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Inicio Annals of Hepatology P-53 FAILURE IN ALL STEPS OF HEPATOCELLULAR CARCINOMA SURVEILLANCE PROCESS IS FR...
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
Open Access
P-53 FAILURE IN ALL STEPS OF HEPATOCELLULAR CARCINOMA SURVEILLANCE PROCESS IS FREQUENT IN DAILY PRACTICE.
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Melisa Dirchwolf1, Sebastián Marciano2, Andres E. Ruf1, Amit G. Singal3, Vanina D'Ercole4, Paola Coisson5, Alina Zerega6,7, Federico Orozco8, Ana Palazzo9, Eduardo Fassio10, Diego Arufe11, Margarita Anders12, Claudia D'Amico13, Luis Gaite14,15, Marcos Thompson16, Daniela Perez9, Leila Haddad2, Ezequiel Demirdjian11, Moira Zunino9, Adrián Gadano2..., María Dolores Murga9, Carla Bermudez2, Jesica Tomatis1, Nadia Grigera12, Florencia Antinucci12, Manuel Baravalle1, Maria Mercedes Rodriguez Gazari17, Melina Ferreiro18, Manuel Barbero5, Andrea Curia18, Manuel Demonte14, Gisela Gualano10Ver más
1 Hospital Privado de Rosario, Rosario, Santa Fe, Argentina
2 Hospital Italiano de Buenos Aires, Caba, Argentina
3 Department Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
4 Hospital Complejo Médico de la Policía Federal Churruca – Visca, Caba, Argentina
5 Hospital el Cruce – Néstor Kirchner, Florencio Varela, Buenos Aires, Argentina
6 Sanatorio Allende, Córdoba, Argentina
7 Hospital Córdoba, Córdoba, Córdoba, Argentina
8 Hospital César Milstein, Caba, Argentina
9 Hospital Ángel C. Padilla, San Miguel de Tucumán, Tucumán, Argentina
10 Hospital Nacional Prof. Alejandro Posadas, El Palomar, Buenos Aires, Argentina
11 Sanatorio Sagrado Corazón, Caba, Argentina
12 Hospital Alemán, Caba, Argentina.
13 Centro Especialidades Médicas Ambulatoria, Mar del Plata, Buenos Aires, Argentina
14 Hospital José M. Cullen, Santa Fe, Argentina
15 Clínica de Nefrología, Urología y Enfermedades Cardiovasculares, Santa Fe, Argentina
16 Hospital Universitario Austral, Pilar, Buenos Aires, Argentina
17 Hospital Británico, Caba, Argentina
18 Hospital de Clínicas José de San Martín (UBA), Caba, Argentina
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Vol. 24. Núm S1

Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)

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Introduction

Failures at any step in the hepatocellular carcinoma (HCC) surveillance process can result in HCC diagnostic delays and associated worse prognosis.

Objectives

We aimed to estimate the prevalence of surveillance failure and its associated risk factors in patients with HCC in Argentina, considering three steps: 1) recognition of at-risk patients, 2) implementation of HCC surveillance, 3) success of HCC surveillance.

Methods

We performed a multi-center cross-sectional study of patients at-risk for HCC in Argentina seen between10.01.2018 and 10.30.2019. Multivariable logistic regression analysis was used to identify correlates of surveillance failure.

Results

Of 301 included patients, the majority were male (74.8%) with a mean age of 64 years old. At the time of HCC diagnosis, 75 (24.9%) patients were unaware of their diagnosis of chronic liver disease, and only 130 (43.2%) patients were under HCC surveillance. Receipt of HCC surveillance was significantly associated with follow-up by a hepatologist. Of 119 patients with complete surveillance, surveillance failure occurred in 30 (25.2%) patients. Patients under complete surveillance were significantly more likely to be diagnosed within Milan criteria than those without surveillance (75% vs. 50%, p<0.001),(Figure). Surveillance failure was significantly associated with alpha fetoprotein ≥20 ng/ml (OR 4.0, CI 95% 1.43-11.55).

Conclusions

HCC surveillance failure was frequent in all the evaluated steps. These data should help guide strategies to improve the implementation and results of HCC surveillance in our country.

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