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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) In vitro antibiotic susceptibility to fluoroquinolones
Journal Information
Vol. 87. Issue 3.
Pages 72-78 (March 2012)
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Vol. 87. Issue 3.
Pages 72-78 (March 2012)
Original article
In vitro antibiotic susceptibility to fluoroquinolones
Susceptibilidad antibiótica in vitro a fluoroquinolonas
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2185
C.A. Wong
Corresponding author
cwongm@institutowong.com

Corresponding author.
, V. Galvis, A. Tello, D. Villareal, J.J. Rey
Fundación Oftalmológica de Santander–Clínica Carlos Ardila Lülle (FOSCAL), Universidad Industrial de Santander, Laboratorio Higuera Escalante–Centro de Diagnóstico Ocular OCULAB
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Tables (4)
Table 1. Antibiotic sensitivity to moxifloxacin.
Table 2. Antibiotic sensitivity to gatifloxacin.
Table 3. Antibiotic sensitivity to levofloxacin.
Table 4. Antibiotic sensitivity to ciprofloxacin.
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Abstract
Objective

To determine the antibiotic susceptibility of bacteria recovered from cultures of ocular infections in the Fundación Oftalmológica de Santander–Clínica Carlos Ardila Lulle (FOSCAL).

Materials and methods

Retrospective descriptive study of a series of registries of cultures of samples from ocular surfaces and intraocular fluids from the OCULAB-FOSCAL laboratory in Floridablanca (Colombia) made between January and December of 2007. Antibiotic sensitivity screening by the method of Kirby–Bauer with impregnated Sensi-Discs™ of determined antibiotic concentrations was performed.

Results

A total of 352 samples were studied: 160 from conjunctiva, 150 from cornea and 42 from intraocular fluids. Of the total of the samples more than one microorganism was recovered 45.65% of the samples. Gram-positive and gram-negative bacteria were identified in 78.7 and 18.4%, respectively. Resistance to gatifloxacin, moxifloxacin, ciprofloxacin and levofloxacin was observed in 6.3, 8.9, 33.2 and 35.6%, respectively, of gram-positive bacteria. Resistance to gatifloxacin, moxifloxacin, ciprofloxacin and levofloxacin was also observed in 7.4, 16.7, 16.7% and 25.9%, respectively, of gram-negative bacteria. The overall bacterial resistance (gram-positive and gram-negative) to moxifloxacin was 10.15%, and to gatifloxacin it was 6.46%, being which showed a statistically significant difference (p<0.05).

Conclusions

In our study the development of bacterial resistance to fourth generation fluoroquinolones was demonstrated in ocular samples. However, lower levels of resistance to fourth generation fluoroquinolones compared with that of third and second generation were found, particularly to gram-positive. Gatifloxacin showed lower resistance levels than moxifloxacin. Nevertheless, interpretation of this superiority must be made with caution in the clinical field, since other factors, such as tissue penetration and in vivo activity, must be taken into account.

Keywords:
Bacterial resistance
Antibiotics
Fluoroquinolones
Moxifloxacin
Gatifloxacin
Resumen
Objetivo

Determinar la susceptibilidad antibiótica de la bacterias obtenidas en cultivos de infecciones oculares en la Fundación Oftalmológica de Santander - Clínica Carlos Ardila Lulle (FOSCAL).

Materiales y métodos

Estudio descriptivo retrospectivo de una serie de registros de cultivos de muestras de superficie ocular y líquidos intraoculares del laboratorio OCULAB-FOSCAL en Floridablanca (Colombia) realizados entreenero y diciembre de 2007. Se realizó antibiograma por el método de Kirby-Bauer con sensidiscos impregnados de concentraciones determinadas de antibiótico.

Resultados

Se recogieron un total de 352 muestras de los cuales 160 fueron de conjuntiva, 150 fueron de córnea y 42 de líquidos intraoculares. Se recuperó más de un microorganismo en el 45,65% del total de las muestras. El 78,7 y el 18,4% de las bacterias identificadas correspondieron a Gram positivos y a Gram negativos, respectivamente. El 6,3, 8,9, 33,2 y 35,6% de las bacterias Gram positivas fueron resistentes a gatifloxacino, moxifloxacino, ciprofloxacino y levofloxacino, respectivamente. El 7,4, 16,7, 16,7 y 25,9% de las bacterias Gram negativas fueron resistentes a gatifloxacino, moxifloxacino, ciprofloxacino y levofloxacino, respectivamente. La resistencia bacteriana global (tanto Gram positivos como Gram negativos) a moxifloxacino fue del 10,15% y a gatifloxacino del 6,46%, siendo esta diferencia estadísticamente significativa (p < 0,05).

Conclusiones

En nuestro estudio, se evidenció el desarrollo de resistencia bacteriana en muestras oculares incluso con las fluoroquinolonas de cuarta generación. Sin embargo se encontraron menores niveles de resistencia para las fluoroquinolonas de cuarta generación que para las de tercera y segunda generación, especialmente entre Gram positivos. Gatifloxacino mostró menores niveles de resistencia que la moxifloxacino. La interpretación de esta superioridad debe, sin embargo, hacerse con cuidado en el campo clínico, ya que se deben tener en cuenta otros factores como la penetración tisular y la actividad in vivo.

Palabras clave:
Resistencia bacteriana
Antibióticos
Fluoroquinolonas
Moxifloxacino
Gatifloxacino

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