Late leukoencephalopathy in patients with methanol intoxication

Rivero Rodriguez, Dannys; Sam, Kimberly; Bravo, Michelle

doi:10.1016/j.medcle.2019.09.019

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(A) C vs. G; (B) CC+GC vs. GG; (C) CC vs. GG." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zulvikar Syambani Ulhaq, Gita Vita Soraya" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Zulvikar Syambani" "apellidos" => "Ulhaq" ] 1 => array:2 [ "nombre" => "Gita Vita" "apellidos" => "Soraya" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0025775320304498" "doi" => "10.1016/j.medcli.2020.07.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320304498?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020620305519?idApp=UINPBA00004N" "url" => "/23870206/0000015500000012/v1_202012131835/S2387020620305519/v1_202012131835/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "Scientific letter" "titulo" => "Late leukoencephalopathy in patients with methanol intoxication" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "557" "paginaFinal" => "558" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Dannys Rivero Rodriguez, Kimberly Sam, Michelle Bravo" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Dannys" "apellidos" => "Rivero Rodriguez" "email" => array:1 [ 0 => "dannyriverorodriguez@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Kimberly" "apellidos" => "Sam" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Michelle" "apellidos" => "Bravo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "San Francisco University of Quito USFQ, Ecuador" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Neurology Department, Eugenio Espejo Hospital, Quito, Ecuador" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Neurology Department, Donald, United States" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Barbara Zucker School of Medicine at Hofstra/Northwell, United States" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leucoencefalopatía tardía posterior a intoxicación por metanol" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 633 "Ancho" => 1405 "Tamanyo" => 127514 ] ] "descripcion" => array:1 [ "en" => "Patient 1. (P1) MRI Scan | MRI demonstrates bilateral hemorrhagic necrosis (white arrows) of the putamen, displaying the T1WI, T2WI, FLAIR, DWI, and ADC images. On day 8, the DWI is positive in the putamen and occipital lobe (red arrows), suggesting evidence of cytotoxic edema with acute leukoencephalopathy. At 36 days (B), signal hyperintensity in the subcortical/occipital and frontal white matter shows progression towards chronic leukoencephalopathy (green arrows) (high signal intensity on T2WI, FLAIR, DWI and ADC, T2 shine-through effect)." ] ] ] "textoCompleto" => "Methanol is a clear substance with pronounced similarities in flavor and aroma to ethanol. It is highly toxic to the CNS and damage to the optic nerve and basal ganglia, accompanied by severe metabolic acidosis, have been observed within hours following ingestion. Common clinical manifestations of methanol intoxication (MI) include blindness, headache, abdominal pain, drowsiness, seizures, coma, and death.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>The most recurrent neuroradiological finding demonstrated by CT and MR imaging (MRI) is putaminal necrosis, with varying degrees of putaminal hemorrhage; however, optic nerve damage and white and grey matter lesions in various locations have also been reported, though less frequently.In this study, we report two patients (P1, 2) with accidental methanol ingestion who developed late toxic leukoencephalopathy. The symptoms most frequently reported during the first medical evaluation (6-h after ingestion) were abdominal pain, headache, diaphoresis, and declined visual acuity. The progressive decrease in Glasgow coma score (GCS) during the initial 24h (P1, 13-9/15-GCS. P2, 15-12/15-GCS) of hospitalization, coupled with metabolic acidosis (P1, PH-6.80, PCO2-25.7, HCO3-3.90, Lactic acid-12.1mmol/L. P2, PH-7.13, PCO2-12.0, HCO3-4.0, Lactic acid-1.9mmol/L) and a notably high anion gap (P1-41.8mEq/l. P2-39.0mEq/l), suggested the diagnosis of MI. The diagnosis was confirmed after methanol levels in the blood were tested and exceeded 20mg/dL (P1-43mg/l. P2-28mg/l).In the both cases (P1, P2) was it possible to perform an initial MRI scan, allowed by their stable clinical status; more than 30 days later, follow-up MRI was performed, demonstrating the progression of active toxic leukoencephalopathy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In all patients, putaminal hemorrhagic necrosis was observed, with subcortical and deep white matter damage.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>MI causes severe damage to the CNS. Putaminal hemorrhagic necrosis has been described as the most frequent radiological and clinical-pathological finding in these patients. White matter (WM) lesions are another finding seen in MI; they have been observed to be bilateral, deep, or subcortical, although occasionally the subcortical fibers have been preserved.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> There are few case studies in the literature investigating DWI findings that use follow-up MRI evaluation after MI.<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a> It is probable that the prominent obstacles leading to difficulties in studying the severity of illness is the high level of morbidity and mortality associated with MI, which can cause difficulties in performing follow-up MRI studies, and the unstable initial state of the patient upon admission.One of the few descriptions of serial MRI studies in MI patients was described in a 2006 case study. Takao et al.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> reported restricted diffusion in the putamen and subcortical fibers, with a putaminal lesion in the initial MRI scan. Following three days, MRI revealed a new lesion in the subcortical fibers, leading the authors to hypothesize that the new lesion was related to the cytotoxic edema observed in the first MRI scan. On the 19th day, MRI revealed progressed, hemorrhagic damage to the subcortical fibers.In our two patients, we were able to demonstrate how relatively symmetric leukoencephalopathy in the frontal and/or occipital lobes continued to worsen more than 30 days after MI. We hypothesize that the initial restricted diffusion in the subcortical fibers in the DWI, indicative of cytotoxic edema, represents an early marker of potential WM damage seen in later imaging. In the patient with more extensive leukoencephalopathy detected in the later stages of MI (P1), we observed worsened morbidity at three months following hospital discharge, leading us to suspect that WM lesions predict poor outcome following MI. From our patients’ imaging studies, we suspect that progressive WM lesions may be a significant finding in these patients, highlighting the severity over time following MI.Further investigation of the relationship between the development of chronic leukoencephalopathy and the quantity of methanol ingested provides additional insight that can be used as a valuable predictive tool for prognostics.Due to the few studies that have conducted follow-up MRI studies during the later stages of MI, and with our sample size being small, we cannot conclude that leukoencephalopathy is a long-term finding associated with MI. Nevertheless, it is worth exploring whether there is a relationship between worsened neuronal damage on serial MRI and patient outcomes.FundingThis research received no external funding." "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 633 "Ancho" => 1405 "Tamanyo" => 127514 ] ] "descripcion" => array:1 [ "en" => "Patient 1. (P1) MRI Scan | MRI demonstrates bilateral hemorrhagic necrosis (white arrows) of the putamen, displaying the T1WI, T2WI, FLAIR, DWI, and ADC images. On day 8, the DWI is positive in the putamen and occipital lobe (red arrows), suggesting evidence of cytotoxic edema with acute leukoencephalopathy. At 36 days (B), signal hyperintensity in the subcortical/occipital and frontal white matter shows progression towards chronic leukoencephalopathy (green arrows) (high signal intensity on T2WI, FLAIR, DWI and ADC, T2 shine-through effect)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MRI findings in methanol intoxication: a report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Arora" 1 => "I.B. Nijjar" 2 => "A.S. Multani" 3 => "J.P. Singh" 4 => "R. Abrol" 5 => "R. Chopra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1259/bjr/40137535" "Revista" => array:6 [ "tituloSerie" => "Br J Radiol" "fecha" => "2007" "volumen" => "80" "paginaInicial" => "e243" "paginaFinal" => "e246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17959915" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CT and MR imaging findings in methanol intoxication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Blanco" 1 => "R. Casado" 2 => "F. Vázquez" 3 => "J.M. Pumar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR Am J Neuroradiol" "fecha" => "2006" "volumen" => "27" "paginaInicial" => "452" "paginaFinal" => "454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16484428" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffusion-weighted magnetic resonance imaging in a case of methanol intoxication" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Deniz" 1 => "C. Oppenheim" 2 => "S. Lehéricy" 3 => "T. Sharshar" 4 => "T.F. Lalam" 5 => "D. Dormont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurotoxicology" "fecha" => "2000" "volumen" => "21" "paginaInicial" => "405" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10894130" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conventional and diffusion-weighted MR IMAGING in the evaluation of methanol poisoning" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Server" 1 => "K.E. Hovda" 2 => "P.H. Nakstad" 3 => "D. Jacobsen" 4 => "R. Dullerud" 5 => "M. Haakonsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Radiol" "fecha" => "2003" "volumen" => "44" "paginaInicial" => "691" "paginaFinal" => "695" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serial diffusion-weighted magnetic resonance imaging in methanol intoxication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Takao" 1 => "I. Doi" 2 => "T. Watanabe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.rct.0000228165.16592.0d" "Revista" => array:6 [ "tituloSerie" => "J Comput Assist Tomogr" "fecha" => "2006" "volumen" => "30" "paginaInicial" => "742" "paginaFinal" => "744" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16954921" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015500000012/v1_202012131835/S2387020620305490/v1_202012131835/en/main.assets" "Apartado" => array:4 [ "identificador" => "43311" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015500000012/v1_202012131835/S2387020620305490/v1_202012131835/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020620305490?idApp=UINPBA00004N"]

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Vol. 155. Issue 12.

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