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Case report
Anaesthetic implications for Pompe disease. A case description
Implicaciones anestésicas en la enfermedad de Pompe. Descripción de un caso
M. Ruano Santiago
Corresponding author
mrsantiago93@gmail.com

Corresponding author.
, E. Soto Garrucho, Y. González Marín, A.M. Pérez Muñoz, M. Echevarría Moreno
Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Universitario de Valme, Sevilla, Spain
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cardiac&#44; and smooth muscle&#41;&#44; leading to clinically progressive muscle weakness&#44; the development of multisystem disease&#44; and often early death&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Muscle involvement can extend to the respiratory muscles leading to diaphragmatic paralysis&#44; alveolar hypoventilation and&#44; in some cases&#44; respiratory failure&#46; Cardiac accumulation has also been documented with manifestations such as cardiac hypertrophy and heart rhythm disturbances&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">There are 2 classical forms&#58; infantile- and late-onset disease&#46; Patients with the classic infantile-onset form manifest a rapidly progressive disease characterised by hypertrophic cardiomyopathy&#44; hepatomegaly&#44; skeletal muscle weakness&#44; significant hypotonia&#44; and even death from cardiorespiratory failure during the first year of life&#46; Patients with the late-onset form have a milder phenotype&#44; typically consisting of proximal skeletal muscle weakness with slowly progressive myopathy&#44; but rarely have cardiac involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Published data on the anaesthetic management of Pompe disease are relatively scarce and consist primarily of case reports&#44; guidelines&#44; and protocols in patients with general myopathies or lysosomal diseases&#46; The anaesthetic techniques described include both locoregional and general anaesthesia&#44; highlighting the pathophysiological implications of the different drugs used&#44; and their potential complications&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">This manuscript describes the case of a 47-year-old male&#44; diagnosed with type II glycogenosis in its adult form&#44; who underwent surgery for fracture of the proximal end of the left humerus&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical case</span><p id="par0025" class="elsevierStylePara elsevierViewall">The patient is a 47-year-old male with no known allergic reactions to medication&#46; Ex-smoker&#46; Personal history of late-onset Pompe disease&#59; initial screening in 2019&#44; in view of symptoms compatible with metabolic myopathy&#44; performed at the Virgen del Roc&#237;o University Hospital by dried blood drop testing&#44; which was pathological&#44; and a confirmatory genetic study performed at the La Paz University Hospital&#44; with a double pathological mutation in heterozygosis in the <span class="elsevierStyleItalic">GAA</span> gene &#91;c&#46;-32-13 T&#8239;&#62;&#8239;G &#40;IVS1-13 T&#8239;&#62;&#8239;G&#41; and c&#46;236&#95;246del &#40;p&#46;P79Rfs&#42;13&#41;&#93;&#46; He currently shows moderate restriction pattern in forced spirometry and paroxysmal atrial fibrillation without anticoagulation or structural heart disease observed on echocardiography&#46; There is no evidence of aneurysms on CT angiography&#46; On treatment with alglucosidase alfa &#40;Myozyme&#174;&#41;&#44; bisoprolol&#44; and low-dose acetylsalicylic acid&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was admitted to the emergency department for pain and functional impotence of the left upper limb after an accidental fall&#44; and a fracture of the proximal end of the humerus was confirmed by conventional radiography&#46; In the pre-anaesthetic assessment&#44; the following predictive parameters for a difficult airway were observed&#58; Mallampati score 4&#44; limited mouth opening &#40;4&#8239;cm&#41;&#44; thyromental distance 6&#8239;cm&#44; bite test 1&#44; normal cervical extension&#44; slight retrognathia&#44; and prominent dentition&#46; There was a slight overall decrease in vesicular murmur on cardiopulmonary auscultation&#44; sinus bradycardia at 50&#8211;55&#8239;bpm on the electrocardiogram&#44; and an unremarkable blood test&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Given the patient&#8217;s clinical stability&#44; it was decided to schedule operation of his fracture in the operating theatre&#44; after observing the preoperative fasting period&#46; On arrival&#44; continuous monitoring was carried out with a 5-lead electrocardiogram&#44; pulse oximeter&#44; serial non-invasive blood pressure measurement&#44; anaesthetic depth &#40;BIS&#41;&#44; and neuromuscular blockade with train-of-four&#46; Cefazolin 2&#8239;g was used for antibiotic prophylaxis and ranitidine 50&#8239;mg for bronchoaspiration prophylaxis&#46; Then&#44; using an aseptic and ultrasound-guided technique&#44; the brachial plexus block was performed at the interscalene level with an in-plane approach&#44; administering ropivacaine 0&#46;5&#37; and mepivacaine 0&#46;7&#37; 15&#8239;ml&#44; without incident&#46; General anaesthesia was induced with a pre-oxygenation sequence&#44; administering 100&#8239;&#956;g&#44; lidocaine 60&#8239;mg&#44; propofol 120&#8239;mg&#44; and rocuronium 40&#8239;mg&#44; and orotracheal intubation was performed by direct laryngoscopy assisted with Eschmann guide &#40;Cormack 3&#41;&#44; with a 7&#46;5&#8239;mm internal diameter ringed endotracheal tube &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Mechanical ventilation was programmed in volume control mode on a General Electric Datex Ohmeda&#174; machine with the following respiratory parameters&#58; tidal volume 6&#8239;ml&#47;kg&#44; 14&#8239;rpm&#44; inspiration&#58; expiration ratio 1&#58;2&#44; positive end-expiratory pressure 6&#8239;cm&#8239;H<span class="elsevierStyleInf">2</span>O&#44; and fraction of inspired oxygen of &#46;45&#46; Anaesthesia maintenance was performed with remifentanil at doses between &#46;02 and &#46;05&#8239;&#956;g&#47;kg&#47;min and continuously perfused propofol between 4 and 6&#8239;mg&#47;kg&#47;h for BIS values between 40 and 60&#46; No further neuromuscular relaxant was administered during the surgical procedure&#46; Antiemetic prophylaxis with dexamethasone 8&#8239;mg on induction and ondansetron 4&#8239;mg on emergence was decided in the presence of an Apfel score of 2&#46; Fluid therapy comprised 1000&#8239;ml of lactated Ringer&#39;s lactate and 300&#8239;ml of &#46;9&#37; physiological saline&#46; The procedure lasted 120&#8239;min&#46; At the end&#44; maintenance drugs were withdrawn&#44; analgesic rescue was administered with metamizole 2&#8239;g and dexketoprofen 50&#8239;mg and residual neuromuscular blockade &#40;train-of-four &#46;7&#41; was reversed with sugammadex 2&#8239;mg&#47;kg&#44; achieving a train-of-four &#62;&#46;9 ratio&#46; The patient was extubated without incident and transferred to the post-anaesthesia recovery unit&#44; haemodynamically stable&#44; with good respiratory mechanics and optimal oxygen saturation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">There were no incidents in the immediate postoperative period in the post-anaesthesia recovery unit or subsequently on the hospital ward&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">The anaesthetic management of Pompe disease&#44; a rare entity&#44; is considered a challenge&#44; as there are no generalised standards to follow&#44; and it depends mainly on the age at clinical onset and associated comorbidities&#46; As a consequence of the clinical manifestations presented&#44; these patients may require multiple surgical interventions involving both cardiac and respiratory problems&#44; although the major complications are those derived from potentially difficult management of the airway &#40;short neck&#44; temporomandibular stiffness&#44; and macroglossia&#41;&#46; This is where the anaesthesiologist should be involved with a thorough preoperative assessment&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">As mentioned above&#44; the infantile-onset form may be accompanied by intellectual disability&#44; cardiomegaly&#44; and hepatomegaly&#44; as well as progressive hypotonia with increased creatine kinase and accessory muscle involvement predisposing to recurrent pneumonias and respiratory failure&#44; whereas adult-onset manifests in some cases with acute respiratory failure without evidence of the above&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Neither form has been associated with hypoglycaemia&#44; unlike other glycogenoses&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As the disease progresses&#44; muscle weakness leads to low lung volumes&#44; frequent unproductive coughing&#44; blood gas disturbances&#44; and sleep-disordered breathing&#44; with associated risk of aspiration pneumonia&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Approximately 60&#37; of patients with late-onset Pompe disease have mild reduction in vital capacity &#40;less than 80&#37; of theoretical&#41; and 30&#37;&#8211;40&#37; moderate reduction &#40;&#60;60&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Diaphragmatic involvement may be an early finding and respiratory failure is often the first clinical manifestation of the disease&#46; Due to underlying muscle weakness&#44; patients with glycogenosis type II may be more sensitive to neuromuscular blockade&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> If postoperative respiratory failure develops due to muscle fatigue&#44; non-invasive mechanical ventilation with pressure support may be required until recovery&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In Pompe disease it is advisable to assess cardiovascular status&#46; The most common cardiac problems include cardiomyopathies&#44; heart failure&#44; and arrhythmias&#44; and there may be a component of cardiac dysfunction that contributes to respiratory failure from a haemodynamic point of view and the impact of cardiac size on lung capacity&#46; Although there is usually no clinically identifiable heart disease in late-onset disease&#44; there are no published data on systolic and diastolic function in this group of patients&#46; Anaesthetic procedures are made more difficult by the hypertrophic cardiomyopathy sometimes found in these patients&#46; This can lead to potentially fatal haemodynamic instability&#44; as it causes myocardial ischaemia and cardiac output depletion&#44; complicating the intra-anaesthetic period&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Cerebral aneurysms are a serious complication of this disease&#44; with a higher incidence in adult-onset disease&#44; and is the second cause of death after respiratory failure&#46; Therefore&#44; screening by imaging tests &#40;angio-CT&#41; is recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">It is important to highlight that the pharmacological treatment used for anaesthetic management should be chosen with caution considering the existence of cardiovascular or generalised complications of the disease&#46; Current recommendations state that benzodiazepines&#44; opioids&#44; intravenous or local anaesthetics&#44; acetylcholinesterase inhibitors and non-depolarising muscle relaxants are safe and low-risk drugs for this disease&#46; Cases of cardiorespiratory arrest and arrhythmias during anaesthetic induction have been reported in the literature &#40;6&#37;&#41; related to the use of anaesthetic agents such as halothane&#44; sevoflurane&#44; and propofol at high doses&#44; which warrants slow induction avoiding or decreasing the doses of these hypnotics if possible&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Propofol&#44; particularly at high doses&#44; is not considered the ideal agent for maintenance anaesthesia due to the reduction in afterload and diastolic pressure&#44; which predispose to the risk of myocardial ischaemia&#46; However&#44; it&#44; along with inhalation agents and thiopental&#44; may be used with caution in patients with less cardiac impact&#46; Several studies recommend the use of ketamine and etomidate&#44; avoiding succinylcholine because of its association with rhabdomyolysis and hyperkalaemia&#46; Ketamine&#44; as a drug&#44; maintains systemic vascular resistance and contractility&#44; and the associated reduction in preload is less likely&#46; In this sense&#44; the anaesthetic goals would encompass the maintenance of adequate preload and systemic vascular resistance to ensure effective coronary perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The association between glycogenosis type II and malignant hyperthermia is only theoretical&#44; as no cases have been reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Nevertheless&#44; it is advisable to avoid drugs that could potentially trigger this disease and to have rapid access to dantrolene in the event it is needed&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">This patient underwent combined anaesthesia&#58; ultrasound-guided interscalene brachial plexus block and total intravenous anaesthesia with propofol and remifentanil&#44; after ruling out structural heart disease and associated cardiovascular manifestations by preoperative echocardiography&#46; Rocuronium was chosen for neuromuscular relaxation&#44; as it is not contraindicated&#44; and its action can be rapidly reversed with sugammadex&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interests</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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            0 => "Pompe disease"
            1 => "Type II glycogenosis"
            2 => "Anaesthesia"
            3 => "Myopathy"
            4 => "Hypertrophic cardiomyopathy"
            5 => "Difficult airway"
            6 => "Malignant hyperthermia"
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            0 => "Enfermedad de Pompe"
            1 => "Glucogenosis tipo II"
            2 => "Anestesia"
            3 => "Miopat&#237;a"
            4 => "Miocardiopat&#237;a hipertr&#243;fica"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pompe disease&#44; or type II glycogenosis&#44; is a rare metabolic myopathy inherited in an autosomal recessive pattern&#44; characterized by progressive muscle weakness and multisystem involvement&#46; The disease often results in premature death&#46; Patients with Pompe disease are at high risk for anaesthesia-related complications&#44; particularly cardiac and respiratory problems&#44; although difficult airway management is the greatest complication&#46; It is essential to perform a comprehensive preoperative study in order to reduce the risk of perioperative morbidity and mortality&#44; and to obtain as much information as possible for the surgical procedure&#46; In this article&#44; we report the case of a patient with a history of adult Pompe disease who underwent combined anaesthesia for osteosynthesis of the proximal end of the left humerus&#46;</p></span>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Pompe o glucogenosis tipo II es una miopat&#237;a metab&#243;lica rara&#44; de herencia autos&#243;mica recesiva&#44; que se caracteriza por debilidad muscular progresiva y afectaci&#243;n multisist&#233;mica&#44; acompa&#241;ada&#44; habitualmente&#44; de muerte temprana&#46; Los pacientes con esta enfermedad presentan alto riesgo anest&#233;sico en relaci&#243;n a problemas tanto de origen cardiaco como respiratorio&#44; aunque las mayores complicaciones son las derivadas del manejo de la v&#237;a a&#233;rea&#44; potencialmente dificultoso&#46; Un buen estudio preoperatorio es fundamental para disminuir la morbimortalidad perioperatoria&#44; optimizando y aportando la mayor informaci&#243;n posible de cara a la intervenci&#243;n quir&#250;rgica&#46; En este art&#237;culo se expone el caso de un paciente con antecedentes de enfermedad de Pompe del adulto sometido a anestesia combinada para osteos&#237;ntesis de extremo proximal de h&#250;mero izquierdo&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">After neuromuscular relaxation and orotracheal intubation&#44; marked retrognathia can be seen&#46; Monitoring with BIS and dressing of the brachial plexus block&#46;</p>"
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                0 => array:2 [
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                      "titulo" => "Gu&#237;a cl&#237;nica de la enfermedad de Pompe de inicio tard&#237;o"
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                      "titulo" => "Enfermedad de Pompe&#58; Protocolo diagn&#243;stico por el laboratorio cl&#237;nico &#91;tesis doctoral&#93;"
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                      "titulo" => "Pompe&#8217;s disease and anesthesia"
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                            0 => "H&#46; McFarlane"
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Article information
ISSN: 23411929
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos