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3
Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expressionJin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding
3
Highlights
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TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.
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FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.
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Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.
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TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.
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Physicians’ attention to patients’ communication cues can improve patient satisfaction with care and perception of physicians’ empathyCarlos Frederico Confort Campos, Clarice Rosa Olivo, Milton de Arruda Martins, Patricia Zen Tempski
3
Highlights
• Patient-doctor communication relates to patient satisfaction and perceived empathy.
• Patients asking questions was linked to poor satisfaction and empathy perceptions.
• Doctor's use of negative communication skills related to worse rapport with patients.
• Satisfaction and empathy are positively linked to patient affective expression.
• Doctors providing advice/suggestions positively correlated to patient satisfaction.
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3
Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severityJamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
3
Highlights
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Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.
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Changes in HDL-C levels, significantly impact Long-COVID-19 progression.
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Ferritin may exacerbate disease progression by increasing oxidative stress.
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HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.
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Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysisMaria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
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Highlights
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Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.
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Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.
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The combination of noradrenergic and antimuscarinic drugs shows promising results.
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Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria ratios are associated with worse prognosis in a cohort of Latin American patients with cirrhosisAugusto Mantovani, Larisse Longo, Rutiane Ullmann Thoen, Pabulo Henrique Rampelotto, Raul Salinas, Gabriel Tayguara Silveira Guerreiro, Mário Reis Álvares-da-Silva
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Highlights
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Gut Microbiota (GM) has an important role in liver diseases progression.
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Notable differences in GM and diversity exist between healthy individuals and cirrhosis patients.
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Changes in GM are associated with an increased risk of mortality within 90 days.
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Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria predict hepatic decompensation and mortality.
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Serum procalcitonin as a marker of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)Tao Jiang, Wen-Xian Ouyang, Yan-Fang Tan, Ying Yu, Xiao-Mei Qin, Hai-Yan Luo, Lian Tang, Hui Zhang, Shuang-Jie Li
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Highlights
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PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.
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PCT was reduced when NICCD was treated.
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PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.
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Health-Related quality of life by 31-item Cervantes scale in breast cancer survivors undergoing adjuvant endocrine therapyIsis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Andressa Miranda Machado, Paula Philbert Lajolo, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
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HIGHLIGHTS
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CS-31 seems to be appropriate for use in oncology and may help to monitoring adverse effects and HRQL.
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Multidisciplinary team for patients with neurocutaneous syndromes: The little discussed importance of dentistryMarcos Roberto Tovani-Palone, Filippo Bistagnino, Pritik A. Shah
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Highlights
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The inclusion of dentists in multidisciplinary teams for patients with neurocutaneous syndromes is essential, both on an outpatient and hospital basis.
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Interestingly, dentistry can play a relevant role in the early diagnosis and differential diagnosis of patients with neurocutaneous syndromes.
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More research in this area is needed.
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microRNA-181a-5p promotes fibroblast differentiation of mesenchymal stem cells in rats with pelvic floor dysfunctionYongHong Zhang, HaiYang Yu, JianChao Li
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Highlights
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miR-181a-5p promotes fibroblast differentiation of BMSCs.
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miR-181a-5p promotes fibroblast differentiation of BMSCs by targeting MFN1.
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BMSCs containing miR-181a-5p improve PFD in SD rats by targeting MFN1 expression, thereby accelerating the fibroblast differentiation of BMSCs.
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Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysisEduardo Carvalho de Arruda Veiga, Marise Samama, Fabio Ikeda, Giovanna Santos Cavalcanti, Amanda Sartor, Suelen Fernanda Parames, Edmund C. Baracat, Joji Ueno, Jose Maria Soares Junior
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Highlights
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Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.
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Melatonin had beneficial effects such as the improvement in the fertilization rate.
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Melatonin has a beneficial effect on the formation of mature oocytes (MII).
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