metricas
covid
Buscar en
Revista Española de Cirugía Ortopédica y Traumatología (English Edition)
Toda la web
Inicio Revista Española de Cirugía Ortopédica y Traumatología (English Edition) Multifocal liposarcoma. Detection of TLS-CHOP translocation. A case report
Journal Information
Vol. 52. Issue 6.
Pages 386-391 (November - December 2008)
Share
Share
Download PDF
More article options
Vol. 52. Issue 6.
Pages 386-391 (November - December 2008)
Case report
Full text access
Multifocal liposarcoma. Detection of TLS-CHOP translocation. A case report
Liposarcoma muilticéntrico. Detección de la translocación TLS-CHOP. A propósito de un caso
Visits
1297
E. López-Anglada Fernández
, J. Fra Rodríguez, A. Braña Vigil
Central University Hospital of Asturias. Oviedo. Asturias. Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics

Se dice que un sarcoma es multicéntrico cuando es detectado en dos o más localizaciones anatómicas diferentes antes de que se extienda a regiones donde es más frecuente encontrarlo como metástasis. Un aspecto controvertido y no demostrado de esta enfermedad es si este patrón de presentación se debe a un origen multicéntrico o, por el contrario, se trata de una forma rara de metástasis cuya causa se desconoce.

Nuestro objetivo es exponer un cuadro clínico compatible con un caso de liposarcoma multicéntrico. Se ha realizado además un estudio de la translocación TLS-CHOP para intentar verificar el origen metastásico o no de las masas.

Key words:
liposarcoma
multicenter
multifocal
translocation

A sarcoma is said to be multicenter when it is detected in two or more different anatomical locations before it extends to regions to which it most frequently metastasizes. However it is not clear and still a matter of controversy whether this presentation of the disease is due to a multicenter origin or whether, on the other hand, it is a rare metastatic form whose cause is still unknown.

Our purpose is to present a clinical case that is compatible with the description of multicenter liposarcoma. In addition, a study of TLS-CHOP translocation was carried out to confirm the alleged metastasic origin of the disease.

Palabras clave:
liposarcoma
multicéntrico
multifocal
translocación
Full text is only aviable in PDF
References
[1.]
S.L. Blair, J.J. Lewis, D. Leung, J. Woodruff, M.F. Brennan.
Multifocal extremity sarcoma: an uncommon and controversial entity.
Ann Surg Oncol, 5 (1998), pp. 37-40
[2.]
H. Sato, S. Minei, S. Sugimoto, Y. Kishimoto, T. Yoshida, Y. Takimoto.
Multicentric liposarcoma.
Int J Urol, 11 (2004), pp. 1133-1135
[3.]
C.R. Antonescu, A. Elahi, J.H. Healey, M.F. Brennan, M.Y. Lui, J. Lewis, et al.
Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis TLS-CHOP or EWS-CHOP rearrangements.
Clin Cancer Res, 6 (2000), pp. 2788-2793
[4.]
C.R. Antonescu, A. Elahi, M. Humphrey, M. Lui, J.H. Healey, M.F. Brennan, et al.
Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma. Absence in predominantly myxoid-well differenciated liposarcomas.
J Mol Diagnostics, 2 (2000), pp. 132-138
[5.]
H. Kanoe, T. Nakayama, T. Hosaka, H. Murakami, H. Yamamoto, Y. Nakashima, et al.
Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of translin and topoisomerase II in the process of translocation.
Oncogene, 18 (1999), pp. 721-729
[6.]
H. Siegmund.
Lipoblastische sarkomatose.
Virchows Arch Pathol Anat, 293 (1934), pp. 458-463
[7.]
F.M. Enzinger, D.J. Winslow.
Liposarcoma. A study of 103 cases.
Virchows Arch Pathol Anat, 335 (1962), pp. 367-388
[8.]
P.A. Reszel, E.H. Soule, M.B. Coventry.
Liposarcoma of the extremities and the limb girdles. A study of two hundred and twenty two cases.
J Bone Joint Surg, 48 (1966), pp. 229-244
[9.]
A. Altho, T.E. Larsen.
A case of multifocal liposarcoma?.
Acta Orthop Scand, 63 (1992), pp. 98-99
[10.]
S.E. Killpatric, J. Doyon, P.F.M. Choong, F.M. Sim, A.G. Nascimento.
The clinicopathologic spectrum of mixoid and round cell liposarcoma. A study of 95 cases.
[11.]
H.R. Chang, S.I. Hajdu, C. Collin, M.F. Brennan.
The prognostic value of histologic subtypes in primary extremity liposarcoma.
Cancer, 64 (1989), pp. 1514-1520
[12.]
C.P. Karakousis, C. Proimakis, D.L. Walsh.
Primary soft tissue sarcoma of the extremities in adults.
Br J Surg, 82 (1995), pp. 1208-1212
[13.]
M.A. Gadd, E.S. Casper, J.M. Woodruff, P.M. McCormack, M.F. Brennan.
Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma.
Ann Surg, 218 (1993), pp. 705-712
[14.]
M.P. Vezeridis, R. Moore, C.P. Karakousis.
Metastatic patterns in soft tissue sarcomas.
Arch Surg, 118 (1983), pp. 915-918
Copyright © 2008. Sociedad Española de Cirugía Ortopédica y Traumatología (SECOT). All rights reserved
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.recote.2019.09.001
No mostrar más