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Recently, cancer immunotherapy targeting PD-1 or PD-L1 has proven effective in causing durable antitumor immune responses with less toxicity in many types of tumors.

PD-1/PD-L1 blockade therapy will be the major cancer immunotherapy modality.

A deeper understanding of personal genomic information, and personalized markers in guiding anti-PD therapy.

Similar to the tip of an iceberg, PD-1/PD-L1 blockade antitumor immunotherapy opens a new era of cancer treatment, and further work on safety and efficiency will be required.

BMMSC-CM therapy on rats with DFUs enhanced the wound healing process.

It accelerated wound closure and promoted cell proliferation and angiogenesis.

It enhancd cell autophagy and reduced cell pyroptosis in ulcers.

There is a high prevalence of depressive symptoms in patients with Crohn's disease.

Depressive symptoms are related to the active disease.

According to the Montreal classification, the penetraing behavior of Crohn's disease, was less related a rates of depression than inflammatory behavior disease.

High quality of bowel cleansing is important to the accuracy of diagnosis and the safety of treatment in colonoscopy.

PEG combined with lactulose has a better efficacy in bowel preparation than PEG alone.

PEG combined with lactulose has fewer adverse reactions than PEG alone in bowel preparation.

WWI was a potential predictor for cardiovascular mortality with a cut-off of 11.33.

Higher WWI associated with an increased 95% risk for cardiovascular mortality.

Higher WWI associated with an increased 68% risk for all-cause mortality.

Decision support systems that can predict the diagnosis of malignancy for pleural effusion will help physicians in patient management.

Advances in computer-aided diagnostic analysis of CT images and obtaining a pre-diagnosis of pleural fluid may reduce the need for interventional procedures by guiding physicians about which patients may have malignancy.

Image-based decision support systems enable early diagnosis and treatment by saving cost and time in patient management.

COVID-19 pandemic was associated with an increase in healthcare-associated infection.

For the majority of microorganisms, the proportion of resistance did not increase.

The large spectrum antibiotic consumption increased disproportionately during the pandemic.

miR-96-5p and 182-5p are associated with FOXO3a dysregulation and cancer.

FOXO3a and miRNAs represent molecular markers in Brazilian breast cancer patients.