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Letter to the Director
Response to the letter to the editor: “Is there a real consensus among anaesthetists and surgeons about the neuromuscular block? Methodological considerations about the ACHILLES study”
Respuesta a la carta al director: «Existe realmente consenso entre los anestesistas y los cirujanos sobre el bloqueo neuromuscular: algunas consideraciones metodológicas sobre el estudio AQUILES»
C.L. Errandoa,
Corresponding author
errando013@gmail.com

Corresponding author.
, C. Moreno-Sanzb, P. Vila-Caralc, J.C. Ruiz de Adana-Belbeld, E. Vázquez-Alonsoe, J.M. Ramírez-Rodríguezf, G. Veiga-Ruizg, E. Guasch-Arévaloh, J.I. Lora-Tamayo D’Ocóni
a Servicios Quirúrgicos, Consorcio Hospital General Universitario de Valencia, Valencia, Spain
b Servicio de Cirugía General y Aparato Digestivo, Hospital General La Mancha Centro, Alcázar de San Juan, Ciudad Real, Spain
c Servicio de Anestesiología y Reanimación, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
d Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario de Getafe, Getafe, Madrid, Spain
e Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario de Granada, Granada, Spain
f Servicio de Cirugía, Hospital Clínico Universitario de Zaragoza, Zaragoza, Spain
g Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario Santa Lucía, Cartagena, Murcia, Spain
h Servicio de Anestesia y Reanimación, Hospital Universitario La Paz, Madrid, Spain
i Servicio de Anestesiología y Reanimación, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
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        "titulo" => "Respuesta a la carta al director&#58; &#171;Existe realmente consenso entre los anestesistas y los cirujanos sobre el bloqueo neuromuscular&#58; algunas consideraciones metodol&#243;gicas sobre el estudio AQUILES&#187;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We thank Nicolau Gozalbo and Vives Piqueres for their letter to the director regarding our article on the consensus among surgeons and anaesthesiologists on the use of deep neuromuscular blockade &#40;NMB&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">First&#44; we will comment on the methodological issues raised&#44; and secondly on aspects that could be considered clinical&#46; The Delphi method is a structured process of building consensus among groups of experts from various fields&#44; and is currently the most widely used method of selecting quality indicators in health sciences&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Defining consensus as 70&#37; or more of agreement is standard in Delphi studies&#44; although as Boulkedid et al&#46; observe in their systematic review on the use of the Delphi method in healthcare&#44; there is no consensus on the definition of what is considered consensus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> To avoid bias&#44; this definition must be established a priori&#44; as was done in the AQUILES study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">True enough&#44; statistics of central tendency &#40;mean&#44; median&#41; or dispersion &#40;standard deviation or interquartile range&#41; and the statistical significance of the comparison of each questionnaire item between rounds are not shown in our article&#46; These were omitted to save space and focus attention on the most significant results&#46; This information was obtained and presented to the scientific committee of the AQUILES study&#44; but it was not considered relevant enough to include in the article&#44; given the limited space and the amount of information presented&#46; The information is available to readers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The authors also query the statistical power of the study to evaluate differences of opinion between anaesthesiologists and surgeons&#44; and the potential effect of conducting the study with these 2 groups of specialists&#46; Regarding this point&#44; we believe this multidisciplinary approach to be one of the most interesting aspects of the AQUILES project&#44; since it enables us to evaluate the surgical situation from the perspective of the 2 main specialist fields involved&#46; Logically&#44; there is no way of knowing whether the results would have been different if the study had been conducted with specialists from only 1 of these fields&#46; However&#44; the scientific committee of the AQUILES study and the scientific societies involved intentionally set themselves the challenge of working with these 2 groups in order to reach a consensus on fundamental issues affecting patients requiring general anaesthesia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; on the issue of the Likert scale used in the study&#44; a 7-point scale was chosen because it is the scale most frequently used in this type of study&#46; Again&#44; there is no consensus on the best scale&#44; and scales of ranging from 4 to 9 points have been reported in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a> The 7-point Likert gives an odd number of responses&#44; and is wide enough to allow participants to refine their opinion while being easy to use&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">With regard to recommendation 3 in particular&#58; &#8220;deep NMB until the end of surgery optimises intraoperative working conditions&#46;&#46;&#46;&#8221;&#44; Table 1 gives the results of the panellists as a whole &#40;both anaesthesiologists and surgeons&#41;&#44; and shows that consensus is greater than 70&#37; on 9 of the possible benefits of NMB&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Regarding the benefits of deep NMB after surgery &#40;Table 2&#41;&#44; in this case no consensus is reached at all&#44; and the <span class="elsevierStyleItalic">p</span> values show that there are no statistically significant differences between specialties&#46; Results from round 1 were similar&#44; insofar as no consensus was reached on any of the items&#46; This suggests the need for pragmatic clinical studies to provide scientific evidence on the potential clinical benefits of deep NMB after surgery&#44; since&#44; in the opinion of both anaesthesiologists and surgeons&#44; there is no consensus regarding the benefits of this anaesthesia strategy &#40;see below&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Recommendation 4&#44; meanwhile&#44; &#8220;it is recommended to use quantitative monitoring and NMB reversers to improve the safety and predictability of deep NMB&#8221;&#44; is an amalgam of several questions&#46; Specifically&#44; the panellists were asked the following question&#58; &#8220;In the absence of quantitative monitoring devices&#44; please indicate the extent to which the clinical indicators are suitable for evaluating neuromuscular block reversal&#8221;&#46; The responses showed that&#44; in the opinion of the panellists&#44; none of the clinical indicators presented were considered adequate to evaluate NMB reversal &#40;the highest percentage of agreement &#40;26&#37;&#41; was achieved on&#58; &#8220;Ask the patient to raise their head for 5 seconds&#8221;&#41;&#46; However&#44; there was wide consensus on the benefits of quantitative monitoring and the use of fast-acting reversers&#44; as shown in Table 3&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Another explanation for the lack of consensus on the foregoing items could be that anaesthesiologists are more involved in and have a deeper understanding of the technical aspects of these perioperative stages than surgeons&#46; Interestingly&#44; fewer responses were obtained from the latter on this point&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">With regard to the relevance and of the items in the questionnaire and their potential for bias&#44; we would point out that they were formulated and revised up to 7 times by the committee of experts made up of experienced surgeons and anaesthesiologists before being submitted to the panellists&#46; An alternative approach would have been to conduct a pilot study of a round of questions with fewer participants&#46; This would have enabled us to make structural changes or include additional explanatory text&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">We take this opportunity to again thank the authors for their observations and their interest in our manuscript&#46; Their contribution has enriched the debate surrounding an issue that&#44; as stated in our article&#44; calls for further research and the creation of consensus protocols that will improve the efficacy&#44; safety and effectiveness of surgical procedures and ensure the best possible outcomes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Errando CL&#44; Moreno-Sanz C&#44; Vila-Caral P&#44; Ruiz de Adana-Belbel JC&#44; V&#225;zquez-Alonso E&#44; Ram&#237;rez-Rodr&#237;guez JM&#44; et al&#46; Respuesta a la carta al director&#58; &#171;Existe realmente consenso entre los anestesistas y los cirujanos sobre el bloqueo neuromuscular&#58; algunas consideraciones metodol&#243;gicas sobre el estudio AQUILES&#187;&#46; Rev Esp Anestesiol Reanim&#46; 2017&#59;64&#58;603&#8211;604&#46;</p>"
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ISSN: 23411929
Original language: English
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