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The Vortex model: A different approach to the difficult airway
El modelo del Vórtex: una aproximación diferente a una vía aérea difícil
P. Charco-Moraa,c,
Corresponding author
pcharco@gmail.com

Corresponding author.
, R. Urtubiab, L. Reviriego-Agudoa
a Servicio de Anestesiología y Cuidados Críticos, Airway Management Teaching Center (FIDIVA), Universidad de Valencia, Hospital Clínico Universitario de Valencia, Valencia, Spain
b Servicio de Anestesiología, Clínica Vespucio, Santiago de Chile, Chile
c Vicepresidente de la Sección de Vía Aérea de la SEDAR, Spain
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From the perspective of the patient &#40;and legal regulations&#41;&#44; a difficult airway can be considered a typical&#44; quantifiable and predictable complication&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">2</span></a> Similarly&#44; although infrequent in routine clinical practice&#44; surgical teams must be prepared to deal with and successfully resolve an airway crisis&#46; Inappropriate clinical management can worsen the situation and further restrict airway access&#44;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">3</span></a> and ignorance and inadequate training contribute to the appearance of complications in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Generally speaking&#44; there are 4 airway management approaches or strategies&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Facial approach</span></span>&#58; including the different oxygen therapy techniques &#40;ranging from common nasal cannula to high-flow systems&#41;&#44; manual ventilation with a face mask &#40;with adjuvants&#41;&#44; and different forms of ventilatory support using a facemask &#40;such as non-invasive mechanical ventilation&#44; Oxylator&#44; etc&#46;&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Transglottic approach</span></span>&#58; involves introducing a device into the trachea through the glottic opening&#46; Tracheal intubation is the gold standard for airway management&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Supraglottic</span></span> &#40;or extraglottic&#41; <span class="elsevierStyleItalic"><span class="elsevierStyleBold">approach&#58;</span></span> involves the use of devices that seal the hypopharynx to deliver positive ventilation&#46; Some of these supraglottic devices include adjuvants to prevent gastric aspiration &#40;such as a gastric suction channel or drainage tube&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Infraglottic approach</span></span> &#40;front of neck access&#44; or FONA&#41;&#58; involves accessing the airway by means of an incision that&#44; due to the anatomy of the neck&#44; is usually made through the cricothyroid membrane &#40;cricothyroidotomy&#41;&#46;</p></li></ul></p><p id="par0040" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> lists the failure rates of the different airway approaches&#46; It is important to note that the failure of 1 approach increases the possibility of failure of the next&#46; For example&#44; in an obese patient with positive predictors of difficult intubation&#44; the likelihood of ventilation difficulty is greater &#40;including ventilation through a supraglottic airway&#41;&#59; likewise&#44; percutaneous access to the airway can also be complicated&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Fortunately&#44; when 1 approach fails&#44; another can be tried&#44; and all can be used indistinctly to secure the airway and oxygenate the patient&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The number of anaesthesia-related complications has declined in recent decades&#46; Serious complications caused by hypoxaemia after intubation failure&#44; such as permanent neurological damage or death&#44;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">5&#44;6</span></a> have spurred researchers to develop new strategies and technologies to improve the standard of care and improve patient safety&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Efforts to improve airway management have led to the development of new technologies&#46; These include videolaryngoscopes &#40;with standard or difficult intubation blades&#41;&#44; various optical devices that incorporate the latest CMOS technology &#40;such as video stylets and video endoscopes&#41;&#44; as well as sophisticated&#44; state-of-the-art supraglottic devices&#44; even with passive oxygen insufflation&#46; To these can be added the latest techniques for denitrogenation or oxygenation through high flow nasal cannula &#40;THRIVE&#41;&#44; together with advanced systems for monitoring tissue oxygenation and different ventilatory methods &#40;neural control of ventilation&#41;&#46; Scientific societies&#44; for their part&#44; have developed their own treatment algorithms to implement all these new technologies in a structured manner&#44; based on expert consensus and the best available evidence&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Despite all these efforts&#44; incorrect management of an unanticipated difficult airway still results in serious complications&#46; Some of these problems stem from our approach to decision-making and our reaction to these highly stressful crisis scenarios&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Human factors and resource management during an airway crisis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Why are technical skills and algorithms insufficient to manage the most critical situations&#63; The fact is that stress impacts decision-making and performance&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">7</span></a> To explain this&#44; we must first define &#8220;the human factor&#8221; and &#8220;crisis resource management&#8221; &#40;CRM&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">There is currently no evidence to show the benefits of CRM tools in airway management&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">8</span></a> However&#44; CRM has been successfully tested in other areas where potentially high-risk situation can arise &#40;for example&#44; in the nuclear industry&#44; the aviation industry&#44; etc&#46;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">9&#8211;11</span></a> and since the 90s&#44; when Gaba et al&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">12</span></a> adapted these new concepts to the field of anaesthesia &#40;Anaesthesia CRM&#41;&#44; they have been used in airway management&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The human factor is related to personal and team performance within a given system&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">13</span></a> This means that humans are fallible&#44; and our performance during a crisis is affected by personal and environmental factors&#44; external pressure&#44; and cognitive overload&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">14</span></a> The most important personal factors are&#58; fatigue&#44; lack of sleep&#44; emotional disturbance&#44; and inexperience&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">15&#44;16</span></a> The 4th National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society reported that human factors contributed to adverse outcomes in 40&#37; of all cases involving serious or fatal injuries&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">1</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The concept of anaesthesia CRM refers to the non-technical skills required for effective teamwork in a crisis situation&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">17</span></a> Although Gaba described 15 key principles&#44; team performance during a crisis is determined by 4 decisive factors&#58; situational awareness&#44; decision-making&#44; task management&#44; and teamwork&#46; In an airway crisis&#44; cognitive overload often means that physicians &#8220;can&#8217;t see the forest for the trees&#8221;&#44; and become obsessed with a single task &#40;fixation error&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Therefore&#44; it is important to consider human factors and manage them appropriately&#44;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">18</span></a> since CRM training has been shown to improve performance<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">19</span></a> and with it&#44; patient outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Why do difficult airway guidelines and algorithms fail&#63;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Several different clinical guidelines for difficult airway management have been drawn up by the leading international scientific societies&#46; All are based on a critical review of the scientific literature&#44; together with consensus recommendations put forward by a panel of experts approved by the different national societies that regularly publish and update such guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">21&#8211;25</span></a> They provide a standardised approach to common clinical situations&#44; such as known and unanticipated difficult airway&#44; and a final solution for can&#8217;t intubate&#44; can&#8217;t oxygenate cases &#40;CICO&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">26</span></a> in addition to important recommendations for safe extubation&#46;<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">27&#44;28</span></a> For this purpose&#44; they recommend different strategies and intubation or ventilation devices&#44; depending on the experience or the state of the art&#46; However&#44; despite the widespread use of these algorithms&#44; there is no strong evidence to show the degree of benefit of any particular strategy&#44;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">29</span></a> although there is moderate evidence that the use of these guidelines improves airway management&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">30</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The NAP4 report is an in-depth analysis of the factors that contribute to poor airway outcomes&#44; and shows that these are clearly related to the patient&#39;s comorbidities or failure to predict the presence of a difficult airway&#46; The report also found other important positive factors&#44; such as good judgement&#44; planning&#44; the right equipment&#44; good communication within the team&#44; and training in airway management techniques&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Algorithms outline a sequence of steps to be taken when intubation fails&#44; always prioritising oxygenation and limiting the number of airway interventions to minimise trauma and complications&#46; However&#44; these recommendations often fail for various reasons&#58; clinical inertia&#44; the difficulties of implementing the recommended action within a particular the health system&#44; and limited access to the devices required&#46;<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">31&#44;32</span></a> Burgers et al&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">33</span></a> have shown that the main barriers to guideline implementation are the difficulties involved in learning new techniques or skills and in applying the rescue sequence in practice&#46; Leentjens and Burgers<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">34</span></a> conclude that successful implementation of such guidelines depends on creating a team with a shared vision&#44; where all members willingly follow the recommendations and accept them as a meaningful safety strategy&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Another reason for guideline inadequacy is their failure of guidelines to address two fundamental questions&#58; how should decisions be made in these highly stressful events&#63; And how the team be organised&#63; We know that algorithms are intended as teaching and learning tools&#44;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">35</span></a> and although they have also been useful in crisis management planning&#44; they are presented in a format that is of little use to a highly stressed team in the midst of an airway crisis&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">36</span></a> Only the latest DAS guidelines recommend that clinicians &#8220;stop and think&#8221; to avoid fixation errors in stressful situations&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Finally&#44; as the latest DAS guidelines acknowledge&#58; &#8220;The complexities of difficult airway management cannot be distilled into a single algorithm&#8221;&#46; The recommended actions are difficult to implement in a stressful&#44; emergency airway situation&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">This is why following guidelines and implementing algorithms do not in themselves guarantee a successful outcome or prevent serious complications&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">What are cognitive aids&#63; Are they useful in the management of an airway crisis&#63;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Some schematics or flowcharts have been used to help in the management of a series of anaesthesia-related emergencies&#44; such as anaphylactic shock&#44; malignant hyperthermia crisis&#44; etc&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">37</span></a> in the belief that they will help clinicians improve performance and successfully complete the task&#46; These strategies are called &#8220;cognitive aids&#44; or checklists&#44;&#8221; and are designed to guide stressed physicians through a sequence of complex steps and prevent them from skipping key actions&#46; Clinicians under stress are less capable of remembering lists of actions&#44; and are more likely to become fixated&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">38</span></a> Checklists and cognitive aids also help reduce errors and maximise effective teamwork&#46; For this to happen&#44; according to Marshall&#44;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">39</span></a> a good cognitive aid must meet the following criteria&#58; &#40;1&#41; Its content must be derived from &#8220;best practice&#8221; guidelines or protocols&#59; &#40;2&#41; Its design should be appropriate for use in the context of the emergency situation&#59; &#40;3&#41; It should be familiar&#44; in a format that has been used in practice and training&#59; and &#40;4&#41; It should also assist other team members to perform their tasks in a coordinated manner&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Perhaps the best known crisis management tool&#44; and one that is easily remembered and implemented&#44; is the Advanced Cardiac Life Support &#40;ACLS&#41; protocol&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">40</span></a> This is a standardised tool that is applicable to all cardiac arrest situations&#44; and can be taught universally to all team members&#46; This tool has been enriched&#44; updated and validated by years of experience in its use worldwide&#46; Unlike the ACLS&#44; the development of an emergency airway management protocol involves unique challenges&#44; principally because the many different management options depend on the skill and preferences of the operator&#46;<a class="elsevierStyleCrossRefs" href="#bib0495"><span class="elsevierStyleSup">41&#8211;43</span></a> Cognitive aids have been used in emergency scenarios&#44; and although they are widely believed to improve performance&#44;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">44</span></a> this has never been proven&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">45</span></a> Marshall et al&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">46</span></a> performed a prospective study in airway crisis scenarios to evaluate the use of a visual algorithm in a simulated environment&#46; They found no significant differences in technical performance between the groups using and not using the aid&#44; but participants developed better non-technical skills&#46; More recently&#44; Long et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">47</span></a> evaluated the use of cognitive aids in the preparation of emergency paediatric airway equipment&#44; and concluded that its use reduces errors of omission&#46; Burden et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">48</span></a> meanwhile&#44; suggested that technical performance is improved when a team member reads out the contents of the checklist&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Anaesthesia non-technical skills &#40;ANTS&#41;</span><p id="par0130" class="elsevierStylePara elsevierViewall">The NAP4 report revealed some unexpected facts about the poor airway management practices of British anaesthesiologists&#44; and found evidence of poor or suboptimal performance in over 78&#37; of cases involving airway complications&#46; After analysing of the causes of this chilling finding&#44; the authors listed the main contributing factors as&#58; a poorly trained team&#44; poor communication within the team&#44; and poor clinical judgement in airway management&#46; Good training and communication would improve results&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">1</span></a> These factors are part of the so-called non-technical skills defined by Flin et al&#46; as &#8220;the cognitive&#44; social&#44; and personal resource skills that complement technical skills&#44; and contribute to safe and efficient task performance&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">17</span></a> These ANTS&#44; therefore&#44; define all actions performed by the anaesthesiologist in the operating theatre that are not related to their clinical experience or to the use of drugs and clinical devices&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">49</span></a> These include interpersonal communication&#44; teamwork and leadership skills&#44; together with cognitive aids to take stock of the situation and optimise decision-making&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">50</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Learning these non-technical skills can help improve routine clinical performance&#44; particularly in stressful situations that require the whole team to function correctly&#44; in terms of establishing the action plan&#44; following each step in the algorithm&#44; assigning tasks to each team member&#44; and correctly performing the procedures indicated&#46;<a class="elsevierStyleCrossRefs" href="#bib0545"><span class="elsevierStyleSup">51&#8211;53</span></a> Both technical and ANTS can be learnt in a simulated environment that allows participants to perfect their skills&#46;<a class="elsevierStyleCrossRefs" href="#bib0560"><span class="elsevierStyleSup">54&#44;55</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; there is no conclusive evidence that cognitive aids and non-technical skills are effective in anaesthesia&#44; mainly due to the limitations of research into these tools&#46; Therefore&#44; more studies are needed to determine the real contribution of these methods&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">The V&#211;RTEX algorithm</span><p id="par0145" class="elsevierStylePara elsevierViewall">The tragic case of Elaine Bromiley occurred in 2005&#46; Mrs&#46; Bromiley was scheduled for endoscopic sinus surgery and septoplasty under general anaesthesia&#46; Apart from slightly restricted cervical mobility&#44; there were no predictors of difficult intubation&#46; However&#44; after a series of ineffective manoeuvres to secure her airway&#44; Ms&#46; Bromiley entered can&#8217;t intubate &#8211; can&#8217;t oxygenate &#40;CICO&#41; status that could not be resolved&#44; and she eventually died&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">It was probably this unfortunate accident that prompted Nicholas Chrimes to develop a highly sensitive tool called Vortex<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">56</span></a> for early detection and resolution of problems stemming from poor airway management&#46; The tool was developed to prevent clinicians from become fixated on a particular technique or tool&#44; to improve decision-making&#44; and promote teamwork and is based on the four airway management approaches described above&#46; To simplify the protocol&#44; each strategy is called a &#8220;lifeline&#8221; in Vortex&#44; thus intentionally avoiding naming or recommending specific techniques or airway devices&#46; Vortex is intended to be easy to learn and use&#44; and is designed to simplify rescue during an airway crisis&#46; Following the algorithm&#44; clinicians can move from one lifeline to another&#44; based on&#44; but not limited to&#44; tracheal intubation as the standard technique&#46;</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">General description</span><p id="par0155" class="elsevierStylePara elsevierViewall">The Vortex &#40;or funnel-shaped diagram&#41; is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; It consists of three concentric rings representing three zones or layers&#58; the outer ring is the &#8220;green zone&#8221;&#44; and the centre is the &#8220;vortex&#8221;&#44; which includes the zone of &#8220;emergency front-of-neck access&#8221; or CICO rescue area&#46; The central blue ring &#40;vortex&#41; represents the 3 non-surgical lifelines&#58; facemask ventilation&#44; endotracheal tube&#44; and supraglottic airway&#46; The dark blue ring&#44; or emergency surgical airway&#44; is differentiated from the other rings to show the exceptional nature of the FONA approach&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0160" class="elsevierStylePara elsevierViewall">Before the intervention&#44; the patient is breathing spontaneously and is in the outer &#8220;green zone&#8221;&#44; with normal alveolar oxygenation&#46; This is a &#8220;safety zone&#8221;&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Once the intervention begins with anaesthesia induction&#44; the patient falls into the &#8220;vortex zone&#8221; where one of the three lifelines must restore and maintain alveolar oxygenation&#46; Airway management can begin with any lifeline and proceed through the subsequent lifelines in any order&#44; according to the plan of action and the objectives of the intervention &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Pre-operative airway assessment and checklist</span><p id="par0170" class="elsevierStylePara elsevierViewall">The Vortex algorithm also includes a pre-operative airway assessment and a safety checklist&#46; The pre-operative assessment is essential&#44; because it will alert the clinician to potential complications and allow him or her to draw up a contingency plan in the event of difficult intubation&#46; This airway assessment or airway prediction takes into account not only anatomical and physiological considerations&#44; but also situational and clinical elements &#40;human factors&#41; that may affect the procedure&#46; This should allow the clinician to evaluate the feasibility of securing the airway using each of the 4 lifelines&#44; and extend the safe apnoea time if any of the techniques should fail&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The checklist is the key to safe interventions&#44; proper teamwork&#44; and preventing hypoxia&#46; Checklists should be used in combination with the primary Vortex algorithm and the chosen airway device in the green zone&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Attempts and optimisations</span><p id="par0180" class="elsevierStylePara elsevierViewall">Each manipulation of the airway can cause trauma and tissue damage that can further hinder access&#44; and repeated unsuccessful attempts at intubation cause oedema and bleeding that can cause difficulties for ventilation and oxygenation&#46; This is why Vortex recommends making no more than three attempts with each lifeline&#46; In addition&#44; any repeated attempt with a lifeline must incorporate optimisations that have not previously been implemented in order to increase the chances of success&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The following is a list of some such optimisations&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0190" class="elsevierStylePara elsevierViewall">Change the position of the head&#47;neck&#47;larynx and of the device itself</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0195" class="elsevierStylePara elsevierViewall">Use the adjuncts that are appropriate for each lifeline</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0200" class="elsevierStylePara elsevierViewall">Changes size&#47;type of airway device</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0205" class="elsevierStylePara elsevierViewall">Suction flow in hypopharynx&#47;oxygen&#44; and&#47;or control&#47;increase oxygen flow</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0210" class="elsevierStylePara elsevierViewall">Muscle tone&#44; administer or up-dose muscle relaxants&#46;</p></li></ul></p><p id="par0215" class="elsevierStylePara elsevierViewall">This means&#44; firstly&#44; that the clinician must decide which optimisations are most effective before each attempt&#44; and secondly&#44; not all three attempts allowed with each lifeline need to be exhausted if all the optimisations have been implemented&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">&#8220;Best effort&#8221;&#58; optimise for success or declare failure</span><p id="par0220" class="elsevierStylePara elsevierViewall">The completion of these 5 optimisation manoeuvres concludes the &#8220;best effort&#8221; with each lifeline &#40;not all 3 attempts are mandatory&#41;&#46; At least one of the attempts should be performed by the most experienced clinician&#46; Completion of the &#8220;best effort&#8221; in a given lifeline means that the optimisation options have been exhausted and&#44; if alveolar oxygenation has not been restored&#44; the attempt has failed and another approach is needed&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">When the &#8220;best effort&#8221; with all three lifelines has failed&#44; the clinician should prepare for the fourth and last lifeline &#40;rescue CICO&#41;&#44; even if oxygenation is still adequate&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">This structured definition of &#8220;best effort&#8221; with each lifeline is important from two perspectives&#58; it compels the clinician to use pre-defined optimisation manoeuvres&#44; and it is a decision-making tool that facilitates the transition from a failed life to another&#44; possibly successful&#44; approach&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">CICO status&#58; the fourth rescue technique</span><p id="par0235" class="elsevierStylePara elsevierViewall">CICO status is also a complementary tool with well-defined steps that prepare the team for rapid initiation of &#8220;CICO Rescue&#8221; once the best effort at all three lifelines has been unsuccessful&#46; Of course&#44; the clinician can decide to jump ahead to the fourth lifeline if warranted by the clinical condition or circumstances&#44; such as&#44; for example&#44; a patient with an anticipated difficult airway and oxygen saturation of less than 90&#37; in progressive deterioration&#44; or after two unsuccessful attempts at two lifelines&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">The NAP4 report showed that the decision to effect CICO rescue was made when the patient was already severely hypoxic or close to death&#46; Therefore&#44; the decision to initiate the fourth lifeline should be based on failure of the &#8220;best effort&#8221; at securing a non-surgical airway&#44; and should be taken before the patient becomes severely hypoxaemic&#46; This would&#44; at least in theory&#44; ensure a better outcome &#40;without the serious sequelae of oxygen deprivation&#41; not only for the CICO rescue situation&#44; but also for all lifelines&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">The &#8220;green zone&#8221;&#8212;a time for decisions</span><p id="par0245" class="elsevierStylePara elsevierViewall">As described above&#44; the &#8220;green zone&#8221; is the area in which the airway has been secured using one of the four lifelines&#46; The &#8220;green zone&#8221; is reached each time a rescue attempt succeeds in restoring alveolar oxygenation&#46; Entry in the &#8220;green zone&#8221; can be confirmed by the presence of an ETCO2 waveform and&#47;or increases in SpO<span class="elsevierStyleInf">2</span>&#46; A sustained SpO<span class="elsevierStyleInf">2</span> value achieved using apnoeic oxygenation techniques is not a &#8220;green zone&#8221;&#44; because these manoeuvres cannot restore oxygenation in an already desaturated patient&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> shows how the &#8220;green zone&#8221; extends from the base to the top of the funnel&#46; This means that it can be entered at different levels of the Vortex&#44; and indicates that the patient has not returned to baseline&#44; spontaneous breathing&#44; but that oxygenation has been restored by using one of the three non-surgical lifelines&#46; The level at which the patient enters the green zone along the Vortex funnel &#40;higher or lower&#41; will be determined by the number of lifelines used up to that point&#46; Of course&#44; a lower level means that more lifelines with their optimisations have been used&#44; and therefore reduces the number of options available before CICO rescue&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0255" class="elsevierStylePara elsevierViewall">However&#44; there is also a green zone in the CICO rescue zone&#44; since this lifeline also provides adequate alveolar oxygenation&#46; Therefore&#44; any point in the &#8220;green zone&#8221; is a temporary safety zone&#46; The only permanent safety area is the return to spontaneous breathing&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Each time the patient enters the &#8220;green zone&#8221;&#44; they are no longer at risk of critical hypoxia&#46; The green zone gives time to oxygenate the patient&#44; gather resources and develop a new strategy&#46; This is the equivalent of &#8220;stop and think&#8221; of the next strategy in the DAS algorithm&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">A new attempt at oxygenating the patient means a new safe apnoea time if further airway instrumentation is needed&#46; Assembling resources included personnel &#40;&#8220;ask for help&#8221;&#41;&#44; equipment&#44; and even changing location &#40;for example&#44; transfer from the emergency room to the operating theatre&#41;&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">The third lifeline should allow the patient to return to a safety zone&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">-</span><p id="par0275" class="elsevierStylePara elsevierViewall">maintain oxygenation with the last successful lifeline used&#44; either to awaken the patient or proceed with surgery if urgent or indicated&#44;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">-</span><p id="par0280" class="elsevierStylePara elsevierViewall">convert the current airway to a more appropriate definitive airway while keeping the patient in the green zone&#44; or</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">-</span><p id="par0285" class="elsevierStylePara elsevierViewall">replace the successful technique with another&#44; more appropriate approach&#44; providing that oxygenation can be maintained when abandoning the green zone and returning to the vortex&#46;</p></li></ul></p><p id="par0290" class="elsevierStylePara elsevierViewall">The different factors influence decision-making in the &#8220;green zone&#8221; can be grouped into 4 categories&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">-</span><p id="par0295" class="elsevierStylePara elsevierViewall">Situational&#58; includes both the emergency and the complexity of the situation in which the airway was secured&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">-</span><p id="par0300" class="elsevierStylePara elsevierViewall">Airway&#58; includes the stability of alveolar oxygenation&#44; SpO<span class="elsevierStyleInf">2</span> level and variations&#44; and the green zone entry level&#46; The lower the green zone entry level&#44; the more limited the options for restoring alveolar oxygenation before implementing CICO rescue&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">-</span><p id="par0305" class="elsevierStylePara elsevierViewall">Patient&#58; includes the risk of aspiration and the advisability of fasting&#44; which can be influenced by the patient&#39;s level of consciousness and previous respiratory state&#44; the use of drugs&#44; and the indication for airway management&#46;</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">-</span><p id="par0310" class="elsevierStylePara elsevierViewall">Clinician&#58; involves the operator&#39;s experience with a specific technique&#46; Any technique that the clinician does not fully master should be avoided&#46;</p></li></ul></p><p id="par0315" class="elsevierStylePara elsevierViewall">Whatever option is decided in the green zone&#44; it must always include an alternative plan in case of failure&#59; this plan can be either performing the remaining optimisation manoeuvres available&#44; or CICO rescue&#46;</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Limitations of the Vortex algorithm</span><p id="par0320" class="elsevierStylePara elsevierViewall">The Vortex strategy was an individual effort to compensate for the limitations found in most algorithms&#44; and to answer the need for dynamic strategies that address more than just the technical factors involved in successful intubation in a difficult airway situation&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Algorithms are based on state-of-the-art scientific evidence&#46; They are analysed and developed in consensus by a group of experts in a particular field&#46; They are&#44; therefore&#44; structures designed and implemented in a specific geographical area&#44; usually a country&#44; although some are used worldwide and have been internationally validated&#46; According to its authors&#44; Vortex was designed to be a simple&#44; global tool&#46;</p><p id="par0330" class="elsevierStylePara elsevierViewall">None of the Vortex strategies have been included or described in any existing algorithms&#44; all of which establish airway management strategies that range from least to most aggressive&#44; depending on the patient&#39;s needs and oxygenation status&#46; The aim of all algorithms&#44; starting with the algorithm of the American Society of Anaesthesia&#44; 1993&#44;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">57</span></a> is to achieve oxygenation as a point of balance from which to decide the next strategy&#46; Once effective oxygenation has been achieved&#44; they recommend evaluating whether to continue with that particular device or technique&#44; change to a better option&#44; awaken the patient&#44; or resort to front of neck access&#46;</p><p id="par0335" class="elsevierStylePara elsevierViewall">The recommendation to &#8220;stop and think what to do next&#8221; after restoration of oxygenation is implicit in all guidelines&#44; and is in fact intrinsic to all humans&#44; including physicians and anaesthesiologists&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">Although the introduction of ANTS in difficult airway management is an advantage of the Vortex strategy&#44; it will also limit the introduction of this tool in resident training programmes &#40;simulation-based training is only included in a few programmes for residents specialising in anaesthesiologists&#44; emergency care or intensive care&#41;&#44; and it is difficult to demonstrate with sufficient scientific evidence&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">How does Vortex contribute to airway management&#63;</span><p id="par0345" class="elsevierStylePara elsevierViewall">The Vortex does not intend to replace&#44; but rather complement&#44; existing algorithms&#46; In fact&#44; it is more a cognitive aid than a true algorithm&#46; The visual design of Vortex has some advantages over the conventional label and arrow structure of algorithms&#44; insofar as it is simple to understand&#44; and easy to remember and implement by all team members&#46; These characteristics help reduce the team&#39;s &#8220;cognitive load&#8221; during a stressful situation such as an airway crisis&#46; Vortex also facilitates effective communication&#44; because it uses the same terms and concepts for the whole team&#44; improves the decision-making process&#44; can be used in any setting&#44; keeps the team focussed on the task at hand&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">58</span></a> Another advantage of the Vortex strategy is that it is applicable to any airway management situation&#46;</p><p id="par0350" class="elsevierStylePara elsevierViewall">In conclusion&#44; this novel approach to airway management using an algorithm based on cognitive aids and checklists may be an alternative tool for difficult airway management&#46; It may be difficult to design studies to validate the Vortex&#44; and its effectiveness will probably only become evident after widespread implementation&#46;</p></span><span id="sec0071" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0091">Conflict of interests</span><p id="par0341" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "identificador" => "sec0010"
          "titulo" => "Human factors and resource management during an airway crisis"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Why do difficult airway guidelines and algorithms fail&#63;"
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        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "What are cognitive aids&#63; Are they useful in the management of an airway crisis&#63;"
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          "identificador" => "sec0025"
          "titulo" => "Anaesthesia non-technical skills &#40;ANTS&#41;"
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          "identificador" => "sec0030"
          "titulo" => "The V&#211;RTEX algorithm"
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              "identificador" => "sec0035"
              "titulo" => "General description"
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            1 => array:2 [
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              "titulo" => "Pre-operative airway assessment and checklist"
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            2 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Attempts and optimisations"
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            3 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "&#8220;Best effort&#8221;&#58; optimise for success or declare failure"
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              "identificador" => "sec0055"
              "titulo" => "CICO status&#58; the fourth rescue technique"
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              "identificador" => "sec0060"
              "titulo" => "The &#8220;green zone&#8221;&#8212;a time for decisions"
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          "identificador" => "sec0065"
          "titulo" => "Limitations of the Vortex algorithm"
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          "identificador" => "sec0070"
          "titulo" => "How does Vortex contribute to airway management&#63;"
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        12 => array:2 [
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          "titulo" => "Conflict of interests"
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    "fechaAceptado" => "2018-05-28"
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          "clase" => "keyword"
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            0 => "Difficult airway"
            1 => "Airway management"
            2 => "Algorithm"
            3 => "Vortex approach"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1013109"
          "palabras" => array:4 [
            0 => "V&#237;a a&#233;rea dif&#237;cil"
            1 => "Intubaci&#243;n dif&#237;cil"
            2 => "Algoritmos"
            3 => "Vortex"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Airway management is an essential area in anaesthesia&#44; and anaesthesiologists are considered the most expert professionals to manage airway tasks&#46; However&#44; complications related to inadequate airway management remain the most frequent cause of morbidity and mortality&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Algorithmic strategy to solve difficulties fails&#44; due to several factors related to its structure and clinical application&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The Vortex Approach has emerged as a response to the limitations found in the algorithmic strategy of managing the difficult airway&#44; by using a cognitive aid strategy to reduce cognitive load and fixation error&#46; This new strategy may represent a solution to the elusive problem of the challenging airway and reduce the complications rate&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El aislamiento de la v&#237;a a&#233;rea es un &#225;rea esencial en la anestesia&#46; Los anestesi&#243;logos se consideran los profesionales m&#225;s expertos para resolver cualquier problema relacionado con una v&#237;a a&#233;rea dif&#237;cil&#46; Sin embargo&#44; las complicaciones derivadas del manejo incorrecto de la v&#237;a a&#233;rea siguen siendo una de las causas m&#225;s frecuentes de morbimortalidad asociada a la anestesia&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La estrategia mediante algoritmos de tratamiento para resolver estas dificultades ha demostrado su fracaso debido a varios factores relacionados con su estructura y su aplicaci&#243;n cl&#237;nica&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El enfoque Vortex surge como una respuesta a las limitaciones encontradas en los algoritmos de manejo de una v&#237;a a&#233;rea dif&#237;cil&#44; utilizando una estrategia de ayudas para reducir la carga cognitiva y el error de fijaci&#243;n&#46; Esta nueva estrategia puede representar una soluci&#243;n al problema de la dificultad de la v&#237;a a&#233;rea y&#44; poder as&#237;&#44; reducir la incidencia de complicaciones&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Charco-Mora P&#44; Urtubia R&#44; Reviriego-Agudo L&#46; El modelo del V&#243;rtex&#58; una aproximaci&#243;n diferente a una v&#237;a a&#233;rea dif&#237;cil&#46; Rev Esp Anestesiol Reanim&#46; 2018&#59;65&#58;385&#8211;393&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Vortex diagram with its three concentric rings&#46; &#40;A&#41; frontal view&#44; &#40;B&#41; lateral view &#40;reproduced with permission from Nicholas Chrimes&#41;&#46;</p>"
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Possible sequence of the 3 non-surgical lifelines&#46; Failure of all these will ultimately lead to the fourth level of rescue &#40;reproduced with permission from Nicholas Chrimes&#41;&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The &#8220;green zone&#8221; on the outer ring and descending around the Vortex &#40;reproduced with permission from Nicholas Chrimes&#41;&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Facemask ventilation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;1 in 700&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SAD ventilation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;1 in 50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tracheal intubation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;1 in 1500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CICO status&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;1 in 5000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8764;1 in 50&#44;000&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Failure rates of the four airway management approaches&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">1</span></a></p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:58 [
            0 => array:3 [
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              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Major complications of airway management in the UK&#58; results of the fourth national audit project of the royal college of anaesthetists and the difficult airway society&#46; Part 1&#58; Anaesthesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Cook"
                            1 => "N&#46; Woodall"
                            2 => "C&#46; Frerk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aer058"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2011"
                        "volumen" => "106"
                        "paginaInicial" => "617"
                        "paginaFinal" => "631"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21447488"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of unexpected difficult airway at a teaching institution over a 7 year period"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;R&#46; Connelly"
                            1 => "K&#46; Ghandour"
                            2 => "L&#46; Robbins"
                            3 => "S&#46; Dunn"
                            4 => "C&#46; Gibson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jclinane.2005.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Anesth"
                        "fecha" => "2006"
                        "volumen" => "18"
                        "paginaInicial" => "198"
                        "paginaFinal" => "204"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16731322"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An evidence-based approach to airway management&#58; is there a role for clinical practice guidelines&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
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Article information
ISSN: 23411929
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos