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Inicio Clínica e Investigación en Arteriosclerosis (English Edition) Widespread xanthomas regression by personalized lipid lowering therapy in hetero...
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Vol. 36. Issue 1.
Pages 35-37 (January - February 2024)
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Vol. 36. Issue 1.
Pages 35-37 (January - February 2024)
Clinical report
Widespread xanthomas regression by personalized lipid lowering therapy in heterozygous familial hypercholesterolemia
Regresión generalizada de xantomas mediante terapia hipolipemiante personalizada en hipercolesterolemia familiar heterocigótica
Francesco Sbrana
Corresponding author
francesco.sbrana@ftgm.it

Corresponding author.
, Beatrice Dal Pino, Federico Bigazzi, Tiziana Sampietro
Lipoapheresis Unit – Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana “Gabriele Monasterio”, Via Moruzzi 1, Pisa 56124, Italy
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Abstract

“The lower, the better” is the recommended approach in the management of high LDL cholesterol. Unfortunately, this does not always achieve as in the case of a 69-year-old woman referred to our Institute for her lipid profile (LDL cholesterol 412mg/dl), bilateral xanthelasma and cutaneous xanthomas. With a maximized and personalized lipid-lowering therapies (rosuvastatin, ezetimibe, PCSK9i and lipoprotein apheresis), after only six months, the patient showed an impressive regression in her cutaneous xanthomas.

Keywords:
Cutaneous xanthomas
Heterozygous familial hypercholesterolemia
Lipid lowering therapy
Tendon xanthomas
Xanthelasma
Resumen

«Cuanto más bajo, mejor» es el enfoque recomendado en el tratamiento del colesterol LDL alto. Lamentablemente esto no siempre se logra como en el caso de una mujer de 69 años remitida a nuestro Instituto por su perfil lipídico (colesterol LDL 412 mg/dL), xantelasma bilateral y xantomas cutáneos. Con terapias hipolipemiantes maximizadas y personalizadas (rosuvastatina, ezetimiba, iPCSK9 y aféresis de lipoproteínas), después de solo seis meses, la paciente mostró una regresión impresionante en sus xantomas cutáneos.

Palabras clave:
Xantomas cutáneos
Hipercolesterolemia familiar heterocigótica
Terapia hipolipemiante
Xantomas tendinosos
Xantelasma

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