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Inicio Medicina Clínica Risk factors of death from vascular events among cancer survivors: A SEER databa...
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Vol. 156. Issue 2.
Pages 49-54 (January 2021)
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Vol. 156. Issue 2.
Pages 49-54 (January 2021)
Original article
Risk factors of death from vascular events among cancer survivors: A SEER database analysis
Factores de riesgo de muerte por episodios vasculares entre los supervivientes de cáncer: análisis de la base de datos SEER
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Jian Wang, Xin Yan, Wei Feng, Wenhua Shi, Qingting Wang, Qianqian Zhang, Limin Chai, Pengtao Liu, Yuqian Chen, Cong Li, Manxiang Li
Corresponding author
manxiangli@hotmail.com

Corresponding author.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, PR China
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Abstract
Introduction

Cancer is the most important leading cause of death in the world and vascular events are the second-leading cause of death in cancer patients after cancer itself. Understanding related risk factors associated with vascular events may help clinicians develop appropriate treatment strategies. However, few large-scale population-based studies have investigated the risk factors for vascular events among cancer patients.

Materials and methods

The study involved a retrospective evaluation of medical records from the SEER database. Ten most common cancers in the past 20 years were extracted from the database. Cox proportional hazards model was used to analyze risk factors affecting vascular events that caused death among cancer patients.

Results

This study revealed that cancer patients had a serious risk of vascular events caused death, the 1-year, 3-year, 5-year and the overall rates of mortality from vascular events were 6.0%, 10.8%, 17.9% and 25.8%, respectively. The results showed that male, black race, elderly, AJCC stage II, stage III and stage IV, with no multiple primary cancers and no surgical treatment were associated with a significantly increased risk of vascular events caused death.

Discussion

We hope this research can alert clinicians and help them select high-risk cancer patients who may die from vascular events. And for those patients, we recommend that clinicians regularly monitor the patient's coagulation function and perform individualized thromboprophylaxis promptly to reduce the risk of death from vascular events.

Keywords:
Cancer
Thromboembolism
Bleeding
Risk factor
SEER database
Resumen
Introducción

El cáncer es la causa más importante de muerte a nivel mundial, y los episodios vasculares son la segunda causa más importante de muerte en los pacientes de cáncer, tras la enfermedad en sí misma. Comprender los factores de riesgo relacionados con los episodios vasculares puede ayudar a los facultativos a desarrollar estrategias terapéuticas adecuadas. Sin embargo, son pocos los estudios a gran escala basados en población que investigan los factores de riesgo de los episodios vasculares entre los pacientes de cáncer.

Materiales y métodos

El estudio incluyó la evaluación retrospectiva de las historias médicas de la base de datos SEER, de donde se extrajeron los 10 tipos de cáncer más comunes en los últimos 20 años. Se utilizó el modelo de regresión de Cox para analizar los factores de riesgo que afectan a los episodios vasculares que causaron la muerte entre los pacientes de cáncer.

Resultados

Este estudio reveló que los pacientes de cáncer tenían un riesgo grave de muerte causada por episodios vasculares. Las tasas de mortalidad causada por episodios vasculares a 1, 3, 5 años y global, fueron del 6, 10,8, 17,9 y 25,8%, respectivamente. Los resultados reflejaron que los varones, de raza negra, mayores, con AJCC estadios II, III y IV, sin cánceres primarios múltiples y sin tratamiento quirúrgico estaban relacionados con el incremento del riesgo significativo de muertes causadas por episodios vasculares.

Discusión

Esperamos que esta investigación pueda alertar a los clínicos, y ayudarles a seleccionar a los pacientes de cáncer con alto riesgo de muerte causada por episodios vasculares. Y recomendamos también que los facultativos supervisen regularmente la función de coagulación de dichos pacientes, realizando tromboprofilaxis individualizada para reducir el riesgo de muertes causadas por episodios vasculares.

Palabras clave:
Cáncer
Tromboembolismo
Sangrado
Factor de riesgo
Base de datos SEER

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