos"
              ]
              3 => array:2 [
                "nombre" => "Paola"
                "apellidos" => "Pe&#241;a"
              ]
              4 => array:2 [
                "nombre" => "Enrique"
                "apellidos" => "Calvo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0121812317300488"
          "doi" => "10.1016/j.rcreu.2017.02.009"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300488?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300572?idApp=UINPBA00004N"
      "url" => "/24444405/0000002400000003/v1_201712210816/S2444440517300572/v1_201712210816/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0121812317300725"
    "issn" => "01218123"
    "doi" => "10.1016/j.rcreu.2017.05.007"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "138"
    "copyright" => "Asociaci&#243;n Colombiana de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Colomb Reumatol. 2017;24:159-63"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4327
      "formatos" => array:3 [
        "EPUB" => 7
        "HTML" => 4009
        "PDF" => 311
      ]
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Investigaci&#243;n original</span>"
      "titulo" => "Efectos del belimumab en pacientes colombianos con lupus eritematoso sist&#233;mico&#44; un estudio prospectivo observacional"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "159"
          "paginaFinal" => "163"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Effects of belimumab in Colombian patients with systemic lupus erythematosus&#59; a prospective observational study"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Alex Echeverri, Iv&#225;n Posso-Osorio, Christian Figueroa, Juan-Pablo Suso, Andr&#233;s Hormaza, Fabio Bonilla-Abad&#237;a, Andr&#233;s Agualimpia, Carlos A&#46; Ca&#241;as, Gabriel J&#46; Tob&#243;n"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Alex"
              "apellidos" => "Echeverri"
            ]
            1 => array:2 [
              "nombre" => "Iv&#225;n"
              "apellidos" => "Posso-Osorio"
            ]
            2 => array:2 [
              "nombre" => "Christian"
              "apellidos" => "Figueroa"
            ]
            3 => array:2 [
              "nombre" => "Juan-Pablo"
              "apellidos" => "Suso"
            ]
            4 => array:2 [
              "nombre" => "Andr&#233;s"
              "apellidos" => "Hormaza"
            ]
            5 => array:2 [
              "nombre" => "Fabio"
              "apellidos" => "Bonilla-Abad&#237;a"
            ]
            6 => array:2 [
              "nombre" => "Andr&#233;s"
              "apellidos" => "Agualimpia"
            ]
            7 => array:2 [
              "nombre" => "Carlos A&#46;"
              "apellidos" => "Ca&#241;as"
            ]
            8 => array:2 [
              "nombre" => "Gabriel J&#46;"
              "apellidos" => "Tob&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2444440517300596"
        "doi" => "10.1016/j.rcreue.2017.09.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300596?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300725?idApp=UINPBA00004N"
    "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300725/v2_201709141206/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0121812317300312"
    "issn" => "01218123"
    "doi" => "10.1016/j.rcreu.2017.02.006"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "121"
    "copyright" => "Asociaci&#243;n Colombiana de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Colomb Reumatol. 2017;24:145-52"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4161
      "formatos" => array:3 [
        "EPUB" => 9
        "HTML" => 3524
        "PDF" => 628
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Investigaci&#243;n original</span>"
      "titulo" => "Esclerodermia localizada juvenil&#58; &#191;es una enfermedad benigna&#63;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "145"
          "paginaFinal" => "152"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Juvenile localized scleroderma&#58; is it a benign disease&#63;"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 746
              "Ancho" => 995
              "Tamanyo" => 121917
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Cambios cr&#243;nicos de la esclerodermia caracterizados por zonas de hiperpigmentaci&#243;n&#44; hipopigmentaci&#243;n y esclerosis cut&#225;nea&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Christine Arango, Clara Malag&#243;n, Mar&#237;a del Pilar G&#243;mez, Catalina Mosquera, Ricardo Y&#233;pez, Tatiana Gonz&#225;lez, Camilo Vargas"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Christine"
              "apellidos" => "Arango"
            ]
            1 => array:2 [
              "nombre" => "Clara"
              "apellidos" => "Malag&#243;n"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a del Pilar"
              "apellidos" => "G&#243;mez"
            ]
            3 => array:2 [
              "nombre" => "Catalina"
              "apellidos" => "Mosquera"
            ]
            4 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Y&#233;pez"
            ]
            5 => array:2 [
              "nombre" => "Tatiana"
              "apellidos" => "Gonz&#225;lez"
            ]
            6 => array:2 [
              "nombre" => "Camilo"
              "apellidos" => "Vargas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2444440517300511"
        "doi" => "10.1016/j.rcreue.2017.08.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440517300511?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300312?idApp=UINPBA00004N"
    "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300312/v2_201709141206/es/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Investigation</span>"
    "titulo" => "Performance and agreement between classification criteria and rheumatologist&#39;s diagnosis of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "153"
        "paginaFinal" => "158"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "John Londo&#241;o, Marlon Porras, Ana Mar&#237;a Santos, Paola Pe&#241;a, Enrique Calvo"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "John"
            "apellidos" => "Londo&#241;o"
            "email" => array:1 [
              0 => "john&#46;londono&#64;unisabana&#46;edu&#46;co"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Marlon"
            "apellidos" => "Porras"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ana Mar&#237;a"
            "apellidos" => "Santos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Paola"
            "apellidos" => "Pe&#241;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Enrique"
            "apellidos" => "Calvo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Reumatolog&#237;a e Inmunolog&#237;a&#44; Facultad de Medicina &#8211; Universidad de La Sabana&#44; Campus del Puente del Com&#250;n&#44; Ch&#237;a&#44; Cundinamarca&#44; Colombia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital Militar Central &#8211; Universidad Militar Nueva Granada&#44; Bogot&#225;&#44; D&#46;C&#46;&#44; Colombia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Radiolog&#237;a&#44; Universidad Nacional de Colombia&#44; Bogot&#225;&#44; D&#46;C&#46;&#44; Colombia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Acuerdo entre los criterios m&#225;s utilizados para la clasificaci&#243;n de las espondiloartritis &#40;SpA&#41; y el diagn&#243;stico cl&#237;nico hecho por un reumat&#243;logo experto en un grupo de pacientes j&#243;venes con dolor lumbar cor&#225;nico"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Spondyloarthritis &#40;SpA&#41; are a group of chronic inflammatory disorders that share clinical&#44; radiological&#44; HLA-B27 association&#44; positive family history and pathophysiological characteristics&#46; SpA affect approximately 1&#46;5&#37; of the general population&#46; Predominantly&#44; SpA begins in individuals younger than 45 years and clinically compromises the axial spine&#44; peripheral joints&#44; tendons and ligament insertions &#40;entheses&#41;&#44; having also extra-musculoskeletal manifestations in the skin&#44; mucosa&#44; gut and the eyes&#44; producing impairment of functional capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">1</span></a> The incidence of SpA in the general population is related to the prevalence of HLA-B27&#46; This explains why SpA is most commonly diagnosed in Anglo-Saxon populations where the prevalence of HLA-B27 could reach up to 14&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the clinical manifestations present in all stages of the disease&#44; is inflammatory back pain &#40;IBP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">3</span></a> In clinical practice is difficult to differentiate between the mechanical or inflammatory origin of pain&#46; Traditionally clinical and epidemiological studies have used classification criteria to identify the two groups of patients&#46; The frequency of inflammatory back pain has been estimated at 5&#37; of all patients with chronic low back pain &#40;CLBP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">4</span></a> At the same time&#44; the CLBP is the most common cause of disability in men between 15 and 45 years of age and it is important to differentiate between the sources of pain given the prognostic and therapeutic implications&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In the last 30 years&#44; several classification criteria for SpA have attempted to include the early stages as well as the undifferentiated forms of the disease &#40;uSpA&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">6&#8211;10</span></a> According to the European Spondyloarthropathy Study Group &#40;ESSG&#41; criteria&#44; SpA has been traditionally classified as follows&#58; ankylosing spondylitis &#40;AS&#41;&#44; reactive arthritis &#40;ReA&#41;&#44; undifferentiated spondyloarthritis &#40;uSpA&#41;&#44; psoriatic arthritis &#40;PsA&#41;&#44; and arthritis associated with inflammatory bowel disease &#40;IBD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The Assessment of Spondyloarthritis International Society &#40;ASAS&#41; proposes a new classification criteria that includes two sets&#59; axial and peripheral according to the prevalence of symptoms&#46; The new ASAS criteria include the use of MRI of the sacroiliac joints and HLA-B27 as a fundamental part of the diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">8&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">There is no gold standard for the diagnosis of SpA because of the heterogeneity of the musculoskeletal symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a> Sometimes epidemiological classification criteria are used as a tool in the diagnosis of these diseases with acceptable clinical performance&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">12</span></a> However&#44; the results may vary depending on the prevalence of the disease&#46; In the Latin American countries uSpA corresponds to the most common form of presentation&#44; with predominance of a mixture of axial and peripheral symptoms&#44; low frequency of HLA-B27 and with less radiological &#40;joint&#41; damage of the axial skeleton&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">13&#8211;15</span></a> Other HLA molecules have been implicated as responsible for this variation in clinical presentation&#46; In routine clinical practice&#44; the diagnostic decision depends exclusively on the experience of the rheumatologist who assesses the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The objective of this study is to establish an agreement between the most widely used classification criteria and a rheumatologist&#39;s diagnosis in a group of Colombian patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Participants and clinical assessment of patients</span><p id="par0035" class="elsevierStylePara elsevierViewall">A total of 133 patients&#44; &#62;18 years&#44; with past or current history of CLBP &#40;&#8805;3 months&#41; occurring before age 45 years&#44; who attended consecutively over a period of six months at outpatient clinic of CLBP were included in the study&#46; These patients were referred by other medical specialties&#58; general practitioner&#44; family medicine&#44; internal medicine&#44; orthopedics&#44; rehabilitation medicine and neurosurgery&#46; All patients underwent in the same diagnostic algorithm that included the use of a structured questionnaire completed by the rheumatologist from the available data at the time of visit with socio-demographic information&#59; history related to pain&#58; date of the onset&#44; trigger&#44; morning stiffness&#44; insidious onset&#44; improved with the exercise&#44; worsening with rest&#44; awakening at night because of pain&#44; good response to no steroidal anti-inflammatory drugs&#44; degree of disability by pain&#44; cervical and thoracic spine compromise&#44; button pain&#59; history of arthritis&#44; enthesitis&#44; dactilitys&#59; personal and family history related to the SpA&#58; infections&#44; uveitis&#44; psoriasis or inflammatory bowel disease&#46; All patients were applied specific instruments related to functional status and activity of the SpA&#58; BASFI&#44;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">17</span></a> BASDAI&#44;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">18</span></a> visual analog scale &#40;VAS&#41; of pain and disease activity&#46; For the physical examination ASAS recommendations were followed and included&#58; occiput to wall distance&#44; thoracic expansibility&#44; Shober test&#44; painful enthesis account by Mander&#39;s Index and tender and swollen joints account on a total of 44&#46; HLA typing&#44; PCR and VSG&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">19</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Imaging</span><p id="par0040" class="elsevierStylePara elsevierViewall">All patients underwent MRI of sacroiliac joints using contrast agents and fat suppression techniques &#40;projections in T1&#44; T2 and STIR&#41;&#44; radiographs of the pelvis&#46; All images were evaluated by a radiologist with experience in SpA who remained blinded to the clinical information of the patients&#46; Sacroiliitis by images was defined by New York and ASAS criteria for X-ray and MRI respectively&#46; Pre-radiographic sacroiliitis in cases of normal pelvic X-ray with sacroiliitis evidence by MRI&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Diagnosis and classification of patients</span><p id="par0045" class="elsevierStylePara elsevierViewall">Finally&#44; an expert rheumatologist in the field of SpA evaluated independently the clinical and laboratory findings of the patients and divided the patients into the two groups&#58; SpA and none SPA&#46; No SpA patients were diagnosed with different pathologies&#58; osteoarthritis&#44; postural syndrome&#44; rheumatoid arthritis and fibromyalgia SpA&#46; Using the expert opinion as gold standard for diagnosis of SpA&#44; the operation &#40;sensitivity and specificity&#41; of the EGSS and ASAS criteria were established&#46; In addition&#44; the degree of agreement between the ESSG and the ASAS classification criteria with clinical diagnosis&#44; was calculated using the kappa index&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistics</span><p id="par0050" class="elsevierStylePara elsevierViewall">Data analysis was performed using Stata 10&#46;0&#46; Measures of central tendency and dispersion for the continuous variables were used for data presentation&#46; Frequency and percentage values were used for the categorical variables&#46; The Student&#39;s <span class="elsevierStyleItalic">t</span>-test and the Kruskal&#8211;Wallis test were used to compare the continuous variables&#46; For the nominal variables&#44; the chi-squared test was used&#44; and Fisher&#39;s exact test was used if necessary&#46; In this study&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered statistically significant&#44; and 95&#37; confidence intervals &#40;CIs&#41; were calculated&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethics approval</span><p id="par0055" class="elsevierStylePara elsevierViewall">The study followed the norms established by the Helsinki Declaration&#44; The Guidelines for Good Clinical Practice&#44; and the Resolution 8430 &#40;1993&#41; of the Colombian Ministry for Social Protection&#46; Moreover&#44; was reviewed and approved by the Ethics Committees of the University of La Sabana and the Central Military Hospital&#46; Each patient signed an informed consent form&#44; and confidentiality was strictly maintained&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">A total of 133 patients were included&#44; 81 patients with SpA and 52 none SpA&#46; Of SpA patients&#44; 33 &#40;40&#46;7&#37;&#41; had AS&#44; 32 &#40;39&#46;5&#37;&#41; uSpA and 16 &#40;19&#46;8&#37;&#41; ReA&#46; 55 &#40;67&#46;9&#37;&#41; were males&#44; with a ratio male&#47;female of 2&#58;1&#46; The more frequent clinical manifestations were IBP&#44; and enthesopathy&#46; In none SpA patients&#44; 24 had postural syndrome&#44; 14 fibromyalgia&#44; 12 osteoarthritis and two rheumatoid arthritis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">There was no significant difference between the two groups of patients in age at the onset of symptoms&#44; disease duration&#44; age at the time of evaluation and indices of function and activity of disease&#46; HLA-B27 was present in 42&#37; of the patients with SpA &#40;57&#46;6&#37; in AS&#44; 18&#46;8&#37; in uSpA and 56&#46;3&#37; in ReA&#41; and only in 3&#46;8&#37; of the patients with other diseases &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; In terms of clinical characteristics&#44; there were significant differences in all variables&#46; Arthritis and uveitis were more common in SpA patients and were associated with HLA-B27 allele&#46; Blood markers of inflammation were more elevated in patients with SpA than in controls &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#46; IBP&#44; enthesopathy&#44; blood and radiological evidence of sacroiliitis&#44; were the variables with more significance in SpA &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">X-ray and MRI results</span><p id="par0070" class="elsevierStylePara elsevierViewall">In the patients with SpA&#44; the pelvic X-ray showed evidence of sacroiliitis in 44&#37;&#44; compared with 43&#37; with MRI&#46; Sacroiliitis in the X-ray was strongly correlated with SpA 44&#46;4&#37; vs 15&#46;4&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and was present in 33 &#40;100&#37;&#41; of the patients with AS&#44; 2 patients with uSpA &#40;6&#46;25&#37;&#41; and 1 patient with ReA &#40;6&#46;25&#37;&#41; and 8 &#40;15&#46;4&#37;&#41; non-SpA patients&#46; The MRI was positive in &#40;35&#47;81&#41; 43&#46;2&#37; of the SpA patients and &#40;6&#47;52&#41; 11&#46;5&#37; of non-SpA patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000&#41;&#46; MRI provided evidence of pre-radiographic sacroiliitis in 10 of the 30 patients with uSpA &#40;33&#46;3&#37;&#41; and 5 of the 15 patients with ReA &#40;33&#46;3&#37;&#41;&#46; Furthermore&#44; the MRI showed pre-radiographic sacroiliitis in 6 patients in the control group&#44; of whom only 1 patient had similar radiographical findings &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Performance of the ESSG and ASAS classification criteria</span><p id="par0075" class="elsevierStylePara elsevierViewall">When we analyzed the performance of the ESSG criteria in this population&#44; we found that 95&#37; of the SpA patients met the criteria&#46; None of the non-SpA patients met the criteria&#46; The results also showed that 96&#46;3&#37; of the SpA patients and 19&#46;2&#37; of the non-SpA patients met the new ASAS criteria&#46; ASAS criteria have 96&#37; of sensibility and 80&#37; of specificity&#44; and ESSG criteria 95&#37; and 100&#37;&#44; respectively&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">When we analyzed the agreement of the classification criteria with the diagnosis established by the rheumatologist&#44; we found a Cohen&#39;s kappa index of 0&#46;938 for the ESSG criteria &#40;95&#37; CI&#58; 0&#46;877&#8211;0&#46;998&#41; and 0&#46;790 for the ASAS criteria &#40;95&#37; CI&#58; 0&#46;682&#8211;0&#46;898&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">The population described here is a sample of patients who suffer from different forms of SpA&#46; All of the patients were recruited during outpatient consultations at the Rheumatology Department of one national referral hospitals for highly complex diseases&#46; These patients were referred to the Department after having been evaluated by other medical specialties &#40;Orthopedics&#44; Rehabilitation Medicine&#44; Neurosurgery&#44; Ophthalmology and Internal Medicine&#41;&#44; when SpA was established as a possible diagnosis due to the presence of chronic low back pain&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">As described in other populations&#44; the predominant symptoms among the SpA patients were lower back pain&#44; arthritis and enthesopathy&#46; Other symptoms such as dactylitis and uveitis were observed in the same proportions reported in previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">9&#44;21</span></a> In the non-SpA patients&#44; the most common symptoms were chronic lower back pain and gluteal pain&#46; The time of disease progression was lower in our group of patients than that reported by Feldtkeller in 2003 &#40;6&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;3 years vs&#46; 8&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;6 years&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">22</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">HLA-B27 was present in a smaller proportion of our patients &#40;42&#37;&#41; compared with other populations&#46; Although this lower prevalence seems to be the trend in current publications&#44; the lower prevalence may reflect the racial composition of our population and the relatively high number of patients with undifferentiated and reactive forms of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">21</span></a> In this study&#44; 28 patients fulfilled the new ASAS criteria with axial involvement&#58; 24 patients met the radiological requirement and 15 patients met the requirement contingent on a positive HLA-B27 test &#40;11 patients met both requirements&#59; thus&#44; 4 patients were only positive for HLA-B27&#44; and 13 patients only had images showing sacroiliitis&#41;&#46; This difference is an important detail because it appears that imaging offered better results for patient classification than HLA-B27 characterization&#44; with a better performance of plain radiography for sacroiliitis diagnosis than MRI in our study&#46; However&#44; in this group of patients&#44; HLA-B27 positivity was strongly associated with the clinical markers traditionally considered to be associated with more severe forms of the disease &#40;AS&#44; uveitis and arthritis&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">As reported by Weber&#44; non-SpA patients may have positive results in the MRI of the sacroiliac joints and spine&#46; Healthy controls can have isolated foci of hyperintensity on STIR &#40;bone pseudo-edema&#41; with a frequency close to 27&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">23&#44;24</span></a> The other hand&#44; arthrosis is common condition in patients over 40 years old&#46; It can cause unilateral or bilateral&#44; symmetrical or asymmetrical sacroiliac joint inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">25</span></a> This conditions could explain why several of our patients in whom SpA was ruled out had positive MRI results &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41; and justifies the increase in the number of false positives that resulted from using this set of criteria&#46; When the sacroiliac joint MRI results were combined with the ESSG criteria&#44; 1 additional patient met the requirements for SpA&#46; These data may justify reconsidering the use of this diagnostic method in patients with a diagnosis of uSpA because the other clinical and laboratory criteria can provide the necessary diagnostic information&#46; This uncommon pre-radiographic sacroiliitis suggests a better prognosis in our population&#44; with less likelihood of progression to AS&#44; which is the more severe form of SpA&#46; However&#44; this progression must be examined using a different study design in larger patient populations&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Nevertheless&#44; after reviewing the most recent literature on this regard Banegas Illescas and collaborators conclude that the ASAS criteria have limitations concerning the diagnostic and prognostic utility of MRI in these patients&#46; Firstly&#44; in absence of bone edema or osteitis the MRI-identified structural lesions are not diagnostic of sacroilitis&#46; This exclusion is contradictory due to the fact that the other radiological marker of sacroiliitis is based on structural changes seen on the simple X-ray according to New York new modified criteria despite the great inter-observer variability&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">26&#8211;28</span></a> Several trials have shown that MRI is not only capable of finding structural lesions before they can be seen on the X-ray without active inflammatory lesions&#44;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">24&#44;29</span></a> but it is also capable of increasing its diagnostic sensibility from 67&#37; to 81&#37;&#44; when erosions are analyzed besides bone edema without changes in specificity &#40;88&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">24</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Considering these observations&#44; the agreement between the classification criteria and the clinical diagnosis was good in this group of patients and also highlighted a better interpretation of the ESSG criteria&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The results obtained in this study should be analyzed with the understanding that there is a higher proportion of reactive and undifferentiated forms of SpA in Latin American patients than in Anglo-Saxon populations&#46; In our populations&#44; peripheral manifestations are predominant compared with axial involvement&#44; and the prevalence of HLA-B27 is low as a result of miscegenation&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The patients who were evaluated and participated in this study were referred to the SpA clinic after an outpatient consultation at the Department of Rheumatology of one tertiary care hospital that are the national referral center for a population of over half a million people&#46; This referral creates a filter so that the patients included in this study represented the most severe forms of the disease&#46; This meant that only patients with more complex were evaluated by the rheumatologist&#44; causing a selection bias&#46; For this reason&#44; the number of patients with SpA is significantly higher than the other diseases&#46; However&#44; in the context of the objective of the present study&#44; the sample size&#44; allowed the agreement between the clinical diagnosis in real life of outpatient care of patients and the classification criteria for SpA used most frequently&#46; This explains why the performance of the classification criteria is greater than previously reported in open community&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">30&#8211;32</span></a> Therefore&#44; it is necessary to study in Latin-American countries which really is the performance ESSG and ASAS criteria&#44; where the percentage of patients with HLA-B27 positive and axial compromise is smaller compared with Anglo-Saxon populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">33&#44;34</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; the ESSG and ASAS classification criteria and the clinical diagnosis made by expert rheumatologists were well correlated in the Colombian population&#46; However&#44; in the present study&#44; the ESSG criteria showed a higher degree of agreement with clinical diagnosis&#44; which should be analyzed in other Latin American populations&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Ethical disclosures</span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Protection of human and animal subjects</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Confidentiality of data</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Right to privacy and informed consent</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Financial</span><p id="par0145" class="elsevierStylePara elsevierViewall">Supported by the University of La Sabana&#46; No financial support or benefits from commercial sources&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflict of interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">Not any additional conflict of interest exist with regard to this work&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres901014"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec882081"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres901013"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec882080"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Participants and clinical assessment of patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Imaging"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Diagnosis and classification of patients"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistics"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Ethics approval"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0040"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "X-ray and MRI results"
            ]
            1 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Performance of the ESSG and ASAS classification criteria"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Discussion"
        ]
        8 => array:3 [
          "identificador" => "sec0060"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Financial"
        ]
        10 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conflict of interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-04-03"
    "fechaAceptado" => "2017-02-08"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec882081"
          "palabras" => array:4 [
            0 => "Spondyloarthritis"
            1 => "Classification criteria"
            2 => "ESSG"
            3 => "ASAS"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec882080"
          "palabras" => array:4 [
            0 => "Espondiloartritis"
            1 => "Criterios de clasificaci&#243;n"
            2 => "ESSG"
            3 => "ASAS"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the performance of the most widely used SpA classification criteria in a Colombian group of patients with chronic low back pain&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We assessed the ASAS and the European Spondyloarthropathy Study Group &#40;ESSG&#41; classification criteria in a group of 133 patients who attended consecutively over a period of six months at outpatient clinic of low back pain&#46; All the patients were evaluated with the same protocol&#46; The patients were divided into two groups according to the diagnosis&#46; The diagnosis was compared with the diagnosis made by a expert rheumatologist blinded to patient information&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">81 patients with SpA and 52 with other diagnoses were included&#46; There were no differences in age and age of onset of symptoms between the two groups&#46; The SpA group included 55 males and more common clinical findings were&#58; enthesitis&#44; arthritis&#44; sacroiliitis&#44; HLA-B27-positive&#44; previous infection&#44; and dactylitis&#46; The sensitivity and specificity of criteria were&#58; ASAS criteria 96&#37; of sensibility and 80&#37; of specificity&#44; and ESSG criteria 95&#37; and 100&#37; respectively&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The agreement between the classification criteria and the diagnosis established by the rheumatologist showed a Cohen&#39;s kappa index of 0&#46;938 for ESSG criteria &#40;95&#37; CI&#58; 0&#46;877&#8211;0&#46;998&#41; and 0&#46;790 for the ASAS criteria &#40;95&#37; CI&#58; 0&#46;682&#8211;0&#46;898&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In a Colombian group of SpA patients&#44; the new ASAS classification criteria have a good concordance with clinical diagnosis but are not superior to the ESSG criteria&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Evaluar el acuerdo entre los criterios de clasificaci&#243;n para SpA y el diagn&#243;stico de un experto reumat&#243;logo en un grupo de pacientes con dolor lumbar&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; el comportamiento de los criterios de ASAS y del ESSG en 133 pacientes que acudieron de forma consecutiva durante seis meses a la cl&#237;nica ambulatoria de dolor lumbar&#46; Todos los pacientes se evaluaron con el mismo protocolo&#46; Los pacientes fueron divididos en dos grupos de acuerdo con el diagn&#243;stico&#46; Posteriormente se estableci&#243; del acuerdo diagn&#243;stico con el de un experto reumat&#243;logo ciego a la informaci&#243;n previa de los pacientes&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">81 pacientes con SpA y 52 con otros diagn&#243;sticos fueron incluidos&#46; No hubo diferencias en la edad y la edad de aparici&#243;n de los s&#237;ntomas&#46; El grupo SpA incluy&#243; a 55 varones y los hallazgos m&#225;s comunes fueron&#58; entesitis&#44; artritis&#44; sacroile&#237;tis&#44; infecci&#243;n previa&#44; HLA-B27&#44; y dactilitis&#46; La sensibilidad y especificidad de los criterios fueron&#58; ASAS 96&#37; de sensibilidad y 80&#37; de especificidad&#44; y ESSG 95&#37; y 100&#37; respectivamente&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El acuerdo entre los criterios de clasificaci&#243;n y el diagn&#243;stico del reumat&#243;logo mostr&#243; un &#237;ndice kappa de 0&#44;938 con criterios ESSG &#40;IC del 95&#37;&#58; 0&#44;877&#8211;0&#44;998&#41; y 0&#44;790 para los criterios ASAS &#40;IC del 95&#37;&#58; 0&#44;682&#8211;0&#44;898&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En un grupo de pacientes colombianos SpA&#44; los nuevos criterios de clasificaci&#243;n ASAS tienen una buena concordancia con el diagn&#243;stico cl&#237;nico&#44; pero no son superiores a los criterios ESSG&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">All patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>133&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non SpA &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age in years&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;7 &#40;10&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;6 &#40;11&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;9 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age in years at the onset of symptoms&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;6 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;6 &#40;7&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;2 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;070&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Males&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#46;6 &#40;6&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;1 &#40;8&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Disease duration &#40;y&#41;&#44; mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;8 &#40;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Male gender&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">HLA-B27&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Family history of SpA&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">ESR&#44; mm&#47;h &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;9 &#40;11&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;5 &#40;12&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;5 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">C-reactive protein&#44; g&#47;dl&#44; mean</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;023&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">&#42;&#42;</span></span></a><span class="elsevierStyleItalic">BASDAI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">&#42;&#42;&#42;</span></span></a><span class="elsevierStyleItalic">BASFI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">General patient</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">&#42;</span></span></a><span class="elsevierStyleItalic">VAS</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">General physician</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">&#42;</span></span></a><span class="elsevierStyleItalic">VAS</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sacroiliitis evidenced by radiography &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;33&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;15&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Active inflammation in sacroiliac joints &#40;MRI&#41;&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;21&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sacroiliitis by X-ray or MRI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;23&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1513534.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">VAS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Visual Analog Scale&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Bath Ankylosing Spondylitis Disease Activity Index&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "&#42;&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Bath Ankylosing Spondylitis Functional Index&#59; MRI&#58; Magnetic Resonance Image&#44; ESR&#58; Erythrocyte sedimentation rate</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the evaluated patients&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ASAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ESSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SpA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Does not meet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Does not meet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Meets&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Meets&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1513533.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Agreement between the classification criteria and the clinical diagnoses&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:34 [
            0 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ankylosing spondylitis&#58; introductory comments on its diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2002"
                        "volumen" => "61"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "iii3"
                        "paginaFinal" => "iii7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12381505"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ankylosing spondylitis&#58; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Sieper"
                            1 => "J&#46; Braun"
                            2 => "M&#46; Rudwaleit"
                            3 => "A&#46; Boonen"
                            4 => "A&#46; Zink"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2002"
                        "volumen" => "61"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "iii8"
                        "paginaFinal" => "iii18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12381506"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical history as a screening test for ankylosing spondylitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Calin"
                            1 => "J&#46; Porta"
                            2 => "J&#46;F&#46; Fries"
                            3 => "D&#46;J&#46; Schurman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1977"
                        "volumen" => "237"
                        "paginaInicial" => "2613"
                        "paginaFinal" => "2614"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/140252"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How to diagnose axial spondyloarthritis early"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Rudwaleit"
                            1 => "D&#46; van der Heijde"
                            2 => "M&#46;A&#46; Khan"
                            3 => "J&#46; Braun"
                            4 => "J&#46; Sieper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2003.011247"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2004"
                        "volumen" => "63"
                        "paginaInicial" => "535"
                        "paginaFinal" => "543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15082484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of disabilities and associated health conditions among adults--United States&#44; 1999"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "CDC"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "MMWR Morb Mortal Wkly Rep"
                        "fecha" => "2001"
                        "volumen" => "50"
                        "paginaInicial" => "120"
                        "paginaFinal" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11393491"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Criteria of the classification of spondylarthropathies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Amor"
                            1 => "M&#46; Dougados"
                            2 => "M&#46; Mijiyawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Rhum Mal Osteoartic"
                        "fecha" => "1990"
                        "volumen" => "57"
                        "paginaInicial" => "85"
                        "paginaFinal" => "89"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2181618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Dougados"
                            1 => "S&#46; van der Linden"
                            2 => "R&#46; Juhlin"
                            3 => "B&#46; Huitfeldt"
                            4 => "B&#46; Amor"
                            5 => "A&#46; Calin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "1218"
                        "paginaFinal" => "1227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1930310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis &#40;part I&#41;&#58; classification of paper patients by expert opinion including uncertainty appraisal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rudwaleit"
                            1 => "R&#46; Landewe"
                            2 => "D&#46; van der Heijde"
                            3 => "J&#46; Listing"
                            4 => "J&#46; Brandt"
                            5 => "J&#46; Braun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2009.108217"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "paginaInicial" => "770"
                        "paginaFinal" => "776"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19297345"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis &#40;part II&#41;&#58; validation and final selection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rudwaleit"
                            1 => "D&#46; van der Heijde"
                            2 => "R&#46; Landewe"
                            3 => "J&#46; Listing"
                            4 => "N&#46; Akkoc"
                            5 => "J&#46; Brandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2009.108233"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "paginaInicial" => "777"
                        "paginaFinal" => "783"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19297344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rudwaleit"
                            1 => "D&#46; van der Heijde"
                            2 => "R&#46; Landewe"
                            3 => "N&#46; Akkoc"
                            4 => "J&#46; Brandt"
                            5 => "C&#46;T&#46; Chou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2010.133645"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2011"
                        "volumen" => "70"
                        "paginaInicial" => "25"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21109520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thoughts concerning the early diagnosis of ankylosing spondylitis and related diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "numero" => "Suppl 28"
                        "paginaInicial" => "S6"
                        "paginaFinal" => "S10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12463439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of cases of inflammatory rheumatic disorders&#58; performance of a telephone questionnaire designed for use by patient interviewers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Guillemin"
                            1 => "A&#46; Saraux"
                            2 => "P&#46; Fardellone"
                            3 => "P&#46; Guggenbuhl"
                            4 => "J&#46;M&#46; Behier"
                            5 => "J&#46; Coste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2003"
                        "volumen" => "62"
                        "paginaInicial" => "957"
                        "paginaFinal" => "963"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12972474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ankylosing spondylitis in the Mexican mestizo&#58; patterns of disease according to age at onset"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Burgos-Vargas"
                            1 => "A&#46; Naranjo"
                            2 => "J&#46; Castillo"
                            3 => "G&#46; Katona"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1989"
                        "volumen" => "16"
                        "paginaInicial" => "186"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2787404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Caracterizaci&#243;n de las espondiloartropat&#237;as y determinaci&#243;n de factores de mal pron&#243;stico en una poblaci&#243;n de pacientes colombianos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Londono"
                            1 => "L&#46; Gonz&#225;lez"
                            2 => "A&#46; Ram&#237;rez"
                            3 => "P&#46; Santos"
                            4 => "L&#46; &#193;vila"
                            5 => "A&#46; Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Colomb Reumatol"
                        "fecha" => "2005"
                        "volumen" => "12"
                        "paginaInicial" => "195"
                        "paginaFinal" => "207"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary ankylosing spondylitis&#58; patterns of disease in a Brazilian population of 147 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;D&#46; Sampaio-Barros"
                            1 => "M&#46;B&#46; Bertolo"
                            2 => "M&#46;H&#46; Kraemer"
                            3 => "J&#46;F&#46; Neto"
                            4 => "A&#46;M&#46; Samara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "560"
                        "paginaFinal" => "565"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296959"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and classification in spondyloarthritis&#58; identifying a chameleon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; van Tubergen"
                            1 => "U&#46; Weber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrrheum.2012.33"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Rheumatol"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "253"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22450552"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new approach to defining functional ability in ankylosing spondylitis&#58; the development of the Bath Ankylosing Spondylitis Functional Index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Calin"
                            1 => "S&#46; Garrett"
                            2 => "H&#46; Whitelock"
                            3 => "L&#46;G&#46; Kennedy"
                            4 => "J&#46; O&#8217;Hea"
                            5 => "P&#46; Mallorie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "2281"
                        "paginaFinal" => "2285"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7699629"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new approach to defining disease status in ankylosing spondylitis&#58; the Bath Ankylosing Spondylitis Disease Activity Index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Garrett"
                            1 => "T&#46; Jenkinson"
                            2 => "L&#46;G&#46; Kennedy"
                            3 => "H&#46; Whitelock"
                            4 => "P&#46; Gaisford"
                            5 => "A&#46; Calin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "2286"
                        "paginaFinal" => "2291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7699630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Assessment of SpondyloArthritis international Society &#40;ASAS&#41; handbook&#58; a guide to assess spondyloarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46;M&#46; Sieper"
                            1 => "X&#46; Baraliakos"
                            2 => "J&#46; Brandt"
                            3 => "J&#46; Braun"
                            4 => "R&#46; Burgos-Vargas"
                            5 => "M&#46; Dougados"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2008.104018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "paginaInicial" => "ii1"
                        "paginaFinal" => "ii44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19433414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining active sacroiliitis on magnetic resonance imaging &#40;MRI&#41; for classification of axial spondyloarthritis&#58; a consensual approach by the ASAS&#47;OMERACT MRI group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rudwaleit"
                            1 => "A&#46;G&#46; Jurik"
                            2 => "K&#46;G&#46; Hermann"
                            3 => "R&#46; Landewe"
                            4 => "D&#46; van der Heijde"
                            5 => "X&#46; Baraliakos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2009.110767"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "paginaInicial" => "1520"
                        "paginaFinal" => "1527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rudwaleit"
                            1 => "D&#46; van der Heijde"
                            2 => "R&#46; Landewe"
                            3 => "N&#46; Akkoc"
                            4 => "J&#46; Brandt"
                            5 => "C&#46;T&#46; Chou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2010"
                        "volumen" => "24"
                        "paginaInicial" => "24"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age at disease onset and diagnosis delay in HLA-B27 negative vs&#46; positive patients with ankylosing spondylitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Feldtkeller"
                            1 => "M&#46;A&#46; Khan"
                            2 => "D&#46; van der Heijde"
                            3 => "S&#46; van der Linden"
                            4 => "J&#46; Braun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00296-002-0237-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatol Int"
                        "fecha" => "2003"
                        "volumen" => "23"
                        "paginaInicial" => "61"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12634937"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "U&#46; Weber"
                            1 => "R&#46;G&#46; Lambert"
                            2 => "S&#46;J&#46; Pedersen"
                            3 => "J&#46; Hodler"
                            4 => "M&#46; Ostergaard"
                            5 => "W&#46;P&#46; Maksymowych"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "1763"
                        "paginaFinal" => "1771"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic utility of magnetic resonance imaging in spondylarthritis&#58; an international multicenter evaluation of one hundred eighty-seven subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "U&#46; Weber"
                            1 => "R&#46;G&#46; Lambert"
                            2 => "M&#46; Ostergaard"
                            3 => "J&#46; Hodler"
                            4 => "S&#46;J&#46; Pedersen"
                            5 => "W&#46;P&#46; Maksymowych"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.27571"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "3048"
                        "paginaFinal" => "3058"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20496416"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028213034250"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sacroiliac joints&#58; osteoarthritis or arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;I&#46; Garcia Diez"
                            1 => "X&#46; Tomas Batlle"
                            2 => "J&#46; Pomes Tallo"
                            3 => "M&#46;D&#46; Amo Conill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2008.12.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2009"
                        "volumen" => "5"
                        "paginaInicial" => "40"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New ASAS criteria for the diagnosis of spondyloarthritis&#58; diagnosing sacroiliitis by magnetic resonance imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;E&#46; Banegas Illescas"
                            1 => "C&#46; Lopez Menendez"
                            2 => "M&#46;L&#46; Rozas Rodriguez"
                            3 => "R&#46;M&#46; Fernandez Quintero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rx.2013.05.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiologia"
                        "fecha" => "2014"
                        "volumen" => "56"
                        "paginaInicial" => "7"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24119715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of diagnostic criteria for ankylosing spondylitis&#46; A proposal for modification of the New York criteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; van der Linden"
                            1 => "H&#46;A&#46; Valkenburg"
                            2 => "A&#46; Cats"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1984"
                        "volumen" => "27"
                        "paginaInicial" => "361"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6231933"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variacion entre dos observadores en la evaluacion radiografica de las articulaciones sacroiliacas&#58; I Estudio en poblaciones con riesgo y sin riesgo de sacroiliitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Sanabria"
                            1 => "J&#46; Orozco"
                            2 => "L&#46; Gomez"
                            3 => "R&#46; Burgos-Vargas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Mex Reumatol"
                        "fecha" => "1994"
                        "volumen" => "9"
                        "paginaInicial" => "6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis&#63; A cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "U&#46; Weber"
                            1 => "S&#46;J&#46; Pedersen"
                            2 => "M&#46; Ostergaard"
                            3 => "K&#46; Rufibach"
                            4 => "R&#46;G&#46; Lambert"
                            5 => "W&#46;P&#46; Maksymowych"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar3854"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "R124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22626458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performances of the Assessment of SpondyloArthritis International Society axial spondyloarthritis criteria for diagnostic and classification purposes in patients visiting a rheumatologist because of chronic back pain&#58; results from a multicenter&#44; cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Molto"
                            1 => "S&#46; Paternotte"
                            2 => "D&#46; Comet"
                            3 => "E&#46; Thibout"
                            4 => "M&#46; Rudwaleit"
                            5 => "P&#46; Claudepierre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res"
                        "fecha" => "2013"
                        "volumen" => "65"
                        "paginaInicial" => "1472"
                        "paginaFinal" => "1481"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis&#58; data from the DESIR cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Molto"
                            1 => "S&#46; Paternotte"
                            2 => "D&#46; van der Heijde"
                            3 => "P&#46; Claudepierre"
                            4 => "M&#46; Rudwaleit"
                            5 => "M&#46; Dougados"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2013-204262"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2015"
                        "volumen" => "74"
                        "paginaInicial" => "746"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24389295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of different criteria sets for inflammatory back pain in patients with axial spondyloarthritis with and without radiographic sacroiliitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Solmaz"
                            1 => "S&#46; Akar"
                            2 => "O&#46; Soysal"
                            3 => "Y&#46; Akkoc"
                            4 => "G&#46; Can"
                            5 => "V&#46; Gerdan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10067-014-2622-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "2014"
                        "volumen" => "33"
                        "paginaInicial" => "1475"
                        "paginaFinal" => "1479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24770795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of the Assessment of Spondyloarthritis International Society criteria for the classification of spondyloarthritis in early spondyloarthritis clinics participating in the ESPERANZA programme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Tomero"
                            1 => "J&#46; Mulero"
                            2 => "E&#46; de Miguel"
                            3 => "C&#46; Fernandez-Espartero"
                            4 => "M&#46; Gobbo"
                            5 => "M&#46;A&#46; Descalzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#44; England&#41;"
                        "fecha" => "2014"
                        "volumen" => "53"
                        "paginaInicial" => "353"
                        "paginaFinal" => "360"
                        "itemHostRev" => array:3 [
                          "pii" => "S1462388911001669"
                          "estado" => "S300"
                          "issn" => "14623889"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ankylosing Spondylitis Related Diseases in the Mexican Mestizo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Burgos-Vargas"
                            1 => "J&#46; Granados-Arriola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Spine"
                        "fecha" => "1990"
                        "volumen" => "4"
                        "paginaInicial" => "665"
                        "paginaFinal" => "678"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/01218123/0000002400000003/v2_201709141206/S0121812317300488/v2_201709141206/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "45322"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Investigaciones originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/01218123/0000002400000003/v2_201709141206/S0121812317300488/v2_201709141206/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812317300488?idApp=UINPBA00004N"
]

Información del artículo

ISSN: 01218123
Idioma original: Inglés

DOI:10.1016/j.rcreu.2017.02.009

Datos actualizados diariamente

año/Mes	Html	Pdf	Total

2024 Octubre	12	0	12
2024 Septiembre	34	3	37
2024 Agosto	26	3	29
2024 Julio	18	2	20
2024 Junio	14	6	20
2024 Mayo	22	2	24
2024 Abril	19	7	26
2024 Marzo	19	9	28
2024 Febrero	13	5	18
2024 Enero	17	2	19
2023 Diciembre	7	4	11
2023 Noviembre	17	6	23
2023 Octubre	24	3	27
2023 Septiembre	9	1	10
2023 Agosto	16	2	18
2023 Julio	23	3	26
2023 Junio	29	7	36
2023 Mayo	51	6	57
2023 Abril	44	10	54
2023 Marzo	26	2	28
2023 Febrero	27	5	32
2023 Enero	19	6	25
2022 Diciembre	44	10	54
2022 Noviembre	46	20	66
2022 Octubre	32	18	50
2022 Septiembre	63	17	80
2022 Agosto	25	13	38
2022 Julio	37	6	43
2022 Junio	30	10	40
2022 Mayo	32	10	42
2022 Abril	40	13	53
2022 Marzo	35	8	43
2022 Febrero	33	7	40
2022 Enero	46	8	54
2021 Diciembre	23	10	33
2021 Noviembre	21	13	34
2021 Octubre	31	13	44
2021 Septiembre	22	16	38
2021 Agosto	13	11	24
2021 Julio	22	11	33
2021 Junio	21	6	27
2021 Mayo	27	10	37
2021 Abril	32	22	54
2021 Marzo	15	13	28
2021 Febrero	15	9	24
2021 Enero	32	14	46
2020 Diciembre	19	3	22
2020 Noviembre	48	11	59
2020 Octubre	47	8	55
2020 Septiembre	28	39	67
2020 Agosto	31	28	59
2020 Julio	23	17	40
2020 Junio	34	10	44
2020 Mayo	27	8	35
2020 Abril	15	6	21
2020 Marzo	31	6	37
2020 Febrero	27	15	42
2020 Enero	19	6	25
2019 Diciembre	18	6	24
2019 Noviembre	12	7	19
2019 Octubre	18	6	24
2019 Septiembre	24	7	31
2019 Agosto	12	2	14
2019 Julio	34	10	44
2019 Junio	37	21	58
2019 Mayo	110	35	145
2019 Abril	38	8	46
2019 Marzo	3	2	5
2019 Febrero	12	4	16
2019 Enero	9	3	12
2018 Diciembre	7	3	10
2018 Noviembre	9	2	11
2018 Octubre	8	6	14
2018 Septiembre	24	2	26
2018 Agosto	10	1	11
2018 Julio	8	5	13
2018 Junio	11	0	11
2018 Mayo	7	2	9
2018 Abril	12	2	14
2018 Marzo	7	0	7
2018 Febrero	16	1	17
2018 Enero	16	3	19
2017 Diciembre	21	1	22
2017 Noviembre	22	2	24
2017 Octubre	25	8	33
2017 Septiembre	14	2	16
2017 Agosto	2	2	4
2017 Julio	4	3	7
2017 Junio	1	8	9

Mostrar todo

Indexada en:

Síguenos:

Estadísticas

Indexada en:

Síguenos:

Estadísticas

Suscríbase a la newsletter