Article
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
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Análisis cuantitativo mediante MI Neurology de Siemens® sin alteraciones estadísticamente significativas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Carrillo-Villamizar, A. Cardozo-Saavedra, C. Lorenzo-Bosquet, S. Lucas del Pozo, E. Martínez-Sáez, J. Hernández-Vara" "autores" => array:6 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Carrillo-Villamizar" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Cardozo-Saavedra" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Lorenzo-Bosquet" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Lucas del Pozo" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Martínez-Sáez" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Hernández-Vara" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808921001038" "doi" => "10.1016/j.remnie.2021.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921001038?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X21000573?idApp=UINPBA00004N" "url" => "/2253654X/0000004100000001/v1_202201060709/S2253654X21000573/v1_202201060709/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2253808921001646" "issn" => "22538089" "doi" => "10.1016/j.remnie.2021.11.001" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "1348" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41:55-65" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Continuing Education</span>" "titulo" => "Peptide receptor radionuclide therapy with [<span class="elsevierStyleSup">177</span>Lu]Lu-DOTA-TATE" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "55" "paginaFinal" => "65" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Terapia con péptidos radiomarcados con [<span class="elsevierStyleSup">177</span>Lu]Lu-DOTA-TATE" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1761 "Ancho" => 2500 "Tamanyo" => 279049 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mechanism of action of [<span class="elsevierStyleSup">177</span>Lu]Lu-DOTA-TATE.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. 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Carrillo-Villamizar, A. Cardozo-Saavedra, C. Lorenzo-Bosquet, S. Lucas del Pozo, E. Martínez-Sáez, J. Hernández-Vara" "autores" => array:6 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Carrillo-Villamizar" "email" => array:1 [ 0 => "elicavi88@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Cardozo-Saavedra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Lorenzo-Bosquet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "S." 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"apellidos" => "Hernández-Vara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, Hospital Universitari Vall d’Hebron, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grupo de Investigación en Enfermedades Neurodegenerativas, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Sección Neuropatología, Hospital Universitari Vall d’Hebron, Banco de Tejidos Neurológicos, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Neurología, Hospital Universitari Vall d’Hebron, Grupo de Investigación en Enfermedades Neurodegenerativas, Vall d’Hebron Institut de Recerca (VHIR), Banco de Tejidos Neurológicos, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome córticobasal: un caso de discordancia entre la clínica y los biomarcadores de imagen" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3199 "Ancho" => 2500 "Tamanyo" => 686615 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG. Quantitative analysis using MI Neurology from Siemens® without statistically significant alterations.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a 59-year-old man who consulted for a clinical condition that had started in the previous 6 months, consisting of motor clumsiness and gait disorder. The physical examination highlighted a predominantly left akinetic-rigid syndrome, ipsilateral hemiapraxia, left hand pyramidalism with dystonic posture, and the "Alien Hand" phenomenon. General laboratory tests were normal. Brain MRI showed a moderate/severe degree of symmetric global brain atrophy and signs of leukoaraiosis. The presynaptic dopamine transporters SPECT (123I-FP-CIT SPECT) showed no alterations (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG showed no alterations in brain metabolism (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The electromyogram showed a marked impairment of the first motor neuron in the left lower limb.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Clinically, the patient fulfilled the clinical criteria for a probable corticobasal syndrome (CBS). In the following months, he presented a progressive clinical worsening, dying due to a hematoma secondary to traumatic brain injury.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the anatomopathological study, a systematic sampling of different areas was carried out, finding abundant phosphorylated tau deposits in the form of neurofibrillary tangles and pretangles, balloonized neurons, tufted astrocytes and oligodendroglial inclusions. The distribution of this deposits was mainly brainstem, with little cortical involvement. It was compatible with progressive supranuclear palsy (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleSup">123</span>I-FP-CIT SPECT evaluates the presynaptic integrity of the nigrostriatal dopaminergic neurons of the pars compact of the substantia nigra, showing a high sensitivity for parkinsonisms; however, in some series, as many as 10% of patients with diagnosis of CBS did not present a pathological result.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On the other hand, brain PET with <span class="elsevierStyleSup">18</span>F-FDG evaluates different patterns of brain hypometabolism with a sensitivity up to 93% and specificity up to 90% for differentiating the different atypical parkinsonisms (PSP,<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">1</span></a> MSA<a class="elsevierStyleCrossRef" href="#fn0010"><span class="elsevierStyleSup">2</span></a> and CBD<a class="elsevierStyleCrossRef" href="#fn0015"><span class="elsevierStyleSup">3</span></a>); likewise, some series have established different patterns of hypometabolism in relation to the underlying primary neurodegenerative pathology, correlating these findings with a post-mortem neuropathological examination and thus demonstrating that brain PET scan with <span class="elsevierStyleSup">18</span>F-FDG is an effective complementary tool in differentiation of atypical parkinsonisms.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">From the clinical point of view, the absence of alterations in the brain <span class="elsevierStyleSup">18</span>F- FDG PET could lead to reconsideration of the diagnosis of a CBS, regardless of the underlying pathological substrate (CBD, Alzheimer's Disease, PSP).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Atypical parkinsonisms are complex pathologies whose phenotypic overlap and pathophysiological mechanisms, not yet fully clarified, make their "in vivo" diagnosis remain a clinical challenge, despite the currently available biomarkers that have improved the diagnostic approaches and characterization of the different entities. These should not be considered as definitive and excluding criteria, since, as we exemplify with the current case, despite the negativity of all of all these tests, finally, the histopathological study can confirm the presence of a taupathy that, in this patient, explained the neurological symptoms and his clinical evolution.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:4 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Carrillo-Villamizar E, Cardozo-Saavedra A, Lorenzo-Bosquet C, Lucas del Pozo S, Martínez-Sáez E, Hernández-Vara J. Síndrome Córticobasal: un caso de discordancia entre la clínica y los biomarcadores de imagen. Rev Esp Med Nucl Imagen Mol. 2022;41:51–53.</p>" ] 1 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Progressive supranuclear palsy.</p>" "identificador" => "fn0005" ] 2 => array:3 [ "etiqueta" => "2" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Multiple system atrophy.</p>" "identificador" => "fn0010" ] 3 => array:3 [ "etiqueta" => "3" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Corticobasal degeneration.</p>" "identificador" => "fn0015" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1797 "Ancho" => 2500 "Tamanyo" => 329048 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">123</span>I-FP-CIT SPECT without presynaptic dopaminergic involvement.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3199 "Ancho" => 2500 "Tamanyo" => 686615 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG. Quantitative analysis using MI Neurology from Siemens® without statistically significant alterations.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1122 "Ancho" => 1500 "Tamanyo" => 318935 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histologically, scarce deposits of phosphorylated tau were observed in the frontal cortex, mainly in the pretangles form (A, AT8, 100x), somewhat more abundant in the caudate nucleus (B, AT8, 100×) and very frequent in the midbrain (C, red nucleus, AT8, 100×) and the pons (D, base nuclei, AT8, 100×), with abundant pretangles, ovoid tangles, tufted astrocytes and oligodendroglial inclusions.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dopamine transporter SPECT imaging in corticobasal syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Cilia" 1 => "C. Rossi" 2 => "D. Frosini" 3 => "D. Volterrani" 4 => "C. Siri" 5 => "C. Pagni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0018301" "Revista" => array:5 [ "tituloSerie" => "PLoS One" "fecha" => "2011" "volumen" => "6" "paginaInicial" => "e18301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21559307" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiological biomarkers for diagnosis in PSP: where are we and where do we need to be?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Whitwell" 1 => "G.U. Höglinger" 2 => "A. Antonini" 3 => "Y. Bordelon" 4 => "A.L. Boxer" 5 => "C. Colosimo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mds.27038" "Revista" => array:6 [ "tituloSerie" => "Mov Disord" "fecha" => "2017" "volumen" => "32" "paginaInicial" => "955" "paginaFinal" => "971" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28500751" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FDG-PET patterns associated with underlying pathology in corticobasal syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Pardini" 1 => "E.D. Huey" 2 => "S. Spina" 3 => "W.C. Kreisl" 4 => "S. Morbelli" 5 => "E.M. Wassermann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/WNL.0000000000007038" "Revista" => array:5 [ "tituloSerie" => "Neurology" "fecha" => "2019" "volumen" => "92" "paginaInicial" => "1" "paginaFinal" => "15" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000004100000001/v1_202201040537/S2253808921001038/v1_202201040537/en/main.assets" "Apartado" => array:4 [ "identificador" => "7927" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000004100000001/v1_202201040537/S2253808921001038/v1_202201040537/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921001038?idApp=UINPBA00004N" ]
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The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.
Science Citation Index Expander, Medline, IME, Bibliomed, EMBASE/Excerpta Medica, Healthstar, Cancerlit, Toxine, Inside Conferences, Scopus
See moreThe Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.
© Clarivate Analytics, Journal Citation Reports 2022
SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
See moreSNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.
See moreRevista Española de Medicina Nuclear e Imagen Molecular (English Edition)
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