metricas
covid
Buscar en
Cirugía Española
Toda la web
Inicio Cirugía Española Cáncer de muñón gástrico: resultados del tratamiento quirúrgico
Información de la revista
Vol. 70. Núm. 1.
Páginas 16-21 (julio 2001)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 70. Núm. 1.
Páginas 16-21 (julio 2001)
Acceso a texto completo
Cáncer de muñón gástrico: resultados del tratamiento quirúrgico
Gastric stump cancer: Results of surgical treatment
Visitas
9588
A. Díaz de Liaño1, F. Oteiza, M.A. Ciga, F. Cobo, M. Aizcorbe, R. Trujillo, N. Moras
Servicios de Cirugía General y Aparato Digestivo. Hospital Virgen del Camino. Pamplona
Este artículo ha recibido
Información del artículo
Resumen
Introducción

El pronóstico de cáncer de muñón gástrico, en general, es peor que el de cáncer gástrico primario.

Métodos

Un total de 33 pacientes con cáncer de muñón tratados en nuestro servicio desde 1984 a 1999, 31 varones y 2 mujeres, con una edad media de 69,6 años. La primera intervención fue por úlcera gástrica en 14 casos, y duodenal o pilórica en 19. Presentaban gastrectomía Billroth II 22 pacientes y Billroth I 11 pacientes. El intervalo medio entre la primera operación y el diagnóstico del tumor fue de 30,6 años.

Resultados

Fueron operados 27 pacientes; el índice de resecabilidad fue del 66,6%. Se realizaron 16 gastrectomías totales, 6 de ellas ampliadas y 2 casi totales.

Predominó el adenocarcinoma tipo intestinal (22 casos); 4 pacientes presentaban tumores precoces (early) y en 13 (72,2%) existía afección de la serosa (pT3-pT4).

La supervivencia actuarial global a los 5 años es del 22%, un 41,4% en los pacientes resecados (p < 0,001). Fue significativa la supervivencia de los casos resecados según el tamaño del tumor (p < 0,05).

Conclusiones

En los pacientes gastrectomizados parece aconsejable el control endoscópico a partir de los 15 años para mejorar la resecabilidad y la supervivencia mediante un diagnóstico más precoz.

La supervivencia obtenida en los casos tratados con gastrectomía total justifica este tratamiento quirúrgico agresivo.

Hubo diferencias significativas en la supervivencia según el tamaño del tumor.

Palabras clave:
Cancer de muñón gástrico
Gastrectomía
Introduction

The prognosis for gastric stump cancer is generally considered to be worse than that for primary gastric cancer.

Methods

We studied 33 patients (31 men and 2 women; mean age: 69.6 years) treated in our department between 1984 and 1999. Primary intervention was for gastric ulcer in 14 patients and for duodenal or pyloric ulcer in 19.Twenty-two patients underwent Billroth II gastrectomy and 11 underwent Billroth I. The mean interval between the first operation and diagnosis of the tumor was 30.6 years.

Results

Twenty-seven patients underwent surgery. The resectability rate was 66.6%. Sixteen total gastrectomies were performed of which six were widened. Two subtotal gastrectomies were performed, which were also widened. The most frequent type of adenocarcinoma was intestinal (22 patients). Four patients presented early tumors and 13 (72.2%) showed serous involvement (pT3-PT4). Overall actuarial survival at 5 years was 22% and was 41.4% in resected patients (p < 0.001). In resected patients survival according to tumoral size was significant (p < 0.05).

Conclusions

Periodic endoscopic surveillance of gastrectomized patients starting 15 years after the initial operation would lead to earlier diagnosis and would improve the resectability rate and survival. The survival rates obtained in patients undergoing total gastrectomy justified the use of this aggressive surgical treatment. Tumoral size was significantly associated with survival.

Key words:
Gastric stump cancer
Gastrectomy
El Texto completo está disponible en PDF
Bibliografía
[1.]
D.C. Balfour.
Factors influencing the life espectancy of patients operated on for gastric ulcer.
Ann Surg, 76 (1922), pp. 405-408
[2.]
M.D. Martínez Torres, A. Miyar.
Aportación de 2 nuevos casos de cáncer gástrico postvagotomía y piloroplastia.
Rev Esp Enf Digest, 72 (1987), pp. 261-263
[3.]
P. Gerhard, I. Schwab, L.D. Gerold, J. Wetscher, A. Klinger, A. Kreczy.
Is there a displasia-carcinoma sequence en rat gastric remnant?.
Dig Dis Sci, (1997), pp. 608-615
[4.]
P. Luukkonen, T. Kalima, E. Kiviloalso.
Decreased Risk of gastric stump carcinoma after partial gastrectomy supplemented with bile diversion.
Hepatogastroenterol, 37 (1990), pp. 171-173
[5.]
L. Greene.
Neoplastic changes in the stomach after gastrectomy.
Surg Gynecol Obstet, 171 (1990), pp. 477-480
[6.]
T. Kamada, S. Kawano, N. Sato, M. Fukuda, H. Fusamoto, H. Abe.
Gastric mucosal blood distribution and its change in healing process of gastric ulcer.
Gastroenterol, 84 (1983), pp. 1541-1546
[7.]
M. Kaminishi, N. Shimizu, S. Shiomoyama, H. Yamaguchi, T. Ogawa, S. Sakai, et al.
Etiology of gastric remnant cancer with special reference to the effects of denervation of the gastric mucosa.
Cancer, 75 (1995), pp. 1490-1496
[8.]
L. Domellof, S. Eriksson, H. Mori, J.H. Weisburger, G.M. Williams.
Effect of bile acid gavage or vagotomy and piloroplasty on gastrointestinal carcinogenesis.
Am J Surg, 142 (1981), pp. 551-554
[9.]
Miwa K, Kamata T, Miyazeki Y, Hattori T. Kinetic changes and experimental carcinogenesis after Billlroth I and Billroth II gastrectomy. Br J Surg; 80: 893-896
[10.]
P. Langhans, M. Bues, R.A. Hager, J. Hohenstein, K.H. Korfsmeier.
Cell-kinetic investigations in the operated rat stomach to show the influence of duodenogastric reflux. An experimental long-term study.
Scand J Gastroenterol, 92 (1984), pp. 57-90
[11.]
P.C.H. Watt, J.M. Choan, J.D. Donaldson, C.C. Patterson, T.L. Kennedy.
Relationship between histology and gastric juice pH and nitrite in the stomach after operation for duodenal ulcer.
Gut, 25 (1984), pp. 246-252
[12.]
W.S. Ruddel, E.S. Bone, M.J. Hill, L.M. Blendis, C.L. Walters.
Gastric juice nitrite: a risk factor for cancer in the hypochlorohydric stomach.
Lancet, 2 (1976), pp. 1039-1047
[13.]
T.J. Muscroft, S.A. Deane, D. Youngs, D.W. Burdon.
The microflora of the postoperative stomach.
Br J Surg, 68 (1981), pp. 560-564
[14.]
P. Piso, H.J. Meyer, C. Edris, J. Jöhne.
Surgical therapy of gastric stump carcinoma. A retrospective analysis of 109 patients.
Hepatogastroenterol, 46 (1999), pp. 2643-2647
[15.]
A.C. Tersmette, S.N. Goodman, G.J.A. Offarheus.
Multivariate analysis of the risk of stomach cancer after ulcer surgery in an Amsterdarm cohort of post-gastrectomy patients.
Am J Epidemiol, 134 (1991), pp. 14-21
[16.]
F. Lacaine, S. Houry, M. Hughier.
Stomach cancer after partial gastrectomy for benign ulcer disease: a critical analisis of epidemiological reports.
Hepatogastroenterol, 74 (1992), pp. 805-809
[17.]
R. Pointner, G. Schawab, A. Königrainer, E. Bodner, K.W. Schmid.
Gastric stump cancer: etopathological and clinical aspects.
Endoscopy, 21 (1989), pp. 115-119
[18.]
S. Thorban, K. Böttcher, M. Etter, J. Roder, R. Busch, J. Siewert.
Prognostic factors in gastric stump carcinoma.
Ann Surg, 231 (2000), pp. 188-194
[19.]
K. Fukuzawa, Y. Noguchi, A. Matsumoto.
Alterations in DNA proliferation in gastric stump mucosa with special reference to topography.
Surgery, 119 (1996), pp. 191-197
[20.]
K. Kaneko, H. Kondo, D. Saito, K. Shireo, H. Yamaguchi, et al.
Early gastric stump cancer following distal gastrectomy.
Gut, 43 (1998), pp. 342-344
[21.]
J.C. Nicholls.
Stump cancer following gastric surgery.
World J Surg, 3 (1979), pp. 731-736
[22.]
K. Hioki, Y. Nakena, M. Yamamoto.
Surgical strategy for early gastric cancer.
Br J Surg, 77 (1990), pp. 1330-1334
[23.]
Y. Yonemura, Y. Ninomiya, K. Tsugawa.
Limph node metastases from carcinoma of the gastric stump.
Hepatogastroenterol, 41 (1994), pp. 248-252
[24.]
R. Pointner, G. Xchwab, E. Köningstrainer.
Early cancer of the gastric remnant.
Gut, 29 (1988), pp. 298-301
[25.]
Y. Yonemura, K. Sugiyama, T. Fujimura, T. Kamata, T. Sawa, T. Takashima, et al.
A new surgical technique (left upper abdominal evisceration) for advanced carcinoma of the gastric stump.
Hepatogastroenterol, 41 (1994), pp. 130-133
[26.]
A. Viste, G.E. Edie, C. Real, et al.
Cancer of the gastric stump; analyses of 819 patients and comparison with other stomach cancer patients.
World J Surg, 10 (1986), pp. 454-461
[27.]
M. Lawrence, M.H. Shiu.
Early gastric cancer. Twenty-eight year experience.
Ann Surg, 213 (1991), pp. 327-334
[28.]
C. Stael Von Holstein, E. Hammar, S. Eriksson, B. Huldt.
Clinical significance of dysplasia in gastric remnant biopsy specimens.
Cancer, 72 (1993), pp. 1532-1535
[29.]
M. Sasako, K. Maruyama, T. Kinoshita, K. Okabayashi.
Surgical treatment of carcinoma of the gastric stump.
Br J Surg, 78 (1991), pp. 822-824
[30.]
C. Stael Von Holstein, S. Eriksson, E. Hammar.
Role of re-resection in early gastric stump carcinoma.
Br J Surg, 78 (1991), pp. 1238-1241
[31.]
H. Isozaki, N. Tanaka, K. Fuji, E. Nomura, N. Tanigawa.
Surgical treatment for advanced carcinoma of the gastric remnant.
Hepatogastroenterol, 45 (1998), pp. 1896-1900
Copyright © 2001. Asociación Española de Cirujanos
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos