High admission levels of γ-glutamyltransferase predict poor myocardial perfusion after primary percutaneous intervention

array:24 ["pii" => "S1807593222023298" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000010" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2329" "copyright" => "CLINICS" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1729-34" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222023304" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000011" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2330" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1735-42" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Comparative study of earthquake-related and non-earthquake-related head traumas using multidetector computed tomography" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1735" "paginaFinal" => "1742" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 904 "Ancho" => 416 "Tamanyo" => 51886 ] ] "descripcion" => array:1 [ "en" => "(A) A 26-year-old man with earthquake-related head trauma caused by a collapsed building in the Sichuan earthquake. The volume-rendering image shows fractures involving the right orbit, zygomata and maxilla. (B) A 40-year-old man with head trauma caused by a traffic accident. The volume-rendering image shows multiple fractures involving the bilateral orbits, zygomata, nasal bone, left maxilla and mandible, and the bilateral maxillas are detached." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zhi-gang Chu, Zhi-gang Yang, Zhi-hui Dong, Tian-wu Chen, Zhi-yu Zhu, Heng Shao" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Zhi-gang" "apellidos" => "Chu" ] 1 => array:2 [ "nombre" => "Zhi-gang" "apellidos" => "Yang" ] 2 => array:2 [ "nombre" => "Zhi-hui" "apellidos" => "Dong" ] 3 => array:2 [ "nombre" => "Tian-wu" "apellidos" => "Chen" ] 4 => array:2 [ "nombre" => "Zhi-yu" "apellidos" => "Zhu" ] 5 => array:2 [ "nombre" => "Heng" "apellidos" => "Shao" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023304?idApp=UINPBA00004N" "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023304/v1_202212011334/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222023286" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000009" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2328" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1721-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Effects of preoperative inspiratory muscle training in obese women undergoing open bariatric surgery: respiratory muscle strength, lung volumes, and diaphragmatic excursion" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1721" "paginaFinal" => "1727" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 226 "Ancho" => 431 "Tamanyo" => 7564 ] ] "descripcion" => array:1 [ "en" => "MEP evaluations of T1, T2, and T3 in IMT (n = 15) and Control (n = 17) groups. (values expressed as mean)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcela Cangussu Barbalho-Moulim, Gustavo Peixoto Soares Miguel, Eli Maria Pazzianotto Forti, Flávio do Amaral Campos, Dirceu Costa" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Marcela Cangussu" "apellidos" => "Barbalho-Moulim" ] 1 => array:2 [ "nombre" => "Gustavo Peixoto Soares" "apellidos" => "Miguel" ] 2 => array:2 [ "nombre" => "Eli Maria Pazzianotto" "apellidos" => "Forti" ] 3 => array:2 [ "nombre" => "Flávio" "apellidos" => "do Amaral Campos" ] 4 => array:2 [ "nombre" => "Dirceu" "apellidos" => "Costa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023286?idApp=UINPBA00004N" "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023286/v1_202212011334/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "High admission levels of γ-glutamyltransferase predict poor myocardial perfusion after primary percutaneous intervention" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1729" "paginaFinal" => "1734" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Uygar Cagdas Yuksel, Turgay Celik, Murat Celik, Baris Bugan, Atila Iyisoy, Halil Yaman" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Uygar Cagdas" "apellidos" => "Yuksel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "Turgay" "apellidos" => "Celik" "email" => array:1 [ 0 => "benturgay@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "Murat" "apellidos" => "Celik" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Baris" "apellidos" => "Bugan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Atila" "apellidos" => "Iyisoy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Halil" "apellidos" => "Yaman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, Etlik-Ankara/TURKEY" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Gulhane Military Medical Academy, School of Medicine, Department of Medical Biochemistry, Etlik-Ankara/TURKEY" "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 90 312 3044268" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 519 "Ancho" => 498 "Tamanyo" => 18862 ] ] "descripcion" => array:1 [ "en" => "Comparison of Gamma-glutamyltransferase levels between study groups. (TMPG: TIMI myocardial perfusion grade)." ] ] ] "textoCompleto" => "INTRODUCTIONThe objective of primary percutaneous coronary intervention (pPCI) is to restore normal blood flow in the infarct-related artery (IRA). Previous studies have shown that preservation of the microcirculation is critical for a positive clinical outcome.<a class="elsevierStyleCrossRef" href="#bib1">1</a> It is well-known that achieving Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow is insufficient to ensure myocardial salvage.<a class="elsevierStyleCrossRefs" href="#bib1">1,2</a> In one-third of patients undergoing pPCI for acute myocardial infarction, echo-contrast ‘no-reflow' is observed after reperfusion therapy, despite TIMI grade 3 flow. This ‘no-reflow' phenomenon is associated with a higher incidence of congestive heart failure and left ventricular dysfunction.<a class="elsevierStyleCrossRef" href="#bib3">3</a> The TIMI myocardial perfusion grade (TMPG) was designed and validated to further risk-stratify patients in whom succsessful epicardial reperfusion was achieved.<a class="elsevierStyleCrossRef" href="#bib2">2</a> TMPG is a multivariate predictor of 30-day mortality, and is independent of age, gender, anterior MI location, admission pulse rate, corrected TIMI frame count, or TIMI flow grade.<a class="elsevierStyleCrossRef" href="#bib2">2</a> Previous clinical studies have clearly demonstrated that no-reflow predicts short- and long-term adverse clinical outcomes in patients presenting with acute myocardial infarction (AMI).<a class="elsevierStyleCrossRef" href="#bib4">4</a>Gamma-glutamyltransferase (GGT), an enzyme that is normally found in the serum as well as in the plasma membrane of virtually all cells except erythrocytes, catalyzes the first step in the degradation of extracellular glutathione (GSH). This degradation allows for precursor assimilation and reutilization of amino acids for synthesis of intracellular GSH, the primary thiol antioxidant in mammalian cells.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Serum GGT level is widely used as a diagnostic test for hepatobiliary diseases and alcohol abuse.<a class="elsevierStyleCrossRef" href="#bib6">6</a> Several clinical studies have shown that elevated serum GGT is associated with all-cause mortality and increased risk of AMI.<a class="elsevierStyleCrossRef" href="#bib7">7</a> Additionally, degradation of GSH may play a pro-oxidant role under certain conditions. Low density lipoprotein (LDL) oxidation through GSH/GGT-dependent iron reduction has been suggested as an important mechanism in the pathogenesis of atherosclerosis.<a class="elsevierStyleCrossRef" href="#bib8">8</a> Furthermore, GGT activity has been observed in atherosclerotic coronary plaques.<a class="elsevierStyleCrossRef" href="#bib9">9</a> Reperfusion injury due to free radical release and increased oxidative stress has been suggested as a possible mechanism in the pathophysiology of the no-reflow phenomenon.<a class="elsevierStyleCrossRef" href="#bib10">10</a> Therefore, we aimed to examine the possible relationship between admission levels of GGT and myocardial perfusion grades after pPCI in patients presenting with AMI.MATERIALS AND METHODSPatientsThe study population consisted of 40 patients with poor myocardial perfusion (TMPG 0-1) after pPCI and 40 age and sex-matched patients with better perfusion grades (TMPG 2-3) after the procedure (total 80 patients, 64 men and 16 women, mean age = 67.5±6.6 years). The retrospective selection included 265 acute ST-segment elevation myocardial infarction (STEMI) patients who were treated by pPCI from January 2003 to December 2007 at our institution. The diagnosis of AMI was established using ACC/AHA criteria.<a class="elsevierStyleCrossRef" href="#bib11">11</a> All patients presented TIMI 0/1 flow prior to intervention. The study population was divided into two groups according to TMPG assessed immediately after pPCI. No-reflow was defined as poor TMPG scores (TMPG 0-1) in the distal vasculature without apparent proximal coronary artery obstruction after intervention. Each group (group 1 and group 2) consisted of 40 patients with TMPG 0-1 and TMPG 2-3, respectively. Part of the data included in this study was previously published elsewhere.<a class="elsevierStyleCrossRef" href="#bib12">12</a>Patients with liver dysfunction and a history of chronic alcohol consumption, culprit lesion in the left main coronary artery, left main stenosis >50%, previous coronary artery bypass surgery, hemodialysis therapy, cardiogenic shock, pain to balloon time >12 hours, history of acute infection within the previous 10 days, presence of any chronic inflammatory-autoimmune disease, and any known malignancy were excluded from the study.Coronary Intervention, Analysis of Collateral Circulation and TIMI Myocardial Perfusion GradeCoronary angiography (Siemens HICOR T.O.P Image System, Forcheim, Germany) was performed in multiple orthogonal projections using Judkins' technique. Coronary angiographic data were quantitatively analyzed. A stenosis of greater than 70% diameter in coronary arteries 1, 2, and 3 was defined as a one, two, or three-vessel disease, respectively. Collateral vessels were assessed according to the Rentrop classification.<a class="elsevierStyleCrossRef" href="#bib13">13</a> Routine stenting following balloon angioplasty was systematically attempted with standard techniques, including high-pressure balloon inflation (>14 atm) to expand deployed stents. A successful primary PCI procedure was defined as establishing a TIMI grade 3 flow in the artery responsible for AMI with a residual stenosis <20%.<a class="elsevierStyleCrossRef" href="#bib14">14</a> TMPG was graded densitometrically according to visual assessment of relative contrast opacification in the myocardial territory subtended by the infarct vessel in relation to epicardial density.<a class="elsevierStyleCrossRef" href="#bib1">1</a>EchocardiographyTransthoracic echocardiography was performed using an ESAOTE 2.5 MHz probe (ESAOTE, Genova, Italy) at the left lateral decubitis position before pPCI. Wall motion of 16 myocardial segments was interpreted according to the criteria of the American Society of Echocardiography.<a class="elsevierStyleCrossRef" href="#bib15">15</a>Blood ChemistryVenous blood samples were obtained on admission to the emergency room and analyzed for blood urea nitrogen, GGT, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine kinase-MB isoenzyme (CKMB) levels. The next day, fasting plasma samples were obtained to measure: fasting plasma glucose (FPG), total serum cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol. Total serum cholesterol, TG, HDL, glucose, and GGT levels were measured via spectrophotometric technique on an Olympus AU-2700 autoanalyzer using commercial kits (Olympus, Hamburg, Germany). LDL cholesterol levels were calculated by the Friedwald formula.Statistical AnalysisThe One Sample Kolmogorov-Smirnov and Levene tests were used to determine the distribution characteristics of variables and variance homogeneity. Results are expressed as mean ± SD, median (interquartile range) and percentages. The differences between groups were tested by chi-square, independent samples t-test and Mann-Whitney U tests. Differences were considered significant at p<0.05. We investigated the effects of different variables on myocardial perfusion grade by calculating the odds ratios in a univariate analysis for all variables. Variables displaying an unadjusted p-value <0.15 in logistic regression analysis were identified as potential risk markers and included in the multivariate regression analysis. We reduced the model using backward elimination, and we eliminated potential risk markers through likelihood ratio tests. Statistical analyses were performed using the SPSS 15.0 Statistical Package Program for Windows (SPSS Inc., Chicago, IL, USA).RESULTSThis retrospective study included 80 patients who presented with acute ST-segment elevation myocardial infarction (64 men and 16 women, mean age = 67.5±6.6 years). All patients presented TIMI 0/1 flow pre-procedurally. Post-procedural TMPGs were analyzed by two different interventional cardiologists who were blinded to the patients' clinical data. Intra- and interobserver variability for TMPGs 0-1 were 7.5% and 10.5%, respectively. Although intra- and interobserver variability for TMPG 2 were 1.9% and 2.7%, respectively, both the intra- and interobserver variability for TMPG 3 were 0%. In cases of disagreement between the observers, the cases were re-evaluated by both investigators and grouped according to the common final decision. Patients with TMPG 0-1 and 2-3 formed Group 1 (n = 40, 30 men, mean age = 68.8±5.3 years) and Group 2 (n = 40, 34 men, mean age = 66.2±7.5 years), respectively. Comparison between baseline demographical, clinical, and biochemical characteristics of patients with no-reflow and controls showed no statistically significant differences, except for peak CKMB and GGT levels, as shown in <a class="elsevierStyleCrossRefs" href="#tbl1">Tables 1 and 2</a> (for CKMB: 172.4±45.1 U/l vs. 144.5±37.8 U/l, p = 0.003 and for GGT: 64.32±16.43 U/L vs. 41.07±10.18 U/L, p<0.001; <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). We performed an ROC curve analysis to define the optimal cut-off value of admission-GGT to predict no-reflow. A cut-off value of 50 U/L GGT predicted no-reflow with a sensitivity and specificity of 82.5% and 80%, respectively (AUC = 0.873; 95% CI = 0.791-0.955; p<0.001, <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>).<elsevierMultimedia ident="tbl1"></elsevierMultimedia><elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="fig2"></elsevierMultimedia>The two groups presented with similar angiographic, echocardiographic, and electrocardiographic characteristics. However, pain to balloon time and admission TIMI flow grades (TIMI flow 0-1) were significantly different between the two groups (<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>). Direct stenting was performed in three patients from Group 1 and 2 patients from Group 2. Drug-eluting stents were used in two patients from each group. In Group 1, pain to balloon time was longer (6.07±0.72 h vs. 4.63±1.16 h, p<0.001) and the percentage of low admission TIMI flow grades was higher than for patients in Group 2 (95% vs. 80%, p = 0.03).<elsevierMultimedia ident="tbl3"></elsevierMultimedia>The effects of different variables on myocardial perfusion were analyzed using univariate and multivariate logistic regression analyses. Data for the two groups was combined, and all the variables were analyzed via univariate analysis for predictors of poor myocardial perfusion. As shown in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>, pain to balloon time, GGT levels, peak CKMB levels, low LVEF, poor TIMI grade, wall motion score, and older age displayed a significant relationship with poor myocardial perfusion in the univariate analysis. When multivariate analyses were performed with eight variables in backward logistic regression analysis, only pain to balloon time and GGT levels continued to display a statistically significant independent association with poor myocardial perfusion in the model. Adjusted odds ratios were calculated as 4.92 for pain to balloon time (p = 0.009; CI = 1.50-16.13) and 1.13 for GGT (p<0.001; CI = 1.05-1.21), as shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>.<elsevierMultimedia ident="tbl4"></elsevierMultimedia>DISCUSSIONOur study revealed that in patients with AMI undergoing pPCI, high admission GGT levels are associated with lower myocardial perfusion grades after intervention.The no-reflow phenomenon is primarily attributed to the disturbed microvascular integrity that occurs due to free radical release, microvascular constriction and obstruction, platelet microembolism, thrombosis and neutrophil aggregation and plugging.<a class="elsevierStyleCrossRefs" href="#bib16">16–18</a>Reperfusion of the ischemic myocardium in AMI results in oxidative stress caused by the release of quantities of reactive oxygen species (ROS) that exceed the neutralizing potential of the cells' anti-oxidative defense mechanisms.<a class="elsevierStyleCrossRef" href="#bib19">19</a> Oxidative cellular damage induced by high levels of reactive oxygen species is considered a primary cause of lethal myocardial reperfusion injury. The generation of reactive oxygen species during reperfusion is a complex process involving cardiomyocytes, endothelial cells, and activated neutrophils. Re-energization of the electron transport chain in the mitochondria of cardiomyocytes leads to the formation of ubiquinone and oxygen-derived radicals.<a class="elsevierStyleCrossRefs" href="#bib20">20,21</a> After breaking down ATP, post-ischemic cardiomyocytes release large amounts of adenosine and inosine, which are further degraded by xanthine oxidase in endothelial cells, constituting another important source of ROS.<a class="elsevierStyleCrossRef" href="#bib21">21</a>Serum GGT level has been suggested as an independent cardiovascular risk factor.<a class="elsevierStyleCrossRef" href="#bib22">22</a> It is also a predictor of all-cause and coronary heart disease-related mortality, independent of alcohol intake or liver disease.<a class="elsevierStyleCrossRef" href="#bib7">7</a> GGT expression is increased by oxidants, and GGT activity serves as a marker for oxidative stress in rat lung epithelial cells.<a class="elsevierStyleCrossRef" href="#bib23">23</a> Increased serum GGT activity can be used as a marker for increased oxidative stress in humans.<a class="elsevierStyleCrossRef" href="#bib24">24</a> Increased GGT activity is also present in atherosclerotic coronary plaques.<a class="elsevierStyleCrossRef" href="#bib8">8</a>Oxidative and inflammatory events are closely related in the pathophysiology of acute coronary syndrome (ACS).<a class="elsevierStyleCrossRef" href="#bib25">25</a> Serum GGT activity has been suggested as an independent predictor of major adverse cardiovascular events in patients with ACS during coronary care unit stay and after hospitalization.<a class="elsevierStyleCrossRef" href="#bib26">26</a>In the microvasculature of the heart, post-ischemic reperfusion results in endothelial cell swelling and luminal membrane blebbing, both of which may contribute to the no-reflow phenomenon.<a class="elsevierStyleCrossRef" href="#bib27">27</a> Ischemia results in impaired antioxidant defense, and subsequent reperfusion results in an increased concentration of reactive oxygen species.<a class="elsevierStyleCrossRef" href="#bib19">19</a> In the current study, we demonstrated that increased pre-procedural GGT levels display a statistically significant independent association with poor myocardial perfusion. From this perspective, we suggest that increased pre-procedural oxidative stress represented by GGT levels may be an important factor contributing to microvascular damage in patients with AMI. Higher levels of GGT in patients with poor TMPG may be the result of increased microvascular injury and increased oxidative stress. High GGT activity can also represent a compensatory response against the microvascular injury caused by free radicals. It is also reasonable to expect increased GGT activity due to delayed pain-balloon time and subsequent increased myocardial injury. On the other hand, peak CKMB levels, which are a specific marker of myocardial injury, have been found to be independent of TMPG. Therefore, the significant association between TMPG and increased GGT activity as a non-specific marker for myocardial injury highlights the importance of oxidative stress in reperfusion injury, poor TMPG and ischemic injury.The role of admission GGT levels in the prediction of poor myocardial perfusion grades after pPCI in patients with AMI has not been extensively studied.<a class="elsevierStyleCrossRef" href="#bib28">28</a> The dynamic nature of acute coronary syndromes is usually associated with spontaneous ischemia-reperfusion injury in the infarct-related artery.<a class="elsevierStyleCrossRef" href="#bib29">29</a> Therefore, we considered the fact that poor myocardial perfusion after pPCI is not only related to procedural factors and clinical characteristics of the patients but may also be related to reperfusion injury and oxidative stress occurring before coronary intervention. GGT can be used as a marker of poor post-procedural flow. However, the current data is not sufficient to suggest GGT as a causal agent.The major limitations of this study are small sample size and retrospective design. Additionally, self-reported alcohol consumption may not be reliable. This study did not include a control group to compare the GGT levels of the AMI patients with healthy subjects. Lastly, we did not analyze other important plasma markers of oxidative stress, such as oxidized LDL and plasma and/or intracellular GSH levels.In conclusion, high admission GGT levels are associated with poor myocardial perfusion after pPCI in patients with AMI. High GGT levels and door to balloon time relate to the degree of reperfusion after pPCI. An animal model comparing reperfusion injury in animals with higher and lower GGT levels would provide further evidence to support our findings. Additional large-scale randomized studies are needed to clarify the clinical utility of admission GGT levels in the prediction of poor myocardial perfusion." "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "xpalclavsec1582221" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Coronary Intervention, Analysis of Collateral Circulation and TIMI Myocardial Perfusion Grade" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Echocardiography" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Blood Chemistry" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Statistical Analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec90" "titulo" => "DISCUSSION" ] 5 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-03-23" "fechaAceptado" => "2011-06-23" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582221" "palabras" => array:3 [ 0 => "Myocardial infarction" 1 => "No-reflow phenomenon" 2 => "Gamma-glutamyltransferase" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVE:This retrospective study aimed to investigate the relationship between admission levels of serum γ-glutamyltransferase and poor myocardial perfusion after primary percutaneous coronary intervention in patients with acute myocardial infarction. INTRODUCTION:Reperfusion injury caused by free radical release and increased oxidative stress is responsible for the pathophysiology of the no-reflow phenomenon in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Serum γ-glutamyltransferase is an established marker of increased oxidative stress. METHODS:The study population consisted of 80 patients (64 men and 16 women, mean age = 67.5±6.6 years) with thrombolysis in myocardial infarction 0/1 flow pre-procedurally. The patients were divided into two groups according to thrombolysis in myocardial perfusion grades that were assessed immediately following primary percutaneous coronary intervention. The two groups (group 1 and group 2) each consisted of 40 patients with thrombolysis in myocardial perfusion grades 0-1 and thrombolysis in myocardial perfusion grades 2-3, respectively. RESULTS:Admission pain to balloon time, γ-glutamyltransferase and creatine kinase-MB isoenzyme levels of group 1 patients were significantly higher than those of group 2 patients. Pain to balloon time, γ-glutamyltransferase, peak creatine kinase-MB isoenzyme, low left ventricular ejection fraction and poor pre-procedural thrombolysis in myocardial infarction grade were significantly associated with poor myocardial perfusion by univariate analysis. However, only pain to balloon time and γ-glutamyltransferase levels showed a significant independent association with poor myocardial perfusion by backward logistic regression analysis. Adjusted odds ratios were calculated as 4.92 for pain to balloon time and 1.13 for γ-glutamyltransferase. CONCLUSION:High admission γ-glutamyltransferase levels are associated with poor myocardial perfusion in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention, particularly in patients with prolonged pain to balloon time." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "INTRODUCTION:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSION:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 519 "Ancho" => 498 "Tamanyo" => 18862 ] ] "descripcion" => array:1 [ "en" => "Comparison of Gamma-glutamyltransferase levels between study groups. (TMPG: TIMI myocardial perfusion grade)." ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 513 "Ancho" => 498 "Tamanyo" => 22840 ] ] "descripcion" => array:1 [ "en" => "ROC curve of Gamma-glutamyltransferase for predicting no-reflow. (AUC: area under curve)." ] ] 2 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "I, Body mass index; MI, myocardial infarction; HR, heart rate; BAB, beta adrenergic blocker; ACE-I, angiotensin converting enzyme inhibitor." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 1 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 2 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Age (years)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">68.8±5.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">66.2±7.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Sex (M), n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">30 (75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">34 (85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Age >70 years, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 (35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">8 (20) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">BMI (kg/m2)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.9±2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.5±1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Hypercholesterolemia, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 (35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 (30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.63 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Diabetes mellitus, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17 (42.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.64 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Family history, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 (25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6 (15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Hypertension, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26 (65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">21 (52.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Smoking, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">19 (47.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26 (65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Preinfarction angina, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17 (42.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.64 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Previous MI, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 (12.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 (17.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.53 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black">Admission HR (bpm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">91±12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">86±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Killip Class \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Class I, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">36 (90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">37 (92.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.69 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top" style="border-bottom: 2px solid black">Class II-III, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">4 (10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">3 (7.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Preprocedural medications \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Aspirin, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">21 (52.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Nitrate, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">18 (45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.49 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">BAB, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 (30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ACE-I, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">19 (47.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.36 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top" style="border-bottom: 2px solid black">Statin, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">22 (55) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.11 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Baseline demographic and clinical characteristics of the study patients." ] ] 3 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "GT, Gamma-glutamyltransferase; CKMB, Creatine kinase-MB isoenzyme; AST, Alanine aminotransferase; ALT, Aspartate aminotransferase; LDL, Low density lipoprotein; HDL, High density lipoprotein.Results are expressed as mean±SD or median (interquartile range)." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 1 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 2 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">GGT (U/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">41.07±10.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">64.32±16.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Peak CKMB (U/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">172.4±45.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">144.5±37.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">AST (U/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">50.90±9.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">52.81±12.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.44 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ALT (U/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">34.27±8.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">37.10±9.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Total cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">253.75 (227-290) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">255.00 (236-300) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.37 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Triglyceride (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">165.00 (132-244) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">153.75 (144-254) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">LDL cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">172.87 (142-215) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">166.10 (142-224) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top" style="border-bottom: 2px solid black">HDL cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">40.50 (37-48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">39.25 (27-50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Baseline biochemical characteristics of the study patients." ] ] 4 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "LAD, Left anterior descending coronary artery; RCA, Right coronary artery; CFX, Circumflex coronary artery; MLD, Minimal lumen diameter; LVEF, Left ventricular ejection fraction; TIMI, Thrombolysis in myocardial infarction; WMS, Wall motion score." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 1 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Group 2 (n = 40) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Pain to balloon time (h)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.07±0.72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.63±1.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Tirofiban use, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13 (32.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11 (27.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Preprocedural TIMI 0/1, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">38 (95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">32 (80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">LVEF (<35%), n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 (30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.34 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black">Multivessel disease, n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">13 (32.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">10 (25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Infarct- related artery \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">LAD, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 (35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 (40.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">RCA, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">20 (50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">19 (47.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top" style="border-bottom: 2px solid black">CFX, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">6 (15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">5 (12.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Reference diameter (mm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.03±0.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.12±0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Lesion length (mm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17.05±2.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.90±2.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.79 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Final balloon pressure (Atm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15.25±2.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15.82±1.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Collateral score</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.87±0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.90±0.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Number of Q waves</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2.92±1.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2.40± 1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">LVEF (<35%), n (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 (30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.34 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black">WMS</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">12.92±2.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">12.15±1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Angiographic, echocardiographic, and electrocardiographic characteristics of the patients." ] ] 5 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "WMS, Wall motion score; CKMB, Creatine kinase MB isoenzyme; LVEF, left ventricular ejection fraction; TIMI, Thrombolysis in myocardial infarction; GGT, Gamma-glutamyltransferase." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Unadjusted OR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">95% CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Adjusted OR<a class="elsevierStyleCrossRef" href="#tfn6">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">95% CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Age >70 years</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.78–5.92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.23-14.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">WMS</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.94-1.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.65-1.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Number of Q waves</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.94-1.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.57-2.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.69 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Peak CKMB</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.00-1.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.98-1.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.44 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">LVEF (<35%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.18-8.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.50-23.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">TIMI 0/1</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.56-10.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.47-17.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.24 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Pain to balloon time</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2.70-14.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.50-16.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">GGT (U/L)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.09-1.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.05-1.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Diabetes mellitus</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.50-3.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Killip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Class I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Class II-III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.28-6.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Tirofiban use</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.30-2.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Multivessel disease</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.54-3.82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Reference diameter</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.05-1.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Lesion length</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.86-1.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top">Final inflation pressure</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.67-1.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black">Collateral score</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.45-1.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn6" "etiqueta" => "*" "nota" => "Adjusted for age>70 years, wall motion score, number of Q waves, peak CKMB, LVEF<35%, TIMI 0/1, pain to balloon time and GGT." ] ] ] "descripcion" => array:1 [ "en" => "Effects of various variables on the myocardial perfusion grade assessed following primary percutaneous coronary intervention in univariate and multivariate logistic regression analyses." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SB King 3rd \n \t\t\t\t\t\t\t\t """ 1 => """ SC Smith Jr \n \t\t\t\t\t\t\t\t """ 2 => """ JW Hirshfeld Jr \n \t\t\t\t\t\t\t\t """ 3 => """ AK Jacobs \n \t\t\t\t\t\t\t\t """ 4 => """ DA Morrison \n \t\t\t\t\t\t\t\t """ 5 => """ DO Williams \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2007.10.002" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2008" "volumen" => "51" "paginaInicial" => "172" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18191745" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jacc.2007.10.002" "WWW" => array:1 [ "link" => "10.1016/j.jacc.2007.10.002" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CM Gibson \n \t\t\t\t\t\t\t\t """ 1 => """ CP Cannon \n \t\t\t\t\t\t\t\t """ 2 => """ SA Murphy \n \t\t\t\t\t\t\t\t """ 3 => """ KA Ryan \n \t\t\t\t\t\t\t\t """ 4 => """ R Mesley \n \t\t\t\t\t\t\t\t """ 5 => """ SJ Marble \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.101.2.125" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2000" "volumen" => "101" "paginaInicial" => "125" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10637197" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical implications of the 'no reflow' phenomenon. A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ H Ito \n \t\t\t\t\t\t\t\t """ 1 => """ A Maruyama \n \t\t\t\t\t\t\t\t """ 2 => """ K Iwakura \n \t\t\t\t\t\t\t\t """ 3 => """ S Takiuchi \n \t\t\t\t\t\t\t\t """ 4 => """ T Masuyama \n \t\t\t\t\t\t\t\t """ 5 => """ M Hori \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.93.2.223" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "223" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8548892" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ I Morishima \n \t\t\t\t\t\t\t\t """ 1 => """ T Sone \n \t\t\t\t\t\t\t\t """ 2 => """ K Okumura \n \t\t\t\t\t\t\t\t """ 3 => """ H Tsuboi \n \t\t\t\t\t\t\t\t """ 4 => """ J Kondo \n \t\t\t\t\t\t\t\t """ 5 => """ H Mukawa \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0735-1097(00)00865-2" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "1202" "paginaFinal" => "1209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11028471" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002937820302271" "estado" => "S300" "issn" => "00029378" ] ] ] 1 => array:2 [ "doi" => "10.1016/s0735-1097(00)00865-2" "WWW" => array:1 [ "link" => "10.1016/S0735-1097(00)00865-2" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enzymes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RG Krefetz \n \t\t\t\t\t\t\t\t """ 1 => """ GA McMillin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "ML FEBishop, LESchoeff" "titulo" => "Clinical Chemistry" "paginaInicial" => "255" "paginaFinal" => "256" "serieFecha" => "2005" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum gamma glutamyl transpeptidase in relation to alcohol consumption" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ JG Rollason \n \t\t\t\t\t\t\t\t """ 1 => """ G Pincherle \n \t\t\t\t\t\t\t\t """ 2 => """ D Robinson \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/0009-8981(72)90301-4" "Revista" => array:6 [ "tituloSerie" => "Clin Chim Acta" "fecha" => "1972" "volumen" => "39" "paginaInicial" => "75" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5038765" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/0009-8981(72)90301-4" "WWW" => array:1 [ "link" => "10.1016/0009-8981(72)90301-4" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ G Wannamethee \n \t\t\t\t\t\t\t\t """ 1 => """ S Ebrahim \n \t\t\t\t\t\t\t\t """ 2 => """ AG Shaper \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/oxfordjournals.aje.a117699" "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1995" "volumen" => "142" "paginaInicial" => "699" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7572939" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ M Emdin \n \t\t\t\t\t\t\t\t """ 1 => """ A Pompella \n \t\t\t\t\t\t\t\t """ 2 => """ A Paolicchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.105.571919" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2005" "volumen" => "112" "paginaInicial" => "2078" "paginaFinal" => "2080" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16203922" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.105.571919" "WWW" => array:1 [ "link" => "10.1161/CIRCULATIONAHA.105.571919" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Images in cardiovascular medicine. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Paolicchi \n \t\t\t\t\t\t\t\t """ 1 => """ M Emdin \n \t\t\t\t\t\t\t\t """ 2 => """ E Ghliozeni \n \t\t\t\t\t\t\t\t """ 3 => """ E Ciancia \n \t\t\t\t\t\t\t\t """ 4 => """ C Passino \n \t\t\t\t\t\t\t\t """ 5 => """ G Popoff \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1161/01.CIR.0000120558.41356.E6" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2004" "volumen" => "109" "paginaInicial" => "1440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15037540" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028209001484" "estado" => "S300" "issn" => "00150282" ] ] ] 1 => array:2 [ "doi" => "10.1161/01.CIR.0000120558.41356.E6" "WWW" => array:1 [ "link" => "10.1161/01.CIR.0000120558.41356.e6",-1,"xxx/41356.e6" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ RL Engler \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/0002-9149(89)90225-7" "Revista" => array:7 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1989" "volumen" => "63" "paginaInicial" => "19E" "paginaFinal" => "23E" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2538048" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028221021373" "estado" => "S300" "issn" => "00150282" ] ] ] 1 => array:2 [ "doi" => "10.1016/0002-9149(89)90225-7" "WWW" => array:1 [ "link" => "10.1016/0002-9149(89)90225-7" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaboration With the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 Writing Group to Review New Evidence and Update the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction, Writing on Behalf of the 2004 Writing Committee" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ EM Antman \n \t\t\t\t\t\t\t\t """ 1 => """ M Hand \n \t\t\t\t\t\t\t\t """ 2 => """ PW Armstrong \n \t\t\t\t\t\t\t\t """ 3 => """ ER Bates \n \t\t\t\t\t\t\t\t """ 4 => """ LA Green \n \t\t\t\t\t\t\t\t """ 5 => """ LK Halasyamani \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.107.188209" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "2008" "volumen" => "117" "paginaInicial" => "296" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18071078" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028208032652" "estado" => "S300" "issn" => "00150282" ] ] ] 1 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.107.188209" "WWW" => array:1 [ "link" => "10.1161/CIRCULATIONAHA.107.188209" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of admission glomerular filtration rate on the development of poor myocardial perfusion after primary percutaneous intervention in patients with acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ T Celik \n \t\t\t\t\t\t\t\t """ 1 => """ A Iyisoy \n \t\t\t\t\t\t\t\t """ 2 => """ CU Yuksel \n \t\t\t\t\t\t\t\t """ 3 => """ S Kilic \n \t\t\t\t\t\t\t\t """ 4 => """ MI Yilmaz \n \t\t\t\t\t\t\t\t """ 5 => """ EO Akgul \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/MCA.0b013e3283108fef" "Revista" => array:6 [ "tituloSerie" => "Coron Artery Dis" "fecha" => "2008" "volumen" => "19" "paginaInicial" => "543" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19005288" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/MCA.0b013e3283108fef" "WWW" => array:1 [ "link" => "10.1097/MCA.0b013e3283108fef" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serial angiographic assessment of coronary artery obstruction and collateral flow in acute myocardial infarction. Report from the second Mount Sinai-New York University Reperfusion Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ KP Rentrop \n \t\t\t\t\t\t\t\t """ 1 => """ F Feit \n \t\t\t\t\t\t\t\t """ 2 => """ W Sherman \n \t\t\t\t\t\t\t\t """ 3 => """ JC Thornton \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1161/01.cir.80.5.1166" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1989" "volumen" => "80" "paginaInicial" => "1166" "paginaFinal" => "1175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2509103" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090825818310965" "estado" => "S300" "issn" => "00908258" ] ] ] 1 => array:2 [ "doi" => "10.1161/01.cir.80.5.1166" "WWW" => array:1 [ "link" => "10.1161/01.CIR.80.5.1166" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase I findings. TIMI Study Group" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The Thrombolysis in Myocardial Infarction (TIMI) trial" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198504043121437" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1985" "volumen" => "312" "paginaInicial" => "932" "paginaFinal" => "936" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4038784" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ NB Schiller \n \t\t\t\t\t\t\t\t """ 1 => """ PM Shah \n \t\t\t\t\t\t\t\t """ 2 => """ M Crawford \n \t\t\t\t\t\t\t\t """ 3 => """ A DeMaria \n \t\t\t\t\t\t\t\t """ 4 => """ R Devereux \n \t\t\t\t\t\t\t\t """ 5 => """ H Feigenbaum \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Soc Echocardiog" "fecha" => "1989" "volumen" => "2" "paginaInicial" => "358" "paginaFinal" => "367" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microvascular involvement in cardiac pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ JB Gavin \n \t\t\t\t\t\t\t\t """ 1 => """ L Maxwell \n \t\t\t\t\t\t\t\t """ 2 => """ SG Edgar \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1006/jmcc.1998.0824" "Revista" => array:7 [ "tituloSerie" => "J Mol Cell Cardiol" "fecha" => "1998" "volumen" => "30" "paginaInicial" => "2531" "paginaFinal" => "2540" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9990524" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002937817311808" "estado" => "S300" "issn" => "00029378" ] ] ] 1 => array:2 [ "doi" => "10.1006/jmcc.1998.0824" "WWW" => array:1 [ "link" => "10.1006/jmcc.1998.0824" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ WJ Dreyer \n \t\t\t\t\t\t\t\t """ 1 => """ LH Michael \n \t\t\t\t\t\t\t\t """ 2 => """ MS West \n \t\t\t\t\t\t\t\t """ 3 => """ CW Smith \n \t\t\t\t\t\t\t\t """ 4 => """ R Rothlein \n \t\t\t\t\t\t\t\t """ 5 => """ RD Rossen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.84.1.400" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1991" "volumen" => "84" "paginaInicial" => "400" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2060111" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ XL Ma \n \t\t\t\t\t\t\t\t """ 1 => """ PS Tsao \n \t\t\t\t\t\t\t\t """ 2 => """ GE Viehman \n \t\t\t\t\t\t\t\t """ 3 => """ AM Lefer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.res.69.1.95" "Revista" => array:6 [ "tituloSerie" => "Circ Res" "fecha" => "1991" "volumen" => "69" "paginaInicial" => "95" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2054945" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct measurement of free radical generation following reperfusion of ischemic myocardium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ JL Zweier \n \t\t\t\t\t\t\t\t """ 1 => """ JT Flaherty \n \t\t\t\t\t\t\t\t """ 2 => """ ML Weisfeldt \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1073/pnas.84.5.1404" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "1987" "volumen" => "84" "paginaInicial" => "1404" "paginaFinal" => "1407" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3029779" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1073/pnas.84.5.1404" "WWW" => array:1 [ "link" => "10.1073/pnas.84.5.1404" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ P Jezek \n \t\t\t\t\t\t\t\t """ 1 => """ L Hlavata \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.biocel.2005.05.013" "Revista" => array:6 [ "tituloSerie" => "Int J Biochem Cell Biol" "fecha" => "2005" "volumen" => "37" "paginaInicial" => "2478" "paginaFinal" => "2503" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16103002" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.biocel.2005.05.013" "WWW" => array:1 [ "link" => "10.1016/j.biocel.2005.05.013" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of oxidants and free radicals in reperfusion injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JL Zweier \n \t\t\t\t\t\t\t\t """ 1 => """ MA Talukder \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.cardiores.2006.02.025" "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Res" "fecha" => "2006" "volumen" => "70" "paginaInicial" => "181" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16580655" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.cardiores.2006.02.025" "WWW" => array:1 [ "link" => "10.1016/j.cardiores.2006.02.025" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Additive prognostic value of gamma-glutamyltransferase in coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ M Emdin \n \t\t\t\t\t\t\t\t """ 1 => """ C Passino \n \t\t\t\t\t\t\t\t """ 2 => """ C Michelassi \n \t\t\t\t\t\t\t\t """ 3 => """ L Donato \n \t\t\t\t\t\t\t\t """ 4 => """ A Pompella \n \t\t\t\t\t\t\t\t """ 5 => """ A Paolicchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2008.04.030" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2009" "volumen" => "136" "paginaInicial" => "80" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18656271" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ijcard.2008.04.030" "WWW" => array:1 [ "link" => "10.1016/j.ijcard.2008.04.030" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ A Kugelman \n \t\t\t\t\t\t\t\t """ 1 => """ HA Choy \n \t\t\t\t\t\t\t\t """ 2 => """ R Liu \n \t\t\t\t\t\t\t\t """ 3 => """ MM Shi \n \t\t\t\t\t\t\t\t """ 4 => """ E Gozal \n \t\t\t\t\t\t\t\t """ 5 => """ HJ Forman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/ajrcmb.11.5.7946387" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "1994" "volumen" => "11" "paginaInicial" => "586" "paginaFinal" => "592" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7946387" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ Y Ikeda \n \t\t\t\t\t\t\t\t """ 1 => """ J Fujii \n \t\t\t\t\t\t\t\t """ 2 => """ N Taniguchi \n \t\t\t\t\t\t\t\t """ 3 => """ A Meister \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1073/pnas.92.1.126" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci. U S A" "fecha" => "1995" "volumen" => "92" "paginaInicial" => "126" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7816801" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1073/pnas.92.1.126" "WWW" => array:1 [ "link" => "10.1073/pnas.92.1.126" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The vascular biology of atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ P Libby \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "DP LPZipes, ROBonow, EBraunwald" "titulo" => "Heart disease; a textbook of cardiovascular medicine 7th.edition" "paginaInicial" => "924" "paginaFinal" => "933" "serieFecha" => "2005" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum gamma-glutamyl transferase activity: new high-risk criteria in acute coronary syndrome patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ T Ulus \n \t\t\t\t\t\t\t\t """ 1 => """ A Yildirir \n \t\t\t\t\t\t\t\t """ 2 => """ LE Sade \n \t\t\t\t\t\t\t\t """ 3 => """ A Temiz \n \t\t\t\t\t\t\t\t """ 4 => """ E Polat \n \t\t\t\t\t\t\t\t """ 5 => """ H Bozbaş \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/MCA.0b013e32830eab8c" "Revista" => array:7 [ "tituloSerie" => "Coron Artery Dis" "fecha" => "2008" "volumen" => "19" "paginaInicial" => "489" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18923245" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1550728918305781" "estado" => "S300" "issn" => "15507289" ] ] ] 1 => array:2 [ "doi" => "10.1097/MCA.0b013e32830eab8c" "WWW" => array:1 [ "link" => "10.1097/MCA.0b013e32830eab8c" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antioxidants attenuate postischemic endothelial cell swelling and luminal membrane blebbing in cardiac capillaries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ BJ Ward \n \t\t\t\t\t\t\t\t """ 1 => """ M Scoote \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1006/mvre.1996.1997" "Revista" => array:6 [ "tituloSerie" => "Microvasc Res" "fecha" => "1997" "volumen" => "53" "paginaInicial" => "179" "paginaFinal" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9143551" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1006/mvre.1996.1997" "WWW" => array:1 [ "link" => "10.1006/mvre.1996.1997" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Gamma-glytamiltransferase activity and cardiovascular diseases (ischemic heart disease and cerebral stroke)]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ IuP Nikitin \n \t\t\t\t\t\t\t\t """ 1 => """ SV Burakov \n \t\t\t\t\t\t\t\t """ 2 => """ GI Simonova \n \t\t\t\t\t\t\t\t """ 3 => """ SK Maliutina \n \t\t\t\t\t\t\t\t """ 4 => """ LV Shcherbakova \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Kardiologiia" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "4" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19076087" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603149665" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microvascular dysfunction in acute myocardial infarction: focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ AD Michaels \n \t\t\t\t\t\t\t\t """ 1 => """ CM Gibson \n \t\t\t\t\t\t\t\t """ 2 => """ HV Barron \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0002-9149(00)00811-0" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2008" "volumen" => "85" "paginaInicial" => "50B" "paginaFinal" => "60B" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11076131" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0002-9149(00)00811-0" "WWW" => array:1 [ "link" => "10.1016/S0002-9149(00)00811-0" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023298/v1_202212011334/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006600000010/v1_202212011334/S1807593222023298/v1_202212011334/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023298?idApp=UINPBA00004N"]

Statistics

CLINICAL SCIENCE

Uygar Cagdas YukselI, Turgay CelikI,

Corresponding author

benturgay@yahoo.com

Tel.: 90 312 3044268

, Murat CelikI, Baris BuganI, Atila IyisoyI, Halil YamanII

I Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, Etlik-Ankara/TURKEY

II Gulhane Military Medical Academy, School of Medicine, Department of Medical Biochemistry, Etlik-Ankara/TURKEY

Read

1029

Times
was read the article

277

Total PDF

752

Total HTML

Share statistics

 array:24 [
  "pii" => "S1807593222023298"
  "issn" => "18075932"
  "doi" => "10.1590/S1807-59322011001000010"
  "estado" => "S300"
  "fechaPublicacion" => "2011-10-01"
  "aid" => "2329"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2011;66:1729-34"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222023304"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322011001000011"
    "estado" => "S300"
    "fechaPublicacion" => "2011-10-01"
    "aid" => "2330"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2011;66:1735-42"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Comparative study of earthquake-related and non-earthquake-related head traumas using multidetector computed tomography"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1735"
          "paginaFinal" => "1742"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig3"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 904
              "Ancho" => 416
              "Tamanyo" => 51886
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; A 26-year-old man with earthquake-related head trauma caused by a collapsed building in the Sichuan earthquake&#46; The volume-rendering image shows fractures involving the right orbit&#44; zygomata and maxilla&#46; &#40;B&#41; A 40-year-old man with head trauma caused by a traffic accident&#46; The volume-rendering image shows multiple fractures involving the bilateral orbits&#44; zygomata&#44; nasal bone&#44; left maxilla and mandible&#44; and the bilateral maxillas are detached&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Zhi-gang Chu, Zhi-gang Yang, Zhi-hui Dong, Tian-wu Chen, Zhi-yu Zhu, Heng Shao"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Zhi-gang"
              "apellidos" => "Chu"
            ]
            1 => array:2 [
              "nombre" => "Zhi-gang"
              "apellidos" => "Yang"
            ]
            2 => array:2 [
              "nombre" => "Zhi-hui"
              "apellidos" => "Dong"
            ]
            3 => array:2 [
              "nombre" => "Tian-wu"
              "apellidos" => "Chen"
            ]
            4 => array:2 [
              "nombre" => "Zhi-yu"
              "apellidos" => "Zhu"
            ]
            5 => array:2 [
              "nombre" => "Heng"
              "apellidos" => "Shao"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023304?idApp=UINPBA00004N"
    "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023304/v1_202212011334/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222023286"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322011001000009"
    "estado" => "S300"
    "fechaPublicacion" => "2011-10-01"
    "aid" => "2328"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2011;66:1721-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Effects of preoperative inspiratory muscle training in obese women undergoing open bariatric surgery&#58; respiratory muscle strength&#44; lung volumes&#44; and diaphragmatic excursion"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1721"
          "paginaFinal" => "1727"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig3"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 226
              "Ancho" => 431
              "Tamanyo" => 7564
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">MEP evaluations of T1&#44; T2&#44; and T3 in IMT &#40;n &#61; 15&#41; and Control &#40;n &#61; 17&#41; groups&#46; &#40;values expressed as mean&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marcela Cangussu Barbalho-Moulim, Gustavo Peixoto Soares Miguel, Eli Maria Pazzianotto Forti, Fl&#225;vio do Amaral Campos, Dirceu Costa"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Marcela Cangussu"
              "apellidos" => "Barbalho-Moulim"
            ]
            1 => array:2 [
              "nombre" => "Gustavo Peixoto Soares"
              "apellidos" => "Miguel"
            ]
            2 => array:2 [
              "nombre" => "Eli Maria Pazzianotto"
              "apellidos" => "Forti"
            ]
            3 => array:2 [
              "nombre" => "Fl&#225;vio"
              "apellidos" => "do Amaral Campos"
            ]
            4 => array:2 [
              "nombre" => "Dirceu"
              "apellidos" => "Costa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023286?idApp=UINPBA00004N"
    "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023286/v1_202212011334/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
    "titulo" => "High admission levels of &#947;-glutamyltransferase predict poor myocardial perfusion after primary percutaneous intervention"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "1729"
        "paginaFinal" => "1734"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Uygar Cagdas Yuksel, Turgay Celik, Murat Celik, Baris Bugan, Atila Iyisoy, Halil Yaman"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "Uygar Cagdas"
            "apellidos" => "Yuksel"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Turgay"
            "apellidos" => "Celik"
            "email" => array:1 [
              0 => "benturgay@yahoo.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Murat"
            "apellidos" => "Celik"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Baris"
            "apellidos" => "Bugan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Atila"
            "apellidos" => "Iyisoy"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Halil"
            "apellidos" => "Yaman"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Gulhane Military Medical Academy&#44; School of Medicine&#44; Department of Cardiology&#44; Etlik-Ankara&#47;TURKEY"
            "etiqueta" => "I"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Gulhane Military Medical Academy&#44; School of Medicine&#44; Department of Medical Biochemistry&#44; Etlik-Ankara&#47;TURKEY"
            "etiqueta" => "II"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; 90 312 3044268"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 519
            "Ancho" => 498
            "Tamanyo" => 18862
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Comparison of Gamma-glutamyltransferase levels between study groups&#46; &#40;<span class="elsevierStyleBold">TMPG</span>&#58; TIMI myocardial perfusion grade&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">The objective of primary percutaneous coronary intervention &#40;pPCI&#41; is to restore normal blood flow in the infarct-related artery &#40;IRA&#41;&#46; Previous studies have shown that preservation of the microcirculation is critical for a positive clinical outcome&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a> It is well-known that achieving Thrombolysis in Myocardial Infarction &#40;TIMI&#41; grade 3 flow is insufficient to ensure myocardial salvage&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1&#44;2</a> In one-third of patients undergoing pPCI for acute myocardial infarction&#44; echo-contrast &#8216;no-reflow&#39; is observed after reperfusion therapy&#44; despite TIMI grade 3 flow&#46; This &#8216;no-reflow&#39; phenomenon is associated with a higher incidence of congestive heart failure and left ventricular dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib3">3</a> The TIMI myocardial perfusion grade &#40;TMPG&#41; was designed and validated to further risk-stratify patients in whom succsessful epicardial reperfusion was achieved&#46;<a class="elsevierStyleCrossRef" href="#bib2">2</a> TMPG is a multivariate predictor of 30-day mortality&#44; and is independent of age&#44; gender&#44; anterior MI location&#44; admission pulse rate&#44; corrected TIMI frame count&#44; or TIMI flow grade&#46;<a class="elsevierStyleCrossRef" href="#bib2">2</a> Previous clinical studies have clearly demonstrated that no-reflow predicts short- and long-term adverse clinical outcomes in patients presenting with acute myocardial infarction &#40;AMI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib4">4</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Gamma-glutamyltransferase &#40;GGT&#41;&#44; an enzyme that is normally found in the serum as well as in the plasma membrane of virtually all cells except erythrocytes&#44; catalyzes the first step in the degradation of extracellular glutathione &#40;GSH&#41;&#46; This degradation allows for precursor assimilation and reutilization of amino acids for synthesis of intracellular GSH&#44; the primary thiol antioxidant in mammalian cells&#46;<a class="elsevierStyleCrossRef" href="#bib5">5</a> Serum GGT level is widely used as a diagnostic test for hepatobiliary diseases and alcohol abuse&#46;<a class="elsevierStyleCrossRef" href="#bib6">6</a> Several clinical studies have shown that elevated serum GGT is associated with all-cause mortality and increased risk of AMI&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> Additionally&#44; degradation of GSH may play a pro-oxidant role under certain conditions&#46; Low density lipoprotein &#40;LDL&#41; oxidation through GSH&#47;GGT-dependent iron reduction has been suggested as an important mechanism in the pathogenesis of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a> Furthermore&#44; GGT activity has been observed in atherosclerotic coronary plaques&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a> Reperfusion injury due to free radical release and increased oxidative stress has been suggested as a possible mechanism in the pathophysiology of the no-reflow phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib10">10</a> Therefore&#44; we aimed to examine the possible relationship between admission levels of GGT and myocardial perfusion grades after pPCI in patients presenting with AMI&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Patients</span><p id="para30" class="elsevierStylePara elsevierViewall">The study population consisted of 40 patients with poor myocardial perfusion &#40;TMPG 0-1&#41; after pPCI and 40 age and sex-matched patients with better perfusion grades &#40;TMPG 2-3&#41; after the procedure &#40;total 80 patients&#44; 64 men and 16 women&#44; mean age &#61; 67&#46;5&#177;6&#46;6 years&#41;&#46; The retrospective selection included 265 acute ST-segment elevation myocardial infarction &#40;STEMI&#41; patients who were treated by pPCI from January 2003 to December 2007 at our institution&#46; The diagnosis of AMI was established using ACC&#47;AHA criteria&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a> All patients presented TIMI 0&#47;1 flow prior to intervention&#46; The study population was divided into two groups according to TMPG assessed immediately after pPCI&#46; No-reflow was defined as poor TMPG scores &#40;TMPG 0-1&#41; in the distal vasculature without apparent proximal coronary artery obstruction after intervention&#46; Each group &#40;group 1 and group 2&#41; consisted of 40 patients with TMPG 0-1 and TMPG 2-3&#44; respectively&#46; Part of the data included in this study was previously published elsewhere&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a></p><p id="para40" class="elsevierStylePara elsevierViewall">Patients with liver dysfunction and a history of chronic alcohol consumption&#44; culprit lesion in the left main coronary artery&#44; left main stenosis &#62;50&#37;&#44; previous coronary artery bypass surgery&#44; hemodialysis therapy&#44; cardiogenic shock&#44; pain to balloon time &#62;12 hours&#44; history of acute infection within the previous 10 days&#44; presence of any chronic inflammatory-autoimmune disease&#44; and any known malignancy were excluded from the study&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Coronary Intervention&#44; Analysis of Collateral Circulation and TIMI Myocardial Perfusion Grade</span><p id="para50" class="elsevierStylePara elsevierViewall">Coronary angiography &#40;Siemens HICOR T&#46;O&#46;P Image System&#44; Forcheim&#44; Germany&#41; was performed in multiple orthogonal projections using Judkins&#39; technique&#46; Coronary angiographic data were quantitatively analyzed&#46; A stenosis of greater than 70&#37; diameter in coronary arteries 1&#44; 2&#44; and 3 was defined as a one&#44; two&#44; or three-vessel disease&#44; respectively&#46; Collateral vessels were assessed according to the Rentrop classification&#46;<a class="elsevierStyleCrossRef" href="#bib13">13</a> Routine stenting following balloon angioplasty was systematically attempted with standard techniques&#44; including high-pressure balloon inflation &#40;&#62;14 atm&#41; to expand deployed stents&#46; A successful primary PCI procedure was defined as establishing a TIMI grade 3 flow in the artery responsible for AMI with a residual stenosis &#60;20&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib14">14</a> TMPG was graded densitometrically according to visual assessment of relative contrast opacification in the myocardial territory subtended by the infarct vessel in relation to epicardial density&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a></p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Echocardiography</span><p id="para60" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography was performed using an ESAOTE 2&#46;5 MHz probe &#40;ESAOTE&#44; Genova&#44; Italy&#41; at the left lateral decubitis position before pPCI&#46; Wall motion of 16 myocardial segments was interpreted according to the criteria of the American Society of Echocardiography&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a></p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Blood Chemistry</span><p id="para70" class="elsevierStylePara elsevierViewall">Venous blood samples were obtained on admission to the emergency room and analyzed for blood urea nitrogen&#44; GGT&#44; alanine aminotransferase &#40;ALT&#41;&#44; aspartate aminotransferase &#40;AST&#41; and creatine kinase-MB isoenzyme &#40;CKMB&#41; levels&#46; The next day&#44; fasting plasma samples were obtained to measure&#58; fasting plasma glucose &#40;FPG&#41;&#44; total serum cholesterol &#40;TC&#41;&#44; triglyceride &#40;TG&#41;&#44; high-density lipoprotein &#40;HDL&#41;&#44; and low-density lipoprotein &#40;LDL&#41; cholesterol&#46; Total serum cholesterol&#44; TG&#44; HDL&#44; glucose&#44; and GGT levels were measured via spectrophotometric technique on an Olympus AU-2700 autoanalyzer using commercial kits &#40;Olympus&#44; Hamburg&#44; Germany&#41;&#46; LDL cholesterol levels were calculated by the Friedwald formula&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Statistical Analysis</span><p id="para80" class="elsevierStylePara elsevierViewall">The One Sample Kolmogorov-Smirnov and Levene tests were used to determine the distribution characteristics of variables and variance homogeneity&#46; Results are expressed as mean &#177; SD&#44; median &#40;interquartile range&#41; and percentages&#46; The differences between groups were tested by chi-square&#44; independent samples t-test and Mann-Whitney U tests&#46; Differences were considered significant at <span class="elsevierStyleItalic">p</span>&#60;0&#46;05&#46; We investigated the effects of different variables on myocardial perfusion grade by calculating the odds ratios in a univariate analysis for all variables&#46; Variables displaying an unadjusted <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;15 in logistic regression analysis were identified as potential risk markers and included in the multivariate regression analysis&#46; We reduced the model using backward elimination&#44; and we eliminated potential risk markers through likelihood ratio tests&#46; Statistical analyses were performed using the SPSS 15&#46;0 Statistical Package Program for Windows &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">RESULTS</span><p id="para90" class="elsevierStylePara elsevierViewall">This retrospective study included 80 patients who presented with acute ST-segment elevation myocardial infarction &#40;64 men and 16 women&#44; mean age &#61; 67&#46;5&#177;6&#46;6 years&#41;&#46; All patients presented TIMI 0&#47;1 flow pre-procedurally&#46; Post-procedural TMPGs were analyzed by two different interventional cardiologists who were blinded to the patients&#39; clinical data&#46; Intra- and interobserver variability for TMPGs 0-1 were 7&#46;5&#37; and 10&#46;5&#37;&#44; respectively&#46; Although intra- and interobserver variability for TMPG 2 were 1&#46;9&#37; and 2&#46;7&#37;&#44; respectively&#44; both the intra- and interobserver variability for TMPG 3 were 0&#37;&#46; In cases of disagreement between the observers&#44; the cases were re-evaluated by both investigators and grouped according to the common final decision&#46; Patients with TMPG 0-1 and 2-3 formed Group 1 &#40;n &#61; 40&#44; 30 men&#44; mean age &#61; 68&#46;8&#177;5&#46;3 years&#41; and Group 2 &#40;n &#61; 40&#44; 34 men&#44; mean age &#61; 66&#46;2&#177;7&#46;5 years&#41;&#44; respectively&#46; Comparison between baseline demographical&#44; clinical&#44; and biochemical characteristics of patients with no-reflow and controls showed no statistically significant differences&#44; except for peak CKMB and GGT levels&#44; as shown in <a class="elsevierStyleCrossRefs" href="#tbl1">Tables 1 and 2</a> &#40;for CKMB&#58; 172&#46;4&#177;45&#46;1 U&#47;l vs&#46; 144&#46;5&#177;37&#46;8 U&#47;l&#44; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;003 and for GGT&#58; 64&#46;32&#177;16&#46;43 U&#47;L vs&#46; 41&#46;07&#177;10&#46;18 U&#47;L&#44; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#59; <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>&#41;&#46; We performed an ROC curve analysis to define the optimal cut-off value of admission-GGT to predict no-reflow&#46; A cut-off value of 50 U&#47;L GGT predicted no-reflow with a sensitivity and specificity of 82&#46;5&#37; and 80&#37;&#44; respectively &#40;AUC &#61; 0&#46;873&#59; 95&#37; CI &#61; 0&#46;791-0&#46;955&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#44; <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para100" class="elsevierStylePara elsevierViewall">The two groups presented with similar angiographic&#44; echocardiographic&#44; and electrocardiographic characteristics&#46; However&#44; pain to balloon time and admission TIMI flow grades &#40;TIMI flow 0-1&#41; were significantly different between the two groups &#40;<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#41;&#46; Direct stenting was performed in three patients from Group 1 and 2 patients from Group 2&#46; Drug-eluting stents were used in two patients from each group&#46; In Group 1&#44; pain to balloon time was longer &#40;6&#46;07&#177;0&#46;72 h vs&#46; 4&#46;63&#177;1&#46;16 h&#44; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41; and the percentage of low admission TIMI flow grades was higher than for patients in Group 2 &#40;95&#37; vs&#46; 80&#37;&#44; p &#61; 0&#46;03&#41;&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia><p id="para110" class="elsevierStylePara elsevierViewall">The effects of different variables on myocardial perfusion were analyzed using univariate and multivariate logistic regression analyses&#46; Data for the two groups was combined&#44; and all the variables were analyzed via univariate analysis for predictors of poor myocardial perfusion&#46; As shown in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#44; pain to balloon time&#44; GGT levels&#44; peak CKMB levels&#44; low LVEF&#44; poor TIMI grade&#44; wall motion score&#44; and older age displayed a significant relationship with poor myocardial perfusion in the univariate analysis&#46; When multivariate analyses were performed with eight variables in backward logistic regression analysis&#44; only pain to balloon time and GGT levels continued to display a statistically significant independent association with poor myocardial perfusion in the model&#46; Adjusted odds ratios were calculated as 4&#46;92 for pain to balloon time &#40;<span class="elsevierStyleItalic">p</span> &#61; 0&#46;009&#59; CI &#61; 1&#46;50-16&#46;13&#41; and 1&#46;13 for GGT &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#59; CI &#61; 1&#46;05-1&#46;21&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">DISCUSSION</span><p id="para120" class="elsevierStylePara elsevierViewall">Our study revealed that in patients with AMI undergoing pPCI&#44; high admission GGT levels are associated with lower myocardial perfusion grades after intervention&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">The no-reflow phenomenon is primarily attributed to the disturbed microvascular integrity that occurs due to free radical release&#44; microvascular constriction and obstruction&#44; platelet microembolism&#44; thrombosis and neutrophil aggregation and plugging&#46;<a class="elsevierStyleCrossRefs" href="#bib16">16&#8211;18</a></p><p id="para140" class="elsevierStylePara elsevierViewall">Reperfusion of the ischemic myocardium in AMI results in oxidative stress caused by the release of quantities of reactive oxygen species &#40;ROS&#41; that exceed the neutralizing potential of the cells&#39; anti-oxidative defense mechanisms&#46;<a class="elsevierStyleCrossRef" href="#bib19">19</a> Oxidative cellular damage induced by high levels of reactive oxygen species is considered a primary cause of lethal myocardial reperfusion injury&#46; The generation of reactive oxygen species during reperfusion is a complex process involving cardiomyocytes&#44; endothelial cells&#44; and activated neutrophils&#46; Re-energization of the electron transport chain in the mitochondria of cardiomyocytes leads to the formation of ubiquinone and oxygen-derived radicals&#46;<a class="elsevierStyleCrossRefs" href="#bib20">20&#44;21</a> After breaking down ATP&#44; post-ischemic cardiomyocytes release large amounts of adenosine and inosine&#44; which are further degraded by xanthine oxidase in endothelial cells&#44; constituting another important source of ROS&#46;<a class="elsevierStyleCrossRef" href="#bib21">21</a></p><p id="para150" class="elsevierStylePara elsevierViewall">Serum GGT level has been suggested as an independent cardiovascular risk factor&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a> It is also a predictor of all-cause and coronary heart disease-related mortality&#44; independent of alcohol intake or liver disease&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> GGT expression is increased by oxidants&#44; and GGT activity serves as a marker for oxidative stress in rat lung epithelial cells&#46;<a class="elsevierStyleCrossRef" href="#bib23">23</a> Increased serum GGT activity can be used as a marker for increased oxidative stress in humans&#46;<a class="elsevierStyleCrossRef" href="#bib24">24</a> Increased GGT activity is also present in atherosclerotic coronary plaques&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a></p><p id="para160" class="elsevierStylePara elsevierViewall">Oxidative and inflammatory events are closely related in the pathophysiology of acute coronary syndrome &#40;ACS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib25">25</a> Serum GGT activity has been suggested as an independent predictor of major adverse cardiovascular events in patients with ACS during coronary care unit stay and after hospitalization&#46;<a class="elsevierStyleCrossRef" href="#bib26">26</a></p><p id="para170" class="elsevierStylePara elsevierViewall">In the microvasculature of the heart&#44; post-ischemic reperfusion results in endothelial cell swelling and luminal membrane blebbing&#44; both of which may contribute to the no-reflow phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib27">27</a> Ischemia results in impaired antioxidant defense&#44; and subsequent reperfusion results in an increased concentration of reactive oxygen species&#46;<a class="elsevierStyleCrossRef" href="#bib19">19</a> In the current study&#44; we demonstrated that increased pre-procedural GGT levels display a statistically significant independent association with poor myocardial perfusion&#46; From this perspective&#44; we suggest that increased pre-procedural oxidative stress represented by GGT levels may be an important factor contributing to microvascular damage in patients with AMI&#46; Higher levels of GGT in patients with poor TMPG may be the result of increased microvascular injury and increased oxidative stress&#46; High GGT activity can also represent a compensatory response against the microvascular injury caused by free radicals&#46; It is also reasonable to expect increased GGT activity due to delayed pain-balloon time and subsequent increased myocardial injury&#46; On the other hand&#44; peak CKMB levels&#44; which are a specific marker of myocardial injury&#44; have been found to be independent of TMPG&#46; Therefore&#44; the significant association between TMPG and increased GGT activity as a non-specific marker for myocardial injury highlights the importance of oxidative stress in reperfusion injury&#44; poor TMPG and ischemic injury&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">The role of admission GGT levels in the prediction of poor myocardial perfusion grades after pPCI in patients with AMI has not been extensively studied&#46;<a class="elsevierStyleCrossRef" href="#bib28">28</a> The dynamic nature of acute coronary syndromes is usually associated with spontaneous ischemia-reperfusion injury in the infarct-related artery&#46;<a class="elsevierStyleCrossRef" href="#bib29">29</a> Therefore&#44; we considered the fact that poor myocardial perfusion after pPCI is not only related to procedural factors and clinical characteristics of the patients but may also be related to reperfusion injury and oxidative stress occurring before coronary intervention&#46; GGT can be used as a marker of poor post-procedural flow&#46; However&#44; the current data is not sufficient to suggest GGT as a causal agent&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">The major limitations of this study are small sample size and retrospective design&#46; Additionally&#44; self-reported alcohol consumption may not be reliable&#46; This study did not include a control group to compare the GGT levels of the AMI patients with healthy subjects&#46; Lastly&#44; we did not analyze other important plasma markers of oxidative stress&#44; such as oxidized LDL and plasma and&#47;or intracellular GSH levels&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">In conclusion&#44; high admission GGT levels are associated with poor myocardial perfusion after pPCI in patients with AMI&#46; High GGT levels and door to balloon time relate to the degree of reperfusion after pPCI&#46; An animal model comparing reperfusion injury in animals with higher and lower GGT levels would provide further evidence to support our findings&#46; Additional large-scale randomized studies are needed to clarify the clinical utility of admission GGT levels in the prediction of poor myocardial perfusion&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "xpalclavsec1582221"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "MATERIALS AND METHODS"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "cesec40"
              "titulo" => "Coronary Intervention&#44; Analysis of Collateral Circulation and TIMI Myocardial Perfusion Grade"
            ]
            2 => array:2 [
              "identificador" => "cesec50"
              "titulo" => "Echocardiography"
            ]
            3 => array:2 [
              "identificador" => "cesec60"
              "titulo" => "Blood Chemistry"
            ]
            4 => array:2 [
              "identificador" => "cesec70"
              "titulo" => "Statistical Analysis"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "cesec80"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec90"
          "titulo" => "DISCUSSION"
        ]
        5 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-03-23"
    "fechaAceptado" => "2011-06-23"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1582221"
          "palabras" => array:3 [
            0 => "Myocardial infarction"
            1 => "No-reflow phenomenon"
            2 => "Gamma-glutamyltransferase"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE&#58;</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">This retrospective study aimed to investigate the relationship between admission levels of serum &#947;-glutamyltransferase and poor myocardial perfusion after primary percutaneous coronary intervention in patients with acute myocardial infarction&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION&#58;</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">Reperfusion injury caused by free radical release and increased oxidative stress is responsible for the pathophysiology of the no-reflow phenomenon in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention&#46; Serum &#947;-glutamyltransferase is an established marker of increased oxidative stress&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">METHODS&#58;</span><p id="spara140" class="elsevierStyleSimplePara elsevierViewall">The study population consisted of 80 patients &#40;64 men and 16 women&#44; mean age &#61; 67&#46;5&#177;6&#46;6 years&#41; with thrombolysis in myocardial infarction 0&#47;1 flow pre-procedurally&#46; The patients were divided into two groups according to thrombolysis in myocardial perfusion grades that were assessed immediately following primary percutaneous coronary intervention&#46; The two groups &#40;group 1 and group 2&#41; each consisted of 40 patients with thrombolysis in myocardial perfusion grades 0-1 and thrombolysis in myocardial perfusion grades 2-3&#44; respectively&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS&#58;</span><p id="spara150" class="elsevierStyleSimplePara elsevierViewall">Admission pain to balloon time&#44; &#947;-glutamyltransferase and creatine kinase-MB isoenzyme levels of group 1 patients were significantly higher than those of group 2 patients&#46; Pain to balloon time&#44; &#947;-glutamyltransferase&#44; peak creatine kinase-MB isoenzyme&#44; low left ventricular ejection fraction and poor pre-procedural thrombolysis in myocardial infarction grade were significantly associated with poor myocardial perfusion by univariate analysis&#46; However&#44; only pain to balloon time and &#947;-glutamyltransferase levels showed a significant independent association with poor myocardial perfusion by backward logistic regression analysis&#46; Adjusted odds ratios were calculated as 4&#46;92 for pain to balloon time and 1&#46;13 for &#947;-glutamyltransferase&#46;</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSION&#58;</span><p id="spara160" class="elsevierStyleSimplePara elsevierViewall">High admission &#947;-glutamyltransferase levels are associated with poor myocardial perfusion in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention&#44; particularly in patients with prolonged pain to balloon time&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVE&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "INTRODUCTION&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "METHODS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "RESULTS&#58;"
          ]
          4 => array:2 [
            "identificador" => "ceabs50"
            "titulo" => "CONCLUSION&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 519
            "Ancho" => 498
            "Tamanyo" => 18862
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Comparison of Gamma-glutamyltransferase levels between study groups&#46; &#40;<span class="elsevierStyleBold">TMPG</span>&#58; TIMI myocardial perfusion grade&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 513
            "Ancho" => 498
            "Tamanyo" => 22840
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">ROC curve of Gamma-glutamyltransferase for predicting no-reflow&#46; &#40;<span class="elsevierStyleBold">AUC</span>&#58; area under curve&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">I</span>&#44; Body mass index&#59; <span class="elsevierStyleBold">MI</span>&#44; myocardial infarction&#59; <span class="elsevierStyleBold">HR</span>&#44; heart rate&#59; <span class="elsevierStyleBold">BAB</span>&#44; beta adrenergic blocker&#59; <span class="elsevierStyleBold">ACE-I</span>&#44; angiotensin converting enzyme inhibitor&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 1 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 2 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">68&#46;8&#177;5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">66&#46;2&#177;7&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Sex &#40;M&#41;&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">30 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">34 &#40;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Age &#62;70 years&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">8 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;9&#177;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;5&#177;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Hypercholesterolemia&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">17 &#40;42&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Family history&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Hypertension&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26 &#40;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">21 &#40;52&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Smoking&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">19 &#40;47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26 &#40;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Preinfarction angina&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">17 &#40;42&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Previous MI&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5 &#40;12&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Admission HR &#40;bpm&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">91&#177;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">86&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Killip Class</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Class I&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">36 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">37 &#40;92&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Class II-III&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">4 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">3 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Preprocedural medications</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Aspirin&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">21 &#40;52&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Nitrate&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">18 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">BAB&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">ACE-I&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">19 &#40;47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Statin&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">22 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Baseline demographic and clinical characteristics of the study patients&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">GT&#44;</span> Gamma-glutamyltransferase&#59; <span class="elsevierStyleBold">CKMB</span>&#44; Creatine kinase-MB isoenzyme&#59; <span class="elsevierStyleBold">AST&#44;</span> Alanine aminotransferase&#59; <span class="elsevierStyleBold">ALT&#44;</span> Aspartate aminotransferase&#59; <span class="elsevierStyleBold">LDL</span>&#44; Low density lipoprotein&#59; <span class="elsevierStyleBold">HDL</span>&#44; High density lipoprotein&#46;</p><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Results are expressed as mean&#177;SD or median &#40;interquartile range&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 1 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 2 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">GGT &#40;U&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">41&#46;07&#177;10&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">64&#46;32&#177;16&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Peak CKMB &#40;U&#47;l&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">172&#46;4&#177;45&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">144&#46;5&#177;37&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">AST &#40;U&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">50&#46;90&#177;9&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">52&#46;81&#177;12&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">ALT &#40;U&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">34&#46;27&#177;8&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">37&#46;10&#177;9&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Total cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">253&#46;75 &#40;227-290&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">255&#46;00 &#40;236-300&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Triglyceride &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">165&#46;00 &#40;132-244&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">153&#46;75 &#40;144-254&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">LDL cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">172&#46;87 &#40;142-215&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">166&#46;10 &#40;142-224&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">HDL cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">40&#46;50 &#40;37-48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">39&#46;25 &#40;27-50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Baseline biochemical characteristics of the study patients&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl3"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara90" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">LAD&#44;</span> Left anterior descending coronary artery<span class="elsevierStyleBold">&#59; RCA</span>&#44; Right coronary artery<span class="elsevierStyleBold">&#59; CFX</span>&#44; Circumflex coronary artery&#59; <span class="elsevierStyleBold">MLD</span>&#44; Minimal lumen diameter&#59; <span class="elsevierStyleBold">LVEF</span>&#44; Left ventricular ejection fraction&#59; <span class="elsevierStyleBold">TIMI</span>&#44; Thrombolysis in myocardial infarction&#59; <span class="elsevierStyleBold">WMS</span>&#44; Wall motion score&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 1 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Group 2 &#40;n &#61; 40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Pain to balloon time &#40;h&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;07&#177;0&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&#46;63&#177;1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Tirofiban use&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13 &#40;32&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11 &#40;27&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Preprocedural TIMI 0&#47;1&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">38 &#40;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">32 &#40;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">LVEF &#40;&#60;35&#37;&#41;&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Multivessel disease&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">13 &#40;32&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">10 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Infarct- related artery</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">LAD&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16 &#40;40&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">RCA&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">20 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">19 &#40;47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">CFX&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">6 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">5 &#40;12&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Reference diameter &#40;mm&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;03&#177;0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;12&#177;0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Lesion length &#40;mm&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">17&#46;05&#177;2&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&#46;90&#177;2&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Final balloon pressure &#40;Atm&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&#46;25&#177;2&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&#46;82&#177;1&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Collateral score</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;87&#177;0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;90&#177;0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Number of Q waves</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;92&#177;1&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;40&#177; 1&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">LVEF &#40;&#60;35&#37;&#41;&#44; n &#40;&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">WMS</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">12&#46;92&#177;2&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">12&#46;15&#177;1&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Angiographic&#44; echocardiographic&#44; and electrocardiographic characteristics of the patients&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl4"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spara110" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">WMS</span>&#44; Wall motion score&#59; <span class="elsevierStyleBold">CKMB</span>&#44; Creatine kinase MB isoenzyme&#59; <span class="elsevierStyleBold">LVEF</span>&#44; left ventricular ejection fraction&#59; <span class="elsevierStyleBold">TIMI</span>&#44; Thrombolysis in myocardial infarction&#59; <span class="elsevierStyleBold">GGT&#44;</span> Gamma-glutamyltransferase&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Unadjusted OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Adjusted OR<a class="elsevierStyleCrossRef" href="#tfn6">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Age &#62;70 years</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;78&#8211;5&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;23-14&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">WMS</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;94-1&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;65-1&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Number of Q waves</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;94-1&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;57-2&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Peak CKMB</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;00-1&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;98-1&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">LVEF &#40;&#60;35&#37;&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;18-8&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;50-23&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">TIMI 0&#47;1</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;56-10&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;47-17&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Pain to balloon time</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;70-14&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;50-16&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">GGT &#40;U&#47;L&#41;</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;09-1&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;05-1&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;50-3&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Killip</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Class I</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Class II-III</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;28-6&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Tirofiban use</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;30-2&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Multivessel disease</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;54-3&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Reference diameter</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;05-1&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Lesion length</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;86-1&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Final inflation pressure</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;67-1&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="top" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Collateral score</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;45-1&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn6"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">Adjusted for age&#62;70 years&#44; wall motion score&#44; number of Q waves&#44; peak CKMB&#44; LVEF&#60;35&#37;&#44; TIMI 0&#47;1&#44; pain to balloon time and GGT&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Effects of various variables on the myocardial perfusion grade assessed following primary percutaneous coronary intervention in univariate and multivariate logistic regression analyses&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2007 focused update of the ACC&#47;AHA&#47;SCAI 2005 guideline update for percutaneous coronary intervention&#58; a report of the American College of Cardiology&#47;American Heart Association Task Force on Practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SB King 3rd \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SC Smith Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JW Hirshfeld Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AK Jacobs \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              DA Morrison \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              DO Williams \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2007.10.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2008"
                        "volumen" => "51"
                        "paginaInicial" => "172"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18191745"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jacc.2007.10.002"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;jacc&#46;2007&#46;10&#46;002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CM Gibson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CP Cannon \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SA Murphy \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KA Ryan \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Mesley \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              SJ Marble \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.101.2.125"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2000"
                        "volumen" => "101"
                        "paginaInicial" => "125"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10637197"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical implications of the &#39;no reflow&#39; phenomenon&#46; A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              H Ito \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Maruyama \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Iwakura \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Takiuchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              T Masuyama \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Hori \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.93.2.223"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "93"
                        "paginaInicial" => "223"
                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8548892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              I Morishima \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Sone \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Okumura \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              H Tsuboi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              J Kondo \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              H Mukawa \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0735-1097(00)00865-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "1202"
                        "paginaFinal" => "1209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11028471"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002937820302271"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0735-1097(00)00865-2"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0735-1097&#40;00&#41;00865-2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enzymes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RG Krefetz \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GA McMillin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "ML FEBishop, LESchoeff"
                        "titulo" => "Clinical Chemistry"
                        "paginaInicial" => "255"
                        "paginaFinal" => "256"
                        "serieFecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum gamma glutamyl transpeptidase in relation to alcohol consumption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              JG Rollason \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Pincherle \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              D Robinson \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/0009-8981(72)90301-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chim Acta"
                        "fecha" => "1972"
                        "volumen" => "39"
                        "paginaInicial" => "75"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5038765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/0009-8981(72)90301-4"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;0009-8981&#40;72&#41;90301-4"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gamma-glutamyltransferase&#58; determinants and association with mortality from ischemic heart disease and all causes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              G Wannamethee \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Ebrahim \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AG Shaper \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/oxfordjournals.aje.a117699"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1995"
                        "volumen" => "142"
                        "paginaInicial" => "699"
                        "paginaFinal" => "708"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7572939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gamma-glutamyltransferase&#44; atherosclerosis&#44; and cardiovascular disease&#58; triggering oxidative stress within the plaque"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              M Emdin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Pompella \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Paolicchi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.105.571919"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "112"
                        "paginaInicial" => "2078"
                        "paginaFinal" => "2080"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16203922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.105.571919"
                      "WWW" => array:1 [
                        "link" => "10&#46;1161&#47;CIRCULATIONAHA&#46;105&#46;571919"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Images in cardiovascular medicine&#46; Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Paolicchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Emdin \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              E Ghliozeni \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Ciancia \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Passino \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              G Popoff \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000120558.41356.E6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "1440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15037540"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028209001484"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1161/01.CIR.0000120558.41356.E6"
                      "WWW" => array:1 [
                        "link" => "10&#46;1161&#47;01&#46;CIR&#46;0000120558&#46;41356&#46;e6&#34;&#44;-1&#44;&#34;xxx&#47;41356&#46;e6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              RL Engler \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/0002-9149(89)90225-7"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "19E"
                        "paginaFinal" => "23E"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2538048"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028221021373"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/0002-9149(89)90225-7"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;0002-9149&#40;89&#41;90225-7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2007 Focused Update of the ACC&#47;AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction&#58; a report of the American College of Cardiology&#47;American Heart Association Task Force on Practice Guidelines&#58; developed in collaboration With the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians&#58; 2007 Writing Group to Review New Evidence and Update the ACC&#47;AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction&#44; Writing on Behalf of the 2004 Writing Committee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              EM Antman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Hand \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PW Armstrong \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              ER Bates \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LA Green \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              LK Halasyamani \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.107.188209"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2008"
                        "volumen" => "117"
                        "paginaInicial" => "296"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18071078"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0015028208032652"
                          "estado" => "S300"
                          "issn" => "00150282"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.107.188209"
                      "WWW" => array:1 [
                        "link" => "10&#46;1161&#47;CIRCULATIONAHA&#46;107&#46;188209"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of admission glomerular filtration rate on the development of poor myocardial perfusion after primary percutaneous intervention in patients with acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              T Celik \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Iyisoy \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CU Yuksel \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Kilic \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MI Yilmaz \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              EO Akgul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1097/MCA.0b013e3283108fef"
                      "Revista" => array:6 [
                        "tituloSerie" => "Coron Artery Dis"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "543"
                        "paginaFinal" => "549"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19005288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1097/MCA.0b013e3283108fef"
                      "WWW" => array:1 [
                        "link" => "10&#46;1097&#47;MCA&#46;0b013e3283108fef"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serial angiographic assessment of coronary artery obstruction and collateral flow in acute myocardial infarction&#46; Report from the second Mount Sinai-New York University Reperfusion Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              KP Rentrop \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Feit \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              W Sherman \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JC Thornton \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.80.5.1166"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1989"
                        "volumen" => "80"
                        "paginaInicial" => "1166"
                        "paginaFinal" => "1175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2509103"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0090825818310965"
                          "estado" => "S300"
                          "issn" => "00908258"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1161/01.cir.80.5.1166"
                      "WWW" => array:1 [
                        "link" => "10&#46;1161&#47;01&#46;CIR&#46;80&#46;5&#46;1166"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phase I findings&#46; TIMI Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The Thrombolysis in Myocardial Infarction &#40;TIMI&#41; trial"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198504043121437"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1985"
                        "volumen" => "312"
                        "paginaInicial" => "932"
                        "paginaFinal" => "936"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4038784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommendations for quantitation of the left ventricle by two-dimensional echocardiography&#46; American Society of Echocardiography Committee on Standards&#44; Subcommittee on Quantitation of Two-Dimensional Echocardiograms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              NB Schiller \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PM Shah \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Crawford \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A DeMaria \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Devereux \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              H Feigenbaum \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Soc Echocardiog"
                        "fecha" => "1989"
                        "volumen" => "2"
                        "paginaInicial" => "358"
                        "paginaFinal" => "367"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular involvement in cardiac pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              JB Gavin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              L Maxwell \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SG Edgar \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1006/jmcc.1998.0824"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Mol Cell Cardiol"
                        "fecha" => "1998"
                        "volumen" => "30"
                        "paginaInicial" => "2531"
                        "paginaFinal" => "2540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9990524"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002937817311808"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1006/jmcc.1998.0824"
                      "WWW" => array:1 [
                        "link" => "10&#46;1006&#47;jmcc&#46;1998&#46;0824"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil accumulation in ischemic canine myocardium&#46; Insights into time course&#44; distribution&#44; and mechanism of localization during early reperfusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              WJ Dreyer \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LH Michael \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              MS West \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CW Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Rothlein \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RD Rossen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.84.1.400"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1991"
                        "volumen" => "84"
                        "paginaInicial" => "400"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2060111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              XL Ma \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PS Tsao \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GE Viehman \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AM Lefer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.res.69.1.95"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ Res"
                        "fecha" => "1991"
                        "volumen" => "69"
                        "paginaInicial" => "95"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2054945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Direct measurement of free radical generation following reperfusion of ischemic myocardium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              JL Zweier \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JT Flaherty \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              ML Weisfeldt \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.84.5.1404"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "1987"
                        "volumen" => "84"
                        "paginaInicial" => "1404"
                        "paginaFinal" => "1407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3029779"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1073/pnas.84.5.1404"
                      "WWW" => array:1 [
                        "link" => "10&#46;1073&#47;pnas&#46;84&#46;5&#46;1404"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mitochondria in homeostasis of reactive oxygen species in cell&#44; tissues&#44; and organism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              P Jezek \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              L Hlavata \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.biocel.2005.05.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Biochem Cell Biol"
                        "fecha" => "2005"
                        "volumen" => "37"
                        "paginaInicial" => "2478"
                        "paginaFinal" => "2503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16103002"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.biocel.2005.05.013"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;biocel&#46;2005&#46;05&#46;013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of oxidants and free radicals in reperfusion injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              JL Zweier \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MA Talukder \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cardiores.2006.02.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2006"
                        "volumen" => "70"
                        "paginaInicial" => "181"
                        "paginaFinal" => "190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16580655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.cardiores.2006.02.025"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;cardiores&#46;2006&#46;02&#46;025"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Additive prognostic value of gamma-glutamyltransferase in coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              M Emdin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Passino \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Michelassi \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              L Donato \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Pompella \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              A Paolicchi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2008.04.030"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2009"
                        "volumen" => "136"
                        "paginaInicial" => "80"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18656271"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.ijcard.2008.04.030"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;ijcard&#46;2008&#46;04&#46;030"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              A Kugelman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              HA Choy \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Liu \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MM Shi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Gozal \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              HJ Forman \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.11.5.7946387"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "1994"
                        "volumen" => "11"
                        "paginaInicial" => "586"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7946387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              Y Ikeda \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Fujii \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              N Taniguchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Meister \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.92.1.126"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci&#46; U S A"
                        "fecha" => "1995"
                        "volumen" => "92"
                        "paginaInicial" => "126"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7816801"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1073/pnas.92.1.126"
                      "WWW" => array:1 [
                        "link" => "10&#46;1073&#47;pnas&#46;92&#46;1&#46;126"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The vascular biology of atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              P Libby \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "DP LPZipes, ROBonow, EBraunwald"
                        "titulo" => "Heart disease&#59; a textbook of cardiovascular medicine 7th&#46;edition"
                        "paginaInicial" => "924"
                        "paginaFinal" => "933"
                        "serieFecha" => "2005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum gamma-glutamyl transferase activity&#58; new high-risk criteria in acute coronary syndrome patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              T Ulus \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Yildirir \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              LE Sade \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Temiz \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Polat \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              H Bozba&#351; \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1097/MCA.0b013e32830eab8c"
                      "Revista" => array:7 [
                        "tituloSerie" => "Coron Artery Dis"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "489"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18923245"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1550728918305781"
                          "estado" => "S300"
                          "issn" => "15507289"
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1097/MCA.0b013e32830eab8c"
                      "WWW" => array:1 [
                        "link" => "10&#46;1097&#47;MCA&#46;0b013e32830eab8c"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antioxidants attenuate postischemic endothelial cell swelling and luminal membrane blebbing in cardiac capillaries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              BJ Ward \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Scoote \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1006/mvre.1996.1997"
                      "Revista" => array:6 [
                        "tituloSerie" => "Microvasc Res"
                        "fecha" => "1997"
                        "volumen" => "53"
                        "paginaInicial" => "179"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9143551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1006/mvre.1996.1997"
                      "WWW" => array:1 [
                        "link" => "10&#46;1006&#47;mvre&#46;1996&#46;1997"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Gamma-glytamiltransferase activity and cardiovascular diseases &#40;ischemic heart disease and cerebral stroke&#41;&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              IuP Nikitin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SV Burakov \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GI Simonova \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              SK Maliutina \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LV Shcherbakova \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Kardiologiia"
                        "fecha" => "2008"
                        "volumen" => "48"
                        "paginaInicial" => "4"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19076087"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673603149665"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular dysfunction in acute myocardial infarction&#58; focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              AD Michaels \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CM Gibson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              HV Barron \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9149(00)00811-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "85"
                        "paginaInicial" => "50B"
                        "paginaFinal" => "60B"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11076131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0002-9149(00)00811-0"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0002-9149&#40;00&#41;00811-0"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023298/v1_202212011334/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006600000010/v1_202212011334/S1807593222023298/v1_202212011334/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023298?idApp=UINPBA00004N"
]

Article information

ISSN: 18075932
Original language: English

DOI:10.1590/S1807-59322011001000010

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	8	0	8
2024 October	54	23	77
2024 September	41	14	55
2024 August	51	22	73
2024 July	42	22	64
2024 June	25	6	31
2024 May	40	13	53
2024 April	34	11	45
2024 March	56	10	66
2024 February	52	13	65
2024 January	32	11	43
2023 December	23	16	39
2023 November	27	19	46
2023 October	27	29	56
2023 September	21	19	40
2023 August	13	10	23
2023 July	8	14	22
2023 June	15	17	32
2023 May	35	3	38
2023 April	41	0	41
2023 March	54	1	55
2023 February	14	1	15
2023 January	2	2	4
2022 December	37	1	38

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter