Mucinosis nodular de la mama

Resumen

La mucinosis nodular de la mama es una rara entidad de histogénesis incierta y con comportamiento benigno. Suele presentarse como una tumoración asintomática en torno a pezón o areola y localizada en dermis o tejido celular subcutáneo. Presentamos un caso de mucinosis nodular típica. Histológicamente se define por estar constituida por lagos irregulares de mucina negativos con PAS pero positivos con hierro coloidal y azul alcián. La mucina se acompaña de estroma fibroso con un escaso componente de células fusiformes. Algunos autores sugieren un posible origen miofibroblástico. No obstante no se han realizado estudios moleculares de la mucinosis nodular. El diagnóstico diferencial se ha de hacer principalmente con lesiones mamarias benignas y malignas de estroma mucinoso. En la literatura se describen 13 casos de mucinosis nodular.

Abstract

Nodular mucinosis of the breast is a rare entity of uncertain histogenesis and with benign behavior. It usually presents as an asymptomatic tumor around the nipple or areola and located in the dermis or subcutaneous cellular tissue. We present a case of typical nodular mucinosis. Histologically it is defined as being composed of irregular lakes of mucin negative with PAS but positive with colloidal iron and alcian blue. Mucin is accompanied by fibrous stroma with a scarce component of fusiform cells. Some authors suggest a possible myofibroblastic origin. However, molecular studies of nodular mucinosis have not been performed. The differential diagnosis must be made mainly with benign and malignant mammary lesions of mucinous stroma. In the literature, 13 cases of nodular mucinosis are described.