array:23 [ "pii" => "S2444440524000633" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.03.004" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2049" "copyright" => "Asociación Colombiana de Reumatología" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2024;31:264-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S2444440524000803" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.05.002" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2056" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2024;31:268-75" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Granulomatosis with polyangiitis and skin ulcers mimicking pyoderma gangrenosum: A case report of a diagnostic challenge" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "268" "paginaFinal" => "275" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Granulomatosis con poliangeítis y úlceras cutáneas simuladoras de pioderma gangrenoso: reporte de caso de un reto diagnóstico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1688 "Ancho" => 2750 "Tamanyo" => 352764 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evolution of the primary lesion on the right forearm. (A) Initial lesion with its progression prior to institutional assessment (photos taken by the patient and published under her consent). (B) Ulcer progression with deep tissue exposure during hospital stay (photos taken under patient’s consent). (C) Outpatient evolution under treatment with steroid and methotrexate (photos taken by the patient and published under her consent).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Linda Navarrete-Motta, Onaldo-José Barrios, Sebastián Gil-Tamayo, Daniela Saaibi, Juan M. Gutiérrez, Daniel G. Fernández-Ávila, Santiago Bernal-Macías, Jorge L. Rodríguez, María-Claudia Díaz" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Linda" "apellidos" => "Navarrete-Motta" ] 1 => array:2 [ "nombre" => "Onaldo-José" "apellidos" => "Barrios" ] 2 => array:2 [ "nombre" => "Sebastián" "apellidos" => "Gil-Tamayo" ] 3 => array:2 [ "nombre" => "Daniela" "apellidos" => "Saaibi" ] 4 => array:2 [ "nombre" => "Juan M." "apellidos" => "Gutiérrez" ] 5 => array:2 [ "nombre" => "Daniel G." "apellidos" => "Fernández-Ávila" ] 6 => array:2 [ "nombre" => "Santiago" "apellidos" => "Bernal-Macías" ] 7 => array:2 [ "nombre" => "Jorge L." "apellidos" => "Rodríguez" ] 8 => array:2 [ "nombre" => "María-Claudia" "apellidos" => "Díaz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0121812323000439" "doi" => "10.1016/j.rcreu.2023.05.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812323000439?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440524000803?idApp=UINPBA00004N" "url" => "/24444405/0000003100000002/v1_202407190845/S2444440524000803/v1_202407190845/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2444440524000773" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.02.013" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2041" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2024;31:259-63" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Haematological complication with pulmonary impact in a patient with Sjögren’s syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "259" "paginaFinal" => "263" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Complicación hematológica con impacto pulmonar en una paciente con síndrome de Sjögren" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1391 "Ancho" => 2508 "Tamanyo" => 267179 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Protein electrophoresis: Monoclonal peak in gamma region. B) Serum immunofixation: Positive IgG lambda. C) κ/λ light chains. D) Major salivary gland positive for amyloid infiltrate. E) Minor salivary gland positive for amyloid infiltrate; positive Congo Red staining.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Gallego, Jhon Buitrago, Diana Guavita-Navarro, Jairo Cajamarca-Barón, Ana María Arredondo, José Fernando Polo Nieto, Juan Pablo Castañeda-González, Alejandro Escobar" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Gallego" ] 1 => array:2 [ "nombre" => "Jhon" "apellidos" => "Buitrago" ] 2 => array:2 [ "nombre" => "Diana" "apellidos" => "Guavita-Navarro" ] 3 => array:2 [ "nombre" => "Jairo" "apellidos" => "Cajamarca-Barón" ] 4 => array:2 [ "nombre" => "Ana María" "apellidos" => "Arredondo" ] 5 => array:2 [ "nombre" => "José Fernando" "apellidos" => "Polo Nieto" ] 6 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Castañeda-González" ] 7 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Escobar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S012181232300021X" "doi" => "10.1016/j.rcreu.2023.02.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S012181232300021X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440524000773?idApp=UINPBA00004N" "url" => "/24444405/0000003100000002/v1_202407190845/S2444440524000773/v1_202407190845/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Lower limb arterial thrombosis due to biopolymer injection: A case report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "264" "paginaFinal" => "267" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Milly J. Vecino-Moreno, Álvaro J. Vivas, Gabriel J. Tobón, David Aguirre-Valencia" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Milly J." "apellidos" => "Vecino-Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Álvaro J." "apellidos" => "Vivas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Gabriel J." "apellidos" => "Tobón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:4 [ "nombre" => "David" "apellidos" => "Aguirre-Valencia" "email" => array:1 [ 0 => "david.aguirre@fvl.org.co" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Department of Clinical Sciences, Rheumatology Unit, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Research and Innovation, Clinical Research Center, Fundación Valle del Lili, Cali, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, Springfield, IL, USA" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Clinical Sciences, Center for Research in Rheumatology, Autoimmunity and Translational Medicine, Universidad Icesi, Cali, Colombia" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Internal Medicine, Rheumatology Unit, Fundación Valle del Lili, Cali, Colombia" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trombosis arterial de miembros inferiores por inyección de biopolímeros: reporte de caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1113 "Ancho" => 2925 "Tamanyo" => 223070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Timeline of the clinical findings and evolution.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Biopolymer injections for esthetic purposes is a public health problem; although its usage dates back from more than a century, its demand has steadily increased in the last decade.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> A wide variety of complications are associated with this procedure, which can be innocuous or even life-threatening; presenting from immediately to years later, locally or systemically, with mechanical, inflammatory or autoimmune characteristics.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> In our country there are a lot of oil preparations with and without biopolymers or silicone used for esthetic purposes in different body areas, such as face, hands, breasts, gluteus and thighs. Unfortunately, these procedures are in many times performed by non-health care professionals.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> The pharmacological effects of these substances are largely unknown, although it has been reported that these can migrate to other organs as emboli, causing a secondary inflammatory or ischemic process.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> We report a case of a patient who presented long-standing symptoms, but only consulted after the onset of an acute lower limb arterial thrombosis that could have been fatal without a rapid intervention.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 63-year-old mestizo woman, with a history of biopolymer injection in hands and thighs and augmentation mammoplasty fifteen years ago was admitted to the emergency department because of thigh pain. The patient reported chronic fatigue and myalgia predominantly in the lower limbs in recent years. One month before admission, she reportedly had a progressive bilateral medial thigh pain associated with tumefaction, erythema and changes in skin color; she also presented paresthesia, dysesthesia and bilateral weakness of lower extremities. Then, four days before consulting, her pain became unbearable, with reddish and purplish skin color in the distal third of her right leg that limited its mobility. She reported absence of fever, thoracic pain or dyspnea; she reported being an active smoker and taking no medications. Her medical history was unremarkable.</p><p id="par0015" class="elsevierStylePara elsevierViewall">On examination, the patient was alert and fully oriented. She was pale and appeared ill. The temperature was 36<span class="elsevierStyleHsp" style=""></span>°C, the blood pressure 125/72<span class="elsevierStyleHsp" style=""></span>mmHg, the pulse 64 beats per minute, the respiratory rate 17 breaths per minute, and the oxygen saturation 98% while she was breathing ambient air, and the weight 46<span class="elsevierStyleHsp" style=""></span>kg. The heart and lung sounds were normal. Medial surface of her right thigh was warm, with tenderness, mild induration and associated erythema (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), while distal portion of the same extremity was cold and had associated erythema and diminished sensitivity; her popliteal and dorsalis pedis pulses of the same limb were absent and capillary refill time was 4–5<span class="elsevierStyleHsp" style=""></span>s. Her left leg was cold; both soles of her feet had violaceous discoloration, which was more pronounced in the right foot (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The remainder of the examination was normal.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A critical limb ischemia was suspected, a CT angiography was performed; it showed thrombosis of the right femoral artery since its origin, thrombosis of the right popliteal artery and of the distal segment of the posterior tibial artery. Anterior tibial and distal peroneal artery of the same limb had adequate blood flow provided by collateral circulation. Additionally, deep and superficial venous thrombosis with extension into the ipsilateral iliac vessels was observed, as well as partial thrombosis of the left popliteus artery with extension into the tibioperoneal trunk. Laboratory tests revealed a normal hemogram, ESR 10<span class="elsevierStyleHsp" style=""></span>mm/h (reference range 0–30<span class="elsevierStyleHsp" style=""></span>mm/h), C-reactive protein 3.64 (reference range 0–1<span class="elsevierStyleHsp" style=""></span>mg/dL), prothrombin time 11.8<span class="elsevierStyleHsp" style=""></span>s, partial thromboplastin time 51.6<span class="elsevierStyleHsp" style=""></span>s, international normalized ratio 1.02. Likewise, IgM and IgG anticardiolipin antibodies (aCL) were negative, as were IgM and Ig Anti-Beta-2-Glycoproten I antibodies, antinuclear antibodies (ANAs), extractable nuclear antigen antibodies (ENAs), and anti-neutrophil cytoplasmic antibodies (ANCAs). Complement levels were normal (C3 levels 122.13<span class="elsevierStyleHsp" style=""></span>mg/dL, C4 levels 42<span class="elsevierStyleHsp" style=""></span>mg/dL). No other laboratory parameters were obtained.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A femoral and popliteal embolectomy was performed, in which severe soft tissue fibrosis and encapsulated bodies were observed. She received enoxaparin 50<span class="elsevierStyleHsp" style=""></span>mg bid and low dose oral glucocorticoid (prednisone 5<span class="elsevierStyleHsp" style=""></span>mg QD) by considering biopolymers as possible triggers of this inflammatory/autoimmune phenomenon. The patient had favorable evolution. A timeline of the clinical findings and evolution is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. Unfortunately, the patient did not attend the respective follow-up in subsequent controls. Thus, its clinical and laboratory evolution is unknown.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In 2011 Shoenfeld proposed that siliconosis, macrophagic myofasciitis syndrome (MMF), gulf war syndrome (GWS) and post-vaccination phenomena that share clinical and pathogenic resemblances were included under a common syndrome entitled the “Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants” (ASIA).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) groups non-specific disorders characterized by dysregulations in the immune system following exposure to an adjuvant. Amongst systemic clinical manifestations of ASIA syndrome, the most common are arthralgia, chronic fatigue, fever and lymphadenopathy; the median time described between exposure to adjuvants and the onset of clinical symptoms ranges from 1 week to 5 years.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Shoenfeld et al. created several major and minor criteria in the diagnosis of the ASIA syndrome. Some of the major criteria were defined as exposure to an external stimuli (infection, vaccine, silicone, adjuvant) prior to clinical manifestations; typical clinical manifestations like myalgia, arthralgia or arthritis; chronic fatigue; neurological manifestations; cognitive impairment; improvement by removal of inciting agent and biopsy of involved organs. Minor criteria range from the presence of autoantibodies or antibodies against the suspected adjuvant to evolvement of an autoimmune disease.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> In a Colombian cohort of 190 patients with ASIA syndrome, the most frequent symptoms were: myalgia (92.1%), arthralgia (77.9%), asthenia and adynamia (77.9%) and neurological findings (55.8%).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Our patient fulfilled three of the major criteria proposed by Shoenfeld<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a>: exposure to an external stimulus (silicone, adjuvant) prior to clinical manifestations, myalgia, and chronic fatigue.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Adjuvants are substances that enhance antigen-specific immune responses, such as aluminum hydroxide, mineral oils, and silicone gel<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a>; patients are usually exposed to adjuvants in the scenario of implanted foreign bodies for esthetic purposes, activating antigen presenting cells and promoting antibody production. Pachón et al. reported the frequency of adjuvants related to ASIA syndrome in their study group; they found that polydimethylsiloxane was the most prevalent (90%), followed by polymethylmethacrylate (6.8%) and paraffin (2.1%).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> T lymphocytes recognize these substances and orchestrate an inflammatory reaction at the injection site, with the consequent development of granulomas. Mobilization of adjuvants into other tissues produce other local or systemic manifestations, including edema, erythema, fistulas and organ failure. However, to our knowledge, there are no reports of arterial thrombosis related to biopolymer injection.</p><p id="par0050" class="elsevierStylePara elsevierViewall">These compounds lead to tissue alterations and injuries. A study that analyze 500 cases from the ASIA syndrome international registry found that 13.8% of patients already had another prior autoimmune disorder before the exposure to foreign materials; additionally, autoimmune susceptibility given by a family history of autoimmune condition was documented in 34.5% of cases.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Despite our patient had no prior personal or family history of autoimmune disorders it is fundamental to highlight the importance of addressing these questions during the patient's evaluation.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In general terms, acute ischemia of a limb can be caused by arterial trauma or acute arterial obstruction<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a>; the latter as consequence of embolism or arterial thrombosis. In our patient, acute ischemia was secondary to arterial obstruction related to biopolymer migration; this substance probably acted as a foreign body and triggered an inflammatory reaction with a subsequent state of hypercoagulability (as evidenced with concomitant deep vein thrombosis), fibrosis and nodule formation.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Clot removal allowed perfusion of the affected extremity. Nevertheless, considering the presence of subcutaneous nodules and systemic manifestations (such as chronic fatigue and myalgias), and anticoagulation with low-molecular-weight heparin; we administered low-dose oral glucocorticoids and hydroxychloroquine for immunomodulation.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Some researchers have proposed that patients with ASIA syndrome should be treated with a multidisciplinary management that involves pain control, evaluation by rheumatology, physiotherapy, psychiatry, and palliative care if necessary to guarantee an adequate follow-up to prevent functional and psychological sequelae.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The use of biopolymers for cosmetic purposes is increasing, with a diverse range of associated complications, many of which can be life-threatening. Patients should be asked about minor procedures and history of autoimmune or autoinflammatory disease if ASIA syndrome is suspected.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical approval</span><p id="par0070" class="elsevierStylePara elsevierViewall">The patient authorized the publication of this case and signed an informed consent for this purpose. The institutional ethics committee approved this work (#502).</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres2206103" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Materials and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1850778" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2206104" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Materiales y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1850777" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Ethical approval" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-08-05" "fechaAceptado" => "2023-03-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1850778" "palabras" => array:5 [ 0 => "Arterial thrombosis" 1 => "Biopolymers" 2 => "Autoimmune diseases" 3 => "Autoimmune/inflammatory syndrome induced by adjuvants" 4 => "Foreign material" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1850777" "palabras" => array:5 [ 0 => "Trombosis arterial" 1 => "Biopolímeros" 2 => "Enfermedades autoinmunes" 3 => "Síndrome autoinmune/inflamatorio inducido por adyuvantes" 4 => "Material extraño" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Demand of biopolymer injections has steadily increased in the last decade. Complications associated with this procedure can be innocuous or even life-threatening, presenting from immediately to years later, locally or systemically, with mechanical, inflammatory, or autoimmune characteristics.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To present a rare manifestation of an increasing health problem, clinicians must be attentive to this kind of complication.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Clinical and laboratory data were searched from the clinical history; informed consent was obtained, and the Ethics Committee of Fundación Valle del Lili reviewed and approved this study. We report a patient who presented long-standing symptoms but only consulted after the onset of an acute lower limb arterial thrombosis that could have been fatal without rapid intervention. Ischemia was secondary to arterial obstruction related to biopolymer migration.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A femoral and popliteal embolectomy was performed in which severe soft tissue fibrosis and encapsulated bodies were observed. The patient received thromboprophylaxis and low-dose oral glucocorticoid presenting a favorable evolution.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This substance probably acted as a foreign body and triggered an inflammatory reaction with a subsequent state of hypercoagulability, fibrosis, and nodule formation.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Materials and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducción</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La demanda de inyecciones de biopolímeros ha aumentado constantemente en la última década. Las complicaciones asociadas con este procedimiento pueden ser inocuas o incluso potencialmente mortales; se presentan desde inmediatamente hasta años después, local o sistémicamente, con características mecánicas, inflamatorias o autoinmunes.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Presentar una rara manifestación de un problema de salud creciente; los médicos deben estar atentos a este tipo de complicación.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Materiales y métodos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los datos clínicos y de laboratorio se buscaron en la historia clínica; se obtuvo el consentimiento informado y el Comité de Ética de la Fundación Valle del Lili revisó y aprobó este estudio. Reportamos un paciente que presentaba síntomas de larga evolución, pero que solo consultó tras el inicio de una trombosis arterial aguda de miembros inferiores que podría haber sido mortal de no ser por una intervención rápida. La isquemia fue secundaria a obstrucción arterial relacionada con la migración de biopolímeros.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se realizó embolectomía femoral y poplítea en la que se observó fibrosis severa de partes blandas y cuerpos encapsulados. El paciente recibió tromboprofilaxis y glucocorticoides orales a dosis bajas, y presentó evolución favorable.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Esta sustancia probablemente actuó como un cuerpo extraño y desencadenó una reacción inflamatoria con un posterior estado de hipercoagulabilidad, fibrosis y formación de nódulos.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Materiales y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 827 "Ancho" => 1340 "Tamanyo" => 136236 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions of the lower limbs. Panel A. Medial surface of the right thigh: warm, tenderness, mild induration and associated erythema. Panel B. Left leg: her left leg was cold; both soles of her feet had violaceous discoloration, which was more pronounced in the right foot.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1113 "Ancho" => 2925 "Tamanyo" => 223070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Timeline of the clinical findings and evolution.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cosmetic Surgery National Data Bank Statistics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Data" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/asj/sjx076" "Revista" => array:8 [ "tituloSerie" => "Aesthet Surg J" "fecha" => "2017" "volumen" => "37" "numero" => "Suppl. 2" "paginaInicial" => "1" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28388734" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109719305662" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0045" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Shoenfeld" 1 => "N. Agmon-Levin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaut.2010.07.003" "Revista" => array:6 [ "tituloSerie" => "J Autoimmun" "fecha" => "2011" "volumen" => "36" "paginaInicial" => "4" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20708902" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0050" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Características de individuos sometidos a infiltración de materiales extraños con fines estéticos sobre los que se realizó investigación judicial en Colombia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Cala-Uribe" 1 => "A. Navarro-Escobar" 2 => "J.C. León" 3 => "D. Buitrago-García" 4 => "A. Teherán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cir Plást Iberolatinoam [Internet]" "fecha" => "2017" "volumen" => "43" "paginaInicial" => "137" "paginaFinal" => "142" "itemHostRev" => array:3 [ "pii" => "S0735109720378670" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Schmid" 1 => "A. Tzur" 2 => "L. Leshko" 3 => "B.P. Krieger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.6.2276" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "2276" "paginaFinal" => "2281" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947350" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0060" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: insights from an analysis of 500 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Watad" 1 => "N.L. Bragazzi" 2 => "D. McGonagle" 3 => "M. Adawi" 4 => "C. Bridgewood" 5 => "G. Damiani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clim.2019.03.007" "Revista" => array:5 [ "tituloSerie" => "Clin Immunol" "fecha" => "2019" "volumen" => "203" "paginaInicial" => "1" "paginaFinal" => "8" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical and immunological characteristics of patients with biopolymers and autoimmune inflammatory syndrome induced by adjuvants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.E. Pachón" 1 => "M.C. Salazar" 2 => "A.M. Pores" 3 => "V.Z. Rizo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/GOX.0000000000003796" "Revista" => array:5 [ "tituloSerie" => "Plast Reconstr Surg Glob Open" "fecha" => "2021" "volumen" => "9" "paginaInicial" => "e3796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34667709" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification for staging and managing patients with biopolymer-induced human adjuvant disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.E. Pachón" 1 => "M.C. Salazar" 2 => "V.Z. Rizo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/GOX.0000000000004137" "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg Glob Open" "fecha" => "2022" "volumen" => "10" "paginaInicial" => "e4137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35233337" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109722049816" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/24444405/0000003100000002/v1_202407190845/S2444440524000633/v1_202407190845/en/main.assets" "Apartado" => array:4 [ "identificador" => "53647" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24444405/0000003100000002/v1_202407190845/S2444440524000633/v1_202407190845/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440524000633?idApp=UINPBA00004N" ]
Información de la revista
Compartir
Descargar PDF
Más opciones de artículo
Case Report
Lower limb arterial thrombosis due to biopolymer injection: A case report
Trombosis arterial de miembros inferiores por inyección de biopolímeros: reporte de caso
Milly J. Vecino-Morenoa, Álvaro J. Vivasb, Gabriel J. Tobónc, David Aguirre-Valenciad,e,
Autor para correspondencia
a Department of Clinical Sciences, Rheumatology Unit, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia
b Department of Research and Innovation, Clinical Research Center, Fundación Valle del Lili, Cali, Colombia
c Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, Springfield, IL, USA
d Department of Clinical Sciences, Center for Research in Rheumatology, Autoimmunity and Translational Medicine, Universidad Icesi, Cali, Colombia
e Department of Internal Medicine, Rheumatology Unit, Fundación Valle del Lili, Cali, Colombia