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Inicio Medicina Clínica (English Edition) Tuberculosis: Plasma levels of vitamin D and its relation with infection and dis...
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Vol. 144. Issue 3.
Pages 111-114 (February 2015)
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Vol. 144. Issue 3.
Pages 111-114 (February 2015)
Brief report
Tuberculosis: Plasma levels of vitamin D and its relation with infection and disease
Infección y enfermedad tuberculosa en relación con concentraciones plasmáticas de vitamina D
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Erika Esteve Palaua, Francesca Sánchez Martíneza,
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97816@parcdesalutmar.cat

Corresponding author.
, Hernando Knobel Freuda, José-Luís López Colomésa, Adolfo Diez Pérezb
a Servicio de Enfermedades Infecciosas, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
b Servicio de Medicina Interna, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
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Tables (3)
Table 1. Comparison between active tuberculosis (cases) and latent infection (contacts).
Table 2. Anatomical location of tuberculosis and logistic regression analysis of factors associated with anatomical location.
Table 3. Vitamin D deficiency: comparison between severe and non-severe forms of tuberculosis.
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Abstract
Background and objective

Vitamin D (vitD) is involved in the phosphor-calcium metabolism and bone pathology, but also in inflammatory and infectious processes such as tuberculosis. The present study evaluates the clinical and epidemiological aspects of active tuberculosis cases and latently infected contacts in whom plasma concentrations of vitD were obtained to determine whether the deficiency of vitD is a risk factor to develop active tuberculosis, especially the more severe forms.

Method

Observational, retrospective study that included 86 tuberculosis patients and 80 contacts with latent infection in a 2-year period.

Results

When comparing active tuberculosis cases with latent infection contacts, deficiency of vitD (vitD levels <10ng/mL, odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.04–3.93), male sex (OR: 1.9, 95% CI: 0.96–3.71) and non-white race (OR: 0.7, 95% CI: 0.34–1.42) were factors independently associated with the diagnosis of tuberculosis.

Conclusion

Despite the limited number of subjects studied, there was an association between severe deficit of vitD and the presentation of tuberculosis.

Keywords:
Tuberculosis
Vitamin D
Plasma concentration
Resumen
Fundamento y objetivo

La vitamina D (vitD) interviene en el metabolismo fosfocálcico y la enfermedad ósea, pero también en procesos inflamatorio-infecciosos como la tuberculosis. En el presente estudio se evalúan aspectos clínicos y epidemiológicos de enfermos e infectados por Mycobacterium tuberculosis en quienes se obtuvieron concentraciones plasmáticas de vitD para determinar si existe relación entre el déficit de vitD y el riesgo de desarrollar tuberculosis activa, especialmente las formas más graves.

Método

Estudio observacional retrospectivo que incluyó a 86 pacientes con tuberculosis activa y 80 contactos con infección latente, visitados en una unidad especializada, en un período de 2 años.

Resultados

Al comparar enfermos con infectados, el déficit de vitD (valores de vitD<10ng/ml; odds ratio [OR] 2,02; intervalo de confianza del 95% [IC 95%] 1,04-3,93), el sexo varón (OR 1,9; IC 95% 0,96-3,71) y la raza no caucásica (OR 0,7; IC 95% 0,34-1,42) fueron los factores independientemente asociados al diagnóstico de tuberculosis.

Conclusión

A pesar del limitado número de sujetos estudiados, se ha detectado una asociación entre el déficit grave de vitD y la forma de presentación de la tuberculosis.

Palabras clave:
Tuberculosis
Vitamina D
Concentración plasmática

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