Most cited

WWI was a potential predictor for cardiovascular mortality with a cut-off of 11.33.

Higher WWI associated with an increased 95% risk for cardiovascular mortality.

Higher WWI associated with an increased 68% risk for all-cause mortality.

Recently, cancer immunotherapy targeting PD-1 or PD-L1 has proven effective in causing durable antitumor immune responses with less toxicity in many types of tumors.

PD-1/PD-L1 blockade therapy will be the major cancer immunotherapy modality.

A deeper understanding of personal genomic information, and personalized markers in guiding anti-PD therapy.

Similar to the tip of an iceberg, PD-1/PD-L1 blockade antitumor immunotherapy opens a new era of cancer treatment, and further work on safety and efficiency will be required.

COVID-19 pandemic was associated with an increase in healthcare-associated infection.

For the majority of microorganisms, the proportion of resistance did not increase.

The large spectrum antibiotic consumption increased disproportionately during the pandemic.

Bisphenola A (BPA) is an endocrine disruptor widely investigated as a possible environmental contributor to the pathogenesis of Polycystic Ovary Syndrome (PCOS).

Due to its structural similarity with the Estrogen molecule (E2), it acts as a xenoestrogen, binding to genomic and non-genomic estrogen receptors, causing metabolic and hormonal changes that lead to PCOS (hyperandrogenism, insulin resistance, hyperinsulinemia, obesity, atherogenic dyslipidemia, anovulation, and ovarian cysts).

The aim and of this review were to present the mechanisms of bisphenol A participation in the pathogenesis of Polycystic Ovary Syndrome.

BMMSC-CM therapy on rats with DFUs enhanced the wound healing process.

It accelerated wound closure and promoted cell proliferation and angiogenesis.

It enhancd cell autophagy and reduced cell pyroptosis in ulcers.

Gestational trophoblastic neoplasia responds to anti-PD-1 or anti-PD-L1 immunotherapy.

Multi-drug resistant gestational trophoblastic neoplasia may achieve remission with pembrolizumab.

miR-96-5p and 182-5p are associated with FOXO3a dysregulation and cancer.

FOXO3a and miRNAs represent molecular markers in Brazilian breast cancer patients.

This meta-analysis shows that gefitinib plus chemotherapy showed significantly better efficacy in improving objective response rate, disease control rate, progression-free survival, and OS as compared with gefitinib alone.

Similar efficacy of gefitinib plus chemotherapy is found in the sub-population with positive EGFR mutation.

The toxicity of gefitinib plus chemotherapy is also increased but within clinical management.

Decision support systems that can predict the diagnosis of malignancy for pleural effusion will help physicians in patient management.

Advances in computer-aided diagnostic analysis of CT images and obtaining a pre-diagnosis of pleural fluid may reduce the need for interventional procedures by guiding physicians about which patients may have malignancy.

Image-based decision support systems enable early diagnosis and treatment by saving cost and time in patient management.