Información del artículo
Resumen
La naturaleza de la asociación entre radicales libres y cáncer es compleja y paradójica. Parece que los radicales libres y el estrés oxidativo pueden inducir cáncer, pero al mismo tiempo las células transformadas, es decir, las células cancerosas, generan más radicales libres que las células normales. Compuestos endógenos antioxidantes, entre ellos el glutatión y la lisozima, pueden limitar los efectos del estrés oxidativo; sin embargo, dichos sistemas pueden ser rápidamente acaparados por elevadas cantidades de radicales libres. De ahí la importancia de incrementar la concentración de antioxidantes de la célula para prevenir posibles agentes adversos que podrían llegar a originar un proceso canceroso. Una buena alimentación, así como conocer y emplear alimentos con propiedades antioxidantes, puede ser de gran ayuda para la prevención del cáncer.
Palabras clave:
Cáncer
Radicales libres
Antioxidantes
Lisozima
Glutatión
Abstract
The nature of the association between free radicals and cancer is complex and paradoxical, as it seems that free radicals and oxidative stress can induce cancer, but at the same time the transformed cells, that is, the cancer cells generate more free radicals than normal cells. Endogenous antioxidant compounds, including glutathione and lysozyme, can limit the effects of oxidative stress, but these systems can be quickly saturated by high amounts of free radicals. It is important to increase the cellular levels of antioxidants that could provide protection against possible adverse agents that can cause a cell cancer. A good diet and the knowledge of several compounds of foods with antioxidant effects may be helpful to prevent cancer disease.
Keywords:
Cancer
Free radicals
Antioxidant
Lysozyme
Glutathione
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Bibliografía
[1.]
M. Adachi, Y. Zhang, X. Zhao, T. Minami, R. Kawamura, Y. Hinoda, et al.
Clin Cancer Res, 10 (2004), pp. 3853-3862
[2.]
P. Anand, A.B. Kunnumakkara, A.B. Kunnumakara, et al.
Cancer is a preventable disease that requires major lifestyle changes.
Pharm Res, 25 (2008), pp. 2097-2116
[3.]
K.W. Kinzler, B. Vogelstein.
The genetic basis of human cancer.
2.a ed, McGraw-Hill, (2002),
[4.]
P. Irigaray, J.A. Newby, R. Clapp, et al.
Lifestyle-related factors and environmental agents causing cancer: an overview.
Biomed Pharmacother, 61 (2007), pp. 640-658
[6.]
E. Roche, D. Romero.
Estrés oxidativo y degradación de proteínas.
Med Clin (Barc), 103 (1994), pp. 189-196
[7.]
Cotran RS, et al. Patología estructural y funcional. 5.a ed. Mc-Graw-Hill/Interamericana.
[8.]
M.A. Martins, et al.
Interaction between inflammation and systemic haematologic effect of PAF-acether in the rat.
L Pharmacol, 36 (1989), pp. 333-360
[9.]
S. Jiménez.
Antioxidantes y RL en el tabaquismo.
Solo-Mujeres, (2003),
[10.]
Knight J. Free radicals: their history and current status in aging and disease. Ann Clin Lab Sci. 28:331-46.
[11.]
I. Coulter, M. Hardy, S. Morton, L. Hilton, W. Tu, D. Valentine, et al.
Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer.
J Gen Intern Med, 21 (2007), pp. 735-744
[12.]
K. Hirota, M. Murata, Y. Sachi, H. Nakamura, J. Takeuchi, K. Mori, et al.
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-κB.
J Biol Chem., 274 (1999), pp. 27891-27897
[13.]
P. Perez-Galan, G. Roue, N. Villamar, E. Campo, D. Colomer.
The proteasome inhibitor bortezomib induces apoptosis in mantlecell lymphoma through generation of ROS and Noxa activation independent of p53 status.
Blood, 107 (2006), pp. 257-264
[14.]
S. Atalla, L.H. Toledo-Pereya, G.H. McKenzie, J.P. Cederna.
Influence of oxygen-derived free scavengers.
Transplantation, 40 (1985), pp. 584-590
[15.]
McWen BS. Protective and damaging effects of stress mediators. N Engl J Med.
[16.]
A.J. De Ross, et al.
Cancer incident among Glyphosate-Exposed Pesticida Applicators in the Agricultural Health Study.
Environ Health Perspect, 113 (2005), pp. 49-54
[17.]
T. Shimosawa.
[Increasing oxidative stress in aging].
Nippon Rinsho, 63 (2005), pp. 994-999
[18.]
P.A. Southern, G. Powis.
Medicine. II. Involvement in human disease.
Mayo Clin Proc, 63 (1994), pp. 390-404
[19.]
Altamar J. Herbicidas y Malf. Congén. en el Meta, Colombia. Actividad Patogénica de los RL. Orinoquia, Villavicencio, Colombia, 2002; 6: 9-35.
[20.]
A.C. Guyton, et al.
Tratado de Fisiología.
9. aed., Mc-Graw-Hill/Interamericana, (1997),
[21.]
Villa Pérez M. RL de O2 y la enfermedad. Conferencia en la VI Reunión del Grupo Español de RL. Cádiz, 26-28 de Junio de 2002.
[22.]
A.J. De Ross, et al.
Cancer incidente among Glyphosate-Exposed Pesticida Applicators in the Agricultural Health Study.
Environ Health Perspect, 113 (2005), pp. 49-54
[23.]
B. Hallivell, review. Current.
Free reactive oxygen species human disease, a critical evaluation with special reference to aterosclerosis.
B Exp Path, 70 (1995), pp. 737-757
[24.]
D.C. Wallace.
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
Annu Rev Genet, 39 (2005), pp. 359-407
[25.]
J.A. Petros, A.K. Baumann, E. Ruiz-Pesini, M.B. Amin, C.Q. Sun, J. Hall, et al.
Proc Natl Acad Sci U S A., 102 (2005), pp. 719-724
[27.]
P. Schumacker.
Reactive oxygen species in cancer cells: Live by the sword, die by the sword.
Cancer Cell, 10 (2006), pp. 175-176
[28.]
J.A. Bertout, S.A. Patel, M.C. Simon.
The impact of O2 availability on human cancer.
Nat Rev Cancer, 8 (2008), pp. 967-975
[29.]
E.B. Rankin, A.J. Giaccia.
The role of hypoxia-inducible factors i n tumorogenesis.
Cell Death Differ, 15 (2008), pp. 678-685
[30.]
N.C. Denko.
Hypoxia, HIF1 and glucosa metabolism in the solid tumor.
Nat Rev Cancer, 8 (2008), pp. 705-713
[31.]
R.D. Guzy, B. Hoyos, E. Robin, et al.
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Cell Metab, 1 (2005), pp. 401-408
[32.]
J.M. Lluis, F. Buricchi, P. Chiarugi, A. Morales, J.C. Fernandez-Checa.
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-kappa B via c-SRC and oxidant-dependent cell death.
Cancer Res, 67 (2007), pp. 7368-7377
[33.]
D. Han, N. Hanawa, B. Saberi, N. Kaplowitz.
Mechanisms of liver injury Role of glutathione redox status in liver injury.
Am J Physiol Gastrointest Liver Physiol, 291 (2006), pp. G1-G7
[34.]
J. Altamar.
The role of lysozime on etiopathogenesis and treatment on juvenile laryngeal papillomatosis.
Otolaryngol Torino, 44 (1998), pp. 17-20
[35.]
G. Bjelakovic, L.L. Gluud, D. Nikolova, M. Bjelakovic, A. Nagorni, C. Gluud.
Antioxidant supplements for liver diseases.
Cochrane Database Syst Rev, (2011),
[36.]
A. Cranganu, J. Camporeale.
Nutrition aspects of lung cancer.
Nutr Clin Pract, 24 (2009), pp. 688-700
[37.]
C. Persson, S. Sasazuki, M. Inoue, N. Kurahashi, M. Iwasaki, T. Miura, et al.
Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study.
Carcinogenesis, 29 (2008), pp. 1042-1048
[38.]
J.C. Charniot, N. Vignat, J.P. Albertini, V. Bogdanova, K. Zerhouni, J.J. Monsuez, et al.
Oxidative stress in patients with acute heart failure.
Rejuvenation Res, 11 (2008), pp. 393-398
[39.]
Eledrisi MS, McKinney K, Shanti MS. Vitamin A toxicity [citado 2 Sep 2009]. Disponible en: http://emedicine.medscape.com/article/126104-overview
[40.]
G. Litwack, A. Vitamin.
Vitamins and hormones.
Elsevier, (2007),
[41.]
L.G. Wilson.
The clinical definition of scurvy and the discovery of vitamin C.
J Hist Med, (1975), pp. 40-60
[42.]
J.J. Challem, E.W. Taylor.
Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens.
Free Radical Biology and Medicine, 25 (1998), pp. 130-132
[43.]
G. Bánhegyi, L. Braun, M. Csala, F. Puskás, J. Mandl.
Ascorbate metabolism and its regulation in animals.
Free Radical Biology and Medicine, 23 (1997), pp. 793-803
[44.]
E. Villamor, I.N. Koulinska, S. Aboud, C. Murrin, R.J. Bosch, K.P. Manji, et al.
Effect of vitamin supplements on HIV shedding in breast milk.
Am J Clin Nutr, 92 (2010), pp. 881-886
[45.]
J. Huang, D.B. Agus, C.J. Winfree, S. Kiss, W.J. Mack, R.A. McTaggart, et al.
Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.
Proc Natl Acad Sci, 98 (2001), pp. 11720-11724
[46.]
T.E. Ichim, B. Minev, T. Braciak, B. Luna, R. Hunninghake, N.A. Mikirova, et al.
Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?.
J Transl Med, 9 (2011), pp. 25
[47.]
Institute of Medicine, Food and Nutrition board.
Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium and Carotenoids.
National Academy Press, (2000),
[48.]
H. Rosenberg, A.N. Feldzamen.
The book of vitamin therapy.
Berkley, (1974),
[49.]
G.K. Balendiran, R. Dabur, D. Fraser.
The role of glutathione in cancer.
Cell Biochem Funct, 22 (2004), pp. 343-352
[50.]
A. Pompella, A. Visvikis, A. Paolicchi, V. De Tata, A.F. Casini.
The changing faces of glutathione, a cellular protagonist.
Biochem Pharmacol, 66 (2003), pp. 1499-1503
[51.]
G. Bounous, P. Gold.
The biological activity of undenatured dietary whey proteins: role of glutathione.
Clin Invest Med, 14 (1991), pp. 296-309
[52.]
A. Meister, N. Yaniguchi, T. Higashi, Y. Sakamoto.
Glutathione centennial.
Academic Press, (1989),
[53.]
O. Griffith, A. Meister.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine.
J Biol Chem, 254 (1979), pp. 7558-7560
[54.]
A. Meister.
Glutathione metabolism.
Methods Enzymol Rev, 251 (1995), pp. 3-7
[55.]
G. Wu, Y.Z. Fang, S. Yang, J.R. Lupton, N.D. Turner.
Glutathione metabolism and its implications for health.
J Nutr, 134 (2004), pp. 489-492
[56.]
A. Cooper.
Biochemistry of sulfur-containing amino acids.
Annu Rev Biochem, 52 (1983), pp. 187-222
[57.]
A. Wahllander, A. Soboll, H. Sies.
Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S- transferases.
FEBS Lett, 97 (1975), pp. 138-140
[58.]
C. García-Ruiz, A. Morales, A. Colell, A. Ballesta, J. Rodés, N. Kaplowitz, et al.
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes.
J Clin Invest, 94 (1994), pp. 193-201
[59.]
G. Sa, T. Das, C. Moon, et al.
GD3, an overexpressed tumor-derived ganglioside, mediates apoptosis of activated but not resting T cells.
Cancer Res, 69 (2009), pp. 3095-3104
[60.]
A. Witschi, S. Reddy, B. Stofer, B.H. Lauterburg.
The systemic availability of oral glutathione.
Eur J Clin Pharmacol, 43 (1992), pp. 667-669
[61.]
C.S. Liber, S-Adenosyl-L-methionine:.
its role in the treatment of liver disorders.
Am J Clin Nutr, 76 (2002), pp. S1183-S1187
[62.]
G. Vendemiale, E. Altomare, T. Trizio, C. Le Grazie, C. Di Padova, M.T. Salerno, et al.
Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease.
Scand J Gastroenterol, 24 (1989), pp. 407-415
[63.]
C. Loguercio, G. Nardi, F. Argenzio, C. Aurilio, E. Petrone, A. Grella, et al.
Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease.
Alcohol Alcohol, 29 (1994), pp. 597-604
[64.]
C.L. Gross, J.K. Innace, R.C. Hovatter, H.L. Meier, W.J. Smith.
Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard.
Cell Biol, 9 (1993), pp. 259-267
[65.]
Y.F. Moreno, V.C. Sgarbieri, M.N. Da Silva, A.A. Toro, M.M. Vilela.
Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection.
J Trop Pediatr, 52 (2006), pp. 34-38
[66.]
V. Grey, S.R. Mohammed, A.A. Smountas, R. Bahlool, L.C. Lands.
Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein.
J Cyst Fibros, 2 (2003), pp. 195-198
[67.]
P. Micke, K.M. Beeh, R. Buhl.
Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIVinfected patients.
Eur J Nutr, 41 (2002), pp. 12-18
[68.]
G. Bounous, S. Baruchel, J. Falutz, P. Gold.
Whey proteins as a food supplement in HIV-seropositive individuals.
Clin Invest Med, 16 (1993), pp. 204-209
[69.]
K.P. Shay, R.F. Moreau, E.J. Smith, A.R. Smith, T.M. Hagen.
Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential.
Biochim Biophys Acta, 1790 (2009), pp. 1149-1160
[70.]
E. Busse, G. Zimmer, B. Schopohl, B. Kornhuber.
Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.
Arzneimittelforschung, 42 (1992), pp. 829-831
[71.]
L.R. Barlow-Walden, R.J. Reiter, M. Abe, M. Pablos, A. Menendez-Pelaez, L.D. Chen, et al.
Melatonin stimulates brain glutathione peroxidase activity.
Neurochem Int, 26 (1995), pp. 497-502
[72.]
C. Nencini, G. Giorgi, L. Micheli.
Protective effect of silymarin on oxidative stress in rat brain.
Phytomedicine, 14 (2007), pp. 129-135
[73.]
A. Valenzuela, M. Aspillaga, S. Vial, R. Guerra.
Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat.
Planta Med, 55 (1989), pp. 420-422
[74.]
Immunocal Powder Sachets patient advice including side effects.
[75.]
L.A. Herzenberg, S.C. De Rosa, J.G. Dubs, M. Roederer, M.T. Anderson, S.W. Ela, et al.
Glutathione deficiency is associated with impaired survival in HIV disease.
Proc Natl Acad Sci U S A, 94 (1997), pp. 1967-1972
[76.]
Y.H. Han, W.H. Park.
The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione.
Oncol Rep, 22 (2009), pp. 385-391
[77.]
H.H. Chow, I.A. Hakim.
Modulation of human glutathione s-transferases by polyphenone intervention.
Cancer Epidemiol Biomarkers Prev, 16 (2007), pp. 1662-1666
[78.]
G.K. Balendiran, R. Dabur, D. Fraser.
The role of glutathione in cancer.
Cell Biochem Funct, 22 (2004), pp. 343-352
[79.]
K. Jomova, Z. Jenisova, M. Feszterova, S. Baros, J. Liska, D. Hudecova, et al.
Arsenic: toxicity, oxidative stress and human disease.
J Appl Toxicol, 31 (2011), pp. 95-107
[80.]
G. Ambrozova, M. Pekarova, A. Lojek.
The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Toxicol In Vitro, 25 (2011), pp. 145-152
[81.]
H. Rammal, J. Bouayed, C. Younos, R. Soulimani.
Evidence that oxidative stress is linked to anxiety-related behaviour in mice.
Brain Behav Immun, 22 (2008), pp. 1156-1159
[82.]
E. Giovannucci, A. Ascherio, E.B. Rimm, M.J. Stampfer, G.A. Colditz, W.C. Willett.
Intake of carotenoids and retinol in relation to risk of prostate cancer.
J Natl Cancer Inst, 87 (1995), pp. 1767-1776
[83.]
E. Giovannucci, W.C. Willett, M.J. Stampfer, Y. Liu, E.B. Rimm.
A prospective study of tomato products, lycopene, and prostate cancer risk.
J Natl Cancer Inst, 94 (2002), pp. 391-396
[84.]
J. Woodside, D. McCall, C. McGartland, I. Young.
Micronutrients: dietary intake v. supplement use.
Proc Nutr Soc, 64 (2005), pp. 543-553
[85.]
G. Cao, R. Prior.
Comparison of different analytical methods for assessing total antioxidant capacity of human serum.
Clin Chem, 44 (1998), pp. 1309-1315
[86.]
K. Marshall.
Therapeutic applications of whey protein.
Altern Med Rev, 9 (2004), pp. 136-156
[87.]
C.B. Pocernich, M.L. Bader Lange, R. Sultana.
Butterfield DA Nutritional approaches to modulate oxidative stress in Alzheimer's disease.
Curr Alzheimer Res, 8 (2011), pp. 452-469
[88.]
K.J. Lee, C.Y. Choi, Y.C. Chung, Y.S. Kim, S.Y. Ryu, S.H. Roh, et al.
Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity.
Toxicol Lett, 147 (2004), pp. 271-282
[89.]
M. Banni, L. Chouchene, K. Said, A. Kerkeni, I. Messaoudi.
Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio.
Biometals, (2011),
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