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"apellidos" => "de Nadal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff0055" ] ] ] 24 => array:3 [ "nombre" => "F." "apellidos" => "Ramasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">x</span>" "identificador" => "aff0120" ] ] ] 25 => array:3 [ "nombre" => "J.L." "apellidos" => "Tomé-Roca" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">y</span>" "identificador" => "aff0125" ] ] ] 26 => array:3 [ "nombre" => "A." "apellidos" => "Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">w</span>" "identificador" => "aff0115" ] ] ] 27 => array:3 [ "nombre" => "R." "apellidos" => "Uña-Orejón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">z</span>" "identificador" => "aff0130" ] ] ] 28 => array:3 [ "nombre" => "G." "apellidos" => "Yanes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">q</span>" "identificador" => "aff0085" ] ] ] 29 => array:3 [ "nombre" => "A." "apellidos" => "Zorrilla-Vaca" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">aa</span>" "identificador" => "aff0135" ] ] ] 30 => array:3 [ "nombre" => "D." "apellidos" => "Escarraman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">ab</span>" "identificador" => "aff0140" ] ] ] 31 => array:3 [ "nombre" => "J." "apellidos" => "García-Fernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">ac</span>" "identificador" => "aff0145" ] ] ] ] "afiliaciones" => array:29 [ 0 => array:3 [ "entidad" => "Hospital Universitario Infanta Leonor, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Spanish Perioperative Audit and Research Network (ReDGERM), Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Fluid Therapy and Hemodynamic Monitoring Group of the Spanish Society of Anaesthesiology and Critical Care (SEDAR), Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Universidad de Barcelona, Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital Universitario Río Hortega, Valladolid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Hospital Can Misses, Ibiza, Balearic Islands, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Hospital Universitari i Politècnic La Fe, Valencia, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "St George's University Hospitals NHS Foundation Trust, London, United Kingdom" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Hospital Clínico de Barcelona, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] 10 => array:3 [ "entidad" => "Hospital Universitario Vall d’Hebron, Barcelona, Spain" "etiqueta" => "k" "identificador" => "aff0055" ] 11 => array:3 [ "entidad" => "Hospital Área de Salud Don Benito y Villanueva, Don Benito, Badajoz, Spain" "etiqueta" => "l" "identificador" => "aff0060" ] 12 => array:3 [ "entidad" => "Hospital Universitario Virgen de la Victoria, Málaga, Spain" "etiqueta" => "m" "identificador" => "aff0065" ] 13 => array:3 [ "entidad" => "Hospital Universitario Marqués de Valdecilla, Santander, Spain" "etiqueta" => "n" "identificador" => "aff0070" ] 14 => array:3 [ "entidad" => "Hospital Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "o" "identificador" => "aff0075" ] 15 => array:3 [ "entidad" => "Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "p" "identificador" => "aff0080" ] 16 => array:3 [ "entidad" => "Hospital Universitario Virgen de los Lirios, Alcoy, Alicante, Spain" "etiqueta" => "q" "identificador" => "aff0085" ] 17 => array:3 [ "entidad" => "Hospital Universitario Doctor Peset, Valencia, Spain" "etiqueta" => "r" "identificador" => "aff0090" ] 18 => array:3 [ "entidad" => "Hospital Universitario Juan Ramón Jiménez, Huelva, Spain" "etiqueta" => "s" "identificador" => "aff0095" ] 19 => array:3 [ "entidad" => "Parc Taulí Hospital Universitari, Sabadell, Barcelona, Spain" "etiqueta" => "t" "identificador" => "aff0100" ] 20 => array:3 [ "entidad" => "Hospital Universitario Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain" "etiqueta" => "u" "identificador" => "aff0105" ] 21 => array:3 [ "entidad" => "Independent Researcher, Córdoba, Spain" "etiqueta" => "v" "identificador" => "aff0110" ] 22 => array:3 [ "entidad" => "Hospital Universitario de Elche, Elche, Alicante, Spain" "etiqueta" => "w" "identificador" => "aff0115" ] 23 => array:3 [ "entidad" => "Hospital Universitario La Princesa, Madrid, Spain" "etiqueta" => "x" "identificador" => "aff0120" ] 24 => array:3 [ "entidad" => "Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "y" "identificador" => "aff0125" ] 25 => array:3 [ "entidad" => "Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "z" "identificador" => "aff0130" ] 26 => array:3 [ "entidad" => "Brigham and Women's Hospital, Boston, United States" "etiqueta" => "aa" "identificador" => "aff0135" ] 27 => array:3 [ "entidad" => "Centro Médico Nacional La Raza, Mexico City, Mexico" "etiqueta" => "ab" "identificador" => "aff0140" ] 28 => array:3 [ "entidad" => "Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "ac" "identificador" => "aff0145" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prioridades de investigación en términos de fluidoterapia perioperatoria y monitorización hemodinámica: encuesta de consenso Delphi del Subcomité de Fluidoterapia y Monitorización hemodinámica de la Sección de Hemostasia, Medicina Transfusional y Fluidoterapia (SHTF) de la Sociedad Española de Anestesiología y Reanimación (SEDAR)" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2121 "Ancho" => 3341 "Tamanyo" => 374576 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0170" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Results summary.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Postoperative complications after surgery are common, despite advances in health technology.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Fluid therapy guided by hemodynamic monitoring could potentially reduce postoperative complications.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However, despite the existence of multiple studies,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> recommendations<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and guidelines,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> there is still great variability in fluid therapy administration, and very scarce use of hemodynamic monitoring.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Collaborative national research in fluid therapy and hemodynamic monitoring requires effort, time, and financial resources. It is, therefore, necessary to define research priorities through a "context-sensitive" approach in order to improve perioperative outcomes.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The Delphi method has proven to be a reliable measurement tool to establish consensus and determine the appropriate direction of research efforts. This method seeks the opinion of a panel of experts to assess the degree of agreement and resolve disagreements on a particular question.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This study aims to determine the main research priorities in the field of fluid therapy and perioperative hemodynamic monitoring in order to guide future initiatives from the Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Haemostasis, Transfusion Medicine and Fluid Therapy Section (SHTF) of the Spanish Society of Anaesthesiology and Critical Care (SEDAR).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We sent structured electronic Delphi questionnaires via email to blinded experts between June 2021 and December 2021, asking them to prioritize research topics relating to fluid therapy and haemodynamic monitoring in the perioperative setting. The primary goal was to identify a limited number of priority topics that can be investigated with support from SEDAR. The study is presented in accordance with Conducting and REporting of DElphi Studies (CREDES) recommendations.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study participants</span><p id="par0030" class="elsevierStylePara elsevierViewall">Potential panel members were nominated by the 10 core members of the Fluid Therapy and Haemodynamic Monitoring Subcommittee of the SHTF of the SEDAR. To be considered, a nominee had to be an established researcher or active contributor to fluid therapy and/or haemodynamic monitoring education evidenced by authorship of education journal articles and textbooks, a director of fluid therapy and/or haemodynamic monitoring training programs or courses, a member of national or international anaesthesia or critical care education committees and/or anaesthesia education working groups, and have relevant clinical and/or academic expertise.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Each core member of the group freely nominated 2 experts. Reserve experts were selected to replace any nominees that did not respond to the invitation. The goal was to form a panel of at least 30 experts.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In order to avoid bias, we asked all panel members to state any potential conflicts of interest, although these were not necessarily exclusionary. However, all panel members had to consent to the publication of their conflicts of interest for the sake of transparency.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Nominees were sent an email explaining the purpose of the study and invited to participate. After reading the email and the study protocol, willing participants accepted the invitation and gave their informed consent to join the panel.</p><p id="par0050" class="elsevierStylePara elsevierViewall">A coordinating group formed of JRM, MC and GY led the communication with the panel of experts, resolved any incidents arising, and drove the whole process.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Questionnaire development</span><p id="par0055" class="elsevierStylePara elsevierViewall">The initial questionnaire was drawn up on the basis of a literature review. Different search strategies (last updated May 2021) were used to retrieve relevant randomized controlled trials (RCT), systematic reviews, and meta-analyses from MEDLINE Pubmed and The Cochrane Library databases. No date or language restrictions were applied. To reduce publication bias, abstracts were requested. Article were identified using the following search terms: randomized controlled trial, controlled clinical trial, meta-analysis, crystalloid, colloid, gelatine, Hydroxyethyl starch, blood pressure, postoperative complications, surgery, goal-directed, goal oriented, goal target, cardiac output, cardiac index, DO2, oxygen consumption, cardiac volume, stroke volume, fluid therapy, fluid loading, fluid administration, optimization, optimization, supranormal, biomarkers.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Individual research priorities were rewritten in EPICOT (Evidence, Population, Intervention, Comparison, Outcome, Timestamp)<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> format, emphasizing the specific research questions that emerged from the available evidence after the initial literature search. The coordinating group drafted the initial research proposals in EPICOT format and arranged the items into several categories and groups to facilitate understanding. For most individual suggestions for non-cardiac surgery, for non-cardiac surgery in ERAS setting, and for cardiac surgery. Suggestions were grouped into clusters, and included: crystalloids, colloids, hemodynamic monitoring, and others, in which all panellists participated</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Rounds</span><p id="par0065" class="elsevierStylePara elsevierViewall">We defined a Delphi with a minimum of 2 rounds and a maximum of 4. In each round, panellists were given 2 weeks to answer the questionnaire. If no response was received within this time, they were contacted individually and allowed 10 more days. If no response was obtained after this period, the panellist was eliminated.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Round 1: screening</span><p id="par0070" class="elsevierStylePara elsevierViewall">In Round 1, the initial list of EPICOT research topics was emailed to participants. A 9-point Likert scale was used to rate each topic. Panellists were asked to rate each topic on its own merits, and not with respect to other topics. The Likert scale included text anchors on the following numerical scores to assist in rating: 1<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>not recommended for research, 4<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>some value for research, 7<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>important area for research, and 9<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>essential research. Panellists were also able to suggest other research topics in the free-text sections. Panellists returned their first round scores directly to the coordinating group. The aggregated scores of all panellists were used to calculate the mean score for each topic. The questionnaires were anonymous to reduce the dominance of the Delphi organizers and group compliance, and controlled opinion feedback was given. The coordinating group decided the feedback arrangements based on item responses and open-ended comments in each round. After each round, the data obtained were analysed and presented in a format that was easily interpretable to all panellists. The statistics shown to the panellists included measurement of central tendencies with dispersion, percentage, and frequency distribution (mean, median, the IQR). The controlled feedback allowed us to provide individual members with a clearer overview of group trends.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Thresholds were predefined for each topic, and a median score of ≥7 by more than 70% of the participants allowed the topic to be included for final prioritization in Round 3. This was a strict threshold for selecting top-rated topics (with a minimum score of "important" or "essential"). Topics with a median score of ≤6 were excluded from further ranking.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Background information of the experts participating in the study was collected in Round 1.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Prioritization of rounds 2 and 3</span><p id="par0085" class="elsevierStylePara elsevierViewall">Free text topics contributed by each panellists were included in the following rounds. Topics with a mean score of 5 or more in the Round 1 were re-ranked in the Round 2 along with additional topics suggested by participants in the first round. To emphasize the prioritization of topics, panellists were reminded of the main objective of the consensus in each round. Panellists were asked to select the appropriate priority category, choosing a score within that category. In Rounds 2 and 3, participants were able to see the basic statistics (mean, median, IQR, and the absolute percentage of participants who rates the topic ≥6) of all research topics from Round 1, but were unaware of the individual responses; only the coordinating group had access to the individual scores. Items with a mean score of ≤6 were excluded.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In Round 3, the final round, panellists ranked the topics identified as highest priority in Round 1, i.e., a median score of ≥7 by more than 70% of participants. Similar instructions and Likert scales were used in this round. <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows the Delphi methodology.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Consensus was defined as >70% of participants agreeing/strongly agreeing or disagreeing/strongly disagreeing with a statement in Round 3. Finally, a virtual meeting of all panellists and coordinators was held to present the questionnaire results and show the priorities with the highest consensus. This was the first opportunity panellists had to interact. If there was more than 1 priority with highest relevance and consensus, the panellists and study steering committee decided which would have the highest priority for research.</p><p id="par0100" class="elsevierStylePara elsevierViewall">For the purpose of external validation, the final draft of the study was reviewed and approved by an external authority (DE) prior to publication and dissemination.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0105" class="elsevierStylePara elsevierViewall">Thirty experts were invited to participate by email; 28 (93.3%) accepted the invitation, and 2 more panellists were brought in to form a panel of 30 experts. All panellist completed the Round 1 and 2 questionnaires (100% response).</p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Background information on the expert panelists</span><p id="par0110" class="elsevierStylePara elsevierViewall">The pane consisted of 7 (23.3%) women and 23 (76.6%) men; 3 (10%) are intensivists and 27 (90%) anaesthesiologists; 9 (30%) are heads of departments and 20 (66.6%) are consultants; 1 (3%) resident was included. The mean age of the panellists was 45 (standard deviation [SD] 9.8) years, with a mean of 22.5 (9.5 SD) years worked. Twenty-three (76.6%) panellists currently work in tertiary care hospitals, while the rest work in smaller centres. All panellists work in urban hospitals.</p><p id="par0115" class="elsevierStylePara elsevierViewall">The organizing committee included 60 questions in Round 1, classified into 4 groups: crystalloids (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14), colloids (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), haemodynamic monitoring (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19) and others (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11). Forty-four (77.3%) questions were considered a research priority. In this round, the group suggested 33 questions, which were included in Round 2.</p><p id="par0120" class="elsevierStylePara elsevierViewall">In Round 2, 77 topics were ranked (Supplementary Table), of which 57 (74%) were considered as priorities. In Round 3, 31 questions achieved consensus, and 2 of them reached the highest priority. The results are summarized in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. The 10 most relevant priorities for the expert panel are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The top priorities with greatest consensus were:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0130" class="elsevierStylePara elsevierViewall">To determine whether intraoperative hemodynamic optimization algorithms based on invasive or non-invasive Hypotension Prediction Index (HPI) versus other management strategies could decrease the incidence of postoperative complications in adult patients undergoing non-cardiac surgery.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0135" class="elsevierStylePara elsevierViewall">To determine whether the use of renal stress biomarkers together with a goal-directed fluid therapy protocol could reduce hospital stay and the incidence of acute kidney injury (AKI) in adult patients undergoing non-cardiac surgery.</p></li></ul></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The research priorities shown in this study represent the consensus of the Fluid Therapy and Monitoring Subcommittee of the SHTF of the SEDAR for perioperative research in fluid therapy and perioperative haemodynamic monitoring. This initiative brought together a wide range of clinicians from different hospitals, and is sensitive to the challenges and needs of perioperative research in Spain.</p><p id="par0145" class="elsevierStylePara elsevierViewall">The participants in this survey could be considered the ideal group for defining a research protocol, but it is equally true that many of us have conflicts of interest. We decided to conduct this survey to maximize transparency in selecting research topics, not only because of our potential conflicts of interest but also because of the industry's interest in facilitating certain topics. Conducting this survey within SEDAR allows the topics agreed upon to be promoted and researched, and makes it simpler to obtain the necessary research funding.</p><p id="par0150" class="elsevierStylePara elsevierViewall">The highest priority questions might not be related to known clinical dilemmas with conflicting evidence; instead, they were related to the application of new technologies that have the potential to influence patient outcomes but lack sufficient supporting evidence. Determining whether intraoperative haemodynamic optimization algorithms based on invasive or non-invasive HPI versus other approaches to decrease the incidence of postoperative complications in adult patients undergoing non-cardiac surgery was one of the two topics that achieved greatest consensus among panellists. Intraoperative hypotension has been associated with poor postoperative outcomes,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> including AKI and myocardial injury.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The use of HPI algorithms has been shown to reduce the incidence of intraoperative hypotension,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> but there is no firm evidence that they improve postoperative outcomes. The question of whether the use of renal stress biomarkers in conjunction with a goal-guided fluid therapy protocol can reduce hospital stay and the incidence of AKI in adult patients undergoing non-cardiac surgery proved to be the other issue with the greatest consensus. Though scarce, there is some evidence that this approach can reduce postoperative AKI.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> At the meeting following completion of the Delphi rounds, the panel considered that on the basis of feasibility, relevance, and the existence of similar studies actively recruiting patients, only one of the two studies considered equally important by the panel could initially be conducted. RCTs (<a href="ctgov:NCT05105105477">NCT05105105477</a>, <a href="ctgov:NCT04647396">NCT04647396</a>) are actively recruiting patients for studies in both topics, and for this reason the panel decided that the first study promoted by the Subcommittee on Fluid Therapy and Monitoring would be to determine whether an intraoperative haemodynamic optimization algorithm with invasive or non-invasive HPI would reduce the incidence of postoperative complications in adult patients undergoing non-cardiac surgery.</p><p id="par0155" class="elsevierStylePara elsevierViewall">The panel did not consider research into crystalloids or colloids to be a priority at the moment, despite ongoing controversies surrounding this topic.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> While from a physiologic standpoint the use of balanced crystalloids should improve postoperative outcomes compared to 0.9 saline,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> this has not been widely demonstrated in randomized clinical trials, and the evidence from critical care is conflicting. Similarly, some authors have reported slight improvements in analytical and fluid balance when comparing hypotonic crystalloids with isotonic crystalloids, due to their lower sodium and potassium content; however, no RCTs have shown their benefit.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The panel did not consider it important to investigate whether liberal versus restrictive maintenance fluid therapy was a priority, despite the controversy following the RELIEF study.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Neither was colloid research considered a priority, despite this being the subject of extensive investigation, but again, without conclusive results.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">There are limitations to this Delphi research priority-setting process. The priority list reflects the opinions of perioperative physicians, but does not include input from other members of the perioperative process (surgeons, nurses, managers), or service users (patients and caregivers). Despite this, both the patient experience and postoperative outcomes featured prominently in this research priority setting process.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusions</span><p id="par0165" class="elsevierStylePara elsevierViewall">The findings of this study have the potential to develop far-reaching perioperative research by highlighting the areas in which research is most needed. We urge funding scientific societies and public agencies to consider promoting these perioperative research priorities. Furthermore, we encourage partnerships with members involved in perioperative patient care to advocate for these priorities and funding requests. These results set the SEDAR agenda for research in fluid therapy and hemodynamic monitoring in the immediate future, and this in turn will promote the development, funding, and performance of new studies in areas with the greatest need for investigation and the greatest potential impact on healthcare.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Authors' contribution</span><p id="par0170" class="elsevierStylePara elsevierViewall">All authors were involved in conception and design of the study, and interpretation of the data; drafting the article; and final approval of the manuscript.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Funding</span><p id="par0175" class="elsevierStylePara elsevierViewall">There was no source of funding</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">JRM: Honoraria for conferences, courses and research from Edwards Lifesciences; honoraria for conferences from Biomerieux and Fresenius Kabi. MJC: Honoraria for courses and conferences from Baxter, Vifor Pharma, Ferrer and MSD. CA: Honoraria for conferences, courses and research from Fresenius Kabi, Ferrer and Vifor Pharma JAC: Honoraria for courses from Vifor Pharma, Glaxo Smith Kline and MBA. JMAI: Honoraria for lectures from Vygon and Baxter. HA: Funding for symposia by LiDCO and Edwards Lifesciences. Medical Affairs Manager at Getinge since October 2021. MB: Honoraria for conferences from Baxter. ECP: Honoraria for conferences, courses and research from Edwards Lifesciences; honoraria for conferences from BRAUN. RF: Honoraria for conferences from Baxter and Fresenius Kabi. PGM: Honoraria for conferences from Baxter. IJL: Honoraria for courses and conferences from Edwards Lifesciences. JJP: Honoraria for conferences from MSD, Baxter and Fresenius Kabi. JLP: Honoraria for conferences from Baxter and Fresenius Kabi JVL: Honoraria for courses, research, and conferences from Edwards Lifesciences and bioMérieux. Honoraria for courses and conferences from Fresenius Kabi, Grifols, Vifor Pharma and Baxter. MIMG: Honoraria for conferences, courses and research, and acted as medical advisor for Edwards Lifesciences. MdN: Honoraria for conferences, courses and travel expenses from Baxter. Honoraria for courses, research and conferences from Edwards Lifesciences. Honoraria for research from Ferrer and Pfizer</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres1999490" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1713677" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1999491" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1713678" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study participants" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Questionnaire development" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Rounds" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Round 1: screening" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Prioritization of rounds 2 and 3" ] ] ] 6 => array:3 [ "identificador" => "sec0040" "titulo" => "Results" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0045" "titulo" => "Background information on the expert panelists" ] ] ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0060" "titulo" => "Authors' contribution" ] 10 => array:2 [ "identificador" => "sec0065" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflict of interest" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-01-24" "fechaAceptado" => "2022-04-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1713677" "palabras" => array:3 [ 0 => "Fluid therapy" 1 => "Hemodynamics" 2 => "Research" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1713678" "palabras" => array:3 [ 0 => "Fluidoterapia" 1 => "Hemodinámica" 2 => "Investigación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Research in fluid therapy and perioperative hemodynamic monitoring is difficult and expensive. The objectives of this study were to summarize these topics and to prioritize these topics in order of research importance.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Electronic structured Delphi questionnaire over three rounds among 30 experts in fluid therapy and hemodynamic monitoring identified through the Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Hemostasis, Transfusion Medicine and Fluid Therapy Section of the Spanish Society of Anesthesiology and Critical Care.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">77 topics were identified and ranked in order of prioritization. Topics were categorized into themes of crystalloids, colloids, hemodynamic monitoring and others. 31 topics were ranked as essential research priority. To determine whether intraoperative hemodynamic optimization algorithms based on the invasive or noninvasive Hypotension Prediction Index versus other management strategies could decrease the incidence of postoperative complications. As well as whether the use of renal stress biomarkers together with a goal-directed fluid therapy protocol could reduce hospital stay and the incidence of acute kidney injury in adult patients undergoing non-cardiac surgery, reached the highest consensus.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Hemostasis, Transfusion Medicine and Fluid Therapy Section of the Spanish Society of Anesthesiology and Critical Care will use these results to carry out the research.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La investigación sobre fluidoterapia y monitorización hemodinámica perioperatorias es difícil y costosa.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Los objetivos del presente estudio fueron resumir y priorizar estas cuestiones, en orden de importancia investigadora.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cuestionario estructurado electrónico Delphi a lo largo de tres rondas entre 30 expertos en fluidoterapia y monitorización hemodinámica identificados a través del Subcomité de Fluidoterapia y Monitorización hemodinámica de la Sección de Hemostasis, Medicina Transfusional y Fluidoterapia de la Sociedad española de Anestesiología y Reanimación.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se identificaron 77 cuestiones, que se clasificaron en orden de priorización. Las cuestiones se categorizaron en temas de cristaloides, coloides, monitorización hemodinámica y otros. Se categorizaron 31 cuestiones como de prioridad investigadora esencial, para determinar si los algoritmos de optimización hemodinámica intraoperatorios basados en el Índice de predicción de hipotensión invasivo o no invasivo frente a otras estrategias de manejo podrían reducir la incidencia de complicaciones postoperatorias, así como si el uso de biomarcadores del estrés renal junto con un protocolo de fluidoterapia dirigido por objetivos podría reducir la estancia hospitalaria y la incidencia de insuficiencia renal aguda en pacientes adultos sometidos a cirugía no cardiaca, lográndose el más alto consenso.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El Subcomité de Fluidoterapia y Monitorización hemodinámica de la Sección de Hemostasis, Medicina Transfusional y Fluidoterapia de la Sociedad española de Anestesiología y Reanimación utilizará estos resultados para la realización de investigación.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0195" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0080" ] ] ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1180 "Ancho" => 1508 "Tamanyo" => 178218 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0165" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Delphi process.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2121 "Ancho" => 3341 "Tamanyo" => 374576 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0170" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Results summary.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0175" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Item \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Agreement \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison of intraoperative hemodynamic optimization algorithms based on invasive or non-invasive Hypotension Prediction Index (HPI) is a priority to reduce the incidence of postoperative complications in adult patients undergoing non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">It is a priority to determine whether the use of renal stress biomarkers together with a goal-guided fluid therapy protocol can reduce hospital stay and the incidence of acute kidney injury in adult patients undergoing non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison between intraoperative versus intra-postoperative hemodynamic optimization algorithms is a priority to reduce the incidence of postoperative complications in adult patients undergoing major non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison of intraoperative hemodynamic optimization algorithms based on flow (stroke volume optimization) vs pressure (blood pressure optimization) is a priority to reduce the incidence of postoperative complications in adult patients undergoing non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison of intraoperative hemodynamic optimization algorithms based on invasive or non-invasive Hypotension Prediction Index (HPI) is a priority to reduce the incidence of postoperative complications in adult patients undergoing non-cardiac surgery in an ERAS environment. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">It is a priority to determine whether the use of renal stress biomarkers together with a goal-guided fluid therapy protocol can reduce hospital stay and the incidence of acute kidney injury in adult patients undergoing non-cardiac surgery in ERAS settings. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">It is a priority to determine if it is possible to identify at-risk patients using parameters derived from advanced hemodynamic variables derived from advanced non-invasive monitoring (i.e.: Clearsight, including cardiac output, stroke volume or combinations) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison between balanced and unbalanced crystalloids is a priority to reduce the incidence of postoperative kidney injury in adult patients undergoing major non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison between intraoperative compared to intra-postoperative hemodynamic optimization algorithms is a priority to reduce the incidence of postoperative complications in adult patients undergoing major non-cardiac surgery in an ERAS setting. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The comparison of flow/pressure-based intraoperative hemodynamic optimization algorithms with mean arterial pressure targets of 65<span class="elsevierStyleHsp" style=""></span>mmHg or <20% baseline is a priority to reduce the incidence of postoperative complications in adult patients undergoing non-cardiac surgery. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3319982.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Top ten research priorities.</p>" ] ] 3 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 97397 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "International Surgical Outcomes Study group" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/bja/aew316" "Revista" => array:6 [ "tituloSerie" => "Br J Anaesth" "fecha" => "2016" "volumen" => "117" "paginaInicial" => "601" "paginaFinal" => "609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27799174" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between use of enhanced recovery after surgery protocol and postoperative complications in colorectal surgery: The Postoperative Outcomes Within Enhanced Recovery after Surgery Protocol (POWER) study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. 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FCT, FCD, IG, JM, IM, FMF, JMR, FR, GY, AZV and DE have nothing to declare.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/23411929/0000007000000006/v3_202310300659/S2341192923001038/v3_202310300659/en/main.assets" "Apartado" => array:4 [ "identificador" => "34051" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23411929/0000007000000006/v3_202310300659/S2341192923001038/v3_202310300659/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341192923001038?idApp=UINPBA00004N" ]
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Research priorities in perioperative fluid therapy and hemodynamic monitoring: A Delphi Consensus Survey from the Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Hemostasis, Transfusion Medicine and Fluid Therapy Section (SHTF) of the Spanish Society of Anesthesiology and Critical Care (SEDAR)
Prioridades de investigación en términos de fluidoterapia perioperatoria y monitorización hemodinámica: encuesta de consenso Delphi del Subcomité de Fluidoterapia y Monitorización hemodinámica de la Sección de Hemostasia, Medicina Transfusional y Fluidoterapia (SHTF) de la Sociedad Española de Anestesiología y Reanimación (SEDAR)
J. Ripollés-Melchora,b,c,
, M.J. Colominac,d,e, C. Aldecoab,c,f, J. Alonso-Cabellog, J.M. Alonso-Íñigoh, H. Ayai, M. Basoraj, F. Clau-Terrec,k, E. del Cojo-Pecesl, F. Cota-Delgadom, R. Ferrandis-Comesh, P. Galán-Menéndezk, D. García-Lópezn, I. Garrutio, I.J. Lópezp, J.L. Jover-Pinillosc,q, J.V. Llau-Pitarchr, J.V. Lorentec,s, J. Mesquidat, I. Mojarros..., M.I. Monge-Garcíac,u, S.C. Montesinos-Fadriquec,v, J.L. Muñoz-Rodesw, M. de Nadalk, F. Ramascox, J.L. Tomé-Rocac,y, A. Pérezw, R. Uña-Orejónz, G. Yanesc,q, A. Zorrilla-Vacac,aa, D. Escarramanab, J. García-Fernándezc,acVer más
Corresponding author
a Hospital Universitario Infanta Leonor, Madrid, Spain
b Spanish Perioperative Audit and Research Network (ReDGERM), Spain
c Fluid Therapy and Hemodynamic Monitoring Group of the Spanish Society of Anaesthesiology and Critical Care (SEDAR), Spain
d Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
e Universidad de Barcelona, Barcelona, Spain
f Hospital Universitario Río Hortega, Valladolid, Spain
g Hospital Can Misses, Ibiza, Balearic Islands, Spain
h Hospital Universitari i Politècnic La Fe, Valencia, Spain
i St George's University Hospitals NHS Foundation Trust, London, United Kingdom
j Hospital Clínico de Barcelona, Barcelona, Spain
k Hospital Universitario Vall d’Hebron, Barcelona, Spain
l Hospital Área de Salud Don Benito y Villanueva, Don Benito, Badajoz, Spain
m Hospital Universitario Virgen de la Victoria, Málaga, Spain
n Hospital Universitario Marqués de Valdecilla, Santander, Spain
o Hospital Universitario Gregorio Marañón, Madrid, Spain
p Hospital Universitario Virgen del Rocío, Sevilla, Spain
q Hospital Universitario Virgen de los Lirios, Alcoy, Alicante, Spain
r Hospital Universitario Doctor Peset, Valencia, Spain
s Hospital Universitario Juan Ramón Jiménez, Huelva, Spain
t Parc Taulí Hospital Universitari, Sabadell, Barcelona, Spain
u Hospital Universitario Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain
v Independent Researcher, Córdoba, Spain
w Hospital Universitario de Elche, Elche, Alicante, Spain
x Hospital Universitario La Princesa, Madrid, Spain
y Hospital Universitario Virgen de las Nieves, Granada, Spain
z Hospital Universitario La Paz, Madrid, Spain
aa Brigham and Women's Hospital, Boston, United States
ab Centro Médico Nacional La Raza, Mexico City, Mexico
ac Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
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