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Letter to the Director
Snakebite management in a pediatric patient: More doubts than certainties
Manejo de una mordedura de ofidio en un paciente pediátrico: más dudas que certezas
E. Sanjuan, L. Álvarez-Baena, D. Callejo, A. Romera
Corresponding author
andreilla111@hotmail.com

Corresponding author.
Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Snake bites are rare in our setting&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> a factor that complicates decision-making difficult and delays the start of treatment&#44; particularly in paediatric patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> We report the case of a child bitten by a viper who developed compartment syndrome that required 2 fasciotomies&#46; As anaesthesiologists and paediatric critical care specialists&#44; we ask ourselves whether the administration of antivenom would have improved management&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 5-year-old boy weighing 20&#160;kg&#44; with no clinical history&#44; who was bitten by a snake in the thenar space&#46; He was transferred to 2 hospitals before arriving at the Gregorio Mara&#241;&#243;n General University Hospital in Madrid&#44; where he was admitted 12&#160;h after being bitten&#46; The diagnosis of viper bite&#44; probably from a <span class="elsevierStyleItalic">Vipera latastei</span> or &#8220;snub-nosed viper&#8221;&#44; was performed correctly in both hospitals&#44; based on the morphology of the bite&#44; the geographic location&#44; and the description provided by the patient&#46; Both hospitals decided to take a conservative approach and transfer the patient to a tertiary hospital&#46; When he finally arrived in our paediatric critical care unit&#44; the patient was in good general condition with haemodynamic and respiratory stability&#46; The affected hand&#44; in addition to the bite mark&#44; was swollen&#44; hot and flushed&#46; The parents reported that these symptoms had increased gradually and spread upwards&#46; The only laboratory abnormality found was leucocytosis of 17&#44;000&#160;&#956;l&#46; The National Institute of Toxicology and Forensic Sciences was contacted by telephone and&#44; following their protocol&#44; antivenom was not administered&#46; The patient was examined by the trauma unit and underwent fasciotomy in the wrist within 1&#160;h of admission&#44; and a second intervention 48 later&#44; both to treat compartment syndrome&#46; The patient was treated with amoxicillin-clavulanate and intravenous corticosteroids&#46; In the first 24&#160;h&#44; mild phlebitis was observed in the forearm&#44; which progressed to the axilla&#46; The pitting oedema reached as far as his wrist&#46; Aside from the initial leucocytosis&#44; which normalized within 8&#160;h of admission&#44; his laboratory parameters &#40;urine sediment&#44; blood count&#44; biochemistry&#44; coagulation&#44; acute phase markers and muscle damage&#41; were normal&#46; He remained stable during his hospital stay and was discharged home 11 days later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Snake bites in Spain are rare&#44; but potentially serious&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although the patient was treated by a multidisciplinary team&#44; none of the specialists involved&#8212;anaesthesiologists&#44; traumatologists and experts in infectious diseases&#8212;had experience in snake bites&#46; A comprehensive review of the international literature showed that this pathology can be confusing&#44; given the many different classifications of patient severity and different therapeutic criteria&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In terms of the clinical classification&#44; some authors use the Audebert classification or a slightly modified version&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> which divides patients into 4 grades and considers extensive oedema and moderate general symptoms &#40;grade III&#41; to be the determining factors for severity&#46; In our patient&#44; oedema only reached as far as the wrist &#40;although the phlebitis progressed along the arm over the first days&#41; and the leucocytosis lasted only a few hours&#59; both factors suggested mild envenoming&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Children and elderly patients are more likely to develop severe envenoming&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The site of the bite in our patient is the most frequently described in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Although most envenomations are superficial to the fascia and rarely progress to compartment syndrome&#44; bites in the hand are the exception to this rule&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and this has prompted some authors to claim that the anatomical site can be a determining factor in the development of compartment syndrome&#46; Management is similar for all snake species in Spain&#44; so knowing the specific type of viperis is not essential for treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The most important diagnostic studies are electrocardiography&#44; since toxins can have a direct cardiotoxic effect and cause arrhythmias&#8212;particularly supraventricular tachycardia and heart block&#44; and renal function tests for the presence of choluria due to myoglobinuria or haematuria&#44; proteinuria&#44; oliguria or progression to kidney failure&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In terms of therapy&#44; the affected limb should be immobilized and elevated&#44; but never compressed&#44; and cryotherapy &#40;applied indirectly&#41; and bed rest should be considered&#46; Tourniquets&#44; cutting or sucking the wound are not recommended&#44; and cauterizing the bite area&#44; amputation or applying electric current should be avoided&#44; as should the administration of stimulating drugs or drinks that increase cardiac output and facilitate the spread of venom&#46; Anti-tetanus prophylaxis should be administered if needed&#44; analgesics &#40;not salicylates&#41; should be started&#46; The use of antivenom serum should be considered&#44; with or without intravenous mannitol at 1&#8722;2&#160;g&#47;kg&#47;weight&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">There are no randomized clinical trials comparing the benefit of antivenom and the effectiveness of fasciotomy in humans&#46; Although fasciotomy has hitherto been prioritized&#44; more recent studies recommend administering antivenom as first-line treatment&#44; as it is effective and well-tolerated&#44; prevents progression&#44; improves inflammation&#44; and reduces hospital stay&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Early &#40;within 6&#160;h of the bite&#41;&#44; rather than late administration of the antivenom serum is more effective&#44; probably because the venom has had less time to act&#46; However&#44; late administration&#44; though less effective&#44; is also useful &#40;even after 24&#160;h&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Likewise&#44; some authors recommend early administration of antivenom in pregnant women and in patients that already show signs of compartment syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Our diagnosis of compartment syndrome was made on the basis of clinical criteria&#44; without directly measuring compartment pressure&#46; Some authors recommend performing this measurement to determine whether the oedema is intracompartmental or extracompartmental&#44; and to apply the appropriate treatment in each case&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> since snake venom itself causes muscle necrosis and can mimic compartment syndrome&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Furthermore&#44; fasciotomy resolves compartment syndrome&#44; but not muscle necrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Although the administration of antivenom is not without risk&#8212;pruritus&#44; urticaria&#44; angioedema&#44; nausea&#44; hypotension or anaphylactic shock&#8212;most experts agree that adverse effects are rare&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Some authors advise premedicating with antihistamines and corticosteroids and&#47;or performing a hypersensitivity test&#46; The rate of administration should be reduced or suspended altogether if adverse effects appear&#44; although this is highly unlikely given the low antigenicity of these sera&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The prophylactic use of antibiotics has not been shown to be useful&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Corticosteroids are only indicated in the exceptional case of an allergic reaction to the poison or in the event of a very rare adverse reaction after administration of the serum&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">We believe that this was a borderline patient as far as antivenom serum is concerned&#46; Factors advising against administration were the time elapsed since the bite and the extent of the lesion&#59; factors in favour were the age of the patient&#44; the location of the bite and the need for fasciotomy&#46; Given our limited experience and the diversity of criteria found in the literature&#44; we cannot establish an unequivocal guideline for action&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We recommend always contacting the National Institute of Toxicology and taking their opinion and protocol into account&#44; albeit it bearing in mind that they can be too conservative in some cases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have not received funding for this study&#46;</p></span></span>"
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Original language: English
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