Article information
Resumen
Presentamos los resultados en raquis utilizando proteínas morfogénicas de hueso (BMP-7) y células troncales pluripotenciales capacitadas a la línea osteogénica. En el ensayo clínico aleatorizado y controlado, los resultados mostraron que la BMP-7 consiguió una formación de hueso similar al autoinjerto. Igualmente, en otra cohorte prospectiva y controlada, se apreció una formación de hueso cuando se utilizó BMP-7 con aloinjerto mayor que con aloinjerto solo. En ningún paciente se observaron efectos secundarios. Los estudios experimentales mostraron resultados prometedores con la terapia celular. Se discuten las bases actuales de la terapia celular.
Palabras clave:
Proteínas morfogénicas
Terapia celular
Células troncales
Artrodesis vertebral
Ensayo clínico
Estudio de cohortes
Abstract
We report the spinal results of the use of bone morphogenetic protein (BMP-7) and pluripotent stem cells differentiated to the osteogenic lineage. The results of this randomized, controlled clinical trial show that BMP-7 achieved similar bone formation to the use of autograft. Equally, in another controlled prospective cohort, greater bone formation was found when BMP-7 was used with allograft compared with allograft alone. No adverse effects were found. Experimental studies of cell therapy show promising results. The current foundations of cell therapy are discussed.
Keywords:
Morphogenetic proteins
Cell therapy
Stem cells
Vertebral arthrodesis
Clinical trial
Cohort study
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