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Case report
Double intracardiac thrombosis in a patient assisted by a venoarterial extracorporeal membrane oxygenation
Trombosis intracardíaca doble en paciente asistido mediante membrana de oxigenación extracorpórea venoarterial
A. Martínez Salgadoa,
Corresponding author
tinez_26@hotmail.com

Corresponding author.
, M. Taboada Muñiza, J.M. Martínez Cereijob, P. Otero Castroa, J. Álvarez Escuderoa,c
a Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
b Servicio de Cirugía Cardíaca, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
c Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
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who was diagnosed with acute ST elevation myocardial infarction &#40;STEMI&#41;&#44; Killip III&#44; with 3-vessel coronary artery disease and ventricular septal defect &#40;VSD&#41;&#46; An intra-aortic balloon pump &#40;IABP&#41; was placed and emergency on-pump surgery was performed&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Left internal mammary artery to left anterior descending artery bypass graft was performed&#44; and the VSD was closed&#46; Severe mitral regurgitation was observed during surgery&#44; so an artificial mitral valve was placed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">On postoperative day 1&#44; in the postoperative care unit &#40;PACU&#41;&#44; the patient required high doses of catecholamines &#40;up to 0&#46;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;kg&#47;min norepinephrine and 7&#46;8<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;kg&#47;min dobutamine&#41; and IABP 1&#58;1&#46; A transoesophageal echocardiogram &#40;TOE&#41; showed severely depressed right ventricular function&#44; absence of flow through the interventricular septum &#40;IVS&#41;&#44; and correct positioning and functioning of the mitral prosthesis&#46; The patient made good progress over the following days&#44; and he was extubated and the IABP was removed&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">However&#44; he developed a clotting disorder and severe thrombocytopaenia &#40;with a platelet count of less than 50&#44;000&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; which prevented us from starting anticoagulation therapy with intravenous heparin infusion until the fifth postoperative day&#46; Prothrombin time testing was used to monitor clotting time&#44; obtaining serial INR ranges with the lowest value being 70&#46;2<span class="elsevierStyleHsp" style=""></span>s&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">On postoperative day 7&#44; the patient presented sudden clinical worsening&#44; involving respiratory distress&#44; tachypnoea&#44; tachycardia&#44; elevated central venous pressure and low central venous oxygen saturation&#46; Transthoracic echocardiography &#40;TTE&#41; showed reopening of the VSD&#44; so the patient underwent emergency reoperation to replace the IABP and close the new VSD&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">TTE performed after cardiopulmonary bypass &#40;CPB&#41; weaning showed a thrombus in the mitral prosthesis&#44; so CPB was restarted and the thrombus was removed&#46; Due to a serious biventricular dysfunction that prevented CPB weaning&#44; the patient was connected to a VA-ECMO system &#40;Cardiohelp&#44; Maquet&#41; by peripheral cannulation of the ipsilateral femoral vein and artery&#44; maintaining a constant flow rate of between 4&#46;5 and 5&#46;5 l&#47;min&#46; A left ventricle &#40;LV&#41; drain was not placed for 2 reasons&#58; TOE showed that the remaining left ventricular function was sufficient for the aortic valve to open on each beat&#44; and no LV dilation was observed&#46; In addition&#44; the presence of an IABP was considered sufficient to reduce LV afterload&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">On admission to the PACU&#44; anticoagulation therapy was restarted with continuous infusion of heparin&#44; which maintained clotting within INR ranges&#46; The next day&#44; the TOE showed a new thrombus in one of the leaflets of the mitral valve prosthesis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; so another urgent reoperation was required&#44;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In this third intervention&#44; the artificial mitral valve was replaced with a biological prothesis&#46; TOE confirmed correct operation and absence of VSD&#46; A follow-up TOE at 24<span class="elsevierStyleHsp" style=""></span>h showed severe depression of biventricular function and a large thrombus in the left atrium &#40;LA&#41;&#44; blocking the mitral prosthesis and preventing flow to the left chambers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Heparin was up-dosed&#44; without success&#46; Given the patient&#39;s conditions and the extremely high risk&#44; it was agreed jointly not to increase therapeutic measures&#44; so 48<span class="elsevierStyleHsp" style=""></span>h later&#44; with the ICT unresolved&#44; the VA-ECMO was disconnected and the IABP removed&#46; The patient died&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">In the context of a VSD&#44; VA-ECMO can be used to both stabilise the patient for septal repair surgery&#44; and as a bridge to transplantation&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">ICT in patients on VA-ECMO is a rare complication&#44; and few cases have been published&#46; This case is interesting because the patient presented ICT on 2 separate occasions&#44; and with a biological prosthesis&#46; Many factors can favour a procoagulant state in these patients&#58; exposure of blood to synthetic material&#44; ventricular dysfunction&#44; inadequate heart drainage&#44; antithrombin III deficiency&#44; and inadequate anticoagulation therapy&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> The prevention of ICT includes early initiation of anticoagulation&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> a high ECMO flow rate&#44; which prevents the formation of thrombi in the circuit but not ICT&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> and the use of an IABP or an Impella device to improve LV drainage&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Recent evidence has shown that the combination of ECMO and Impella could improve outcomes compared to ECMO alone&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Once ICT has been diagnosed&#44; treatment includes up-dosing heparin&#44; fibrinolysis&#44; and surgical thrombectomy&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> However&#44; further studies are needed to specifically analyse these cases&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0065" class="elsevierStylePara elsevierViewall">ICT is a rare complication in patients on ECMO&#59; nevertheless&#44; a high index of suspicion should be maintained due to its high rate of mortality&#46; Most importantly&#44; ICT formation should be prevented by using a high ECMO flow rate&#44; anticoagulation in the therapeutic range&#44; and good cardiac drainage&#44; considering the use of an Impella&#46; TOE is essential in the management of patients on ECMO&#44; because it can be used to verify correct cannulation and can haemodynamic status by monitoring heart function&#44; thus facilitating early diagnosis of complications such as ICT&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Funding</span><p id="par0070" class="elsevierStylePara elsevierViewall">No funding was received for this study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Intracardiac thrombosis is a rare complication in patients receiving haemodynamic support with venous-arterial extracorporeal membrane oxygenation &#40;VA-ECMO&#41;&#44; but it has a high risk of mortality&#46; This case report describes a patient who suffered cardiogenic shock after a ST-segment elevation myocardial infarction &#40;STEMI&#41; and who presented with intracardiac thrombosis during VA-ECMO support on two occasions after mitral valve replacement&#46; The first one was after the insertion of a mechanical prosthesis&#44; and the second&#44; after replacing it with a biological valve&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La trombosis intracard&#237;aca es una complicaci&#243;n poco frecuente en los pacientes que reciben asistencia hemodin&#225;mica mediante una membrana de oxigenaci&#243;n extracorp&#243;rea venoarterial &#40;ECMO-VA&#41;&#44; pero conlleva una elevada mortalidad&#46; Este caso cl&#237;nico describe un paciente que tuvo un shock cardiog&#233;nico tras un infarto agudo de miocardio con elevaci&#243;n del ST &#40;IAMCEST&#41; y que present&#243; trombosis intracard&#237;aca durante la asistencia con ECMO-VA en 2 ocasiones&#58; la primera en relaci&#243;n con la colocaci&#243;n de una pr&#243;tesis mitral mec&#225;nica y la segunda tras el recambio por una pr&#243;tesis mitral biol&#243;gica&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;nez Salgado A&#44; Taboada Mu&#241;iz M&#44; Mart&#237;nez Cereijo JM&#44; Otero Castro P&#44; &#193;lvarez Escudero J&#46; Trombosis intracard&#237;aca doble en paciente asistido mediante membrana de oxigenaci&#243;n extracorp&#243;rea venoarterial&#46; Rev Esp Anestesiol Reanim&#46; 2019&#59;66&#58;335&#8211;337&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">4-Chamber transoesophageal echocardiogram view&#44; centred on the left cavities&#44; showing a large intracardiac thrombus in the left atrium &#40;red asterisk&#41;&#46; Also note the absence of blood flow through the biological mitral prosthesis&#44; shown on colour Doppler &#40;red arrow&#41;&#46;</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">AI&#58; left atrium&#59; lpm&#58; beats per minute&#59; VD&#58; right ventricle&#59; VI&#58; left ventricle&#46;</p>"
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                    0 => array:2 [
                      "titulo" => "Review of venoarterial extracorporeal membrane oxygenation and development of intracardiac thrombosis in adult cardiothoracic patients"
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                          "etal" => false
                          "autores" => array:2 [
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                            1 => "W&#46; Bernstein"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Extra Corpor Technol"
                        "fecha" => "2016"
                        "volumen" => "48"
                        "paginaInicial" => "162"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [
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            1 => array:3 [
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrent thrombosis after mechanical circulatory support"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Aissaoui"
                            1 => "K&#46; Hakim-Meibodi"
                            2 => "M&#46; Morshuis"
                            3 => "J&#46; Gummert"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1093/icvts/ivs025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "668"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22350773"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asistencia circulatoria con oxigenador extracorp&#243;reo de membrana como puente a trasplante cardiaco en rotura septal ventricular compleja"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Pascual"
                            1 => "F&#46; L&#243;pez"
                            2 => "D&#46; Hern&#225;ndez-Vaquero"
                            3 => "P&#46; Avanzas"
                            4 => "J&#46; Silva"
                            5 => "C&#46; Mor&#237;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rec.2016.02.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2016"
                        "volumen" => "69"
                        "paginaInicial" => "617"
                        "paginaFinal" => "619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27103450"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unexpected bioprosthetic mitral valve thrombus during left ventricular assist device implantation"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Imada"
                            1 => "S&#46;C&#46; Shibata"
                            2 => "K&#46; Okitsu"
                            3 => "Y&#46; Fujino"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s40981-017-0086-5"
                      "Revista" => array:5 [
                        "tituloSerie" => "JA Clin Rep"
                        "fecha" => "2017"
                        "volumen" => "3"
                        "paginaInicial" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29457059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular thrombus associated with arteriovenous extra corporeal membrane oxygenation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Makdisi"
                            1 => "Z&#46;A&#46; Hashmi"
                            2 => "T&#46;C&#46; Wozniak"
                            3 => "I&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3978/j.issn.2072-1439.2015.11.18"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Thorc Dis"
                        "fecha" => "2015"
                        "volumen" => "7"
                        "paginaInicial" => "E552"
                        "paginaFinal" => "E554"
                      ]
                    ]
                  ]
                ]
              ]
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ISSN: 23411929
Original language: English
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