Información del artículo
Abstract
There is a strong association between cardiovascular diseases, thromboembolism, and atherosclerosis with endothelial dysfunction. The relationship of the latter with neuropsychiatric diseases such as the post traumatic stress disorder (PTSD) stands as a risk factor for the development of atherosclerotic phenomena.
ObjectiveTo disclose a meaningful association between PTSD and higher values of endothelial dysfunction molecules like e-Selectin, s-ICAM-1 and v-CAM-1, in comparison with healthy subjects without PTSD.
Methods24 patients with PTSD and 24 healthy subjects were selected e-Selectin, v-CAM-1 e soluble ICAM-1 levels were measured in plasma. The PTSD severity symptoms scale and the Trauma Symptom Checklist were administered to both samples.
ResultsA meaningful and robust correlation between endothelial dysfunction markers e-Selectin, s-ICAM-1 y v-CAM-1 plasma levels and the severity of the PTSD was disclosed.
ConclusionThere is a continual relationship between PTSD symptoms severity and plasmatic levels of endothelial dysfunction markers. This relationship can explain the probability of developing cardiovascular diseases and atherogenesis and traumatic life events which ends up as PTSD at common grounds with inflammatory vascular response.
Keywords:
Post traumatic stress disorder
Endothelial dysfunction
E-Selectin
V-CAM-1
S-ICAM-1
Resumen
La asociación de enfermedades cardiovasculares, tromboembolismo y aterosclerosis se asocia significativamente con disfunción endotelial. La posibilidad de asociación de esta última con enfermedades psiquiátricas como el trastorno por estrés postraumático (TEPT) constituiría un factor de riesgo para el desarrollo de fenómenos de aterosclerosis.
ObjetivoDetectar una asociación significativa entre el TEPT y mayores valores de moléculas de disfunción endotelial como e-Selectina, s-ICAM-1 y v-CAM-1, en comparación con sujetos sanos sin TEPT.
MétodosSe seleccionaron 24 pacientes con TEPT y 24 sujetos sanos control sin TEPT y se midieron e-Selectina, v-CAM-1 e ICAM-1 soluble en plasma en ambos grupos. Además se les administró la escala de gravedad de síntomas del trastorno por estrés postraumático y el Trauma Symptom Checklist para evaluación del TEPT.
ResultadosSe comprobó una asociación significativa y robusta entre e-Selectina, s-ICAM-1 y v-CAM-1 y la gravedad del TEPT.
ConclusionesHay una relación continua entre la severidad de los síntomas de TEPT y los niveles plasmáticos de marcadores de disfunción endotelial. Este vínculo puede explicar la asociación entre la probabilidad de desarrollar enfermedades cardiovasculares y aterogénesis y los eventos traumáticos conducentes a desarrollar TEPT en el nivel de la respuesta vascular inflamatoria común.
Palabras clave:
Trastorno de estrés postraumático
Disfunción endotelial
E-Selectina
V-CAM-1
S-ICAM-1
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