metricas
covid
Buscar en
Spanish Journal of Psychiatry and Mental Health
Toda la web
Inicio Spanish Journal of Psychiatry and Mental Health Intestinal permeability and low-grade chronic inflammation in schizophrenia: A m...
Información de la revista
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Clinical trials and protocols
Disponible online el 23 de octubre de 2023
Intestinal permeability and low-grade chronic inflammation in schizophrenia: A multicentre study on biomarkers. Rationale, objectives, protocol and preliminary results
Gerard Anmellaa,b,c,1, Silvia Amorettia,b,c,d,1, Gemma Safontb,e, Ana Meseguera,b,c, Eduard Vietaa,b, Maria Teresa Pons-Cabreraa,b,c, Miqueu Alfonsof, Carla Hernándezf, Monica Sanchez-Autetf, Ferran Pérez-Baldelloue, Leticia González-Blancog,h, Maria Paz García-Portillag,h, Miquel Bernardob,c,
Autor para correspondencia
bernardo@clinic.cat

Corresponding author.
, Belén Arranzb,f
a Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Institute of Neuroscience, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain
b Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain
c Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona, Institute of Neuroscience, University of Barcelona, IDIBAPS, Spain
d Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain
e Department of Psychiatry, Hospital Universitari Mutua de Terrassa, Universitat de Barcelona, Barcelona, Spain
f Department of Psychiatry, Hospital Parc Sanitari Sant Joan de Déu, Barcelona, Spain
g Department of Psychiatry, University of Oviedo, Servicio de Salud Mental del Principado de Asturias, Oviedo, Spain
h Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), INEUROPA, Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Oviedo, Spain
Recibido 21 Diciembre 2022. Aceptado 18 Septiembre 2023
Información del artículo
Resumen
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Tablas (1)
Table 1. Characteristics of the sample (N=646).
Material adicional (1)
Abstract
Background

Altered intestinal permeability and low-grade chronic inflammation disrupt the integrity of the blood–brain barrier (microbiota–gut–brain axis), probably playing a role in the pathophysiology of schizophrenia-spectrum disorders. However, studies assessing the microbiota–gut–brain axis are inconsistent. This article describes the rationale, objectives, protocol, and presents descriptive results for a new project.

Methods

The sample of this study came from an observational, cross-sectional and multisite study including four centers in Spain (PI17/00246) recruiting adult patients with DSM-5 schizophrenia-spectrum disorders at any stage of the disease. The aims of the project are to assess the interrelation between intestinal permeability and low-grade chronic inflammation in schizophrenia-spectrum disorders and the role of peripheral biomarkers, diet, exercise, metabolic syndrome, disease severity and functioning as well as cognition. Assessments included the following variables: (1) anthropometric, (2) intestinal permeability, diet, and physical exercise, (3) clinical and functional, (4) neuropsychological and cognitive reserve, and (5) peripheral biomarkers from blood.

Results

A total of 646 patients were enrolled (257, 39.7% female). Mean age was 43.2±13.6 years, illness duration 15.1±11.5 years. 55.8% consumed tobacco. Positive PANSS score was 13.68±6.55, and 20.38±8.69 in the negative symptoms. CGI was 4.16±2.22 and GAF was 60.00±14.84.

Conclusion

The results obtained by this project are expected to contribute toward the understanding of the physiopathology of schizophrenia-spectrum disorders. This will likely aid to personalize treatments in real-world clinical practice, potentially including variables related to intestinal permeability and inflammation.

Keywords:
Intestinal permeability
Microbiota–gut–brain axis
Inflammation
Schizophrenia
Biomarkers, Protocol

Artículo

Opciones para acceder a los textos completos de la publicación Spanish Journal of Psychiatry and Mental Health
Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Suscribirse
Suscribirse a:

Spanish Journal of Psychiatry and Mental Health

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
E-mail
Opciones de artículo
Herramientas
Material suplementario
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos