Utilidad de atazanavir en poblaciones especiales | Enfermedades Infecciosas y Microbiología Clínica

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En el momento actual, con el tratamiento antirretroviral (TAR) se consigue prolongar la supervivencia de las personas que viven con virus de la inmunodeficiencia humana (VIH) de forma indefinida. Debido a ello, nos encontramos cada vez con mayor frecuencia con problemas específicos que anteriormente no daba tiempo a desarrollar o no tenían la importancia que ahora alcanzan, y que configuran, a poblaciones especiales de pacientes. Ejemplos de situaciones que caracterizan a estas poblaciones especiales son: la coinfección por virus de la hepatitis B y/o C, el embarazo, la lipodistrofia, el riesgo cardiovascular, la insuficiencia renal, el tratamiento de los niños y adolescentes, la atención a personas desplazadas (inmigrantes) y el tratamiento de personas que estén recibiendo tratamiento sustitutivo con metadona, entre otras. En el presente artículo revisamos el papel que puede tener atazanavir en el TAR de pacientes en las situaciones mencionadas, excepto las que ya son tratadas específicamente en otros artículos, tal como la coinfección por virus de la hepatitis B y/o C.

Palabras clave:

Atazanavir

Embarazo

Lipodistrofia

Riesgo cardiovascular

Insuficiencia renal

Niños

Inmigrantes

Metadona

ART (antiretroviral therapy) currently continues to indefinitely prolong the survival of patients who live with HIV. Due to this, we are increasingly faced with specific problems that previously did not have time to develop or did not have the importance that they have now, and which are related to the existence of special patient populations. Examples of situations that characterise these special populations are: co-infection with hepatitis virus B and/or C, pregnancy, lipodystrophy, cardiovascular risk, renal failure, treatment of children and adolescents, immigrant health care, and the management of patients receiving methadone replacement therapy, among others. In this article we review the role that Atazanavir (ATV) can play in the ART of patients in the situations mentioned, except those that are already dealt with specifically in other articles, such as co-infection by hepatitis virus B and/or C.

Key words:

Atazanavir

Pregnancy

Lipodystrophy

Cardiovascular risk

Renal failure

Children

Immigrants

Methadone

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